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1. 发明申请

US20070004684A1 Alpha-Carbolines as CDK-1 inhibitors 审中-公开
标题翻译： α-Carbolines作为CDK-1抑制剂
公开(公告)号：US20070004684A1
公开(公告)日：2007-01-04
申请号：US11423008
申请日：2006-06-08
申请人： Peter Sennhenn , Andreas Mantoulidis , Matthias Treu , Ulrike Tontsch-Grunt , Walter Spevak , Darryl McConnell , Andreas Schoop , Ralph Brueckner , Albrecht Jacobi , Ulrich Guertler , Gisela Schnapp , Christian Klein , Frank Himmelsbach , Alexander Pautsch , Bodo Betzmeier , Lars Herfurth , Juergen Mack , Dieter Wiedenmayer , Gerd Bader , Ulrich Reiser
发明人： Peter Sennhenn , Andreas Mantoulidis , Matthias Treu , Ulrike Tontsch-Grunt , Walter Spevak , Darryl McConnell , Andreas Schoop , Ralph Brueckner , Albrecht Jacobi , Ulrich Guertler , Gisela Schnapp , Christian Klein , Frank Himmelsbach , Alexander Pautsch , Bodo Betzmeier , Lars Herfurth , Juergen Mack , Dieter Wiedenmayer , Gerd Bader , Ulrich Reiser
IPC分类号： A61K31/4745 , C07D471/02 , A61K31/655
CPC分类号： C07D471/04
摘要： The present invention encompasses compounds of general formula (1) wherein R2 to R5 and X are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a pharmaceutical composition having the above-mentioned properties.
摘要翻译：本发明包括通式（1）的化合物，其中R 2至R 5和X如权利要求1中所定义，其适用于治疗以下特征的疾病：过度或异常细胞增殖，以及其用于制备具有上述性质的药物组合物的用途。

2. 发明授权

US08203001B2 Chemical compounds 有权
标题翻译：化合物
公开(公告)号：US08203001B2
公开(公告)日：2012-06-19
申请号：US12304256
申请日：2007-06-13
申请人： Ulrich Reiser , Peter Ettmayer , Oliver Kraemer , Peter Sennhenn , Walter Spevak
发明人： Ulrich Reiser , Peter Ettmayer , Oliver Kraemer , Peter Sennhenn , Walter Spevak
IPC分类号： C07D513/14 , A61K31/429 , C07D417/12 , C07D413/12 , C07D401/12 , C07D243/08 , C07D211/32 , C07D419/02 , A61K31/5513 , A61K31/425 , A61K31/497 , A61K31/44 , A61K31/54 , A61K31/5375
CPC分类号： C07D513/04
摘要： The present invention encompasses compounds of general formula (1) wherein R1, M1, L1 and Q are defined as in claim 1, which are suitable for the treatment of diseases characterized by excessive or anomalous cell proliferation, and the use thereof for preparing a pharmaceutical composition with the above-mentioned properties.
摘要翻译：本发明包括通式（1）的化合物，其中R 1，M 1，L 1和Q如权利要求1中所定义，其适用于治疗以过度或异常细胞增殖为特征的疾病，及其用于制备药物具有上述性质的组合物。

3. 发明申请

US20090258857A1 CHEMICAL COMPOUNDS 有权
标题翻译：化学化合物
公开(公告)号：US20090258857A1
公开(公告)日：2009-10-15
申请号：US12304256
申请日：2007-06-13
申请人： Ulrich Reiser , Peter Ettmayer , Oliver Kraemer , Peter Sennhenn , Walter Spevak
发明人： Ulrich Reiser , Peter Ettmayer , Oliver Kraemer , Peter Sennhenn , Walter Spevak
IPC分类号： A61K31/55 , C07D513/02 , A61K31/429 , C07D417/14 , A61K31/496 , C07D413/14 , A61K31/5377 , A61K31/541 , C07D243/08 , A61K31/551 , C07D221/20 , A61K31/438 , A61P35/00 , A61P29/00 , A61P37/06 , A61P31/00
CPC分类号： C07D513/04
摘要： The present invention encompasses compounds of general formula (1) wherein R1, M1, L1 and Q are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or anomalous cell proliferation, and the use thereof for preparing a pharmaceutical composition with the above-mentioned properties.
摘要翻译：本发明包括通式（1）的化合物，其中R 1，M 1，L 1和Q如权利要求1中所定义，其适用于治疗以过度或异常细胞增殖为特征的疾病，及其用于制备药物具有上述性质的组合物。

4. 发明申请

US20090186901A1 CHEMICAL COMPOUNDS 审中-公开
标题翻译：化学化合物
公开(公告)号：US20090186901A1
公开(公告)日：2009-07-23
申请号：US12299204
申请日：2007-05-03
申请人： Ulrich Reiser , Oliver Kraemer , Peter Sennhenn , Walter Spevak
发明人： Ulrich Reiser , Oliver Kraemer , Peter Sennhenn , Walter Spevak
IPC分类号： A61K31/499 , A61K31/438 , C07D471/10
CPC分类号： C07D491/107
摘要： The present invention relates to new heterocyclic compounds of general formula (1) wherein the groups R1 to R7, k, X and Y have the meanings given in the claims and specification, the isomers and salts thereof as well as the use thereof as medicaments. Background to the invention WO 01/36423 describes 3,4-dihydrospiro[chromene-2,4′-piperidine] derivatives for treating diseases of the central nervous system. Spirocyclic heterocycles as δ-opioid receptor ligands for treating pain and anxiety states as well as diseases of the gastrointestinal tract are known from WO 2005/033073. The aim of the present invention is to indicate new active substances which can be used for the prevention and/or treatment of diseases characterised by excessive or abnormal cell proliferation.
摘要翻译：本发明涉及通式（1）的新的杂环化合物，其中基团R 1至R 7，k，X和Y具有权利要求书和说明书中给出的含义，其异构体和盐以及其作为药物的用途。本发明的背景技术WO 01/36423描述了用于治疗中枢神经系统疾病的3,4-二氢螺[色烯-2,4'-哌啶]衍生物。作为用于治疗疼痛和焦虑状态的β-阿片受体配体的螺环杂环以及胃肠道疾病，已知于WO 2005/033073。本发明的目的是指出可用于预防和/或治疗以过度或异常细胞增殖为特征的疾病的新的活性物质。

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