专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20120028320A1 PREPARATION OF ADIPIC ACID 审中-公开
标题翻译：丙二酸的制备
公开(公告)号：US20120028320A1
公开(公告)日：2012-02-02
申请号：US13255473
申请日：2010-03-11
申请人： Petronella Catharina Raemakers-Franken , Martin Schürmann , Axel Christoph Trefzer , Stefaan Marie André De Wildeman
发明人： Petronella Catharina Raemakers-Franken , Martin Schürmann , Axel Christoph Trefzer , Stefaan Marie André De Wildeman
IPC分类号： C12P7/44 , C12P7/62 , C12N1/21 , C12N1/15 , C12N1/19
CPC分类号： C12P7/50 , C12N9/0008 , C12N9/1025 , C12N9/88 , C12P7/44 , C12P13/005 , C12P13/02 , C12P17/10
摘要： The invention relates to a method for preparing adipic acid, comprising converting alpha-ketoglutaric acid (AKG) into alpha-ketoadipic acid (AKA), converting alpha-ketoadipic acid into alpha-ketopimelic acid (AKP), converting alpha-ketopimelic acid into 5-formylpentanoic acid (5-FVA), and converting 5-formylpentanoic acid into adipic acid, wherein at least one of these conversions is carried out using a heterologous biocatalyst.The invention further relates to a heterologous cell, comprising one or more heterologous nucleic acid sequences encoding one or more heterologous enzymes capable of catalysing at least one reaction step in said method.
摘要翻译：本发明涉及一种制备己二酸的方法，包括将α-酮戊二酸（AKG）转化为α-酮己二酸（AKA），将α-酮己二酸转化成α-酮戊二酸（AKP），将α-酮戊二酸转化为5 - 甲酰基戊酸（5-FVA），并将5-甲酰基戊酸转化成己二酸，其中这些转化中的至少一种使用异源生物催化剂进行。本发明还涉及异源细胞，其包含一个或多个异源核酸编码能够在所述方法中催化至少一个反应步骤的一种或多种异源酶的序列。

2. 发明申请

US20110136186A1 PREPARATION OF ALPHA-AMINO-EPSILON-CAPROLACTAM VIA LYSINE CYCLISATION 审中-公开
标题翻译：通过赖氨酸循环制备阿尔法 - 氨基 - 雌二醇
公开(公告)号：US20110136186A1
公开(公告)日：2011-06-09
申请号：US12992660
申请日：2009-05-20
申请人： Petronella Catharina Raemakers-Franken , Martin Schurmann , Axel Christoph Trefzer , Betty Bernice Coussens , Bernardus Kaptein
发明人： Petronella Catharina Raemakers-Franken , Martin Schurmann , Axel Christoph Trefzer , Betty Bernice Coussens , Bernardus Kaptein
IPC分类号： C12P17/10 , C12N1/15 , C12N1/19 , C12N1/21
CPC分类号： C12P17/10
摘要： The present invention relates to a method for preparing α-amino-ε-caprolactam, comprising converting lysine to α-amino-ε-caprolactam, wherein the conversion is catalysed by a biocatalyst. Further, the invention relates to a host cell comprising at least one recombinant vector comprising a nucleic acid sequence encoding a biocatalyst with lysine cyclase activity. Further a method is provided wherein α-amino-ε-caprolactam is used for preparing c-caprolactam.
摘要翻译：本发明涉及一种制备α-氨基 - 己内酰胺的方法，包括将赖氨酸转化为α-氨基 - 己内酰胺，其中转化由生物催化剂催化。此外，本发明涉及包含至少一种重组载体的宿主细胞，其包含编码具有赖氨酸环化酶活性的生物催化剂的核酸序列。此外，提供了一种使用α-氨基 - 己内酰胺制备己内酰胺的方法。

3. 发明申请

US20110183386A1 PREPARATION OF EPSILON-CAPROLACTAM FROM (Z)-6,7-DIHYDRO-1H-AZEPIN-2(5H)-ONE 审中-公开
标题翻译：（Z）-6,7-二氢-1H-亚苄基-2（5H） - 酮的EPSILON-CAPROLACTAM的制备
公开(公告)号：US20110183386A1
公开(公告)日：2011-07-28
申请号：US12991605
申请日：2009-05-20
申请人： Petronella Catharina Raemakers-Franken , Martin Schurmann , Axel Christoph Trefzer , Stefaan Marie Andre De Wildeman
发明人： Petronella Catharina Raemakers-Franken , Martin Schurmann , Axel Christoph Trefzer , Stefaan Marie Andre De Wildeman
IPC分类号： C12P17/10 , C12N1/15 , C12N1/19 , C12N1/21 , C07H21/00
CPC分类号： C12P17/10
摘要： The invention relates to a method for preparing ε-caprolactam comprising reducing the carbon-carbon double bond of (Z)-6,7-dihydro-1H-azepin-2(5H)-one, wherein the reduction is catalysed by a biocatalyst. The invention further relates to a novel host cell comprising a biocatalyst capable of catalysing said reduction and to a novel polynucleotide encoding a biocatalyst capable of catalysing said reduction.
摘要翻译：本发明涉及一种制备ε-己内酰胺的方法，包括还原（Z）-6,7-二氢-1H-吖庚因-2（5H） - 酮的碳 - 碳双键，其中还原是由生物催化剂。本发明还涉及包含能够催化所述还原的生物催化剂的新型宿主细胞和编码能够催化所述还原的生物催化剂的新型多核苷酸。

4. 发明授权

US08999680B2 Preparation of 1,4-diaminobutane 有权
标题翻译： 1,4-二氨基丁烷的制备
公开(公告)号：US08999680B2
公开(公告)日：2015-04-07
申请号：US13386169
申请日：2010-07-20
申请人： Liang Wu , Petronella Catharina Raemakers-Franken
发明人： Liang Wu , Petronella Catharina Raemakers-Franken
IPC分类号： C12P13/00
CPC分类号： C12P13/001
摘要： The present invention relates to a novel method for the preparation of 1,4-diaminobutane [DAB]. The method according to the present invention involves at least one biocatalytic step which comprises the biocatalytic production of at least one N-protected precursor of DAB. The present invention also relates to a method for the preparation of DAB involving at least one biocatalytic step, and comprising the steps of a) biocatalytically preparing an N-protected precursor of DAB yielding a—biocatalytic reaction mixture containing the N-protected precursor of DAB, b) recovering the N-protected precursor from the biocatalytic reaction mixture and c) converting the N-protected precursor into DAB. More in particular, the present invention relates to a method for the preparation of DAB, wherein the at least N-protected precursor of DAB is selected from the group consisting of N5-protected ornithine, N-protected DAB, and N-protected 4-aminobutyraldehyde.
摘要翻译：本发明涉及一种制备1,4-二氨基丁烷[DAB]的新方法。根据本发明的方法涉及至少一种生物催化步骤，其包括至少一种N-保护的DAB前体的生物催化产生。本发明还涉及一种用于制备涉及至少一个生物催化步骤的DAB的方法，并且包括以下步骤：a）生物催化制备N受保护的DAB前体，产生含有N-保护的DAB前体的生物催化反应混合物 b）从生物催化反应混合物回收N-保护的前体，和c）将N-保护的前体转化成DAB。更具体地说，本发明涉及一种制备DAB的方法，其中DAB的至少N-保护的前体选自N5保护的鸟氨酸，N-保护的DAB和N-保护的4- 氨基丁醛。

5. 发明申请

US20120190087A1 PREPARATION OF 1,4-DIAMINOBUTANE 有权
标题翻译： 1,4-二氨基丁酸的制备
公开(公告)号：US20120190087A1
公开(公告)日：2012-07-26
申请号：US13386169
申请日：2010-07-20
申请人： Liang Wu , Petronella Catharina Raemakers-Franken
发明人： Liang Wu , Petronella Catharina Raemakers-Franken
IPC分类号： C12P13/00
CPC分类号： C12P13/001
摘要： The present invention relates to a novel method for the preparation of 1,4-diaminobutane [DAB]. The method according to the present invention involves at least one biocatalytic step which comprises the biocatalytic production of at least one N-protected precursor of DAB. The present invention also relates to a method for the preparation of DAB involving at least one biocatalytic step, and comprising the steps of a) biocatalytically preparing an N-protected precursor of DAB yielding a—biocatalytic reaction mixture containing the N-protected precursor of DAB, b) recovering the N-protected precursor from the biocatalytic reaction mixture and c) converting the N-protected precursor into DAB. More in particular, the present invention relates to a method for the preparation of DAB, wherein the at least N-protected precursor of DAB is selected from the group consisting of N5-protected ornithine, N-protected DAB, and N-protected 4-aminobutyraldehyde.
摘要翻译：本发明涉及一种制备1,4-二氨基丁烷[DAB]的新方法。根据本发明的方法涉及至少一种生物催化步骤，其包括至少一种N-保护的DAB前体的生物催化产生。本发明还涉及一种用于制备涉及至少一个生物催化步骤的DAB的方法，并且包括以下步骤：a）生物催化制备N受保护的DAB前体，产生含有N-保护的DAB前体的生物催化反应混合物 b）从生物催化反应混合物回收N-保护的前体，和c）将N-保护的前体转化成DAB。更具体地说，本发明涉及一种制备DAB的方法，其中DAB的至少N-保护的前体选自N5保护的鸟氨酸，N-保护的DAB和N-保护的4- 氨基丁醛。

6. 发明申请

US20120156737A1 PREPARATION OF ALPHA-KETOPIMELIC ACID 审中-公开
标题翻译： ALPHA-酮二酸的制备
公开(公告)号：US20120156737A1
公开(公告)日：2012-06-21
申请号：US13255161
申请日：2010-03-11
申请人： Petronella Catharina Raemakers-Franken , Martin Schurmann , Axel Christoph Trefzer , Stefaan Marie Andre De Wildeman
发明人： Petronella Catharina Raemakers-Franken , Martin Schurmann , Axel Christoph Trefzer , Stefaan Marie Andre De Wildeman
IPC分类号： C12P7/50 , C12P13/00 , C12P17/10 , C12N1/19 , C12N1/21 , C12P7/40 , C12N1/15
CPC分类号： C12P7/50 , C12N9/0008 , C12N9/1025 , C12N9/88 , C12P7/44 , C12P13/005 , C12P13/02 , C12P17/10
摘要： The invention relates to a method for preparing alpha-ketopimelic acid, comprising converting alpha-ketoglutaric acid into alpha-ketoadipic acid and converting alpha-ketoadipic acid into alpha-ketopimelic acid, wherein at least one of these conversions is carried out using a heterologous biocatalyst. The invention further relates to a heterologous cell, comprising one or more heterologous nucleic acid sequences encoding one or more heterologous enzymes capable of catalysing at least one reaction step in the preparation of alpha-ketopimelic acid from alpha-ketoglutaric acid.
摘要翻译：本发明涉及一种制备α-酮戊二酸的方法，包括将α-酮戊二酸转化成α-酮己二酸，并将α-酮己二酸转化成α-酮戊二酸，其中这些转化中的至少一种是使用异源生物催化剂。本发明还涉及异源细胞，其包含一种或多种编码一种或多种异源酶的异源核酸序列，所述异源酶能够催化从α-酮戊二酸制备α-酮戊二酸的至少一个反应步骤。

7. 发明申请

US20120231512A1 PREPARATION OF ALPHA-KETOPIMELIC ACID 审中-公开
标题翻译： ALPHA-酮二酸的制备
公开(公告)号：US20120231512A1
公开(公告)日：2012-09-13
申请号：US13394235
申请日：2010-09-10
申请人： Petronella Catharina Raemakers-Franken , Axel Christoph Trefzer , Linda Vermote
发明人： Petronella Catharina Raemakers-Franken , Axel Christoph Trefzer , Linda Vermote
IPC分类号： C12P7/50 , C12P7/44 , C12N1/21 , C12P17/10 , C12N1/19 , C12N1/15 , C12N15/53 , C12P13/00 , C12N1/13
CPC分类号： C12P7/50 , C12P7/44 , C12P13/001 , C12P13/005 , C12P13/02
摘要： The present invention relates to a method for preparing alpha-ketopimelic acid, comprising converting 2-hydroxyheptanedioic acid into alpha-ketopimelic acid, which conversion is catalysed using a biocatalyst. Further, the invention relates to a heterologous cell, comprising a nucleic acid sequence encoding an enzyme having catalytic activity in the conversion of 2-hydroxyheptanedioic acid into alpha-ketopimelic acid. Further, the invention relates to the use of a heterologous cell according to the invention in the preparation of caprolactam, diaminohexane or adipic acid.
摘要翻译：本发明涉及一种制备α-酮基庚二酸的方法，包括将2-羟基庚二酸转化成α-酮基庚酸，该转化通过生物催化剂催化。此外，本发明涉及异源细胞，其包含编码在2-羟基庚二酸转化成α-酮戊二酸的催化活性的酶的核酸序列。此外，本发明涉及根据本发明的异源细胞在己内酰胺，二氨基己烷或己二酸的制备中的用途。

8. 发明申请

US20140134681A1 PREPARATION OF 6-AMINOCAPROIC ACID FROM 5-FORMYL VALERI C ACID 有权
标题翻译：从5-甲基戊酸C制备6-氨基己酸
公开(公告)号：US20140134681A1
公开(公告)日：2014-05-15
申请号：US14105705
申请日：2013-12-13
申请人： Petronella Catharina RAEMAKERS-FRANKEN , Martin SCHURMANN , Axel Christoph TREFZER , Stefaan Marie Andre DE WILDEMAN
发明人： Petronella Catharina RAEMAKERS-FRANKEN , Martin SCHURMANN , Axel Christoph TREFZER , Stefaan Marie Andre DE WILDEMAN
IPC分类号： C12P13/00 , C07D201/08
CPC分类号： C12P13/001 , C07C227/06 , C07D201/08 , C07D223/10 , C12P13/005 , C12P13/02 , C07C229/08
摘要： The invention relates to a method for preparing 6-aminocaproic acid (hereinafter also referred to as ‘6-ACA’) using a biocatalyst. The invention further relates to a method for preparing e-caprolactam (hereafter referred to as ‘caprolactam’) by cyclising such 6-ACA. The invention further relates to a host cell, a micro-organism, or a polynucleotide which may be used in the preparation of 6-ACA or caprolactam.
摘要翻译：本发明涉及使用生物催化剂制备6-氨基己酸（以下也称为“6-ACA”）的方法。本发明还涉及通过环化这种6-ACA制备ε-己内酰胺（以下称为“己内酰胺”）的方法。本发明还涉及可用于制备6-ACA或己内酰胺的宿主细胞，微生物或多核苷酸。

9. 发明授权

US08673599B2 Preparation of 6-aminocaproic acid from 5-formylvaleric acid 有权
标题翻译：从5-甲酰戊酸制备6-氨基己酸
公开(公告)号：US08673599B2
公开(公告)日：2014-03-18
申请号：US12921733
申请日：2009-03-11
申请人： Petronella Catharina Raemakers-Franken , Martin Schurmann , Axel Christoph Trefzer , Stefaan Marie Andre De Wildeman
发明人： Petronella Catharina Raemakers-Franken , Martin Schurmann , Axel Christoph Trefzer , Stefaan Marie Andre De Wildeman
IPC分类号： C12P13/00 , C12N1/21 , C12N1/15 , C07C227/06 , C07D223/10
CPC分类号： C12P13/001 , C07C227/06 , C07D201/08 , C07D223/10 , C12P13/005 , C12P13/02 , C07C229/08
摘要： The invention relates to a method for preparing 6-aminocaproic acid (hereinafter also referred to as ‘6-ACA’) using a biocatalyst. The invention further relates to a method for preparing e-caprolactam (hereafter referred to as ‘caprolactam’) by cyclising such 6-ACA. The invention further relates to a host cell, a micro-organism, or a polynucleotide which may be used in the preparation of 6-ACA or caprolactam.
摘要翻译：本发明涉及使用生物催化剂制备6-氨基己酸（以下也称为“6-ACA”）的方法。本发明还涉及通过环化这种6-ACA制备ε-己内酰胺（以下称为“己内酰胺”）的方法。本发明还涉及可用于制备6-ACA或己内酰胺的宿主细胞，微生物或多核苷酸。

10. 发明申请

US20130237698A1 PREPARATION OF 6-AMINOCAPROIC ACID FROM ALPHA-KETOPIMELIC ACID 审中-公开
标题翻译：从阿尔法 - 卡特米皮酸制备6-氨基己酸
公开(公告)号：US20130237698A1
公开(公告)日：2013-09-12
申请号：US13821791
申请日：2011-08-26
申请人： Stefanus Cornelis Hendrikus Turk , Martin Schürmann , Axel Christoph Trefzer , Petronella Catharina Raemakers-Franken , Hildegard Henna Menke
发明人： Stefanus Cornelis Hendrikus Turk , Martin Schürmann , Axel Christoph Trefzer , Petronella Catharina Raemakers-Franken , Hildegard Henna Menke
IPC分类号： C12P13/00 , C07D223/10
CPC分类号： C12P13/001 , C07D223/10 , C12N9/88 , C12P13/005 , C12P17/10 , C12Y401/0102
摘要： The invention is directed to a method for preparing 6-aminocaproic acid, comprising decarboxylating alpha-aminopimelic acid, using at least one biocatalyst comprising an enzyme having alpha-aminopimelic acid decarboxylase activity. The invention is further directed to a method for preparing caprolactam from 6-aminocaproic acid prepared by said method, to a host cell suitable for use in a method according to the invention and to a polynucleotide encoding a decarboxylase that may be used in a method according to the invention.
摘要翻译：本发明涉及一种制备6-氨基己酸的方法，其包括使α-氨基庚二酸脱羧酶活性至少包含一种具有α-氨基庚二酸脱羧酶活性的酶的至少一种生物催化剂脱羧α-氨基庚二酸。本发明还涉及一种由所述方法制备的己内酰胺由6-氨基己酸制备的方法，适用于本发明方法的宿主细胞和编码脱羧酶的多核苷酸，所述多核苷酸可用于根据涉及本发明。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式