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1. 发明授权

US07081536B2 Isoxazoline derivatives as P N ligands 失效
标题翻译：异恶唑啉衍生物作为P N配体
公开(公告)号：US07081536B2
公开(公告)日：2006-07-25
申请号：US10485839
申请日：2002-08-01
申请人： Nicole End , Catherine Stoessel , Ulrich Berens , Pier Giorgio Cozzi
发明人： Nicole End , Catherine Stoessel , Ulrich Berens , Pier Giorgio Cozzi
IPC分类号： C07D263/08
CPC分类号： C07F15/065 , C07C29/143 , C07C45/29 , C07F9/65583 , C07F9/65586 , C07F15/004 , C07F15/0053 , C07F15/0066 , C07F15/008 , C07F15/0093 , C07F15/045 , C07C33/22
摘要： The invention relates to novel ligands of the phosphanylbenzothiophenyl-dihydroisoxazoline, phosphanyl-dihydrooxazolyl-indole and phosphanyl-dihydrooxazolyl-benzofuran type, especially compounds of formula I and mixtures of such compounds, wherein X is oxygen, sulfur, selenium or NQ, wherein Q is unsubstituted or substituted aryl, or alkyl or substituted alkyl; n is 0, 1, 2, 3 or 4; A1 and A2 are each an organic radical capable of bonding to phosphorus, especially unsubstituted or substituted alkyl, unsubstituted or substituted aryl, unsubstituted or substituted heterocyclyl, unsubstituted or substituted cycloalkyl, or —N(D)2 wherein D2 is alkyl or substituted alkyl; or A1 and A2 together with the bonding phosphorus atom form a ring, which may be unsubstituted or substituted; Y, Y′, Y″ and Y′″ are each independently of the other hydrogen or alkyl, substituted alkyl, unsubstituted or substituted aryl, or unsubstituted or substituted heterocyclyl, at least one of the radicals Y, Y′, Y″ or Y′″ being one of the mentioned radicals with the exception of hydrogen; and Z, when present, is a substituent, it being possible when a plurality of substituents Z is present for those substituents to be selected independently of one another, and to processes for their preparation, to novel precursors and intermediates, to complexes with the said ligands, to their preparation and to their use as catalysts in organic synthesis (especially asymmetric organic synthesis).
摘要翻译：本发明涉及膦酰基苯并噻吩基 - 二氢恶唑啉，膦基 - 二氢恶唑基 - 吲哚和膦基 - 二氢恶唑基 - 苯并呋喃型的新配体，特别是式I化合物及其混合物，其中X是氧，硫，硒或NQ，其中Q是未取代或取代的芳基，或烷基或取代的烷基; n为0,1,2,3或4; A 1和A 2分别是能够与磷结合的有机基团，特别是未取代或取代的烷基，未取代或取代的芳基，未取代或取代的杂环基，未取代或取代的环烷基或-N（D）2，其中D 2是烷基或取代的烷基; 或A 1和A 2与键合磷原子一起形成环，其可以是未取代的或取代的; Y，Y'，Y“和Y”'各自独立地为另一个氢或烷基，取代的烷基，未取代或取代的芳基，或未取代或取代的杂环基，基团Y，Y'，Y' '或Y''是除了氢之外的所提及的基团之一; 当存在时，Z是一个取代基，当对于那些彼此独立选择的那些取代基存在多个取代基Z，并且其制备方法，新的前体和中间体与所述的配体，它们的制备和用作有机合成（特别是不对称有机合成）中的催化剂。

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