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1. 发明授权

US06902746B2 Oral pharmaceutical compositions containing non-steroidal anti-inflammatory drugs and method for preparing the same 失效
标题翻译：含有非甾体抗炎药的口服药物组合物及其制备方法
公开(公告)号：US06902746B2
公开(公告)日：2005-06-07
申请号：US10187899
申请日：2002-07-03
申请人： Fang-Yu Lee , Shan-Chiung Chen , Ping-Kuen Chen , Han-Chiang Kuo
发明人： Fang-Yu Lee , Shan-Chiung Chen , Ping-Kuen Chen , Han-Chiang Kuo
IPC分类号： A61K9/32 , A61K9/50 , A61K31/205 , A61K31/407 , A61K47/04 , A61K47/14 , A61K47/26 , A61K47/32 , A61K47/34 , A61K47/36 , A61K47/38 , A61P29/00 , A61K9/16 , A61K9/20 , A61K9/22 , A61K9/24 , A61K9/48
CPC分类号： A61K31/205 , A61K9/5078
摘要： The present invention provides oral pharmaceutical compositions for acetic acid class of non-steroidal anti-inflammatory drug (NSAID), particularly ketorolac. The pharmaceutical composition contains a core, a drug layer (which comprises the drug, a binder, and a disintegrant), a protecting layer, and an enteric coating layer. The oral pharmaceutical compositons are particularly useful for treating patients with moderate to acute pain. The present invention also provides a method for making the pharmaceutical compositions and a method for using the pharmaceutical compositions.
摘要翻译：本发明提供了用于乙酸类非甾体抗炎药（NSAID）的口服药物组合物，特别是酮咯酸。药物组合物含有核心，药物层（其包含药物，粘合剂和崩解剂），保护层和肠溶衣层。口服药物组合物特别适用于治疗中度至急性疼痛的患者。本发明还提供了制备药物组合物的方法和使用该药物组合物的方法。

2. 发明授权

US06673373B2 Antifungal formulation and the methods for manufacturing and using the same 失效
标题翻译：抗真菌配方及其制造和使用方法
公开(公告)号：US06673373B2
公开(公告)日：2004-01-06
申请号：US10115994
申请日：2002-04-05
申请人： Fan-Yu Lee , Shan-Chiung Chen , Ping-Kuen Chen , Han-Chiang Kuo
发明人： Fan-Yu Lee , Shan-Chiung Chen , Ping-Kuen Chen , Han-Chiang Kuo
IPC分类号： A61N916
CPC分类号： A61K9/5078
摘要： The present invention provides novel pharmaceutical compositions for azole antimicrobial drugs such as itraconazole, saperconazole, ketoconazole, and fluconazole. The pharmaceutical compositions are in the form of pellets which comprise a core and a drug emulsion layer, and optionally, a protective layer. The drug emulsion layer contains the azole antimicrobial drug, an emulsifier, a binder, and an absorbent aid. The preferred emulsifier is vitamin E polyethylene glycol succinate. The preferred binder is hydroxypropyl methylcellulose. The preferred absorbent aid is DL malic acid. The drug is dissolved in organic solvents. The preferred organic solvents are ethanol and methylene chloride. The protective layer contains polyethylene glycol (PEG) 20,000, which is coated on the drug emulsion layer.
摘要翻译：本发明提供了用于唑类抗菌药物如伊曲康唑，沙康唑，酮康唑和氟康唑的新型药物组合物。药物组合物是包含核心和药物乳剂层以及任选的保护层的丸粒形式。药物乳剂层含有唑类抗微生物药物，乳化剂，粘合剂和吸收剂。优选的乳化剂是维生素E聚乙二醇琥珀酸酯。优选的粘合剂是羟丙基甲基纤维素。优选的吸收助剂是DL苹果酸。药物溶于有机溶剂。优选的有机溶剂是乙醇和二氯甲烷。保护层含有涂覆在药物乳剂层上的聚乙二醇（PEG）20,000。

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