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1. 发明授权

US4883794A Pyrrolo(1,2-b)cinnolines 失效
标题翻译：吡咯（1,2-b）噌啉
公开(公告)号：US4883794A
公开(公告)日：1989-11-28
申请号：US286396
申请日：1988-12-19
申请人： R. Russell L. Hamer , Richard C. Effland , Joseph T. Klein
发明人： R. Russell L. Hamer , Richard C. Effland , Joseph T. Klein
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： There are described pyrrolo[1,2-b] cinnolines having formula ##STR1## where R.sub.1 when present is hydrogen, loweralky, arylloweralkyl or --CH.sub.2 CO.sub.2 C.sub.2 H.sub.5 ; is hydrogen, loweralkyl, arylloweralkyl, chlorine, bromine, iodine, formyl, nitro, --CH.dbd.CR.sub.3 R.sub.4 or --CH.sub.2 CHR.sub.3 R.sub.4, R.sub.3 and R.sub.4 being independently hydrogen, loweralkyl, aryl or arylloweralkyl; X is oxygen, amino, loweralkylamino, arylloweralkylamino or methoxy; and Y is hydrogen, flourine, chlorine, bromine, iodine, trifluoromethyl or nitro, and pharmaceutically acceptable acid addition salts thereof which are useful as analgesic agents and as enhancers of cholinergic function and hence for the treatment of memory dysfunctions and senile demetia's such as Alzheimer's disease characterized by diminished cholinergic function.
摘要翻译：描述了具有式“IMAGE”的吡咯并[1,2-b]噌啉，其中R 1当存在时是氢，低级烷基，芳基低级烷基或-CH 2 CO 2 C 2 H 5; 芳基低级烷基，氯，溴，碘，甲酰基，硝基，-CH = CR 3 R 4或-CH 2 CHR 3 R 4，R 3和R 4独立地是氢，低级烷基，芳基或芳基低级烷基; X是氧，氨基，低级烷基氨基，芳基低级烷基氨基或甲氧基; 和Y是氢，氟，氯，溴，碘，三氟甲基或硝基，以及其药学上可接受的酸加成盐，其可用作止痛剂和作为胆碱能功能的增强剂，因此用于治疗记忆功能障碍和老年脱氨如阿尔茨海默病以胆碱能功能下降为特征的疾病。

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