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1. 发明申请

US20110189296A1 BONE SUBSTITUTE CONTAINING POROUS BIO-GLASS AND CALCIUM SULPHATE 审中-公开
标题翻译：含有多孔生物玻璃和硫酸钙的骨髓取代物
公开(公告)号：US20110189296A1
公开(公告)日：2011-08-04
申请号：US13060958
申请日：2009-08-24
申请人： André Rauïs , Rachid Zenati
发明人： André Rauïs , Rachid Zenati
IPC分类号： A61K9/00 , A61K33/06 , A61P43/00
CPC分类号： A61K9/00 , A61K33/06
摘要： The invention relates to a composition for a bone substitute that includes powdery or populated porous bio-glass and powdery alpha hemihydrate calcium sulphate. The invention also relates to an injectable composition for forming a bone substitute that includes said composition of powdery or granulated porous bio-glass and powdery alpha hemihydrate calcium sulphate, with 10 to 50 wt % of added water.
摘要翻译：本发明涉及一种用于骨替代物的组合物，其包括粉末状或多孔的多孔生物玻璃和粉末状的α半水合硫酸钙。本发明还涉及一种用于形成骨替代物的可注射组合物，其包括粉末状或粒状多孔生物玻璃组合物和粉末状α半水合硫酸钙，其中加入10至50重量％的水。

2. 发明申请

US20100094418A1 METHOD FOR PREPARING A COMPOSITE MATERIAL, RESULTING MATERIAL AND USE THEREOF 审中-公开
标题翻译：制备复合材料的方法，材料和材料的使用
公开(公告)号：US20100094418A1
公开(公告)日：2010-04-15
申请号：US12527080
申请日：2008-02-13
申请人： Rachid Zenati , Elodie Pacard
发明人： Rachid Zenati , Elodie Pacard
IPC分类号： A61F2/02 , A61K47/34 , B29C39/36
CPC分类号： A61L27/58 , A61L27/446 , A61L27/46 , C03C3/097 , C03C4/0007 , C03C14/008 , C03C2214/12 , C03C2214/17 , C08J3/215 , C08L67/04
摘要： The invention relates to a method for preparing a composite material having a homogeneous composition, containing at least one bioactive ceramic phase and at least one bioresorbable polymer. The inventive method is characterised in that it comprises the following steps: a) a bioactive ceramic phase in powder form is obtained, b) the bioactive ceramic powder is suspended in a solvent, c) a bioresorbable polymer is added to the suspension obtained in (b) and mixed to produce a viscous homogeneous dispersion of said bioactive ceramic powder in a solution formed by the solvent and the polymer, and d) the dispersion obtained in (c) is precipitated in an aqueous solution in order to obtain a homogeneous composite material. The invention also relates to the resulting composite material and to the use thereof in the production of implantable medical devices.
摘要翻译：本发明涉及一种制备具有均匀组成的复合材料的方法，该复合材料含有至少一种生物活性陶瓷相和至少一种生物可再吸收的聚合物。本发明的方法的特征在于其包括以下步骤：a）获得粉末形式的生物活性陶瓷相，b）将生物活性陶瓷粉末悬浮在溶剂中，c）将生物可再吸收的聚合物加入到（ b）并混合以将所述生物活性陶瓷粉末粘稠均匀分散在由溶剂和聚合物形成的溶液中，和d）将（c）中得到的分散体在水溶液中沉淀，以获得均匀的复合材料。本发明还涉及所得到的复合材料及其在生产可植入医疗器械中的用途。

3. 发明授权

US07709081B2 Porous bioactive glass and preparation method thereof 失效
标题翻译：多孔生物活性玻璃及其制备方法
公开(公告)号：US07709081B2
公开(公告)日：2010-05-04
申请号：US11658161
申请日：2005-07-25
申请人： Rachid Zenati , Gilbert Fantozzi , Jerome Chevalier , Mourad Arioua
发明人： Rachid Zenati , Gilbert Fantozzi , Jerome Chevalier , Mourad Arioua
IPC分类号： B32B17/06 , B32B3/00 , C03C3/076 , C03B19/01
CPC分类号： A61L27/10 , A61L27/56 , Y10T428/249956 , Y10T428/249969 , Y10T428/24997 , Y10T428/249978 , Y10T428/249981
摘要： The invention relates to porous bioglass and to the preparation method thereof. More specifically, the invention relates to a solid, porous crystalline or partially-crystalline composition containing at least SiO2, Ca O , Na2O, and P2O5, comprising micropores and macropores. The invention is characterised in that: the pore ratio varies between 50% and 80%, preferably between 60 and 75%, and is measured using the geometric method; the average diameter of the macropores varies between 100 and 1250 micrometers, preferably between 150 and 300 micrometers; the average diameter of the micropores is less than or equal to 5 micrometers; and the compression strength varies between 7 MPa and 70 MPa. The invention also relates to the method of preparing one such composition and to such a composition treated with a physiological liquid having an ionic composition similar to that of human plasma. The invention also relates to an implant which is made from one such composition.
摘要翻译：本发明涉及多孔生物玻璃及其制备方法。更具体地说，本发明涉及至少包含SiO 2，Ca 3 O 3，Na 2 O和P 2 O 5的固体，多孔结晶或部分结晶组合物，其包含微孔和大孔。本发明的特征在于：孔比在50％至80％之间变化，优选在60至75％之间，并使用几何方法测量; 大孔的平均直径在100和1250微米之间变化，优选在150和300微米之间; 微孔的平均直径小于或等于5微米; 压缩强度在7MPa〜70MPa之间变化。本发明还涉及制备一种这样的组合物的方法和用具有类似于人血浆的离子组成的生理液体处理的这种组合物的方法。本发明还涉及由一种这样的组合物制成的植入物。

4. 发明申请

US20080038534A1 Porous Bioactive Glass And Preparation Method Thereof 失效
标题翻译：多孔生物玻璃及其制备方法
公开(公告)号：US20080038534A1
公开(公告)日：2008-02-14
申请号：US11658161
申请日：2005-07-25
申请人： Rachid Zenati , Gilbert Fantozzi , Jerome Chevalier , Mourad Arioua
发明人： Rachid Zenati , Gilbert Fantozzi , Jerome Chevalier , Mourad Arioua
IPC分类号： C03C3/097 , B32B17/06 , B32B3/00 , C03C3/04
CPC分类号： A61L27/10 , A61L27/56 , Y10T428/249956 , Y10T428/249969 , Y10T428/24997 , Y10T428/249978 , Y10T428/249981
摘要： The invention relates to porous bioglass and to the preparation method thereof. More specifically, the invention relates to a solid, porous crystalline or partially-crystalline composition containing at least SiO2, Ca O , Na2O, and P2O5, comprising micropores and macropores. The invention is characterised in that: the pore ratio varies between 50% and 80%, preferably between 60 and 75%, and is measured using the geometric method; the average diameter of the macropores varies between 100 and 1250 micrometers, preferably between 150 and 300 micrometers; the average diameter of the micropores is less than or equal to 5 micrometers; and the compression strength varies between 7 MPa and 70 MPa. The invention also relates to the method of preparing one such composition and to such a composition treated with a physiological liquid having an ionic composition similar to that of human plasma. The invention also relates to an implant which is made from one such composition.
摘要翻译：本发明涉及多孔生物玻璃及其制备方法。更具体地说，本发明涉及一种固体，多孔结晶或部分结晶组合物，其至少包含SiO 2，Ca 2 O 3，N 2 O 2 和P 2 O 5 O 5，包括微孔和大孔。本发明的特征在于：孔比在50％至80％之间变化，优选在60至75％之间，并使用几何方法测量; 大孔的平均直径在100和1250微米之间变化，优选在150和300微米之间; 微孔的平均直径小于或等于5微米; 压缩强度在7MPa〜70MPa之间变化。本发明还涉及制备一种这样的组合物的方法和用具有类似于人血浆的离子组成的生理液体处理的这种组合物的方法。本发明还涉及由一种这样的组合物制成的植入物。

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