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1. 发明授权

US08193236B2 Indolylmaleimide derivatives processes for their production and pharmaceutical compositions 失效
标题翻译：吲哚马来酰亚胺衍生物用于其生产和药物组合物的方法
公开(公告)号：US08193236B2
公开(公告)日：2012-06-05
申请号：US12520025
申请日：2007-12-14
申请人： Maurice van Eis , Peter von Matt , Jurgen Wagner
发明人： Maurice van Eis , Peter von Matt , Jurgen Wagner
IPC分类号： A61K31/405
CPC分类号： C07D487/04 , C07D403/14 , C07D405/14 , C07D471/04
摘要： A compound of formula (I) wherein R denotes another heterocylic residue and wherein Ra, Rb, Rc, Rd and Re, are as defined in the specification, processes for their production, their uses, in particular in transplantation, and pharmaceutical compositions containing them.
摘要翻译：式（I）化合物，其中R表示另一个杂环残基，其中Ra，Rb，Rc，Rd和Re如说明书中所定义，其制备方法，用途，特别是在移植中，以及含有它们的药物组合物。

2. 发明授权

US07691861B2 Indolymaleimide derivatives 失效
标题翻译：吲哚马酰亚胺衍生物
公开(公告)号：US07691861B2
公开(公告)日：2010-04-06
申请号：US10586420
申请日：2005-01-19
申请人： Maurice Van Eis , Peter Von Matt , Jürgen Wagner , Jean-Pierre Evenou
发明人： Maurice Van Eis , Peter Von Matt , Jürgen Wagner , Jean-Pierre Evenou
IPC分类号： A61K31/497 , A61K31/4025 , C07D403/14
CPC分类号： C07D401/14 , C07D403/04 , C07D403/14
摘要： A compound of formula I wherein R, Ra, Rb, Rc, Rd and Re are as defined in the specification, processes for their production, their uses, in particular in transplantation, and pharmaceutical compositions containing them.
摘要翻译：其中R，Ra，Rb，Rc，Rd和Re如说明书中所定义的式I化合物，其制备方法，用途，特别是在移植中，以及含有它们的药物组合物。

3. 发明申请

US20090318463A1 Indolylmaleimide Derivatives 有权
标题翻译：吲哚马来酰亚胺衍生物
公开(公告)号：US20090318463A1
公开(公告)日：2009-12-24
申请号：US12498486
申请日：2009-07-07
申请人： Rainer Albert , Nigel Graham Cooke , Sylvain Cottens , Claus Enrhardt , Jean-Pierre Evenou , Richard Sedrani , Peter Von Matt , Jurgen Wagner , Gerhard Zenke
发明人： Rainer Albert , Nigel Graham Cooke , Sylvain Cottens , Claus Enrhardt , Jean-Pierre Evenou , Richard Sedrani , Peter Von Matt , Jurgen Wagner , Gerhard Zenke
IPC分类号： A61K31/497 , C07D403/14
CPC分类号： C07D403/14 , A61K45/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/14 , C07D403/04 , C07D405/14 , C07D471/10
摘要： Indolylmaleimide derivatives comprising either a substituted phenyl, naphthyl, tetrahydronaphthyl, quinazolinyl, quinolyl, isoquinolyl or pyrimidinyl residue have interesting pharmaceutical properties, e.g. in the treatment and/or prevention of T-cell mediated acute or chronic inflammatory diseases or disorders, autoimmune diseases, graft rejection or cancer.
摘要翻译：包含取代的苯基，萘基，四氢萘基，喹唑啉基，喹啉基，异喹啉基或嘧啶基残基的吲哚基马来酰亚胺衍生物具有有意义的药物性质，例如在治疗和/或预防T细胞介导的急性或慢性炎性疾病或病症，自身免疫性疾病，移植物排斥或癌症中的应用。

4. 发明申请

US20070191401A1 Indolylmaleimide derivatives 审中-公开
公开(公告)号：US20070191401A1
公开(公告)日：2007-08-16
申请号：US11708843
申请日：2007-02-20
申请人： Rainer Albert , Nigel Cooke , Sylvain Cottens , Claus Ehrhardt , Jean-Pierre Evenou , Richard Sedrani , Peter Von Matt , Jurgen Wagner , Gerhard Zenke
发明人： Rainer Albert , Nigel Cooke , Sylvain Cottens , Claus Ehrhardt , Jean-Pierre Evenou , Richard Sedrani , Peter Von Matt , Jurgen Wagner , Gerhard Zenke
IPC分类号： A61K31/517 , A61K31/506 , A61K31/4709
CPC分类号： C07D403/14 , A61K45/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/14 , C07D403/04 , C07D405/14 , C07D471/10
摘要： Indolylmaleimide derivatives comprising either a substituted phenyl, naphthyl, tetrahydronaphthyl, quinazolinyl, quinolyl, isoquinolyl or pyrimidinyl residue have interesting pharmaceutical properties, e.g. in the treatment and/or prevention of T-cell mediated acute or chronic inflammatory diseases or disorders, autoimmune diseases, graft rejection or cancer.

5. 发明申请

US20070155817A1 Indolylmaleimide derivatives 审中-公开
公开(公告)号：US20070155817A1
公开(公告)日：2007-07-05
申请号：US11708840
申请日：2007-02-20
申请人： Rainer Albert , Nigel Cooke , Sylvain Cottens , Claus Ehrhardt , Jean-Pierre Evenou , Richard Sedrani , Peter Von Matt , Jurgen Wagner , Gerhard Zenke
发明人： Rainer Albert , Nigel Cooke , Sylvain Cottens , Claus Ehrhardt , Jean-Pierre Evenou , Richard Sedrani , Peter Von Matt , Jurgen Wagner , Gerhard Zenke
IPC分类号： A61K31/405
CPC分类号： C07D403/14 , A61K45/06 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/14 , C07D403/04 , C07D405/14 , C07D471/10
摘要： Indolylmaleimide derivatives comprising either a substituted phenyl, naphthyl, tetrahydronaphthyl, quinazolinyl, quinolyl, isoquinolyl or pyrimidinyl residue have interesting pharmaceutical properties, e.g. in the treatment and/or prevention of T-cell mediated acute or chronic inflammatory diseases or disorders, autoimmune diseases, graft rejection or cancer.

6. 发明申请

US20070032507A1 Indolylmaleimide derivatives 有权
公开(公告)号：US20070032507A1
公开(公告)日：2007-02-08
申请号：US11546690
申请日：2006-10-12
申请人： Jean-Pierre Evenou , Peter Von Matt , Jurgen Wagner , Gerhard Zenke
发明人： Jean-Pierre Evenou , Peter Von Matt , Jurgen Wagner , Gerhard Zenke
IPC分类号： A61K31/496 , A61K31/404 , C07D403/04
CPC分类号： A61K31/496 , C07D401/14 , C07D403/04 , C07D403/14
摘要： Provided are compounds of formula (I) which are useful in the treatment and/or prevention of diseases or disorders mediated by T lymphocytes and/or PKC, e.g. acute or chronic rejection of organ or tissue allo- or xenografts, graft versus host diseases, atherosclerosis, vascular occlusion due to vascular injury such as angioplasty, restenosis, obesity, syndrome X, impaired glucose tolerance, polycystic ovary syndrome, hypertension, heart failure, chronic obstructive pulmonary disease, CNS diseases such as Alzheimer disease or amyotrophic lateral sclerosis, cancer, infectious diseases such as AIDS, septic shock or adult respiratory distress syndrome, ischemia/reperfusion injury e.g. myocardial infarction, stroke, gut ischemia, renal failure or hemorrhage shock, or traumatic shock, e.g. traumatic brain injury. The compounds of formula I are also useful in the treatment and/or prevention of T-cell mediated acute or chronic inflammatory disease or disorders or autoimmune diseases e.g. rheumatoid arthritis, osteoarthritis, systemic lupus erythematosus, Hashimoto's thyroidis, multiple sclerosis, myasthenia gravis, diabetes type I or II and the disorders associated therewith, e.g. angiopathy, diabetic proliferative retinopathy, diabetic macular edema, nephropathy, neuropathy and dawn phenomenon, respiratory diseases such as asthma or inflammatory lung injury, inflammatory liver injury, inflammatory glomerular injury, cutaneous manifestations of immunologically-mediated disorders or illnesses, inflammatory and hyperproliferative skin diseases (such as psoriasis, atopic dermatitis, allergic contract dermatitis, irritant contact dermatitis and further eczematous dermatitises, seborrhoeic dermatitis), inflammatory eye diseases, e.g. Sjoegren's syndrome, keratoconjunctivitis or uveitis, inflammatory bowel disease, Crohn's disease or ulcerative colitis.

7. 发明授权

US07820672B2 Indolylmaleimide derivatives 有权
标题翻译：吲哚马来酰亚胺衍生物
公开(公告)号：US07820672B2
公开(公告)日：2010-10-26
申请号：US10542175
申请日：2004-02-12
申请人： Peter Von Matt , Jürgen Wagner
发明人： Peter Von Matt , Jürgen Wagner
IPC分类号： A61K31/497 , A61K31/4439 , A61K31/4015 , A61K31/404 , C07D403/14
CPC分类号： C07D401/14 , C07D403/14
摘要： The compounds are indolylmaleimide derivatives comprising either a substituted pyridyl or indolyl residue. The compounds have interesting pharmaceutical properties, e.g. in the treatment and/or prevention of T-cell mediated acute or chronic inflammatory diseases or disorders, autoimmune diseases, or acute or chronic transplant rejection.
摘要翻译：该化合物是含有取代的吡啶基或吲哚基残基的吲哚基马来酰亚胺衍生物。这些化合物具有有趣的药物性质，例如在治疗和/或预防T细胞介导的急性或慢性炎性疾病或病症，自身免疫疾病或急性或慢性移植排斥反应中。

8. 发明授权

US07648989B2 Indolylmaleimide derivatives as PKC inhibitors 失效
标题翻译：吲哚马来酰亚胺衍生物作为PKC抑制剂
公开(公告)号：US07648989B2
公开(公告)日：2010-01-19
申请号：US10586421
申请日：2005-01-19
申请人： Maurice Van Eis , Peter Von Matt , Jürgen Wagner , Jean-Pierre Evenou , Walter Schuler
发明人： Maurice Van Eis , Peter Von Matt , Jürgen Wagner , Jean-Pierre Evenou , Walter Schuler
IPC分类号： A61K31/497 , A61K31/4025 , C07D403/14
CPC分类号： C07D401/14 , C07D403/04 , C07D403/14
摘要： This invention relates to PKC inhibitors which are able to selectively inhibit e.g. the and optionally 0, isoforms of PKC, and their use in particular in transplantation.
摘要翻译：本发明涉及PKC抑制剂，其能够选择性地抑制 PKC的任选的0，同种型，以及它们在移植中的用途。

9. 发明申请

US20080318975A1 Indolylmaleimide Derivatives 有权
标题翻译：吲哚马来酰亚胺衍生物
公开(公告)号：US20080318975A1
公开(公告)日：2008-12-25
申请号：US11995450
申请日：2006-07-10
申请人： Jurgen Wagner , Maurice Van Eis , Peter Von Matt , Jean-Pierre Evenou , Walter Schuler
发明人： Jurgen Wagner , Maurice Van Eis , Peter Von Matt , Jean-Pierre Evenou , Walter Schuler
IPC分类号： A61K31/497 , C07D209/04 , C07D403/04 , C07D231/56 , C07D241/36 , C07D401/04 , A61P43/00 , A61K31/403 , A61K31/416 , A61K31/4184 , A61K31/4725
CPC分类号： C07D471/04 , C07D403/04 , C07D403/14
摘要： A compound of formula (I) wherein R, R1, and R2, ring A and ring B are as defined in the specification, processes for their production, their uses, in particular in transplantation, and pharmaceutical compositions containing them.
摘要翻译：式（I）的化合物，其中R，R 1和R 2，环A和环B如说明书中所定义，其制备方法，其用途，特别是在移植中，以及含有它们的药物组合物。

10. 发明申请

US20080242675A1 Indolylmaleimide Derivatives as Pkc Inhibitors 失效
标题翻译：吲哚马来酰亚胺衍生物作为Pkc抑制剂
公开(公告)号：US20080242675A1
公开(公告)日：2008-10-02
申请号：US10586421
申请日：2005-01-19
申请人： Maurice Van Eis , Peter Von Matt , Jurgen Wagner , Jean-Pierre Evenou , Walter Schuler
发明人： Maurice Van Eis , Peter Von Matt , Jurgen Wagner , Jean-Pierre Evenou , Walter Schuler
IPC分类号： A61K31/496 , C07D403/04 , A61K31/404 , A61P35/00 , C07D401/14
CPC分类号： C07D401/14 , C07D403/04 , C07D403/14
摘要： This invention relates to PKC inhibitors which are able to selectively inhibit e.g. the and optionally 0, isoforms of PKC, and their use in particular in transplantation.
摘要翻译：本发明涉及PKC抑制剂，其能够选择性地抑制 PKC的任选的0，同种型，以及它们在移植中的用途。

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