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    • 5. 发明授权
    • Use of esters of long-chain fatty acids for treatment of autoimmune diseases
    • 使用长链脂肪酸酯来治疗自身免疫性疾病
    • US08614248B2
    • 2013-12-24
    • US10474696
    • 2002-04-11
    • Pinchas BursteinAvraham Ben-Nun
    • Pinchas BursteinAvraham Ben-Nun
    • A01N43/04A01N43/00A61K31/70A61K31/33
    • A61K31/7024A61K31/23A61K31/231A61K31/232A61K2300/00
    • Agents selected from: (i) a C1-C24 alkyl ester of a saturated or cis-unsaturated C10-C24 fatty acid; (ii) a monoester or polyester of a polyol having at least four hydroxy groups with a saturated or cis-unsaturated C10-C24 fatty acid or an anhydro derivative thereof; (iii) a monoester or polyester of a mono-, di- or poly-saccharide with a saturated or cis-unsaturated C10-C24 fatty acid; (iv) an amide of a saturated or cis-unsaturated C10-C24 fatty acid with an aliphatic or aromatic amine or with an amino acid, peptide, protein or aminosaccharide; and (v) combinations of any of (i) to (iv), can be used for treatment of autoimmune diseases and other immune-associated inflammatory disorders. Preferred agents are ethyl oleate and mannide monooleate or a combination thereof.
    • 选自以下的试剂:(i)饱和或顺式不饱和C10-C24脂肪酸的C1-C24烷基酯; (ii)具有至少四个羟基的饱和或顺式不饱和C 10 -C 24脂肪酸或其脱水衍生物的多元醇的单酯或聚酯; (iii)具有饱和或顺式不饱和C10-C24脂肪酸的单糖,二糖或多糖的单酯或聚酯; (iv)饱和或顺式不饱和的C 10 -C 24脂肪酸与脂族或芳族胺或氨基酸,肽,蛋白质或氨基糖的酰胺; 和(v)(i)至(iv)中任一项的组合可用于治疗自身免疫性疾病和其他免疫相关性炎症性疾病。 优选的试剂是油酸乙酯和单油酸甘露酯或其组合。