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1. 发明申请

US20120157495A1 BENZIMIDAZOLE DERIVATIVES 有权
标题翻译：苯并咪唑衍生物
公开(公告)号：US20120157495A1
公开(公告)日：2012-06-21
申请号：US13404169
申请日：2012-02-24
申请人： Michael J. MUNCHHOF , Lawrence A. Reiter , Susan D. La Greca , Christopher S. Jones , Qifang Li
发明人： Michael J. MUNCHHOF , Lawrence A. Reiter , Susan D. La Greca , Christopher S. Jones , Qifang Li
IPC分类号： A61K31/454 , A61P35/02 , A61P35/00
CPC分类号： C07D401/12 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D471/04
摘要： The present invention relates to a compound of the Formula I or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3A, R3B, R4, R5, X, m, and n are as defined herein. Such novel benzamidazole derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
摘要翻译：本发明涉及式I化合物或其药学上可接受的盐，其中R1，R2，R3A，R3B，R4，R5，X，m和n如本文所定义。这种新型苯甲胺唑衍生物可用于治疗哺乳动物中异常细胞生长，如癌症。本发明还涉及使用这些化合物治疗哺乳动物，特别是人类异常细胞生长的方法以及含有这些化合物的药物组合物。

2. 发明授权

US08148401B2 Benzimidazole derivatives 有权
标题翻译：苯并咪唑衍生物
公开(公告)号：US08148401B2
公开(公告)日：2012-04-03
申请号：US12142119
申请日：2008-06-19
申请人： Michael J. Munchhof , Lawrence A. Reiter , Susan D. La Greca , Christopher S. Jones , Qifang Li
发明人： Michael J. Munchhof , Lawrence A. Reiter , Susan D. La Greca , Christopher S. Jones , Qifang Li
IPC分类号： A61K31/454 , A61K31/4545 , C07D401/04 , C07D401/14
CPC分类号： C07D401/12 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D471/04
摘要： The present invention relates to a compound of the Formula I or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3A, R3B, R4, R5, X, m, and n are as defined herein. Such novel benzamidazole derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
摘要翻译：本发明涉及式I化合物或其药学上可接受的盐，其中R1，R2，R3A，R3B，R4，R5，X，m和n如本文所定义。这种新型苯甲胺唑衍生物可用于治疗哺乳动物中异常细胞生长，如癌症。本发明还涉及使用这些化合物治疗哺乳动物，特别是人类异常细胞生长的方法以及含有这些化合物的药物组合物。

3. 发明授权

US08431597B2 Benzimidazole derivatives 有权
标题翻译：苯并咪唑衍生物
公开(公告)号：US08431597B2
公开(公告)日：2013-04-30
申请号：US13404169
申请日：2012-02-24
申请人： Michael J. Munchhof , Lawrence A. Reiter , Susan D. La Greca , Christopher S. Jones , Qifang Li
发明人： Michael J. Munchhof , Lawrence A. Reiter , Susan D. La Greca , Christopher S. Jones , Qifang Li
IPC分类号： C07D401/04 , A61K31/4439
CPC分类号： C07D401/12 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D471/04
摘要： The present invention relates to a compound of the Formula I or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3A, R3B, R4, R5, X, m, and n are as defined herein. Such novel benzamidazole derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
摘要翻译：本发明涉及式I化合物或其药学上可接受的盐，其中R1，R2，R3A，R3B，R4，R5，X，m和n如本文所定义。这种新型苯甲胺唑衍生物可用于治疗哺乳动物中异常细胞生长，如癌症。本发明还涉及使用这些化合物治疗哺乳动物，特别是人类异常细胞生长的方法以及含有这些化合物的药物组合物。

4. 发明申请

US20100029615A1 BENZIMIDAZOLE DERIVATIVES 审中-公开
标题翻译：苯并咪唑衍生物
公开(公告)号：US20100029615A1
公开(公告)日：2010-02-04
申请号：US12518970
申请日：2007-12-05
申请人： Michael John Munchhof , Lawrence Alan Reiter , Andrei Shavnya , Christopher Scott Jones , Qifang Li , Robert Gerald Linde ll
发明人： Michael John Munchhof , Lawrence Alan Reiter , Andrei Shavnya , Christopher Scott Jones , Qifang Li , Robert Gerald Linde ll
IPC分类号： A61K31/55 , A61K31/538 , A61K31/4709 , A61K31/4178 , C07D403/12 , C07D413/12 , C07D401/12
CPC分类号： C07D235/14
摘要： The present invention relates to a compound of the formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, A, X, n, and are as defined herein. Such novel benzamidazole derivatives are useful in trv treatment of abnormal cell growth, such as cancer, in mammals. This invention ate relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing sue compounds.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，其中R1，R2，R3，R4，R5，A，X，n和如本文所定义。这种新型苯甲胺唑衍生物可用于治疗哺乳动物中异常细胞生长，如癌症。本发明涉及使用这些化合物治疗哺乳动物，特别是人类异常细胞生长的方法以及含有绥玲化合物的药物组合物。

5. 发明授权

US09218393B2 Hierarchical data server 有权
标题翻译：分层数据服务器
公开(公告)号：US09218393B2
公开(公告)日：2015-12-22
申请号：US13862546
申请日：2013-04-15
申请人： Qifang Li
发明人： Qifang Li
IPC分类号： G06F7/00 , G06F17/30
CPC分类号： G06F17/30477 , G06F17/30929
摘要： A hierarchical data server provides a query and storage system for hierarchical data with three interfaces that are, data interface for accepting hierarchical data, query interface for accepting a query, and result interface for returning output of the query. The system models hierarchical data with one data object called data vine and one data structure type called data vine list. A data vine includes a name, a property list, and a child list. A data vine list is an ordered list of data vines. A data vine is recursively defined with its child list as a data vine list. The system introduces five basic operators, cast, restrict, unique, sort, and traverse. Each operator acts on one data vine list and returns another data vine list. A property list in a data vine is unordered with set operations implemented, which include default operation, update operation, elimination operation, replacement operation, and intersection operation.
摘要翻译：层次数据服务器为层次数据提供了一个查询和存储系统，它具有三个接口，即接受层次数据的数据接口，用于接受查询的查询接口，以及用于返回查询输出的结果接口。该系统用一个称为数据藤的数据对象和一种称为数据树列表的数据结构类型来建模层次数据。数据藤包括名称，属性列表和子列表。数据藤列表是数据葡萄树的有序列表。数据藤被递归定义为其子列表作为数据藤列表。系统介绍了五种基本操作符，即转换，限制，唯一，排序和遍历。每个操作员对一个数据树列表进行操作，并返回另一个数据树列表。数据藤中的属性列表无序，实现了设置操作，包括默认操作，更新操作，删除操作，替换操作和交叉操作。

6. 发明申请

US20090005416A1 BENZIMIDAZOLE DERIVATIVES 有权
标题翻译：苯并咪唑衍生物
公开(公告)号：US20090005416A1
公开(公告)日：2009-01-01
申请号：US12142119
申请日：2008-06-19
申请人： Michael J. Munchhof , Lawrence A. Reiter , Susan D. La Greca , Christopher S. Jones , Qifang Li
发明人： Michael J. Munchhof , Lawrence A. Reiter , Susan D. La Greca , Christopher S. Jones , Qifang Li
IPC分类号： A61K31/4545 , C07D401/12 , A61K31/454 , A61P35/00
CPC分类号： C07D401/12 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D471/04
摘要： The present invention relates to a compound of the Formula I or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3A, R3B, R4, R5, X, m, and n are as defined herein. Such novel benzamidazole derivatives are useful in the treatment of abnormal cell growth, such as cancer, in mammals. This invention also relates to a method of using such compounds in the treatment of abnormal cell growth in mammals, especially humans, and to pharmaceutical compositions containing such compounds.
摘要翻译：本发明涉及式I化合物或其药学上可接受的盐，其中R1，R2，R3A，R3B，R4，R5，X，m和n如本文所定义。这种新型苯甲胺唑衍生物可用于治疗哺乳动物中异常细胞生长，如癌症。本发明还涉及使用这些化合物治疗哺乳动物，特别是人类异常细胞生长的方法以及含有这些化合物的药物组合物。

7. 发明申请

US20160051582A1 PHARMACEUTICAL COMPOSITION FOR TREATMENT OF CHRONIC PAIN 审中-公开
标题翻译：用于治疗慢性疼痛的药物组合物
公开(公告)号：US20160051582A1
公开(公告)日：2016-02-25
申请号：US14659608
申请日：2015-03-16
申请人： QIFANG LI , HUA KANG , The Ninth Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
发明人： QIFANG LI , HUA KANG , HONG JIANG
IPC分类号： A61K33/14 , A61K31/7004 , A61K33/00 , A61K31/167
CPC分类号： A61K31/7004 , A61K9/0019 , A61K31/167 , A61K47/02 , A61K47/26
摘要： A pharmaceutical composition for treatment of chronic pain includes lidocaine, glucose, sodium chloride and sodium bicarbonate. The pharmaceutical composition could be applied for treatment of chronic pains in local position such as soft tissue, muscle tendon, synovial bursa.
摘要翻译：用于治疗慢性疼痛的药物组合物包括利多卡因，葡萄糖，氯化钠和碳酸氢钠。药物组合物可用于治疗局部位置的慢性疼痛，例如软组织，肌肉腱，滑液囊。

8. 发明申请

US20140310301A1 Hierarchical Data Server 审中-公开
标题翻译：分层数据服务器
公开(公告)号：US20140310301A1
公开(公告)日：2014-10-16
申请号：US13862546
申请日：2013-04-15
申请人： Qifang Li
发明人： Qifang Li
IPC分类号： G06F17/30
CPC分类号： G06F17/30477 , G06F17/30929
摘要： A hierarchical data server provides a query and storage system for hierarchical data with three interfaces that are, data interface for accepting hierarchical data, query interface for accepting a query, and result interface for returning output of the query. The system models hierarchical data with one data object called data vine and one data structure type called data vine list. A data vine includes a name, a property list, and a child list. A data vine list is an ordered list of data vines. A data vine is recursively defined with its child list as a data vine list. The system introduces five basic operators, cast, restrict, unique, sort, and traverse. Each operator acts on one data vine list and returns another data vine list. A property list in a data vine is unordered with set operations implemented, which include default operation, update operation, elimination operation, replacement operation, and intersection operation.
摘要翻译：层次数据服务器为层次数据提供了一个查询和存储系统，它具有三个接口，即接受层次数据的数据接口，用于接受查询的查询接口，以及用于返回查询输出的结果接口。该系统用一个称为数据藤的数据对象和一种称为数据树列表的数据结构类型来建模层次数据。数据藤包括名称，属性列表和子列表。数据藤列表是数据葡萄树的有序列表。数据藤被递归定义为其子列表作为数据藤列表。系统介绍了五种基本操作符，即转换，限制，唯一，排序和遍历。每个操作员对一个数据树列表进行操作，并返回另一个数据树列表。数据藤中的属性列表无序，实现了设置操作，包括默认操作，更新操作，删除操作，替换操作和交叉操作。

9. 发明授权

US06701516B1 P++ software 有权
标题翻译： P ++软件
公开(公告)号：US06701516B1
公开(公告)日：2004-03-02
申请号：US09605642
申请日：2000-06-28
申请人： Qifang Li
发明人： Qifang Li
IPC分类号： G06F944
CPC分类号： G06F8/313
摘要： P++ software that provides a Prolog language data storing and processing method, includes making a plurality of different application programs, introduces two structure types into arguments of clauses, implements these two structure types in predicate inputting, memory storing, processing through unification and back tracking, and outputting for each query. The first structure type is hierarchically defined and recursively processed. Its member can be a variable, a data term, or of any other structure type except itself. Its variable child member can be substituted by one of this structure type making a result in the same structure type with different length. The second structure type is recursively defined and processed. Its member can be a variable, a data term, or of any structure type including itself. It has fixed number of members. With these two structure types, addition and multiplication are extended to multi-dimensional space operations.
摘要翻译：提供Prolog语言数据存储和处理方法的P ++软件，包括制作多个不同的应用程序，将两种结构类型引入到子句的参数中，在谓词输入，存储器存储，通过统一和后向跟踪处理中实现这两种结构类型，并为每个查询输出。第一种结构类型是分层定义和递归处理的。它的成员可以是一个变量，一个数据项，或任何其他结构类型，除了它本身。它的可变子成员可以被这种结构类型之一所取代，使结果具有不同长度的相同结构类型。第二种结构类型被递归地定义和处理。它的成员可以是一个变量，一个数据术语，或任何结构类型，包括它自己。它有固定数量的成员。使用这两种结构类型，加法和乘法扩展到多维空间操作。

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