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    • 5. 发明申请
    • Soluble recombinant alphavbeta3 adhesion receptor
    • 可溶性重组脂蛋白3粘附受体
    • US20050130137A1
    • 2005-06-16
    • US10460672
    • 2003-10-31
    • Simon GoodmanBeate DieffenbachDetlef GussowRaj MehtaEilish CullenAlex Brown
    • Simon GoodmanBeate DieffenbachDetlef GussowRaj MehtaEilish CullenAlex Brown
    • C12N15/09C07K1/22C07K14/705C12N15/12C12P21/02C12R1/91C12Q1/68C07H21/04
    • C07K14/70557C12N2799/026
    • The invention relates to a novel purified recombinant αVβ3 adhesion receptor which shows an unimpaired ligand binding activity, and a process for preparing said soluble non-membrane bound receptor in excellent yields by recombinant techniques using a baculovirus-insect cell expression system. The so-synthesized soluble receptor may be used very easily as screening tool for new therapeutic compounds which may inhibit the natural αvβ3 adhesion receptor. Such therapeutic compounds which can be discovered very easily, fast and without health risk by means of the souluble receptors according to the invention may be, for example, RGD peptides or non-peptidic compounds mimicking the natural ligand epitopes. The invention relates, furthermore, to a corresponding process for preparing recombinant full-length αVβ3 adhesion receptor in excellent yields, additionally using detergents to dissolve the membrane bound receptor from the surface of the host cell.
    • 本发明涉及一种显示出未受损配体结合活性的新型纯化的重组α3 N 3 3 N 3粘附受体,以及制备所述可溶性非膜结合受体的方法 通过使用杆状病毒 - 昆虫细胞表达系统的重组技术获得。 如此合成的可溶性受体可以非常容易地用作可能抑制天然α3β3粘附受体的新的治疗化合物的筛选工具。 可以通过根据本发明的灵魂受体非常容易,快速且没有健康风险发现的这种治疗化合物可以是例如RGD肽或模仿天然配体表位的非肽化合物。 此外,本发明还涉及以优异的产率制备重组全长α1 H 3β3 N粘附受体的相应方法,另外使用洗涤剂将膜结合受体从 宿主细胞的表面。
    • 8. 发明申请
    • MULTI-ACTION DRAIN CLEANING COMPOSITION AND METHOD
    • 多功能排水清洁组合物和方法
    • US20090263884A1
    • 2009-10-22
    • US12107578
    • 2008-04-22
    • RAJ MEHTA
    • RAJ MEHTA
    • C12N1/20C11D7/06C11D10/00
    • C11D7/06C11D3/0052C11D3/044C11D3/1206C11D3/381C11D3/3902C11D7/02C11D7/46C12N1/20
    • The present invention relates to aspects of drain cleaning compositions, methods, and systems involving multiple levels of attack to facilitate decomposition of clogs in pipe systems. Aspects of the invention relate to a multi-action drain cleaning composition including chemical and biological components capable of producing an exothermic reaction, an oxidation reaction, and an enzymatic reaction. Generally, the chemical components act immediately to clear a clog in a pipe system and the biological components act over a longer period of time to provide longer-term maintenance of the pipe system. Additional aspects of the invention relate to a composition for use as a component of a multi-action drain cleaner that includes bacteria selectively cultured to subsist in a peroxygen-rich environment, a high-heat environment, and/or a high-pH environment. A bio-film for reducing or preventing a buildup of organic material in a pipe system including a matrix and a selectively cultured bacteria is also provided.
    • 本发明涉及排水清洗组合物,方法和涉及多级攻击以便于分解管道系统中的堵塞物的系统的方面。 本发明的方面涉及包含能够产生放热反应,氧化反应和酶反应的化学和生物成分的多作用排水清洗组合物。 通常,化学组分立即起作用以清除管道系统中的阻塞,并且生物组分在较长时间内作用以提供管道系统的长期维护。 本发明的另外的方面涉及用作多作用排水净化器的组分的组合物,其包括选择性培养以存在于富含氧的环境,高热环境和/或高pH环境中的细菌。 还提供了用于减少或防止在包括基质和选择性培养细菌的管道系统中积聚有机材料的生物膜。