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1. 发明申请

US20220244242A1 NESTED CELL ENCAPSULATION 有权
公开(公告)号：US20220244242A1
公开(公告)日：2022-08-04
申请号：US17671750
申请日：2022-02-15
申请人： Plasticell Limited
发明人： Yen Choo , Christopher James Johnson , Patrick Klaus Odenwälder , Suwan Nalin Jayasinghe
IPC分类号： G01N33/50 , A61K9/50 , C12M1/12
摘要： The invention relates to a method for encapsulating living cells and labels, as well as encapsulated labelled cells and kits for performing such encapsulation. The encapsulated cells may be useful in multiple parallel tissue culture experiments, where the labels in each microcapsule may be used to decipher a cells path through a series of culturing steps.

2. 发明授权

US10017740B2 Deriving brown adipose tissue cells 有权
公开(公告)号：US10017740B2
公开(公告)日：2018-07-10
申请号：US14664441
申请日：2015-03-20
申请人： PLASTICELL LIMITED
发明人： Marina Tarunina , Yen Choo , Mylvaganam Jeyakumar , Thomas Watson , Meritxell Rosell , Lilian Hook , Diana Hernandez
IPC分类号： C12N5/00 , C12N5/077 , A61K35/35
CPC分类号： C12N5/0653 , A61K35/35 , C12N2500/24 , C12N2500/25 , C12N2501/01 , C12N2501/04 , C12N2501/155 , C12N2501/33 , C12N2502/1352 , C12N2506/1384
摘要： The present invention relates to brown adipose tissue (BAT) cells derived from adult stern or progenitor cells, derived from adult white fat tissue (WAT), as well as to methods for deriving such cells.

3. 发明授权

US11702635B2 Hematopoietic stem cell expansion method 有权
公开(公告)号：US11702635B2
公开(公告)日：2023-07-18
申请号：US16607457
申请日：2018-04-25
申请人： PLASTICELL LIMITED
发明人： Diana Hernandez
IPC分类号： C12N5/0789 , C07K14/705
CPC分类号： C12N5/0647 , C07K14/70503 , C12N2500/44 , C12N2501/065
摘要： A method to expand hematopoietic stem and progenitor cells (HSPC) wherein the method comprises obtaining an isolated population of HSPC the culturing the isolated population of HSPC in the presence of a histone deacetylase inhibitor (HDAC inhibitor), to form a cultured population, then adding an aminothiol compound to the cultured population.

4. 发明申请

US20210379112A1 STEM CELL THERAPY 有权
公开(公告)号：US20210379112A1
公开(公告)日：2021-12-09
申请号：US17287859
申请日：2019-10-24
申请人： PLASTICELL LIMITED
发明人： Diana HERNANDEZ
IPC分类号： A61K35/28 , C12N5/0789 , A61P35/02
摘要： A composition comprising an expanded population of cells is useful in therapy, wherein the cells have been expanded by the method comprising; i) obtaining an isolated population of HSPC ii) culturing the isolated population of HSPC in the presence of a histone deacetylase inhibitor (HDAC inhibitor), to form a cultured population iii) adding an aminothiol compound having the formula RNH(CnH2n)NH(CnH2n)SX, wherein R is hydrogen, an aryl, an acyl, or an alkyl group containing from 1 to 7 carbon atoms, each n has a value of from 2 to 6 and X is H or PO3H2; or a pharmaceutically acceptable salt thereof, to the cultured population of HSPC to form expanded cells.

5. 发明申请

US20130337529A1 Cell Culture 有权
标题翻译：细胞培养
公开(公告)号：US20130337529A1
公开(公告)日：2013-12-19
申请号：US13857888
申请日：2013-04-05
申请人： Plasticell Limited
发明人： Yen Choo
IPC分类号： C12N5/0735
CPC分类号： C12N5/0606 , A01H4/005 , A01H4/008 , A61K38/00 , C12N1/00 , C12N1/20 , C12N5/00 , C12N5/0031 , C12N9/93 , C12N2503/00 , C12N2531/00 , C12P39/00
摘要： A method for determining the effect of a plurality of culture conditions on a cell, comprising the steps of: a) providing a first set of groups of cell units each comprising one or more cells, and exposing said groups to desired culture conditions; (b) pooling two or more of said groups to form at least one second pool; (c) subdividing the second pool to create a further set of groups of cell units; (d) exposing said further groups to desired culture conditions; (e) optionally, repeating steps (b)-(d) iteratively as required; and (f) optionally assessing the effect on a given cell unit of the culture conditions to which it has been exposed.
摘要翻译：一种用于确定多个培养条件对细胞的影响的方法，包括以下步骤：a）提供第一组各自包含一个或多个细胞的细胞单元组，并将所述组暴露于所需培养条件; （b）汇集两个或多个所述组以形成至少一个第二池; （c）细分第二池以创建另一组单元格单元组; （d）将所述另外的组暴露于所需的培养条件下; （e）任选地，根据需要迭代地重复步骤（b） - （d）和（f）可选地评估给定细胞单位对其暴露于培养条件的影响。

6. 发明授权

US11473053B2 Methods for producing cells of the hematopoietic lineage using hydrogel encapsulation 有权
公开(公告)号：US11473053B2
公开(公告)日：2022-10-18
申请号：US16669650
申请日：2019-10-31
申请人： PLASTICELL LIMITED
发明人： Marina Tarunina , Cedric Humbert , Shahzad Ali , Yen Choo , Aaron Tsu Tshen Chuang , Dennis Saw
IPC分类号： C12N5/00 , C12N5/078 , C12N11/10
摘要： A hydrogel capsule comprising a stem cell core that has been induced to differentiate into a hematopoietic lineage cell, and methods for the production of hematopoietic lineage cells from stem cells encapsulated in a hydrogel.

7. 发明授权

US09574174B2 Cell culture 有权
标题翻译：细胞培养
公开(公告)号：US09574174B2
公开(公告)日：2017-02-21
申请号：US13857888
申请日：2013-04-05
申请人： PLASTICELL LIMITED
发明人： Yen Choo
IPC分类号： C12N5/00 , C12N5/02 , C12N1/20 , C12N9/00 , C12N1/00 , C12N5/0735 , A61K38/00 , A01H4/00 , C12P39/00
CPC分类号： C12N5/0606 , A01H4/005 , A01H4/008 , A61K38/00 , C12N1/00 , C12N1/20 , C12N5/00 , C12N5/0031 , C12N9/93 , C12N2503/00 , C12N2531/00 , C12P39/00
摘要： A method for determining the effect of a plurality of culture conditions on a cell, comprising the steps of: a) providing a first set of groups of cell units each comprising one or more cells, and exposing said groups to desired culture conditions; (b) pooling two or more of said groups to form at least one second pool; (c) subdividing the second pool to create a further set of groups of cell units; (d) exposing said further groups to desired culture conditions; (e) optionally, repeating steps (b)-(d) iteratively as required; and (f) optionally assessing the effect on a given cell unit of the culture conditions to which it has been exposed.
摘要翻译：一种用于确定多个培养条件对细胞的影响的方法，包括以下步骤：a）提供第一组各自包含一个或多个细胞的细胞单元组，并将所述组暴露于所需培养条件; （b）汇集两个或多个所述组以形成至少一个第二池; （c）细分第二池以创建另一组单元格单元组; （d）将所述另外的组暴露于所需的培养条件下; （e）任选地，根据需要迭代地重复步骤（b） - （d）和（f）可选地评估给定细胞单位对其暴露于培养条件的影响。

8. 发明申请

US20150191696A1 ADIPOSE TISSUE CELLS 有权
标题翻译： ADIPOSE组织细胞
公开(公告)号：US20150191696A1
公开(公告)日：2015-07-09
申请号：US14664441
申请日：2015-03-20
申请人： PLASTICELL LIMITED
发明人： Marina Tarunina , Yen Choo , Jeyakumar Mylvaganam , Thomas Watson , Meritxell Roseell , Lilian Hook , Diana Hernandez
IPC分类号： C12N5/077 , A61K35/35
CPC分类号： C12N5/0653 , A61K35/35 , C12N2500/24 , C12N2500/25 , C12N2501/01 , C12N2501/04 , C12N2501/155 , C12N2501/33 , C12N2502/1352 , C12N2506/1384
摘要： The present invention relates to brown adipose tissue (BAT) cells derived from adult stern or progenitor cells, derived from adult white fat tissue (WAT), as well as to methods for deriving such cells.
摘要翻译：本发明涉及衍生自成人白脂肪组织（WAT）的成人尾部或祖细胞的棕色脂肪组织（BAT）细胞，以及衍生这种细胞的方法。

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