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1. 发明授权

US07485989B2 Tunable electrical transient generator for electromagnetic pulser 有权
标题翻译：用于电磁脉冲发生器的可调电气瞬态发生器
公开(公告)号：US07485989B2
公开(公告)日：2009-02-03
申请号：US11523879
申请日：2006-09-20
申请人： Charles Crain , Philip Lane , John McClure , James Youngman
发明人： Charles Crain , Philip Lane , John McClure , James Youngman
IPC分类号： H03K3/00
CPC分类号： H03K3/53
摘要： A system for generating a high voltage energy pulse comprises a capacitive energy storage arrangement that is coupled to a direct current (DC) power supply. The capacitive energy storage arrangement stores energy from the power supply. The system also includes a pulse forming network for forming frequency contents of a high voltage energy pulse. A dielectric insulated mechanical switch is coupled to the capacitive energy storage arrangement and the pulse forming network. The dielectric insulated mechanical switch is immersed in a dielectric substance. A controller is coupled to the dielectric insulated mechanical switch. The controller is programmed to selectively open and close the dielectric insulated mechanical switch so as to supply energy stored in the capacitive energy storage device to the pulse forming network and thereby form the high voltage energy pulse.
摘要翻译：用于产生高电压能量脉冲的系统包括耦合到直流（DC）电源的电容性能量存储装置。电容性能量存储装置存储来自电源的能量。该系统还包括用于形成高电压能量脉冲的频率内容的脉冲形成网络。电介质绝缘机械开关耦合到电容性能量存储装置和脉冲形成网络。介电绝缘机械开关浸入电介质中。控制器耦合到绝缘绝缘机械开关。控制器被编程为选择性地打开和关闭绝缘绝缘的机械开关，以将存储在电容性能量存储装置中的能量提供给脉冲形成网络，从而形成高电压能量脉冲。

2. 发明授权

US09365508B2 Aroyl thiourea derivatives 有权
标题翻译：芳酰基硫脲衍生物
公开(公告)号：US09365508B2
公开(公告)日：2016-06-14
申请号：US13377145
申请日：2010-06-09
申请人： Sonia Lain , Nicholas James Westwood , David Philip Lane
发明人： Sonia Lain , Nicholas James Westwood , David Philip Lane
IPC分类号： C07C335/26 , C07C327/54
CPC分类号： C07C335/26 , C07C327/54
摘要： The invention provides compounds according to formula (I): (wherein X, Y, Z1 R1, R2, R3, Ar and Ar′ are as defined herein), and physiologically acceptable salts, solvates, esters or amides thereof, pharmaceutical compositions comprising these compounds and the compounds for use in medicine, for example for the treatment or prophylaxis of diseases involving cell proliferation, such as cancer, and for the treatment or prophylaxis of other diseases.
摘要翻译：本发明提供式（I）化合物：其中X，Y，Z 1 R 1，R 2，R 3，Ar和Ar'如本文所定义）及其生理上可接受的盐，溶剂合物，酯或酰胺，包含这些化合物和用于医药的化合物，例如用于治疗或预防涉及细胞增殖的疾病，例如癌症，以及用于治疗或预防其它疾病。

3. 发明申请

US20120149778A1 COMPOUNDS 有权
标题翻译：化合物
公开(公告)号：US20120149778A1
公开(公告)日：2012-06-14
申请号：US13377145
申请日：2010-06-09
申请人： Sonia Lain , Nicholas James Westwood , David Philip Lane
发明人： Sonia Lain , Nicholas James Westwood , David Philip Lane
IPC分类号： A61K31/17 , A61P35/00 , A61P25/28 , A61P25/16 , A61P19/00 , A61P37/00 , A61P7/06 , A61P3/10 , A61P21/00 , A61P29/00 , A61P3/04 , A61P9/04 , A61P31/18 , A61P33/06 , A61P3/00 , C07D295/15 , A61P7/00 , C07C335/26
CPC分类号： C07C335/26 , C07C327/54
摘要： The invention provides compounds according to formula (I): (wherein X, Y, Z1 R1, R2, R3, Ar and Ar′ are as defined herein), and physiologically acceptable salts, solvates, esters or amides thereof, pharmaceutical compositions comprising these compounds and the compounds for use in medicine, for example for the treatment or prophylaxis of diseases involving cell proliferation, such as cancer, and for the treatment or prophylaxis of other diseases.
摘要翻译：本发明提供式（I）化合物：其中X，Y，Z 1 R 1，R 2，R 3，Ar和Ar'如本文所定义）及其生理上可接受的盐，溶剂合物，酯或酰胺，包含这些化合物和用于医药的化合物，例如用于治疗或预防涉及细胞增殖的疾病，例如癌症，以及用于治疗或预防其它疾病。

4. 发明申请

US20090139844A1 TUNABLE ELECTRICAL TRANSIENT GENERATOR FOR ELECTROMAGNETIC PULSER 审中-公开
标题翻译：用于电磁脉冲的电动瞬态发电机
公开(公告)号：US20090139844A1
公开(公告)日：2009-06-04
申请号：US12365125
申请日：2009-02-03
申请人： Charles Crain , Philip Lane , John McClure , James Youngman
发明人： Charles Crain , Philip Lane , John McClure , James Youngman
IPC分类号： H01H33/06
CPC分类号： H03K3/53
摘要： A dielectric insulated mechanical switch is coupled to a capacitive energy storage arrangement and a pulse forming network. The dielectric insulated mechanical switch is immersed in a dielectric substance. A controller is coupled to the dielectric insulated mechanical switch. The controller is programmed to selectively open and close the dielectric insulated mechanical switch so as to supply energy stored in the capacitive energy storage device to the pulse forming network and thereby form a high voltage energy pulse.
摘要翻译：绝缘绝缘机械开关耦合到电容性能量存储装置和脉冲形成网络。介电绝缘机械开关浸入电介质中。控制器耦合到绝缘绝缘机械开关。控制器被编程为选择性地打开和关闭绝缘绝缘机械开关，以将存储在电容性能量存储装置中的能量提供给脉冲形成网络，从而形成高电压能量脉冲。

5. 发明申请

US20080249025A1 Methods and Means For Inhibition of CDK4 Activity 审中-公开
标题翻译：抑制CDK4活性的方法和手段
公开(公告)号：US20080249025A1
公开(公告)日：2008-10-09
申请号：US12133242
申请日：2008-06-04
申请人： Kathryn Lindsay Ball , David PHilip Lane
发明人： Kathryn Lindsay Ball , David PHilip Lane
IPC分类号： A61K38/10 , C12N5/02 , C12N15/01 , A61P43/00 , A61K38/08
CPC分类号： C07K14/4703 , A61K38/00
摘要： p21WAF1 interacts with cyclin D1 and Cdk4. Peptide fragments of p21 inhibit the interaction and/or affect Cdk4 activity. The peptides, derivative peptides and non-peptidyl mimetics thereof are useful in affecting activity of Cdk4, such as RB phosphorylation and cellular proliferation, indicative of therapeutic usefullness in treatment of tumors and other hyperproliferative disorders. Assay and screening methods allow identification of such modulators, especially inhibitors, of Cdk4 activity.
摘要翻译： p21 WAF1与细胞周期蛋白D1和Cdk4相互作用。 p21的肽片段抑制相互作用和/或影响Cdk4活性。肽，衍生肽和非肽基模拟物可用于影响Cdk4的活性，例如RB磷酸化和细胞增殖，指示治疗肿瘤和其他过度增生性疾病的治疗有用性。测定和筛选方法允许鉴定Cdk4活性的这种调节剂，特别是抑制剂。

6. 发明授权

US07141541B1 Use of peptides 失效
标题翻译：使用肽
公开(公告)号：US07141541B1
公开(公告)日：2006-11-28
申请号：US10019198
申请日：2000-06-21
申请人： Christopher Gregory Proud , Terrence Patrick Herbert , David Philip Lane , Robin Fahraeus
发明人： Christopher Gregory Proud , Terrence Patrick Herbert , David Philip Lane , Robin Fahraeus
IPC分类号： A61K38/00 , A61K49/00
CPC分类号： C07K14/4705 , A61K38/00 , C07K14/4747
摘要： We claim a therapeutic method of inducing programmed cell death comprising administering to a recipient a peptide of 10–25 amino acids, comprising the sequence: (KR)xxYxxx(F/Q)L(L/M) wherein x is any amino acid.
摘要翻译：我们要求诱导程序性细胞死亡的治疗方法，包括向受体施用10-25个氨基酸的肽，其包含序列：（KR）xxYxxx（F / Q）L（L / M），其中x是任何氨基酸。

7. 发明授权

US07113708B1 Data communications link 失效
标题翻译：数据通信链接
公开(公告)号：US07113708B1
公开(公告)日：2006-09-26
申请号：US09437004
申请日：1999-11-09
申请人： Stephen Creaney , Philip Lane , Richard John Ferguson , Thomas Crummey
发明人： Stephen Creaney , Philip Lane , Richard John Ferguson , Thomas Crummey
IPC分类号： H04B10/00
CPC分类号： H04L25/4917 , H04B10/07955
摘要： A data communications link uses a multi-power level optical source to encode and transmit data words along a communications channel to a receiver station. A received signal condition monitor senses the level of a pre-determined characteristic and transmits a control signal to a controller which controls the power output of the optical source.
摘要翻译：数据通信链路使用多功率电平光源来将数据字沿着通信信道编码和发送到接收机站。接收信号状态监视器感测预定特性的电平，并将控制信号发送到控制光源的功率输出的控制器。

8. 发明授权

US6020149A Methods of screening for anti-microbial agents and for inhibiting microbial growth 失效
标题翻译：筛选抗微生物剂和抑制微生物生长的方法
公开(公告)号：US6020149A
公开(公告)日：2000-02-01
申请号：US929738
申请日：1997-09-15
申请人： Frances Victoria Fuller-Pace , David Philip Lane
发明人： Frances Victoria Fuller-Pace , David Philip Lane
IPC分类号： C12N15/09 , A61K39/395 , A61P31/04 , C12N5/10 , C12N9/16 , C12N9/22 , C12N15/55 , C12Q1/18 , C12Q1/42
CPC分类号： A61K31/70 , C12N9/22 , C12Q1/18 , C12Q1/42
摘要： A method for determining the anti-microbial activity of a putative anti-microbial agent includes combining a microbially required nucleotide phosphatase, a nucleoside phosphate and the substance to be tested, and assessing the extent of degradation of the nucleoside phosphate in the presence and absence of the substance. The method thus allows the determination of the extent of inhibition of the nucleotide phosphatase by the substance. Preferably the method determines the degree of inhibition of an RNA helicase such as DbpA, which acts selectively on prokaryotic ribosomal RNA. Suitable DbpA inhibitors as well as genetic material encoding for an active form of DbpA are used.
摘要翻译：用于测定推定的抗微生物剂的抗微生物活性的方法包括将微生物需要的核苷酸磷酸酶，磷酸核苷和待测物质组合，并且在存在和不存在下测定磷酸核苷的降解程度物质。因此，该方法允许确定该物质对核苷酸磷酸酶的抑制程度。优选地，该方法确定RNA解旋酶如DbpA的抑制程度，DbpA选择性地作用于原核核糖体RNA。使用合适的DbpA抑制剂以及编码活性形式的DbpA的遗传物质。

9. 发明授权

US07083983B2 Inhibitors of the interaction between P53 and MDM2 失效
标题翻译：抑制P53和MDM2之间的相互作用
公开(公告)号：US07083983B2
公开(公告)日：2006-08-01
申请号：US09214371
申请日：1997-07-04
申请人： David Philip Lane , Volker Böttger , Angelika Böttger , Steven Michael Picksley , Heinz-Kurt Hochkeppel , Carlos Garcia-Echeverria , Patrick Chène , Pascal Furet
发明人： David Philip Lane , Volker Böttger , Angelika Böttger , Steven Michael Picksley , Heinz-Kurt Hochkeppel , Carlos Garcia-Echeverria , Patrick Chène , Pascal Furet
IPC分类号： G01N33/566 , G01N33/53 , A61K38/00 , A61K38/12 , A61K51/00
CPC分类号： C07K7/04 , A61K38/00 , C07K2319/00
摘要： The present invention relates to compounds capable of binding to the oncogene protein MDM2, processes for the preparation of such compounds, pharmaceutical preparations comprising such compounds, and uses of said compounds, e.g. in the therapeutic (including prophylactic) treatment of an animal or especially of the human body. The present further relates to methods of and compounds for inhibiting the growth of tumor cells which comprise the wild type p53 suppressor by interfering with the interaction between human p53 and human MDM2.
摘要翻译：本发明涉及能够结合致癌基因蛋白MDM2的化合物，制备这些化合物的方法，包含这些化合物的药物制剂，以及所述化合物的用途，例如，在动物或特别是人体的治疗（包括预防性）治疗中。本发明还涉及通过干扰人p53与人MDM2之间的相互作用来抑制包含野生型p53抑制因子的肿瘤细胞生长的方法和化合物。

10. 发明授权

US06754240B1 Format for an optical data link 有权
标题翻译：光学数据链接的格式
公开(公告)号：US06754240B1
公开(公告)日：2004-06-22
申请号：US09353553
申请日：1999-07-14
申请人： Thomas Crummey , Richard John Fergusson , Shaun Kerigan , Philip Lane
发明人： Thomas Crummey , Richard John Fergusson , Shaun Kerigan , Philip Lane
IPC分类号： H04J1256
CPC分类号： G09G5/006 , G09G2360/02 , G09G2370/04 , H04J3/047 , H04J3/1682 , H04L12/6418 , H04L2012/6427 , H04L2012/6429 , H04L2012/6459 , H04N7/52 , H04N21/2381 , H04N21/4113 , H04N21/4363 , H04N21/4381 , H04N21/64307
摘要： An isochronous output data stream format which is time multiplexed and has a fixed time period where input isochronous data streams are multiplexed into the output isochronous data stream and the output data stream is the same data rate as the fastest input isochronous data stream. One or more of the input data streams contain a code which has been run length limited and/or has a zero running digital sum with banded disparity. In another embodiment, an isochronous output data stream format which is time multiplexed and has a fixed time period where input isochronous data streams are multiplexed into the output isochronous data stream and the output data stream is the sum of the maximum input isochronous data streams. One or more of the data streams contain a code which has been run length limited and/or has a zero running digital sum with banded disparity.
摘要翻译：同步输出数据流格式是时间复用并且具有固定时间段，其中输入同步数据流被复用到输出同步数据流和输出数据流中是与最快的输入同步数据流相同的数据速率。输入数据流中的一个或多个包含已经运行长度受限的代码和/或具有带状差异的零运行数字和。在另一个实施例中，等时输出数据流格式是时间复用并且具有固定时间段，其中输入同步数据流被多路复用到输出同步数据流和输出数据流中是最大输入同步数据流的总和。数据流中的一个或多个包含已经运行长度受限的代码和/或具有带状差异的零运行数字和。

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