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1. 发明申请

US20080262512A1 Thrombolysis In Retinal Vessels With Ultrasound 审中-公开
标题翻译：超声波视网膜血栓溶栓
公开(公告)号：US20080262512A1
公开(公告)日：2008-10-23
申请号：US12061120
申请日：2008-04-02
申请人： Mark S. Humayun , Xiaochen Xu , Qifa Zhou , K. Kirk Shung , Hossein Ameri , Gerald Chader
发明人： Mark S. Humayun , Xiaochen Xu , Qifa Zhou , K. Kirk Shung , Hossein Ameri , Gerald Chader
IPC分类号： A61B17/22
CPC分类号： A61B8/10 , A61B8/08 , A61B8/483 , A61F9/008 , A61F2009/0087 , A61F2009/00878 , A61F2009/00887 , G01N2203/0076 , G01N2203/0658 , G06T7/0012 , G06T2207/10132 , G06T2207/30041
摘要： Systems and methods are described providing for the use of ultrasound energy to effect the dislodging of one or more blood clots inside blood vessels. Such clots can include those inside retinal vessels, especially in patients with central retinal vein occlusion. Embodiments of the present disclosure may be used for any retinal arterial or venous occlusion. In exemplary embodiments, a small probe can be inserted into the eye of a patient and placed over the retinal vessels. Acoustic streaming created by the probe can be directed to an area or region including targeted blood vessels, resulting in increased flow in one or more retinal veins and facilitating or effecting mechanical dislodging of one or more blood clots in the targets blood vessels. Exemplary embodiments can utilize ultrasonic energy produced at a frequency of approximately 44 MHz to 46 MHz with pulse repetition frequencies of approximately 100 Hz to 100 kHz.
摘要翻译：描述了使用超声能量来实现血管内的一个或多个血块的移动的系统和方法。视网膜血管，包括视网膜中央静脉阻塞的患者尤其如此。本公开的实施方案可用于任何视网膜动脉或静脉闭塞。在示例性实施例中，可以将小探针插入患者的眼睛并放置在视网膜血管上。由探针产生的声流可以被引导到包括目标血管的区域或区域，导致一个或多个视网膜静脉中的流量增加并且促进或实现靶血管中的一个或多个血块的机械移除。示例性实施例可以利用大约44MHz至46MHz的频率产生的超声能量，脉冲重复频率约为100Hz至100kHz。

2. 发明授权

US08764666B2 Ultrasound guided optical coherence tomography, photoacoustic probe for biomedical imaging 有权
标题翻译：超声引导光学相干断层扫描，用于生物医学成像的光声探头
公开(公告)号：US08764666B2
公开(公告)日：2014-07-01
申请号：US12607958
申请日：2009-10-28
申请人： Zhongping Chen , Jiechen Yin , Qifa Zhou , Changhong Hu , Hao-Chung Yang , Huihua Kenny Chiang , Kirk K. Shung
发明人： Zhongping Chen , Jiechen Yin , Qifa Zhou , Changhong Hu , Hao-Chung Yang , Huihua Kenny Chiang , Kirk K. Shung
IPC分类号： A61B8/08 , A61B5/00 , A61B8/12
CPC分类号： A61B5/0066 , A61B5/0035 , A61B5/0062 , A61B5/0084 , A61B5/0086 , A61B5/0095 , A61B5/02007 , A61B8/12 , A61B8/4461
摘要： An imaging probe for a biological sample includes an OCT probe and an ultrasound probe combined with the OCT probe in an integral probe package capable of providing by a single scanning operation images from the OCT probe and ultrasound probe to simultaneously provide integrated optical coherence tomography (OCT) and ultrasound imaging of the same biological sample. A method to provide high resolution imaging of biomedical tissue includes the steps of finding an area of interest using the guidance of ultrasound imaging, and obtaining an OCT image and once the area of interest is identified where the combination of the two imaging modalities yields high resolution OCT and deep penetration depth ultrasound imaging.
摘要翻译：用于生物样品的成像探针包括OCT探针和与OCT探针结合的超声波探针，其能够通过单次扫描操作提供来自OCT探针和超声探头的图像，以同时提供集成的光学相干断层扫描（OCT））和超声成像相同的生物样品。提供生物医学组织的高分辨率成像的方法包括以下步骤：使用超声成像的指导找到感兴趣区域，并获得OCT图像，并且一旦识别出感兴趣区域，其中两个成像模态的组合产生高分辨率 OCT和深穿透深度超声成像。

3. 发明授权

US08684935B2 Intraocular ultrasound doppler techniques 有权
标题翻译：眼内超声多普勒技术
公开(公告)号：US08684935B2
公开(公告)日：2014-04-01
申请号：US12102293
申请日：2008-04-14
申请人： Mark S. Humayun , Xiaochen Xu , Qifa Zhou , K. Kirk Shung , Hossein Ameri , Gerald Chader
发明人： Mark S. Humayun , Xiaochen Xu , Qifa Zhou , K. Kirk Shung , Hossein Ameri , Gerald Chader
IPC分类号： A61B8/14
CPC分类号： A61B8/10 , A61B5/6848 , A61B8/06 , A61B8/08 , A61B8/12 , A61B8/483 , A61F9/008 , A61F2009/00863 , G01F1/663
摘要： Systems and methods are disclosed providing for the use of ultrasound energy to measure blood flow within blood vessels by Doppler velocity measurement. Directional high-frequency pulsed-wave Doppler measurements can be made with a suitable ultrasonic needle transducers for in vivo measuring of blood flow. A needle probe can include a ultrasonic material such as PMN-PT. Such blood flow measurements can be made in any part of the body, e.g., in the central retinal vein and branch retinal veins.
摘要翻译：公开的系统和方法提供超声能量的使用以通过多普勒速度测量来测量血管内的血流量。可以使用合适的超声波针换能器进行定向高频脉冲波多普勒测量，用于体内血流量测量。针头可以包括诸如PMN-PT的超声波材料。这种血流测量可以在身体的任何部分进行，例如在视网膜中央静脉和视网膜分支静脉中。

4. 发明申请

US20080319319A1 Intraocular Ultrasound Doppler Techniques 有权
标题翻译：眼内超声多普勒技术
公开(公告)号：US20080319319A1
公开(公告)日：2008-12-25
申请号：US12102293
申请日：2008-04-14
申请人： Mark S. Humayun , Xiaochen Xu , Qifa Zhou , K. Kirk Shung , Hossein Ameri , Gerald Chader
发明人： Mark S. Humayun , Xiaochen Xu , Qifa Zhou , K. Kirk Shung , Hossein Ameri , Gerald Chader
IPC分类号： A61B8/06
CPC分类号： A61B8/10 , A61B5/6848 , A61B8/06 , A61B8/08 , A61B8/12 , A61B8/483 , A61F9/008 , A61F2009/00863 , G01F1/663
摘要： Systems and methods are disclosed providing for the use of ultrasound energy to measure blood flow within blood vessels by Doppler velocity measurement. Directional high-frequency pulsed-wave Doppler measurements can be made with a suitable ultrasonic needle transducers for in vivo measuring of blood flow. A needle probe can include a ultrasonic material such as PMN-PT. Such blood flow measurements can be made in any part of the body, e.g., in the central retinal vein and branch retinal veins.
摘要翻译：公开的系统和方法提供超声能量的使用以通过多普勒速度测量来测量血管内的血流量。可以使用合适的超声波针换能器进行定向高频脉冲波多普勒测量，用于体内血流量测量。针头可以包括诸如PMN-PT的超声波材料。这种血流测量可以在身体的任何部分进行，例如在视网膜中央静脉和视网膜分支静脉中。

5. 发明申请

US20110106052A1 ULTRASONIC POSITIONING DEVICE FOR EPIDURAL SPACE AND METHOD USING THE SAME 审中-公开
标题翻译：用于阑尾空间的超声定位装置和使用该超声波定位装置的方法
公开(公告)号：US20110106052A1
公开(公告)日：2011-05-05
申请号：US12726962
申请日：2010-03-18
申请人： Huihua Kenny CHIANG , Shih-Pin LIN , Chien-Kun TING , Qifa ZHOU , K. Kirk SHUNG
发明人： Huihua Kenny CHIANG , Shih-Pin LIN , Chien-Kun TING , Qifa ZHOU , K. Kirk SHUNG
IPC分类号： A61B6/12 , A61M19/00
CPC分类号： A61B8/12 , A61B5/061 , A61B5/4839 , A61B5/4893 , A61B5/4896 , A61B8/0841 , A61B17/3401 , A61B2017/3413 , A61M19/00 , A61M37/0092
摘要： An ultrasonic positioning device for real time measuring the distance between the epidural needle and the epidural space is provided. The ultrasonic positioning device at least includes an epidural needle having a hollow interior; an ultrasound needle transducer disposed in the hollow interior of the epidural needle and connected to an ultrasonic driving device; and a loss-of-resistance checking syringe connected to the epidural needle so as to confirm whether the epidural needle is inserted into the epidural space.
摘要翻译：提供了用于实时测量硬膜外针和硬膜外腔之间的距离的超声波定位装置。超声波定位装置至少包括具有中空内部的硬膜外针; 设置在硬膜外针的中空内部并连接到超声波驱动装置的超声波针换能器; 以及与硬膜外针连接的电流损失检查注射器，以确认硬膜外针是否插入硬膜外腔。

6. 发明申请

US20110098572A1 ULTRASOUND GUIDED OPTICAL COHERENCE TOMOGRAPHY, PHOTOACOUSTIC PROBE FOR BIOMEDICAL IMAGING 有权
标题翻译：超声引导光学相干摄影，用于生物医学成像的光电探测器
公开(公告)号：US20110098572A1
公开(公告)日：2011-04-28
申请号：US12607958
申请日：2009-10-28
申请人： Zhongping Chen , Jiechen Yin , Qifa Zhou , Changhong Hu , Hao-Chung Yang , Huihua Kenny Chiang , Kirk K. Shung
发明人： Zhongping Chen , Jiechen Yin , Qifa Zhou , Changhong Hu , Hao-Chung Yang , Huihua Kenny Chiang , Kirk K. Shung
IPC分类号： A61B8/14
CPC分类号： A61B5/0066 , A61B5/0035 , A61B5/0062 , A61B5/0084 , A61B5/0086 , A61B5/0095 , A61B5/02007 , A61B8/12 , A61B8/4461
摘要： An imaging probe for a biological sample includes an OCT probe and an ultrasound probe combined with the OCT probe in an integral probe package capable of providing by a single scanning operation images from the OCT probe and ultrasound probe to simultaneously provide integrated optical coherence tomography (OCT) and ultrasound imaging of the same biological sample. A method to provide high resolution imaging of biomedical tissue includes the steps of finding an area of interest using the guidance of ultrasound imaging, and obtaining an OCT image and once the area of interest is identified where the combination of the two imaging modalities yields high resolution OCT and deep penetration depth ultrasound imaging.
摘要翻译：用于生物样品的成像探针包括OCT探针和与OCT探针结合的超声波探针，其能够通过单次扫描操作提供来自OCT探针和超声探头的图像，以同时提供集成的光学相干断层扫描（OCT））和超声成像相同的生物样品。提供生物医学组织的高分辨率成像的方法包括以下步骤：使用超声成像的指导找到感兴趣区域，并获得OCT图像，并且一旦识别出感兴趣区域，其中两个成像模态的组合产生高分辨率 OCT和深穿透深度超声成像。

7. 发明申请

US20140243712A1 THROMBOLYSIS IN RETINAL VESSELS WITH ULTRASOUND 审中-公开
标题翻译：超声波血管内血栓形成
公开(公告)号：US20140243712A1
公开(公告)日：2014-08-28
申请号：US13780535
申请日：2013-02-28
申请人： Mark Humayun , Xiaochen Xu , Qifa Zhou , K. Kirk Shung , Hossein Ameri , Gerald Chader
发明人： Mark Humayun , Xiaochen Xu , Qifa Zhou , K. Kirk Shung , Hossein Ameri , Gerald Chader
IPC分类号： A61N7/00
CPC分类号： A61N7/00 , A61B17/22012 , A61F9/00745 , A61N2007/0047
摘要： Systems and methods are described providing for the use of ultrasound energy to effect the dislodging of one or more blood clots inside blood vessels. Such clots can include those inside retinal vessels, especially in patients with central retinal vein occlusion. Embodiments of the present disclosure may be used for any retinal arterial or venous occlusion. In exemplary embodiments, a small probe can be inserted into the eye of a patient and placed over the retinal vessels. Acoustic streaming created by the probe can be directed to an area or region including targeted blood vessels, resulting in increased flow in one or more retinal veins and facilitating or effecting mechanical dislodging of one or more blood clots in the targets blood vessels. Exemplary embodiments can utilize ultrasonic energy produced at a frequency of approximately 44 MHz to 46 MHz with pulse repetition frequencies of approximately 100 Hz to 100 kHz.
摘要翻译：描述了使用超声能量来实现血管内的一个或多个血块的移动的系统和方法。视网膜血管，包括视网膜中央静脉阻塞的患者尤其如此。本公开的实施方案可用于任何视网膜动脉或静脉闭塞。在示例性实施例中，可以将小探针插入患者的眼睛并放置在视网膜血管上。由探针产生的声流可以被引导到包括目标血管的区域或区域，导致一个或多个视网膜静脉中的流量增加并且促进或实现靶血管中的一个或多个血块的机械移除。示例性实施例可以利用大约44MHz至46MHz的频率产生的超声能量，脉冲重复频率约为100Hz至100kHz。

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