专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US10653749B2 Targeting GIV-GEF-GI signaling for treating diverse diseases 有权
公开(公告)号：US10653749B2
公开(公告)日：2020-05-19
申请号：US15565192
申请日：2016-04-15
申请人： The Regents of the University of California , Pradipta Ghosh
发明人： Pradipta Ghosh
IPC分类号： A61K38/17 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/47 , A61P35/04 , C07K14/005 , C07K19/00 , C12N15/63
摘要： The invention provides cell-permeable Ga-Interacting Vesicle associated protein (GIV)-derived peptides and their use for treatment of diverse diseases. The invention further provides C-terminus of Ga-Interacting Vesicle associated protein (GIV-CT)-based peptides and GIV-CT encoding vectors and methods of use thereof, for successfully manipulating the diverse pathophysiologic processes in which GIV has been implicated. In one aspect, the invention provides cell-permeable peptides PTD-GIV-CT comprising (i) a peptide transduction domain (PTD) and (ii) a C-terminus of Ga-Interacting Vesicle associated protein (GIV-CT) or a mutant thereof. In one embodiment, said peptides are capable of activating Gi downstream of receptor tyrosine kinases (RTKs). The invention also provides pharmaceutical compositions comprising one or more of the peptides of the invention as well as vectors encoding such peptides.

2. 发明授权

US09528994B2 Target of the phosphoinositide 3-kinase pathway 有权
标题翻译：磷酸肌醇3-激酶途径的靶标
公开(公告)号：US09528994B2
公开(公告)日：2016-12-27
申请号：US14235036
申请日：2012-07-25
申请人： Pradipta Ghosh
发明人： Pradipta Ghosh
IPC分类号： C07K16/44 , C07K16/18 , G01N33/574
CPC分类号： G01N33/57496 , C07K16/18 , C07K16/44 , G01N33/57415 , G01N33/57484 , G01N2440/14 , G01N2800/50
摘要： The present disclosure generally relates to tyrosine phosphorylation sites of an Akt enhancer, and methods for the detection of the phosphorylated tyrosine residues. In particular, anti-phosphotyrosine antibodies and binding proteins find use in the compositions and methods of the present disclosure.
摘要翻译：本公开内容通常涉及Akt增强子的酪氨酸磷酸化位点，以及用于检测磷酸化酪氨酸残基的方法。特别地，抗磷酸酪氨酸抗体和结合蛋白可用于本发明的组合物和方法。

3. 发明授权

US06449751B1 Method of analyzing static current test vectors with reduced file sizes for semiconductor integrated circuits 有权
标题翻译：分析半导体集成电路文件尺寸减小的静态电流测试矢量的方法
公开(公告)号：US06449751B1
公开(公告)日：2002-09-10
申请号：US09879417
申请日：2001-06-12
申请人： Hunaid Hussain , Pradipta Ghosh , Arun K. Gunda
发明人： Hunaid Hussain , Pradipta Ghosh , Arun K. Gunda
IPC分类号： G06F1750
CPC分类号： G01R31/3004 , G06F17/5022
摘要： A method and apparatus are provided for analyzing test vectors for use in measuring static current consumed by an integrated circuit. A netlist of interconnected cells is read to identify cell types used within the netlist, wherein the netlist includes a plurality of nodes. Once the netlist has been read, cell characteristics for selected ones of the cell types are read from a technology library to identify pins of the selected cell types to be monitored. The nodes in the netlist that correspond to these pins are identified and are added to an list file. Once the list file has been generated, a computer simulation program is used to simulate a steady-state response of a functional model of the integrated circuit to a potential test vector and to output the resulting logic states on the nodes provided in the list file.
摘要翻译：提供了一种用于分析用于测量集成电路消耗的静态电流的测试矢量的方法和装置。读取互连的小区的网表以识别网表中使用的小区类型，其中网表包括多个节点。一旦读取了网表，从技术库中读取所选单元格类型的单元格特征，以识别要监视的所选单元格类型的引脚。与这些引脚相对应的网表中的节点被识别，并被添加到列表文件中。一旦产生了列表文件，就使用计算机模拟程序来模拟集成电路的功能模型到潜在测试向量的稳态响应，并将所得逻辑状态输出到列表文件中提供的节点上。

4. 发明申请

US20140234872A1 TARGET OF THE PHOSPHOINOSITIDE 3-KINASE PATHWAY 有权
标题翻译：磷酸三钙3激酶途径的目标
公开(公告)号：US20140234872A1
公开(公告)日：2014-08-21
申请号：US14235036
申请日：2012-07-25
申请人： Pradipta Ghosh
发明人： Pradipta Ghosh
IPC分类号： G01N33/574 , C07K16/18
CPC分类号： G01N33/57496 , C07K16/18 , C07K16/44 , G01N33/57415 , G01N33/57484 , G01N2440/14 , G01N2800/50
摘要： The present disclosure generally relates to tyrosine phosphorylation sites of an Akt enhancer, and methods for the detection of the phosphorylated tyrosine residues. In particular, anti-phosphotyrosine antibodies and binding proteins find use in the compositions and methods of the present disclosure.
摘要翻译：本公开内容通常涉及Akt增强子的酪氨酸磷酸化位点，以及用于检测磷酸化酪氨酸残基的方法。特别地，抗磷酸酪氨酸抗体和结合蛋白可用于本发明的组合物和方法。

5. 发明授权

US06694495B1 Method of analyzing static current test vectors for semiconductor integrated circuits 失效
标题翻译：分析半导体集成电路静态电流测试矢量的方法
公开(公告)号：US06694495B1
公开(公告)日：2004-02-17
申请号：US09879506
申请日：2001-06-12
申请人： Hunaid Hussain , Pradipta Ghosh
发明人： Hunaid Hussain , Pradipta Ghosh
IPC分类号： G06F1750
CPC分类号： G11C29/56004 , G11C11/41 , G11C29/56 , G11C2029/0401 , G11C2029/5006
摘要： A method is provided for analyzing a test vector for use in measuring static current consumed by an integrated circuit that has an embedded memory device. According to the method, a potential test vector is applied to a functional model of the integrated circuit. The logic states of various nodes in the integrated circuit are detected in response to the potential test vector. At least some of the nodes correspond to the input address bits of the memory device, where the memory device has a valid address range on the input address bits. An output is produced for the potential test vector based on whether these logic states correspond to an address within the valid address range.
摘要翻译：提供了一种用于分析用于测量具有嵌入式存储器件的集成电路消耗的静态电流的测试矢量的方法。根据该方法，将潜在测试矢量应用于集成电路的功能模型。响应于潜在的测试向量来检测集成电路中各个节点的逻辑状态。至少一些节点对应于存储器件的输入地址位，其中存储器件在输入地址位上具有有效的地址范围。基于这些逻辑状态是否对应于有效地址范围内的地址，产生用于潜在测试向量的输出。

6. 发明申请

US20180104307A1 Targeting GIV-GEF-GI Signaling for Treating Diverse Diseases 审中-公开
公开(公告)号：US20180104307A1
公开(公告)日：2018-04-19
申请号：US15565192
申请日：2016-04-15
申请人： Pradipta GHOSH , The Regents of the University of California
发明人： Pradipta Ghosh
IPC分类号： A61K38/17 , C07K14/005 , C07K19/00 , C12N15/63 , C07K14/47 , A61P35/04
CPC分类号： A61K38/179 , A61K38/00 , A61K38/1741 , A61P35/04 , C07K7/06 , C07K7/08 , C07K14/005 , C07K14/4703 , C07K14/4705 , C07K19/00 , C07K2319/02 , C07K2319/03 , C07K2319/10 , C07K2319/21 , C07K2319/23 , C07K2319/33 , C07K2319/43 , C07K2319/74 , C07K2319/81 , C12N15/63
摘要： The invention provides cell-permeable Ga-Interacting Vesicle associated protein (GIV)-derived peptides and their use for treatment of diverse diseases. The invention further provides C-terminus of Ga-Interacting Vesicle associated protein (GIV-CT)-based peptides and GIV-CT encoding vectors and methods of use thereof, for successfully manipulating the diverse pathophysiologic processes in which GIV has been implicated. In one aspect, the invention provides cell-permeable peptides PTD-GIV-CT comprising (i) a peptide transduction domain (PTD) and (ii) a C-terminus of Ga-Interacting Vesicle associated protein (GIV-CT) or a mutant thereof. In one embodiment, said peptides are capable of activating Gi ownstream of receptor tyrosine kinases (RTKs). The invention also provides pharmaceutical compositions comprising one or more of the peptides of the invention as well as vectors encoding such peptides.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式