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1. 发明申请

US20230043035A1 AGAROPHYTON CHILENSIS EXTRACT, RICH IN FREE FATTY ACIDS, AS A NUTRACEUTICAL OR NUTRITIONAL SUPPLEMENT, SUITABLE FOR MODULATING PPAR# ACTIVITY 有权
公开(公告)号：US20230043035A1
公开(公告)日：2023-02-09
申请号：US17756352
申请日：2019-11-22
申请人： UNIVERSIDAD ANDRES BELLO , PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE
发明人： Francisca Verónica BRONFMAN CÁCERES , Karen Andrea FUENZALIDA MORALES , María Raquel IBÁÑEZ HORMAZABAL , Loretto Matilde CONTRERAS PORCIA , Víctor BARRAZA FUENTES
IPC分类号： A61K36/04 , A61P25/28 , A61P9/10 , A61K31/20
摘要： Agarophyton chilensis extract, enriched with free fatty acids and PPARγ modulators, comprising palmitic acid, stearic acid, myristic acid, oleic acid, and 8-hydroxyeicosatetraenoic acid (8-HETE). Method for obtaining the extract. Nutraceutical composition, comprising the extract enriched with free fatty acids and PPARγ modulators, wherein said extract is useful for treating or preventing health problems, which require neuroprotection, wherein said neuroprotection involves activation of PPARγ receptors.

2. 发明授权

US11164483B2 Medical simulator for the simulation of puncture operations 有权
公开(公告)号：US11164483B2
公开(公告)日：2021-11-02
申请号：US16066892
申请日：2015-12-28
申请人： PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE
发明人： Fernando Altermatt Couratier , Constanza Miranda Mendoza , Benjamín Garnham Leniz , Jorge Sanz Guerrero
IPC分类号： G09B23/34 , G09B23/30 , G09B23/28
摘要： A medical simulator of procedures associated with punctures, for simulation and practical training in puncture interventions, the medical simulator comprising a phantom, an intervention device and a processing system in data communication with the phantom and the intervention device, wherein the phantom comprises at least one target structure arranged for the training of the intervention and means for detecting the intervention device, said detection means being in communication of data with the processing system. The intervention device comprises a real puncture instrument that includes sensing means and detection means in data communication with the processing system. The phantom comprises a structure with at least two components, a simulation assembly that simulates the behavior of tissues and anatomical structures, and a base structure that forms the phantom support, wherein the base structure comprises accommodation and fixation means to house and fix the simulation assembly. The simulation assembly comprises at least one detection means of the intervention device arranged on the target structure and at least one detection means of the intervention device arranged under the objective structure, wherein the processing and visualization system collects, stores, processes and displays the data coming from the sensing means and means of detection of the medical simulator for the visualization of the information by the user through a graphic interface.

3. 发明申请

US20210101872A1 C-ABL TYROSINE KINASE INHIBITORY COMPOUND EMBODIMENTS AND METHODS OF MAKING AND USING THE SAME 有权
公开(公告)号：US20210101872A1
公开(公告)日：2021-04-08
申请号：US16976012
申请日：2019-03-08
申请人： The USA, as represented by the Secretary, Dept. of Health and Human Services , Pontificia Universidad Católica de Chile
发明人： Juan J. Marugan , Marc Ferrer , Noel T. Southall , Andres E. Dulcey , Xin Hu , Christopher R. Dextras , Daniel C. Talley , Alejandra Alvarez , Silvana Zanlungo , Rommy M. Von Bernhardi
IPC分类号： C07D243/38 , C07D267/20 , C07F7/08 , C07D281/16 , C07D267/18 , C07C227/22 , C07C201/12 , C07C319/14 , C07D401/04 , C07D403/04 , C07D413/10 , C07F5/02 , C07D413/04 , C07D471/04 , C07D487/04 , C07D413/14 , C07D417/04 , A61P33/06 , A61P25/28 , A61P25/08 , A61P35/02 , A61K31/554 , A61K31/5513 , A61K31/553
摘要： Disclosed herein are embodiments of a compound that inhibits c-Abl tyrosine kinase (also referred to herein as “c-Abl”). The compound embodiments described herein are novel c-Abl inhibitors that can bind to c-Abl at an allosteric site and inhibit its activity in various pathways. The compound embodiments also are capable of crossing the blood brain barrier and therefore are useful in inhibiting c-Abl activity as it affects pathways and/or proteins in the brain. The compound embodiments described herein are effective therapeutic agents for treating diseases involving c-Abl, such as cancers, motor neuron diseases, and neurodegenerative diseases. Also disclosed herein are embodiments of methods for making and using the c-Abl inhibitory compound embodiments.

4. 发明申请

US20190338547A1 COMBINATION OF FOUNDATION ANCHOR AND ENERGY DAMPER FOR VERTICAL LIQUID STORAGE TANKS, VERTICAL PRESSURE CONTAINER, SILO OR THE LIKE WITH A THIN WALL AND A CONTINUOUS SUPPORT 审中-公开
公开(公告)号：US20190338547A1
公开(公告)日：2019-11-07
申请号：US16474808
申请日：2017-12-26
申请人： PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE
发明人： José Luis ALMAZÁN CAMPILLAY , Nathaly Karina VALDEBENITO TAPIA , Nicolás Felipe TAPIA FLORES
IPC分类号： E04H9/02 , E02D5/74 , B65D90/12
摘要： The invention relates to a combination of a foundation anchor and energy damper for vertical tanks or similar containers for liquids with a thin wall and continuous support, comprising an energy dissipation component centrally connected to a foundation anchor component by means of a linking component, the energy dissipation component comprising one or more superimposed and horizontally arranged energy dissipating plates with a rhombic shape truncated at the vertices thereof, wherein the shorter diagonal is normal to the wall of the tank and the side ends or vertices corresponding to the longer diagonal have quadrangular extensions for support on a load transmission component that is connected to the wall of the tank so as to transmit and distribute the forces developed by the one or more energy dissipating plates. Alternatively, the energy dissipating plates are trapezoidal with the longer parallel side tangential to the wall of the tank.

5. 发明申请

US20170115276A1 SPECIFIC MODULATORS OF CONNEXIN HEMICHANNELS 审中-公开
公开(公告)号：US20170115276A1
公开(公告)日：2017-04-27
申请号：US15318291
申请日：2015-04-14
申请人： PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE
发明人： Juan Carlos SAEZ , Carlos LAGOS
IPC分类号： G01N33/50 , A61K31/47 , A61K31/568 , G06F19/18
CPC分类号： G01N33/5041 , A61K8/63 , A61K31/47 , A61K31/56 , A61K31/568 , G01N2333/705 , G16B20/00
摘要： The invention provides identification methods of specific modulators of hemichannels formed by connexin through the use of structural bioinformation methods for the calculation of the interaction energy with ligands and compositions to selectively modulate the activity of hemichannels formed by connexins.Among other aspects, the invention describes a computer-aided method, where estimating the interaction energy between ligands coming from a database of chemical compounds is possible, with a binding pocket defined by the region comprising the residues of 3-10 (NTH), 29-40 (TM1), 74-93 (TM2) of a protomer and residues 29-40 (TM1) of an adjacent protomer in connexin 26 or the equivalent residues in other connexins.In particular, the invention provides compounds specifically inhibiting the activation/opening of connexin hemichannels identified through the method described above, which can be useful for the treatment of inflammatory diseases, vascular disorders, arrhythmias, chronic injuries, retinal neuroprotection, treatment of pain, skeletal muscle denervation, muscular dystrophies, damage to the spinal cord and genetic diseases characterized by the increased activity of hemichannels formed by connexins.

6. 发明申请

US20160238281A1 DEVICE FOR STIFFENING AND SEALING A SOLAR COLLECTOR 审中-公开
标题翻译：用于强化和密封太阳能收集器的装置
公开(公告)号：US20160238281A1
公开(公告)日：2016-08-18
申请号：US15024734
申请日：2014-09-24
申请人： PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE
发明人： Vladimir CHIBIZOV CHIBIZOV , Pablo MATURANA BARAHONA , María Soledad GÓMEZ LORENZINI , Leonardo VEAS PÉREZ , Pavel CHIBIZOV CHIBIZOV
IPC分类号： F24J2/20 , F24J2/46
CPC分类号： F24S10/502 , F24S10/72 , F24S80/30 , F24S80/70 , F24S2080/09 , Y02B10/20 , Y02E10/44
摘要： The invention relates to a device for stiffening and sealing a solar collector, providing protection against breakage and secure sealing of the connection area between an extruded flat plate solar absorber and fluid-inlet and -outlet collectors. The device comprises: a support profile for stiffening the extruded flat plate absorber and the fluid-inlet and -outlet collector, formed by open cylindrical modules together with two parallel plates; and a tray, made of plastic reinforced using fibreglass fabric, for sealing the connection between the extruded flat plate solar absorber and the fluid-inlet and -outlet collectors in such a way as to maintain said elements as a common or single-piece element.
摘要翻译：本发明涉及一种用于加强和密封太阳能收集器的装置，提供防止破裂的保护，并且确保密封挤出的平板太阳能吸收器与流体入口和出口收集器之间的连接区域。该装置包括：用于加强挤出的平板吸收器和流体入口和出口收集器的支撑轮廓，其由开放的圆柱形模块与两个平行板一起形成; 以及由玻璃纤维织物增强的塑料制成的托盘，用于密封挤出的平板太阳能吸收器与流体入口和出口收集器之间的连接，以将所述元件保持为共同或单件元件。

7. 发明申请

US20230133855A1 IMPLANTABLE PROSTHETIC DEVICE FOR PRODUCING A PENILE ERECTION IN MEN WITH ERECTILE DYSFUNCTION AND PRODUCTION METHOD THEREOF 有权
公开(公告)号：US20230133855A1
公开(公告)日：2023-05-04
申请号：US17917769
申请日：2020-04-07
申请人： PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE
发明人： Marcelo Carlos MARCONI TORO , Alberto Alejandro GONZÁLEZ RAMOS , Ivan Alberto CARO PINTO
IPC分类号： A61F2/26 , A61F2/30
摘要： A prosthetic device can be implanted in the corpora cavernosa of a penis with erectile dysfunction. The device being formed by two cylinders that can be inflated with a fluid. The device comprises a variable-length erectable portion formed by a chamber that can be pressurized with a low volume of fluid and is formed between an expandable membrane and an axially extendable and foldable longitudinal rib. The membrane and rib extend between a distal tip element and an intermediate connector from which a shortenable anchoring rod emerges, the rib being a single piece formed by a variable-length distal section, an intermediate section that is foldable and extendable in an axial direction, and a proximal section comprising optimized means for the continuous lateral supply of the fluid to the pressurisable chamber. The device also has an integrated unit for storing and pressurizing the fluid, which can be implanted in the scrotum.

8. 发明申请

US20190027066A1 MEDICAL SIMULATOR FOR THE SIMULATION OF PUNCTURE OPERATIONS 审中-公开
公开(公告)号：US20190027066A1
公开(公告)日：2019-01-24
申请号：US16066892
申请日：2015-12-28
申请人： PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE
发明人： Fernando ALTERMATT COURATIER , Constanza MIRANDA MENDOZA , Benjamín GARNHAM LENIZ , Jorge SANZ GUERRERO
IPC分类号： G09B23/34 , G09B23/28
摘要： A medical simulator of procedures associated with punctures, for simulation and practical training in puncture interventions, the medical simulator comprising a phantom, an intervention device and a processing system in data communication with the phantom and the intervention device, wherein the phantom comprises at least one target structure arranged for the training of the intervention and means for detecting the intervention device, said detection means being in communication of data with the processing system. The intervention device comprises a real puncture instrument that includes sensing means and detection means in data communication with the processing system. The phantom comprises a structure with at least two components, a simulation assembly that simulates the behavior of tissues and anatomical structures, and a base structure that forms the phantom support, wherein the base structure comprises accommodation and fixation means to house and fix the simulation assembly. The simulation assembly comprises at least one detection means of the intervention device arranged on the target structure and at least one detection means of the intervention device arranged under the objective structure, wherein the processing and visualization system collects, stores, processes and displays the data coming from the sensing means and means of detection of the medical simulator for the visualization of the information by the user through a graphic interface.

9. 发明申请

US20180050029A1 SELECTIVE CONNEXIN HEMICHANNELS BLOCKERS FOR THE TREATMENT OF EPILEPSY 审中-公开
公开(公告)号：US20180050029A1
公开(公告)日：2018-02-22
申请号：US15556205
申请日：2016-02-29
申请人： PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE
发明人： Juan Carlos SAEZ , Carlos LAGOS , Carola MATURANA
IPC分类号： A61K31/47 , A61K31/4166 , A61K31/55 , A61K31/19
CPC分类号： A61K31/47 , A61K31/19 , A61K31/4166 , A61K31/496 , A61K31/55 , A61K2300/00 , C07D215/14 , C07D295/092
摘要： The present invention provides connexin hemichannel blockers for the treatment of epilepsy.In particular, the present invention relates to organic compounds which act as selective blockers connexin hemichannels which are useful in the treatment of epilepsy.In another embodiment of the present invention there is provided a composition comprising a selective connexin hemichannels blocker compounds useful in the treatment of epilepsy in combination with other antiepileptic compounds.

10. 发明授权

US11618868B2 Aroma recovery equipment from fermentation vats 有权
公开(公告)号：US11618868B2
公开(公告)日：2023-04-04
申请号：US16475317
申请日：2017-12-20
申请人： PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE , SOCIEDAD ANÓNIMA VIÑA SANTA RITA , DICTUC S.A
发明人： José Ricardo Pérez Correa , Martín Rodrigo Cárcamo Behrens , Camilo Andrés Concha Muñoz , Eduardo Andrés Alemparte Benavente , José Miguel Benavente Pereira , Jorge Alberto Heiremans Bunster , Eduardo Esteban Agosín Trumper
IPC分类号： C12F3/06 , B01D5/00 , C12G1/00 , C12G3/06
摘要： The present invention is a aroma recovery equipment from gases exhausted of fermentation vats comprising a first recovery group (100) comprising a first condenser (110) operating at a first temperature of recovered aromas; one second recovery group (200) comprising a second condenser (210) operating at a second temperature of recovered aromas; a cooling group (300) to provide cold by a cooling fluid (301) to said first recovery group (100) via a first fluid connection (302) and to said second recovery group (200) via a second fluid connection (303); control means (400) configured to coordinately control the temperature of said first recovery group (100) and the temperature of said second recovery group (200); and a mobile housing (500) containing said first recovery group (100), said second recovery group (200), said cooling group (300) and said control means (400).

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