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1. 发明申请

US20080279966A1 Branched-chain amino acid composition for improving skeletal muscle protein metabolism 审中-公开
标题翻译：用于改善骨骼肌蛋白质代谢的支链氨基酸组成
公开(公告)号：US20080279966A1
公开(公告)日：2008-11-13
申请号：US11745859
申请日：2007-05-08
申请人： Ken CLEMENT , Shan CHAUDHURI , Michele MOLINO , Phil APONG , Jason PETERS
发明人： Ken CLEMENT , Shan CHAUDHURI , Michele MOLINO , Phil APONG , Jason PETERS
IPC分类号： A61K36/19 , A61P21/00
CPC分类号： A61K36/19 , A61K2300/00
摘要： The present invention relates to compositions and methods for improving skeletal muscle protein metabolism through encouraging skeletal muscle protein synthesis, reducing skeletal muscle protein degradation, and attenuating inflammatory signaling in exercising muscle.
摘要翻译：本发明涉及通过鼓励骨骼肌蛋白质合成，减少骨骼肌蛋白质降解和减轻运动肌肉中的炎症信号来改善骨骼肌蛋白质代谢的组合物和方法。

2. 发明授权

US08372447B2 Compositions and methods for promoting weight loss and increasing energy 有权
标题翻译：促进体重减轻和增加能量的组合物和方法
公开(公告)号：US08372447B2
公开(公告)日：2013-02-12
申请号：US12849076
申请日：2010-08-03
申请人： John Doherty , Phil Apong , James Akrong , Shawn Shirazi
发明人： John Doherty , Phil Apong , James Akrong , Shawn Shirazi
IPC分类号： A61K36/515
CPC分类号： A61K36/28 , A61K36/258 , A61K36/45 , A61K36/48 , A61K36/534 , A61K36/889 , A61K36/899 , A61K36/9066 , A61K2300/00
摘要： The present invention relates to compositions comprising plants and extracts of plants with chlorogenic acids and antioxidants and/or caffeine; methods for preparing the same; and methods to promote weight loss through the administration of compositions containing these plants and plant extracts in specific proportions.
摘要翻译：本发明涉及含有绿原酸和抗氧化剂和/或咖啡因的植物和植物提取物的组合物; 制备方法; 以及通过以特定比例施用含有这些植物和植物提取物的组合物来促进体重减轻的方法。

3. 发明申请

US20120052137A1 WEIGHT LOSS FORMULATION 有权
标题翻译：重量损失配方
公开(公告)号：US20120052137A1
公开(公告)日：2012-03-01
申请号：US13221141
申请日：2011-08-30
申请人： Shawn Shirazi , James Akrong , Phil Apong , Raza Bashir , Craig Wissent
发明人： Shawn Shirazi , James Akrong , Phil Apong , Raza Bashir , Craig Wissent
IPC分类号： A61K36/82 , A61K36/45 , A61K36/752 , A61P3/04 , A61K36/886 , A61K36/48 , A61K36/81 , A61K36/00 , A61K36/54
CPC分类号： A61K36/815 , A61K31/201 , A61K31/375 , A61K31/522 , A61K36/185 , A61K36/23 , A61K36/45 , A61K36/48 , A61K36/534 , A61K36/54 , A61K36/63 , A61K36/73 , A61K36/752 , A61K36/81 , A61K36/82 , A61K36/886 , A61K2300/00
摘要： A weight loss product comprises a mixture of Alchemilla vulgaris, Olea europaea, Cuminum cyminum, and Mentha longiflora (in the weight proportion 12:10:5:4), to which additional ingredients have been added to increase weight loss efficacy. The additional ingredients may include, but are not limited to, Gamma-oryzanol, Caffeine, Cirsimarin, Fucoxanthin, Guggulsterones, Evodiamine, Forskolin, Sclareolide, Chromium, Hydroxycitric acid, Pinolenic acid, Conjugated linoleic acid, Potato protein, Raspberry ketone, Capsaicin, Synephrine, Dehydroepiandrosterone, Phenylethylamine, Orlistat, Glucomannan, or Vitamin C, or sources thereof, as well as herbal ingredients such as Guarana, Yerba Mate, Damiana, Green tea, Green coffee bean, Cinnamon, White kidney bean, Garcinia Cambogia, Nopal Cactus, Hoodia, Yohimbine, Malpighia glabra, Eurycoma Longifolia, Caralluma Fimbriata, Citrus aurantium, Gymnema Sylvestre, Lyceum barbarurn, Aloe Vera, Cayenne, Pomegranate, Blueberry, Billberry, or extracts of such herbal ingredients, and plant sources of antioxidants. A preferred additional ingredient is caffeine provided by caffeine anhydrous, Coffea Arabica, Coffea canephora, Camellia sinensis, Ilex paraguariensis, Guarana, Theobroma cacao, and kola nut. Other additional ingredients may be used as well in accordance with specific disclosed formulations.
摘要翻译：减肥产品包括通常的炼金术（Alchemilla vulgaris），欧莱雅（Olea europaea），孜然孜然（Cuminum cyminum）和长and and（Mentha longiflora）（重量比例为12:10:5:4）的混合物，加入其它成分以增加减肥功效。另外的成分可以包括但不限于γ-谷维素，咖啡因，Cirsimarin，甲氧基黄嘌呤，Guculsterones，吴茱萸碱，福斯克林，香紫苏内酯，铬，羟基柠檬酸，芥子酸，共轭亚油酸，马铃薯蛋白，树莓酮，辣椒素，昔萘福林，脱氢表雄甾酮，苯乙胺，奥利司他，葡甘露聚糖或维生素C，或其来源，以及草药成分如瓜拉那，雅巴玛特，达米亚那，绿茶，绿咖啡豆，肉桂，白芸豆，藤黄果，胭脂仙人掌，Hoodia，Yohimbine，Malpighia glabra，Eurycoma Longifolia，Caralluma Fimbriata，Citrus aurantium，Gymnema Sylvestre，Lyceum barbarurn，芦荟，Cayenne，Parggranate，Blueberry，Billberry或这些草药成分的提取物和抗氧化剂的植物来源。优选的另外的成分是咖啡因无水咖啡因，咖啡咖啡，芹菜，山茶，冬青，瓜拉那，可可可可和坚果。也可以根据具体公开的制剂使用其它另外的成分。

4. 发明申请

US20110092587A1 Branched-chain amino acid composition for improving skeletal muscle protein metabolism 有权
标题翻译：用于改善骨骼肌蛋白质代谢的支链氨基酸组成
公开(公告)号：US20110092587A1
公开(公告)日：2011-04-21
申请号：US12928481
申请日：2010-12-13
申请人： Ken Clement , Shan Chaudhuri , Jason Peters , Michele Molino , Phil Apong
发明人： Ken Clement , Shan Chaudhuri , Jason Peters , Michele Molino , Phil Apong
IPC分类号： A61K31/341 , A61P21/06 , A61P21/00
CPC分类号： A61K36/19 , A61K2300/00
摘要： The present invention relates to compositions and methods for improving skeletal muscle protein metabolism through encouraging skeletal muscle protein synthesis, reducing skeletal muscle protein degradation, and attenuating inflammatory signaling in exercising muscle.
摘要翻译：本发明涉及通过鼓励骨骼肌蛋白质合成，减少骨骼肌蛋白质降解和减轻运动肌肉中的炎症信号来改善骨骼肌蛋白质代谢的组合物和方法。

5. 发明申请

US20090162458A1 COMPOSITIONS AND METHODS FOR INDUCING THE EXPRESSION OF HEAT SHOCK PROTEINS 审中-公开
标题翻译：诱发热休克蛋白表达的组合物和方法
公开(公告)号：US20090162458A1
公开(公告)日：2009-06-25
申请号：US11962963
申请日：2007-12-21
申请人： Michele Molino , Joseph MacDougall , Phil Apong
发明人： Michele Molino , Joseph MacDougall , Phil Apong
IPC分类号： A61K36/00 , C12N5/00 , A61K31/045
CPC分类号： A61K36/00 , A23L33/10 , A61K31/045
摘要： A nutritional composition comprising at least an effective amount of geranylgeranylacetone or derivative of geranygeranylacetone and/or paeoniflorin or derivative of paeoniflorin and an effective amount of Schisandrin B, wherein the ingredients act substantially simultaneously, via differing mechanism, to enhance the expression of heat shock protein in cells, particularly heat shock protein 72 in skeletal muscle. A method of same is also provided.
摘要翻译：一种营养组合物，其包含至少有效量的香叶基香叶基丙酮或er ger ger anyl anyl one one one and and or lor lor lor lor lor lor lor lor protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein 在细胞中，特别是骨骼肌中的热休克蛋白72。还提供了其方法。

6. 发明申请

US20120034323A1 COMPOSITIONS AND METHODS FOR PROMOTING WEIGHT LOSS AND INCREASING ENERGY 有权
标题翻译：促进重量损失和增加能源的组合物和方法
公开(公告)号：US20120034323A1
公开(公告)日：2012-02-09
申请号：US12849076
申请日：2010-08-03
申请人： John Doherty , Phil Apong , James Akrong , Shawn Shirazi
发明人： John Doherty , Phil Apong , James Akrong , Shawn Shirazi
IPC分类号： A61K36/889 , A61P3/04 , A61K36/45 , A61K36/899 , A61K36/258 , A61K36/9066 , A61K36/534 , A61K36/28 , A61K36/48
CPC分类号： A61K36/28 , A61K36/258 , A61K36/45 , A61K36/48 , A61K36/534 , A61K36/889 , A61K36/899 , A61K36/9066 , A61K2300/00
摘要： The present invention relates to compositions comprising plants and extracts of plants with chlorogenic acids and antioxidants and/or caffeine; methods for preparing the same; and methods to promote weight loss through the administration of compositions containing these plants and plant extracts in specific proportions.
摘要翻译：本发明涉及含有绿原酸和抗氧化剂和/或咖啡因的植物和植物提取物的组合物; 制备方法; 以及通过以特定比例施用含有这些植物和植物提取物的组合物来促进体重减轻的方法。

7. 发明授权

US08062679B2 Composition for maintaining androgen and androgen-like uptake potential by cells 有权
标题翻译：用于维持雄激素和雄激素样摄取潜能的组合物
公开(公告)号：US08062679B2
公开(公告)日：2011-11-22
申请号：US11746825
申请日：2007-05-10
申请人： Ken Clement , Shan Chaudhuri , Michele Molino , Phil Apong
发明人： Ken Clement , Shan Chaudhuri , Michele Molino , Phil Apong
IPC分类号： A61K36/00 , A61K31/4045 , C07D313/00
CPC分类号： A61K31/205 , A23L33/105 , A23L33/175 , A61K31/122 , A61K36/07 , A61K36/53 , A61K2300/00
摘要： A composition comprising at least a therapeutically effective amount of L-carnitine fumarate, and an extract of Coleus forskohlii is provided to maintain androgen and androgen-like uptake potential in cells, via simultaneous increase in the availability of androgen receptors and improved availability of androgen and androgen-like molecules. A method of same is also provided. The present invention further comprises therapeutically effective amounts of one or more of N-acetyl L-carnitine, melatonin. ubidecarenone (coenzyme Q10), idebenone, decylubiquinone, an extract of Agaricus blazei Murill, and ginsenoside Rb1.
摘要翻译：提供了包含至少一种治疗有效量的L-肉碱富马酸盐和一种提取物的柯氏梭菌，以通过同时增加雄激素受体的可用性和改善雄激素的可用性来维持细胞中的雄激素和雄激素样摄取潜力，以及雄激素样分子。还提供了其方法。本发明还包括治疗有效量的一种或多种N-乙酰基L-肉毒碱，褪黑激素。 ubidecarenone（辅酶Q10），艾地苯醌，十倍酮，Agaricus blazei Murill的提取物和人参皂甙Rb1。

8. 发明授权

US07993685B2 Branched-chain amino acid composition for improving skeletal muscle protein metabolism 有权
公开(公告)号：US07993685B2
公开(公告)日：2011-08-09
申请号：US12928481
申请日：2010-12-13
申请人： Ken Clement , Shan Chaudhuri , Phil Apong , Michele Molino , Jason Peters
发明人： Ken Clement , Shan Chaudhuri , Phil Apong , Michele Molino , Jason Peters
IPC分类号： A61K36/00
CPC分类号： A61K36/19 , A61K2300/00
摘要： The present invention relates to compositions and methods for improving skeletal muscle protein metabolism through encouraging skeletal muscle protein synthesis, reducing skeletal muscle protein degradation, and attenuating inflammatory signaling in exercising muscle.

9. 发明申请

US20090263519A1 COMPOSITION AND METHODS FOR INDUCING THE EXPRESSION OF HEAT SHOCK PROTEINS 审中-公开
标题翻译：用于诱导热休克蛋白表达的组合物和方法
公开(公告)号：US20090263519A1
公开(公告)日：2009-10-22
申请号：US12493389
申请日：2009-06-29
申请人： Michele Molino , Joseph MacDougall , Phil Apong
发明人： Michele Molino , Joseph MacDougall , Phil Apong
IPC分类号： A61K36/79 , A61P21/00
CPC分类号： A61K36/00 , A23L33/10 , A61K31/045
摘要： A nutritional composition comprising at least an effective amount of geranylgeranylacetone or derivative of geranygeranylacetone and/or paeoniflorin or derivative of paeoniflorin and an effective amount of Schisandrin B, wherein the ingredients act substantially simultaneously, via differing mechanism, to enhance the expression of heat shock protein in cells, particularly heat shock protein 72 in skeletal muscle. A method of same is also provided.
摘要翻译：一种营养组合物，其包含至少有效量的香叶基香叶基丙酮或er ger ger anyl anyl one one one and and or lor lor lor lor lor lor lor lor protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein protein 在细胞中，特别是骨骼肌中的热休克蛋白72。还提供了其方法。

10. 发明申请

US20080279837A1 Composition for maintaining androgen and androgen-like uptake potential by cells 有权
标题翻译：用于维持雄激素和雄激素样摄取潜能的组合物
公开(公告)号：US20080279837A1
公开(公告)日：2008-11-13
申请号：US11746825
申请日：2007-05-10
申请人： Ken CLEMENT , Shan CHAUDHURI , Michele MOLINO , Phil APONG
发明人： Ken CLEMENT , Shan CHAUDHURI , Michele MOLINO , Phil APONG
IPC分类号： A61K36/53 , A61K31/122 , A61P21/06 , A61K36/06
CPC分类号： A61K31/205 , A23L33/105 , A23L33/175 , A61K31/122 , A61K36/07 , A61K36/53 , A61K2300/00
摘要： A composition comprising at least a therapeutically effective amount of L-carnitine fumarate, and an extract of Coleus forskohlii is provided to maintain androgen and androgen-like uptake potential in cells, via simultaneous increase in the availability of androgen receptors and improved availability of androgen and androgen-like molecules. A method of same is also provided. The present invention further comprises therapeutically effective amounts of one or more of N-acetyl L-carnitine, melatonin. ubidecarenone (coenzyme Q10), idebenone, decylubiquinone, an extract of Agaricus blazei Murill, and ginsenoside Rb1.
摘要翻译：提供了包含至少一种治疗有效量的L-肉碱富马酸盐和一种提取物的柯氏梭菌，以通过同时增加雄激素受体的可用性和改善雄激素的可用性来维持细胞中的雄激素和雄激素样摄取潜力，以及雄激素样分子。还提供了其方法。本发明还包括治疗有效量的一种或多种N-乙酰基L-肉毒碱，褪黑激素。 ubidecarenone（辅酶Q10），艾地苯醌，十倍酮，Agaricus blazei Murill的提取物和人参皂甙Rb1。

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