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1. 发明申请

US20100129360A1 ANTIBODIES AGAINST HUMAN INTERLEUKIN-13 AND USES THEREFOR 有权
标题翻译：抗体人类抗体13及其用途
公开(公告)号：US20100129360A1
公开(公告)日：2010-05-27
申请号：US12575896
申请日：2009-10-08
申请人： Marion T. Kasaian , Lioudmila Gennadievna Tchistiakova , Geertruida Machteld Veldman , Kimberly Ann Marquette , Xiang-Yang Tan , Debra D. Donaldson , Laura Long Lin , Tania Shane , Amy Sze Pui Tam , Eric Feyfant , Nancy L. Wood , Lori J. Fitz , Angela M. Widom , Kevin D. Parris , Samuel J. Goldman , Jose W. Saldanha
发明人： Marion T. Kasaian , Lioudmila Gennadievna Tchistiakova , Geertruida Machteld Veldman , Kimberly Ann Marquette , Xiang-Yang Tan , Debra D. Donaldson , Laura Long Lin , Tania Shane , Amy Sze Pui Tam , Eric Feyfant , Nancy L. Wood , Lori J. Fitz , Angela M. Widom , Kevin D. Parris , Samuel J. Goldman , Jose W. Saldanha
IPC分类号： A61K39/395 , C07K16/24 , C07K16/18 , C07H21/00 , C12N5/10 , C12P21/00 , G01N33/543 , A61P37/02
CPC分类号： C07K16/244 , A61K2039/505 , C07K2299/00 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92
摘要： This application relates to antibodies, e.g., humanized antibodies, and antigen-binding fragments thereof, that bind to interleukin-13 (IL-13), in particular, human IL-13, and their uses in regulating immune responses mediated by IL-13. The antibodies disclosed herein are useful in diagnosing, preventing, and/or treating a subject, e.g., a human patient, one or more IL-13-associated disorders, e.g., respiratory disorders (e.g., asthma); atopic disorders (e.g., allergic rhinitis); inflammatory and/or autoimmune conditions of the skin (e.g., atopic dermatitis), and gastrointestinal organs (e.g., inflammatory bowel diseases (IBD)), as well as fibrotic and cancerous disorders.
摘要翻译：本申请涉及结合白细胞介素-13（IL-13）特别是人IL-13的抗体，例如人源化抗体及其抗原结合片段及其在调节由IL-13介导的免疫应答中的用途。本文公开的抗体可用于诊断，预防和/或治疗受试者，例如人类患者，一种或多种IL-13相关疾病，例如呼吸系统疾病（例如哮喘）; 特应性疾病（如过敏性鼻炎）; 皮肤的炎症和/或自身免疫病症（例如特应性皮炎）和胃肠器官（例如炎性肠病（IBD））以及纤维化和癌性疾病。

2. 发明申请

US20080271702A1 FUEL-SAVING ACCELERATOR FOR INTERNAL COMBUSTION ENGINE 审中-公开
标题翻译：用于内燃机的燃油加速器
公开(公告)号：US20080271702A1
公开(公告)日：2008-11-06
申请号：US12112777
申请日：2008-04-30
申请人： Cheuk Pui TAM
发明人： Cheuk Pui TAM
IPC分类号： F02B47/02
CPC分类号： F02B47/02 , F02M25/0227 , Y02T10/121
摘要： The present invention discloses a fuel-saving accelerator for internal combustion engine, which comprises a water tank for storing water therein as auxiliary fuel for the inner combustion engine; a water processing unit communicating with the water tank to process the water supplied from the water tank; and a water control unit which is connected between the water processing unit and a combustion chamber of the inner combustion engine to control the amount of the processed water supplied from the water processing unit and supply a controlled amount of water to the combustion chamber.
摘要翻译：本发明公开了一种用于内燃机的节油促进器，其包括用于在其中存储水作为内燃机辅助燃料的水箱; 与水箱连通以处理从水箱供应的水的水处理单元; 以及水控制单元，其连接在所述水处理单元和所述内燃机的燃烧室之间，以控制从所述水处理单元供应的处理水的量并向所述燃烧室供应受控量的水。

3. 发明授权

US07615213B2 Antibodies against human interleukin-13 and pharmaceutical compositions thereof 失效
标题翻译：针对人白细胞介素-13的抗体及其药物组合物
公开(公告)号：US07615213B2
公开(公告)日：2009-11-10
申请号：US11149309
申请日：2005-06-09
申请人： Marion T. Kasaian , Lioudmila Tchistiakova , Geertruida M. Veldman , Kimberly Ann Marquette , Xiang-Yang Tan , Debra D. Donaldson , Laura Long Lin , Tania Shane , Amy Sze Pui Tam , Eric Feyfant , Nancy L. Wood , Lori J. Fitz , Angela M. Widom , Kevin D. Parris , Samuel J. Goldman , Jose W. Saldanha
发明人： Marion T. Kasaian , Lioudmila Tchistiakova , Geertruida M. Veldman , Kimberly Ann Marquette , Xiang-Yang Tan , Debra D. Donaldson , Laura Long Lin , Tania Shane , Amy Sze Pui Tam , Eric Feyfant , Nancy L. Wood , Lori J. Fitz , Angela M. Widom , Kevin D. Parris , Samuel J. Goldman , Jose W. Saldanha
IPC分类号： A61K39/395
CPC分类号： C07K16/244 , A61K2039/505 , C07K2299/00 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92
摘要： This application relates to antibodies, e.g., humanized antibodies, and antigen-binding fragments thereof, that bind to interleukin-13 (IL-13), in particular, human IL-13, and their uses in regulating immune responses mediated by IL-13. The antibodies disclosed herein are useful in diagnosing, preventing, and/or treating a subject, e.g., a human patient, one or more IL-13-associated disorders, e.g., respiratory disorders (e.g., asthma); atopic disorders (e.g., allergic rhinitis); inflammatory and/or autoimmune conditions of the skin (e.g., atopic dermatitis), and gastrointestinal organs (e.g., inflammatory bowel diseases (IBD)), as well as fibrotic and cancerous disorders.
摘要翻译：本申请涉及结合白细胞介素-13（IL-13）特别是人IL-13的抗体，例如人源化抗体及其抗原结合片段，以及它们在调节由IL-13介导的免疫应答中的用途。本文公开的抗体可用于诊断，预防和/或治疗受试者，例如人类患者，一种或多种IL-13相关疾病，例如呼吸系统疾病（例如哮喘）; 特应性疾病（如过敏性鼻炎）; 皮肤的炎症和/或自身免疫病症（例如特应性皮炎）和胃肠器官（例如炎性肠病（IBD））以及纤维化和癌性疾病。

4. 发明授权

US08221752B2 Antibodies against human interleukin-13 and uses therefor 有权
标题翻译：针对人白细胞介素-13的抗体并用于其
公开(公告)号：US08221752B2
公开(公告)日：2012-07-17
申请号：US12575896
申请日：2009-10-08
申请人： Marion T. Kasaian , Lioudmila Gennadievna Tchistiakova , Geertruida Machteld Veldman , Kimberly Ann Marquette , Xiang-Yang Tan , Debra D. Donaldson , Laura Long Lin , Tania Shane , Amy Sze Pui Tam , Eric Feyfant , Nancy L. Wood , Lori J. Fitz , Angela M. Widom , Kevin D. Parris , Samuel J. Goldman , Jose W. Saldanha
发明人： Marion T. Kasaian , Lioudmila Gennadievna Tchistiakova , Geertruida Machteld Veldman , Kimberly Ann Marquette , Xiang-Yang Tan , Debra D. Donaldson , Laura Long Lin , Tania Shane , Amy Sze Pui Tam , Eric Feyfant , Nancy L. Wood , Lori J. Fitz , Angela M. Widom , Kevin D. Parris , Samuel J. Goldman , Jose W. Saldanha
IPC分类号： A61K39/395
CPC分类号： C07K16/244 , A61K2039/505 , C07K2299/00 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92
摘要： This application relates to antibodies, e.g., humanized antibodies, and antigen-binding fragments thereof, that bind to interleukin-13 (IL-13), in particular, human IL-13, and their uses in regulating immune responses mediated by IL-13. The antibodies disclosed herein are useful in diagnosing, preventing, and/or treating a subject, e.g., a human patient, one or more IL-13-associated disorders, e.g., respiratory disorders (e.g., asthma); atopic disorders (e.g., allergic rhinitis); inflammatory and/or autoimmune conditions of the skin (e.g., atopic dermatitis), and gastrointestinal organs (e.g., inflammatory bowel diseases (IBD)), as well as fibrotic and cancerous disorders.
摘要翻译：本申请涉及结合白介素13（IL-13），特别是人IL-13的抗体，例如人源化抗体及其抗原结合片段及其在调节由IL-13介导的免疫应答中的用途。本文公开的抗体可用于诊断，预防和/或治疗受试者，例如人类患者，一种或多种IL-13相关疾病，例如呼吸系统疾病（例如哮喘）; 特应性疾病（如过敏性鼻炎）; 皮肤的炎症和/或自身免疫病症（例如特应性皮炎）和胃肠器官（例如炎性肠病（IBD））以及纤维化和癌性疾病。

5. 发明授权

US06981445B2 Method and apparatus for micro-contact printing 失效
标题翻译：微接触印刷的方法和装置
公开(公告)号：US06981445B2
公开(公告)日：2006-01-03
申请号：US10744949
申请日：2003-12-24
申请人： Raymond Francis Cracauer , Rocky Ganske , M. Cynthia Goh , Jane B. Goh , Adam Brian Liederman , Richard Loo , Pui Tam
发明人： Raymond Francis Cracauer , Rocky Ganske , M. Cynthia Goh , Jane B. Goh , Adam Brian Liederman , Richard Loo , Pui Tam
IPC分类号： B41K3/02
CPC分类号： G03F7/0002 , B41F17/006 , B41K1/28 , B82Y10/00 , B82Y40/00
摘要： An apparatus for producing patterns on a surface of a substrate. The apparatus includes a rigid support such as a rigid tubular structure having first and second opposed ends and a fluid flow passageway extending therethrough. A printing stamp is attached at one of the opposed ends of the rigid support. The printing stamp has a flexible diaphragm portion which has an outer surface which is coated with one or more materials in a pre-selected pattern. A pneumatic pressurizing mechanism communicating with an inner surface of the flexible diaphragm portion through the fluid flow passageway is used to bias the flexible diaphragm portion outwardly into intimate and uniform contact with the surface of the substrate for transferring the pre-selected pattern onto the substrate surface. The rigid tubular supports are attached to a robotic positioning mechanism for providing control of positioning of the stamp relative to the substrate surface.
摘要翻译：一种用于在基板的表面上产生图案的装置。该装置包括刚性支撑件，例如具有第一和第二相对端部的刚性管状结构以及从其延伸穿过的流体流动通道。印刷印刷件附接在刚性支撑件的相对端中的一个上。印刷版具有柔性膜部分，其具有以预选图案涂覆有一种或多种材料的外表面。通过流体流动通道与柔性隔膜部分的内表面连通的气动加压机构用于将柔性隔膜部分向外偏压以与基底表面紧密且均匀的接触，以将预先选定的图案转印到基底表面上。刚性管状支撑件附接到机器人定位机构，用于提供印模相对于基底表面的定位的控制。

6. 发明申请

US20050139103A1 Method and apparatus for micro-contact printing 失效
标题翻译：微接触印刷的方法和装置
公开(公告)号：US20050139103A1
公开(公告)日：2005-06-30
申请号：US10744949
申请日：2003-12-24
申请人： Raymond Cracauer , Rocky Ganske , M. Goh , Jane Goh , Adam Liederman , Richard Loo , Pui Tam
发明人： Raymond Cracauer , Rocky Ganske , M. Goh , Jane Goh , Adam Liederman , Richard Loo , Pui Tam
IPC分类号： B41F17/00 , B41K1/28 , G03F7/00 , B41K1/38
CPC分类号： G03F7/0002 , B41F17/006 , B41K1/28 , B82Y10/00 , B82Y40/00
摘要： The present invention provides an apparatus for producing patterns on a surface of a substrate. The apparatus includes a rigid support member such as a rigid tubular structure having first and second opposed ends and a fluid flow passageway extending therethrough. A printing stamp is attached at one of the opposed ends of the rigid support member. The printing stamp has a flexible diaphragm portion which has an outer surface which is coated with one or more materials in a pre-selected pattern. A pneumatic pressurizing mechanism communicating with an inner surface of the flexible diaphragm portion through the fluid flow passageway is used to bias the flexible diaphragm portion outwardly into intimate and substantially uniform contact with the surface of the substrate for transferring the pre-selected pattern onto said surface. The rigid tubular supports are attached to a robotic positioning mechanism for providing control of positioning of the stamp relative to the substrate surface.
摘要翻译：本发明提供一种用于在基板的表面上产生图案的装置。该装置包括刚性支撑构件，例如具有第一和第二相对端部的刚性管状结构以及从其延伸穿过的流体流动通道。在刚性支撑构件的相对端中的一个上附着印刷印章。印刷版具有柔性膜部分，其具有以预选图案涂覆有一种或多种材料的外表面。通过流体流动通道与柔性隔膜部分的内表面连通的气动加压机构用于将柔性隔膜部分向外偏压以与衬底表面紧密且基本上均匀的接触，以将预选图案转移到所述表面上。刚性管状支撑件附接到机器人定位机构，用于提供印模相对于基底表面的定位的控制。

7. 发明授权

US06647577B2 Electric toothbrush 失效
标题翻译：电动牙刷
公开(公告)号：US06647577B2
公开(公告)日：2003-11-18
申请号：US10092785
申请日：2002-03-07
申请人： Kwong Pui Tam
发明人： Kwong Pui Tam
IPC分类号： A61C1726
CPC分类号： A61C17/24 , A61C17/222 , A61C17/3409 , A61C17/3436
摘要： An electric toothbrush includes a handle, a neck having a longitudinal axis and a brush head mounted to the neck and including bristles that rotate about an axis that is at an acute angle with respect to the longitudinal axis of the neck. Upon activation of a motor, the bristles rotate about the acute axis and tips of the bristles always move in a direction away from the user's gumline.
摘要翻译：电动牙刷包括手柄，具有纵向轴线的颈部和安装到颈部的刷头，并且包括绕相对于颈部的纵向轴线成锐角的轴线旋转的刷毛。电动机激活时，刷毛围绕急轴旋转，刷毛尖端总是沿远离使用者胶线的方向移动。

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