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1. 发明申请

US20170038365A1 SMALL MOLECULE INHIBITORS OF 8-OXOGUANINE DNA GLYCOSYLASE-1 (OGG1) 审中-公开
标题翻译： 8-OXOGUANINE DNA GLYCOSYLASE-1（OGG1）的小分子抑制剂
公开(公告)号：US20170038365A1
公开(公告)日：2017-02-09
申请号：US15213124
申请日：2016-07-18
申请人： R. Stephen Lloyd , Amanda K. McCullough , Nathan Donley
发明人： R. Stephen Lloyd , Amanda K. McCullough , Nathan Donley
IPC分类号： G01N33/50
CPC分类号： G01N33/5011 , A61K38/16 , C12N9/24 , C12Q1/34 , C12Q1/68 , G01N2333/924 , G01N2500/04 , G01N2500/10
摘要： Disclosed herein are methods of identifying small molecule compounds that are likely to be OGG1 inhibitors, kits that facilitate the performance of the methods, and methods of inhibiting OGG1 in vitro and in vivo.
摘要翻译：本文公开了鉴定可能是OGG1抑制剂的小分子化合物的方法，有助于该方法的实现的试剂盒和在体外和体内抑制OGG1的方法。

2. 发明授权

US06723548B2 DNA repair polypeptides and methods of use 有权
标题翻译： DNA修复多肽和使用方法
公开(公告)号：US06723548B2
公开(公告)日：2004-04-20
申请号：US09864866
申请日：2001-05-23
申请人： R. Stephen Lloyd , Amanda K. McCullough , Khoa Nguyen
发明人： R. Stephen Lloyd , Amanda K. McCullough , Khoa Nguyen
IPC分类号： C12N926
CPC分类号： C12N9/88 , A61K38/00 , C07K2319/00 , C12N9/2497 , C12Y402/99018
摘要： The present invention provides polypeptides having pyrimidine glycosylase activity, preferably, pyrimidine glycosylase/AP lyase activity. The polypeptides include a targeting sequence, preferably an exogenous target sequence. The invention includes polynucleotides that include a coding sequence encoding the polypeptides of the present invention. Also provided by the invention are methods of using the polypeptides.
摘要翻译：本发明提供了具有嘧啶糖基化酶活性的多肽，优选嘧啶糖基化酶/ AP裂合酶活性。多肽包括靶向序列，优选外源靶序列。本发明包括包含编码本发明多肽的编码序列的多核苷酸。本发明还提供了使用多肽的方法。

3. 发明授权

US08715927B2 Inhibition of DNA polymerases to augment chemotherapeutic and antimicrobial agents 失效
标题翻译：抑制DNA聚合酶以增强化学治疗和抗微生物剂
公开(公告)号：US08715927B2
公开(公告)日：2014-05-06
申请号：US13131936
申请日：2009-04-22
申请人： R. Stephen Lloyd , Irina G. Minko , Amanda K. McCullough
发明人： R. Stephen Lloyd , Irina G. Minko , Amanda K. McCullough
IPC分类号： C12Q1/68 , C12Q1/48 , C12N9/10 , C07H21/00 , C07H21/04
CPC分类号： A61K45/06 , A61K31/195 , A61K31/56 , A61K31/70 , A61K33/24 , G01N2333/9126 , G01N2500/02 , A61K2300/00
摘要： Disclosed herein is the identification of human DNA polymerase κ (pol κ) as the polymerase that mediates repair of DNA containing interstrand cros slinks (ICLs). The mechanism of action of a number of chemotherapeutic and antimicrobial agents is the induction of ICLs. Thus, provided herein is a method of enhancing the efficacy of a chemotherapeutic or antimicrobial agent in a subject, including selecting a subject in need of treatment with an ICL -inducing agent and administering to the subject an ICL-inducing agent and a therapeutically effective amount of an inhibitor of pol κ. Also provided is a composition for treating a hyperproliferative disease, an autoimmune disease or an infectious disease, comprising an ICL-inducing agent and an amount of an inhibitor of pol κ sufficient to enhance the efficacy of the ICL-inducing agent. Further provided is a method of identifying a DNA polymerase inhibitor.
摘要翻译：本文公开了人DNA聚合酶的鉴定; （pol＆kgr））作为介导修复含有串联链的DNA（ICL）的聚合酶。许多化学治疗和抗微生物剂的作用机制是ICL的诱导。因此，本文提供的是提高受试者中化学治疗剂或抗微生物剂的功效的方法，包括选择需要用ICL诱导剂治疗的受试者，并向受试者施用ICL诱导剂和治疗有效量的抑制剂。还提供了用于治疗过度增殖性疾病，自身免疫性疾病或感染性疾病的组合物，其包含ICL诱导剂和一定量的抑制剂，足以增强ICL诱导剂的功效。进一步提供鉴定DNA聚合酶抑制剂的方法。

4. 发明申请

US20110236507A1 INHIBITION OF DNA POLYMERASES TO AUGMENT CHEMOTHERAPEUTIC AND ANTIMICROBIAL AGENTS 失效
标题翻译： DNA聚合酶对全球化疗与抗菌药物的抑制作用
公开(公告)号：US20110236507A1
公开(公告)日：2011-09-29
申请号：US13131936
申请日：2009-04-22
申请人： R. Stephen Lloyd , Irina G. Minko , Amanda K. McCullough
发明人： R. Stephen Lloyd , Irina G. Minko , Amanda K. McCullough
IPC分类号： A61K33/24 , A61K31/198 , A61K31/675 , A61K31/255 , A61K31/407 , C12Q1/48 , C12Q1/68 , A61P35/00 , A61P31/00
CPC分类号： A61K45/06 , A61K31/195 , A61K31/56 , A61K31/70 , A61K33/24 , G01N2333/9126 , G01N2500/02 , A61K2300/00
摘要： Disclosed herein is the identification of human DNA polymerase κ (pol κ) as the polymerase that mediates repair of DNA containing interstrand cros slinks (ICLs). The mechanism of action of a number of chemotherapeutic and antimicrobial agents is the induction of ICLs. Thus, provided herein is a method of enhancing the efficacy of a chemotherapeutic or antimicrobial agent in a subject, including selecting a subject in need of treatment with an ICL-inducing agent and administering to the subject an ICL-inducing agent and a therapeutically effective amount of an inhibitor of pol κ. Subjects in need of treatment with an ICL-inducing agent, include, for example, subjects diagnosed with a hyperproliferative disease, an autoimmune disease or an infectious disease. Also provided is a composition for treating a hyperproliferative disease, an autoimmune disease or an infectious disease, comprising an ICL-inducing agent and an amount of an inhibitor of pol κ sufficient to enhance the efficacy of the ICL-inducing agent. Further provided is a method of identifying a DNA polymerase inhibitor.
摘要翻译：本文公开了人DNA聚合酶的鉴定; （pol＆kgr））作为介导修复含有串联链的DNA（ICL）的聚合酶。许多化学治疗和抗微生物剂的作用机制是ICL的诱导。因此，本文提供的是提高受试者中化学治疗剂或抗微生物剂的功效的方法，包括选择需要用ICL诱导剂治疗的受试者，并向受试者施用ICL诱导剂和治疗有效量的抑制剂。需要用ICL诱导剂治疗的受试者包括例如被诊断患有过度增殖性疾病，自身免疫性疾病或感染性疾病的受试者。还提供了用于治疗过度增殖性疾病，自身免疫性疾病或感染性疾病的组合物，其包含ICL诱导剂和一定量的抑制剂，足以增强ICL诱导剂的功效。进一步提供鉴定DNA聚合酶抑制剂的方法。

5. 发明申请

US20100322916A1 DNA REPAIR POLYPEPTIDES AND METHODS OF DELIVERY AND USE 审中-公开
标题翻译： DNA修复多肽及其使用方法
公开(公告)号：US20100322916A1
公开(公告)日：2010-12-23
申请号：US12865213
申请日：2009-01-30
申请人： Amanda K. McCullough , R. Stephen Lloyd
发明人： Amanda K. McCullough , R. Stephen Lloyd
IPC分类号： A61K38/47 , C12N9/24 , C07H21/04 , C12N15/63 , C12N5/00 , C12N5/02
CPC分类号： C12Y402/99018 , A61K38/00 , C07K2319/02 , C07K2319/07 , C07K2319/09 , C07K2319/10 , C12N9/2497 , C12N9/88
摘要： Described herein are pyrimidine dimer-specific glycosylase (PDG) polypeptides and methods of use for repair of damaged DNA. The PDG polypeptides comprise amino acid sequence from T4-PDG, CV-PDG or engineered mutants thereof. The PDG polypeptides further comprise a targeting sequence, such as a nuclear targeting sequence or a mitochondrial targeting sequence, and a protein transduction domain. The mutant PDG polypeptides described herein retain at least some catalytic activity while exhibiting reduced cytotoxicity in wild-type cells.
摘要翻译：本文描述的是嘧啶二聚体特异性糖基化酶（PDG）多肽和用于修复受损DNA的方法。 PDG多肽包含来自T4-PDG，CV-PDG或其工程改造的突变体的氨基酸序列。 PDG多肽还包含靶向序列，例如核靶向序列或线粒体靶向序列和蛋白转导结构域。本文所述的突变型PDG多肽保留至少一些催化活性，同时在野生型细胞中表现出降低的细胞毒性。

6. 发明授权

US5308762A T4 endonuclease V DNA repair enzyme having specific activity at low salt concentrations 失效
标题翻译： T4内切核酸酶V DNA修复酶在低盐浓度下具有比活性
公开(公告)号：US5308762A
公开(公告)日：1994-05-03
申请号：US827506
申请日：1992-01-27
申请人： R. Stephen Lloyd
发明人： R. Stephen Lloyd
IPC分类号： C12N9/22
CPC分类号： C12N9/22
摘要： A T4 endonuclease V DNA repair enzyme contains an amino acid sequence within its carboxyl terminal region which is involved in dimer specific binding. The region includes polar nonaromatic basic amino acids and aromatic amino acids between amino acid 128 to 137 positions. The specific activity of the enzyme is greatly increased at low salt concentrations when substitutions are made in aromatic amino acids in the carboxy terminal region.
摘要翻译： T4内切核酸酶V DNA修复酶在其羧基末端区域内含有涉及二聚体特异性结合的氨基酸序列。该区域包括极性非芳族碱性氨基酸和氨基酸128至137位置之间的芳香族氨基酸。当在羧基末端区域中的芳族氨基酸进行取代时，酶的比活性在低盐浓度下大大增加。

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