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1. 发明授权

US6159686A Up-converting reporters for biological and other assays 失效
标题翻译：升级转化记者进行生物和其他测定
公开(公告)号：US6159686A
公开(公告)日：2000-12-12
申请号：US016402
申请日：1998-01-30
申请人： Keith W. Kardos , R. Sam Niedbala , Jarrett Lee Burton , David E. Cooper , David A. Zarling , Michel J. Rossi , Norman A. Peppers , James Kane , Gregory W. Faris , Mark J. Dyer , Steve Y. Ng , Luke V. Schneider
发明人： Keith W. Kardos , R. Sam Niedbala , Jarrett Lee Burton , David E. Cooper , David A. Zarling , Michel J. Rossi , Norman A. Peppers , James Kane , Gregory W. Faris , Mark J. Dyer , Steve Y. Ng , Luke V. Schneider
IPC分类号： C12Q1/68 , C40B60/14 , G01N15/14 , G01N21/64 , G01N33/533 , G01N33/542 , G01N33/58 , C07H21/02 , C07H21/04 , C07K16/00 , G01N33/53 , H05B33/00
CPC分类号： G01N21/6452 , B01J2219/00315 , B01J2219/00605 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00635 , B01J2219/00637 , B01J2219/00648 , B01J2219/00659 , B01J2219/00707 , B82Y15/00 , C12Q1/6816 , C12Q1/6818 , C40B60/14 , G01N21/6428 , G01N21/645 , G01N21/6454 , G01N33/533 , G01N33/542 , G01N33/582 , G01N33/588 , G01N2015/149 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441 , C12Q2563/00 , C12Q2563/107 , C12Q2537/143
摘要： The invention provides methods, compositions, and apparatus for performing sensitive detection of analytes, such as biological macromolecules and other analytes, by labeling a probe molecule with an up-converting label. The up-converting label absorbs radiation from an illumination source and emits radiation at one or more higher frequencies, providing enhanced signal-to-noise ratio and the essential elimination of background sample autofluorescence. The methods, compositions, and apparatus are suitable for the sensitive detection of multiple analytes and for various clinical and environmental sampling techniques.
摘要翻译：本发明提供了通过用上转换标记标记探针分子来进行分析物例如生物大分子和其它分析物的敏感检测的方法，组合物和装置。上变换标签吸收来自照明源的辐射并以一个或多个更高频率发射辐射，提供增强的信噪比和基本消除背景样品自发荧光。方法，组合物和装置适用于多种分析物的敏感检测和各种临床和环境取样技术。

2. 发明申请

US20110152850A1 DEVICES AND METHODS FOR DISPENSING A CRYOGENIC FLUID 审中-公开
标题翻译：用于分配低温流体的装置和方法
公开(公告)号：US20110152850A1
公开(公告)日：2011-06-23
申请号：US12974430
申请日：2010-12-21
申请人： R. Sam NIEDBALA , Lincoln C. YOUNG , Peng ZHOU
发明人： R. Sam NIEDBALA , Lincoln C. YOUNG , Peng ZHOU
IPC分类号： A61B18/02 , F16K1/00 , B67D3/00
CPC分类号： A61B18/0218 , A61B2018/0275 , F17C2201/0109 , F17C2201/058 , F17C2203/0604 , F17C2203/0617 , F17C2203/0619 , F17C2203/0639 , F17C2203/0646 , F17C2203/066 , F17C2203/069 , F17C2205/0115 , F17C2205/0126 , F17C2205/032 , F17C2205/0323 , F17C2205/0341 , F17C2205/0382 , F17C2205/0394 , F17C2209/228 , F17C2209/234 , F17C2221/011 , F17C2221/014 , F17C2221/016 , F17C2221/03 , F17C2221/032 , F17C2221/033 , F17C2221/035 , F17C2223/0153 , F17C2223/036 , F17C2260/018 , F17C2270/02
摘要： Self-contained disposable cryosurgical devices dispense a cryogenic fluid, such as a stream of liquid nitrous oxide, carbon dioxide or argon. The cryosurgical devices include a container, including a reservoir containing a cryogenic fluid, a flow passage configured to receive the cryogenic fluid from the reservoir, a valve assembly configured in an ergonomic housing, and a dispensing head. The device further includes at least one filter disposed in the flow passage configured to facilitate the flow of the cryogenic fluid. The valve assembly includes a valve body and valve slide that is actuated to effect the flow of the cryogenic fluid through the flow passage to patient target. The housing includes an activation lever with an eccentric hub that primes the device for use when a container is loaded into the housing and the activation lever is closed.
摘要翻译：独立的一次性冷冻手术装置分配低温流体，例如液体一氧化二氮气流，二氧化碳或氩气。冷冻手术装置包括容器，其包括容纳低温流体的储存器，被配置为从储存器接收低温流体的流动通道，配置在符合人体工程学的壳体中的阀组件和分配头。该装置还包括布置在流动通道中的至少一个过滤器，其配置成促进低温流体的流动。阀组件包括阀体和阀滑块，其被致动以实现低温流体通过流动通道流到患者靶。壳体包括具有偏心轮毂的启动杆，该偏心轮毂在容器被装载到壳体中并且致动杠杆关闭时使该装置用于使用。

3. 发明授权

US07879293B2 Sample collector and test device 有权
标题翻译：样品收集器和测试装置
公开(公告)号：US07879293B2
公开(公告)日：2011-02-01
申请号：US09997023
申请日：2001-11-30
申请人： R. Sam Niedbala , John W. Scott , Peter A. Bourdelle , Hans H. Feindt
发明人： R. Sam Niedbala , John W. Scott , Peter A. Bourdelle , Hans H. Feindt
IPC分类号： G01N33/48
CPC分类号： B01L3/5029 , A61B10/0045 , A61B10/0051 , A61B10/007 , B01L3/5023 , B01L2300/0663 , B01L2300/0835 , B01L2400/0481 , Y10T436/2575
摘要： A sample collector and test device is disclosed. The sample collector and test device may be used together as a diagnostic tool for collecting and assay of analytes contained in a sample. A sample collector is also disclosed which may be used with existing sample containers and or test devices. The sample collector may indicate sample adequacy when a sufficient volume of sample has been collected for assay and may also include a sample retaining feature which retains a portion of expressed sample for confirmatory testing, if desirable. The sample collector may also include a mechanism for expressing sample in a sample collector and/or test device. A test device is also disclosed for retaining and assay of an expressed sample. The disclosed test device may be used with existing sample collectors. In a preferred embodiment, test device is used with a preferred sample collector. Test device may include a locking feature for locking a sample retained on a sample collector or test device may be used to receive expressed sample collected from a syringe or another suitable sample delivery device.
摘要翻译：公开了一种样品收集器和测试装置。样品收集器和测试装置可以一起用作用于收集和测定样品中包含的分析物的诊断工具。还公开了可以与现有样品容器和/或测试装置一起使用的样品收集器。当已经收集足够体积的样品用于测定时，样品收集器可以指示样品充分性，并且如果需要，还可以包括保留一部分表达样品用于确认测试的样品保留特征。样品收集器还可以包括用于在样品收集器和/或测试装置中表达样品的机制。还公开了用于保留和测定表达样品的测试装置。所公开的测试装置可以与现有的样品收集器一起使用。在一个优选实施例中，测试装置与优选的样品收集器一起使用。测试装置可以包括用于锁定保持在样品收集器上的样品的锁定特征，或者测试装置可用于接收从注射器或另一合适的样品输送装置收集的表达样品。

4. 外观设计

USD467665S1 Test device 失效
标题翻译：测试装置
公开(公告)号：USD467665S1
公开(公告)日：2002-12-24
申请号：US29148787
申请日：2001-09-28
申请人： R. Sam Niedbala , John W. Scott , Peter A. Bourdelle , Hans H. Feindt
设计人： R. Sam Niedbala , John W. Scott , Peter A. Bourdelle , Hans H. Feindt

5. 发明授权

US5885789A Solution-based assay for peroxidatively-active substances in bodily fluids 失效
标题翻译：基于溶液的体液中过氧化活性物质的测定
公开(公告)号：US5885789A
公开(公告)日：1999-03-23
申请号：US825670
申请日：1997-03-20
申请人： Keith W. Kardos , R. Sam Niedbala
发明人： Keith W. Kardos , R. Sam Niedbala
IPC分类号： C12Q1/28 , G01N33/72 , C12Q1/00 , G01N33/53
CPC分类号： G01N33/725 , C12Q1/28 , Y10S435/968 , Y10S435/975
摘要： A solution-based assay for determining the presence of peroxidatively-active substance in a bodily fluid is described. The solution-based assay contains a spectrophotometric substrate, a hydroperoxide, a pH 6.0-7.0 buffer, a surfactant, and a solvent such as DMSO, THF, DMF, or mixtures thereof, with the balance of the solution being water. The solution-bascd assay is particularly useful in qualitative and quantitative assays for urinary hemoglobin. Solution-based assay kits and assay methods are also described.
摘要翻译：描述了用于测定体液中过氧化物活性物质的存在的基于溶液的测定法。基于溶液的测定法包含分光光度底物，氢过氧化物，pH 6.0-7.0缓冲液，表面活性剂和溶剂如DMSO，THF，DMF或其混合物，其余溶液为水。溶液 - 基础测定在尿红蛋白的定性和定量测定中特别有用。还描述了基于溶液的测定试剂盒和测定方法。

6. 外观设计

USD681807S1 Devices for dispensing a cryogenic fluid 有权
标题翻译：用于分配低温流体的装置
公开(公告)号：USD681807S1
公开(公告)日：2013-05-07
申请号：US29381620
申请日：2010-12-21
申请人： R. Sam Niedbala , Lincoln C. Young , Peng Zhou , Matthew Sommerfield , Jarrett Seng
设计人： R. Sam Niedbala , Lincoln C. Young , Peng Zhou , Matthew Sommerfield , Jarrett Seng

7. 外观设计

USD474278S1 Test device 失效
公开(公告)号：USD474278S1
公开(公告)日：2003-05-06
申请号：US29167180
申请日：2002-09-11
申请人： R. Sam Niedbala , John W. Scott , Peter A. Bourdelle , Hans H. Feindt
设计人： R. Sam Niedbala , John W. Scott , Peter A. Bourdelle , Hans H. Feindt

8. 外观设计

USD467349S1 Analyzer 失效
标题翻译：分析仪
公开(公告)号：USD467349S1
公开(公告)日：2002-12-17
申请号：US29148789
申请日：2001-09-28
申请人： R. Sam Niedbala , Michael J. Gausling , Philip Michael Formica , John W. Scott
设计人： R. Sam Niedbala , Michael J. Gausling , Philip Michael Formica , John W. Scott

9. 发明申请

US20110120236A1 SAMPLE COLLECTOR AND TEST DEVICE 有权
标题翻译：样品收集器和测试装置
公开(公告)号：US20110120236A1
公开(公告)日：2011-05-26
申请号：US13017324
申请日：2011-01-31
申请人： R. Sam NIEDBALA , John W. SCOTT , Peter A. BOURDELLE , Hans A. FEINDT
发明人： R. Sam NIEDBALA , John W. SCOTT , Peter A. BOURDELLE , Hans A. FEINDT
IPC分类号： G01N1/10
CPC分类号： B01L3/5029 , A61B10/0045 , A61B10/0051 , A61B10/007 , B01L3/5023 , B01L2300/0663 , B01L2300/0835 , B01L2400/0481 , Y10T436/2575
摘要： A sample collector and test device is disclosed. The sample collector and test device may be used together as a diagnostic tool for collecting and assay of analytes contained in a sample. A sample collector is also disclosed which may be used with existing sample containers and or test devices. The sample collector may indicate sample adequacy when a sufficient volume of sample has been collected for assay and may also include a sample retaining feature which retains a portion of expressed sample for confirmatory testing, if desirable. The sample collector may also include a mechanism for expressing sample in a sample collector and/or test device. A test device is also disclosed for retaining and assay of an expressed sample. The disclosed test device may be used with existing sample collectors. In a preferred embodiment, test device is used with a preferred sample collector. Test device may include a locking feature for locking a sample retained on a sample collector or test device may be used to receive expressed sample collected from a syringe or another suitable sample delivery device.
摘要翻译：公开了一种样品收集器和测试装置。样品收集器和测试装置可以一起用作用于收集和测定样品中包含的分析物的诊断工具。还公开了可以与现有样品容器和/或测试装置一起使用的样品收集器。当已经收集足够体积的样品用于测定时，样品收集器可以指示样品充分性，并且如果需要，还可以包括保留一部分表达样品用于确认测试的样品保留特征。样品收集器还可以包括用于在样品收集器和/或测试装置中表达样品的机制。还公开了用于保留和测定表达样品的测试装置。所公开的测试装置可以与现有的样品收集器一起使用。在一个优选实施例中，测试装置与优选的样品收集器一起使用。测试装置可以包括用于锁定保持在样品收集器上的样品的锁定特征，或者测试装置可用于接收从注射器或另一合适的样品输送装置收集的表达样品。

10. 发明授权

US07858396B2 Lateral flow assay device with multiple equidistant capture zones 有权
标题翻译：具有多个等距捕获区域的侧流测定装置
公开(公告)号：US07858396B2
公开(公告)日：2010-12-28
申请号：US11589943
申请日：2006-10-31
申请人： Paul L.A.M. Corstjens , Keith Kardos , R. Sam Niedbala , Hans J. Tanke , Michel Zuiderwijk , Hans H. Feindt , Vijay K. Mokkapati , Jess Aaron Kimball
发明人： Paul L.A.M. Corstjens , Keith Kardos , R. Sam Niedbala , Hans J. Tanke , Michel Zuiderwijk , Hans H. Feindt , Vijay K. Mokkapati , Jess Aaron Kimball
IPC分类号： G01N33/53
CPC分类号： G01N33/558 , G01N33/54386 , Y10S435/805 , Y10S435/823 , Y10S436/807 , Y10S436/823 , Y10T436/25125
摘要： A lateral flow test strip for the analysis of a sample featuring numerous capture zones arranged in an array such that each capture zone is substantially equidistant from the sample containing area. The sample does not pass through another capture zone to reach any one of the other capture zones. The capture zones are preferably arranged in a linear array perpendicular to the flow of the sample through the lateral flow test strip. The lateral flow test strip allows for an increased number of simultaneous analyses of numerous analytes from one sample to occur on one lateral flow test strip.
摘要翻译：一种横向流动测试条，用于分析具有排列成阵列的多个捕获区域的样品，使得每个捕获区域与样品容纳区域基本上等距。样品不通过另一个捕获区域以到达任何其他捕获区域。捕获区优选地被布置成垂直于通过横向流动测试条的样品流动的线性阵列。侧流测试条允许在一个侧向流动测试条上发生来自一个样品的许多分析物的同时分析的更多数量。

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