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1. 发明申请

US20100331415A1 USE OF OMEGA-3-FATTY ACID(S) 审中-公开
标题翻译：使用欧米茄-3-脂肪酸（S）
公开(公告)号：US20100331415A1
公开(公告)日：2010-12-30
申请号：US12734657
申请日：2008-11-18
申请人： Rudolf Krumbholz , Karin Krumbholz , Christine Krumbholz , Norbert Schirra , Peter Lembke
发明人： Rudolf Krumbholz , Karin Krumbholz , Christine Krumbholz , Norbert Schirra , Peter Lembke
IPC分类号： A61K31/20 , C07C57/03 , A61P29/00
CPC分类号： A61K45/06 , A61K31/202 , A61K2300/00
摘要： The invention relates to the use of omega-3-fatty acid(s) in means for pain relief. The means preferably comprise highly unsaturated omega-3-fatty acid(s) that contain, above all, EPA and/or DHA. Preferably, the omega-3-fatty acid is administered in a high dose of more than 2 g, in particular more than 3 to 4 g, for pain relief.
摘要翻译：本发明涉及ω-3-脂肪酸在减轻疼痛的手段中的用途。该方法优选包含高度不饱和的ω-3-脂肪酸，其最重要地包含EPA和/或DHA。优选地，ω-3-脂肪酸以大于2g，特别是大于3至4g的高剂量施用以缓解疼痛。

2. 发明授权

US08293932B2 Process for extracting a substance or a substance group from a mixture 有权
标题翻译：从混合物中提取物质或物质组的方法
公开(公告)号：US08293932B2
公开(公告)日：2012-10-23
申请号：US11479538
申请日：2006-06-30
申请人： Rudolf Krumbholz , Peter Lembke
发明人： Rudolf Krumbholz , Peter Lembke
IPC分类号： C11B3/00
CPC分类号： C11C1/007 , B01D15/14 , B01D15/18 , B01D15/40 , C11B1/104
摘要： A process for extracting a substance or a substance group from a mixture utilizes a solvent for separation. The mixture is treated with the solvent in the presence of a sorbent as the stationary phase, wherein the solvent is conducted past the sorbent in a co-current flow with the mixture or in a counter-current flow against the mixture, or wherein the solvent is conducted past the non-moving mixture and the sorbent. The solvent and the sorbent are selected such that the holding effect of the sorbent supports the separation by the solvent during the separation procedure and/or subsequently supplements the separation by interacting with the solvent as the mobile phase.
摘要翻译：从混合物中提取物质或物质组的方法利用溶剂进行分离。在作为固定相的吸附剂存在下，用溶剂处理该混合物，其中溶剂通过混合物或逆流反应混合物的并流流过吸附剂，或其中溶剂经过不动的混合物和吸附剂。选择溶剂和吸附剂使得吸附剂的保持作用在分离过程期间支持溶剂分离和/或随后通过与作为流动相的溶剂相互作用补充分离。

3. 发明申请

US20110015418A1 CROMATOGRAPHY PROCESS FOR RECOVERING A SUBSTANCE OR A GROUP OF SUBSTANCES FROM A MIXTURE 有权
标题翻译：从混合物中回收物质或一组物质的重构过程
公开(公告)号：US20110015418A1
公开(公告)日：2011-01-20
申请号：US12305942
申请日：2007-06-19
申请人： Rudolf Krumbholz , Peter Lembke , Norbert Schirra
发明人： Rudolf Krumbholz , Peter Lembke , Norbert Schirra
IPC分类号： C11B3/10
CPC分类号： G01N30/28 , B01D15/161 , B01D15/163 , B01D15/40 , B01J20/286 , G01N30/02 , G01N30/32 , G01N30/8658 , G01N30/8689 , G01N2030/3076
摘要： Method for improving the performance of a preparative batchwise Super Critical Fluid Chromatographic separation for the recovery of a target fatty acid or derivative thereof, or of a group of target fatty acids or of derivatives thereof from a mixture, characterized in that the said Super Critical Fluid Chromatographic separation employs a chromatographic column charged with a stationary phase chosen from the group consisting of aluminium oxide or aluminium oxides, titanium oxide or titanium oxides, silica gel or silica gels, amino propyl modified silica gels, diol modified silica gels, phenyl modified silica gels and “reversed phase” phases, the former in turn chosen from the group consisting of RP 18, RP8 and RP3, and in that the said Super Critical Fluid Chromatographic Separation further employs a mobile phase chosen from the group consisting of ethylene, propane, ammonia, dinitrogen dioxide and CO2, wherein in the said method, during the run of the said mixture on the chromatographic column, a pressure and/or temperature gradient is applied to the chromatographic column during the elution of the target fatty acid or derivative thereof.
摘要翻译：用于改进用于从混合物中回收目标脂肪酸或其衍生物或一组目标脂肪酸或其衍生物的制备型间歇超临界流体色谱分离的性能的方法，其特征在于所述超临界流体色谱分离采用带有选自氧化铝或氧化铝，氧化钛或氧化钛，硅胶或硅胶，氨基丙基改性硅胶，二醇改性硅胶，苯基改性硅胶的固定相的色谱柱和“反相”相，前者又选自RP 18，RP 8和RP 3组成，并且所述超临界流体色谱分离还采用选自乙烯，丙烷，氨的流动相，二氧化氮和二氧化碳，其中在所述方法中，在所述混合物在色谱上运行期间图示柱中，在目标脂肪酸或其衍生物洗脱期间，将色谱柱施加压力和/或温度梯度。

4. 发明授权

US6042840A Component of a skin care agent 失效
标题翻译：皮肤护理剂的组分
公开(公告)号：US6042840A
公开(公告)日：2000-03-28
申请号：US39535
申请日：1998-03-16
申请人： Rudolf Krumbholz , Peter Lembke
发明人： Rudolf Krumbholz , Peter Lembke
IPC分类号： A61K9/06 , A61K20060101 , A61K6/00 , A61K8/00 , A61K8/30 , A61K8/34 , A61K8/36 , A61K8/37 , A61K8/40 , A61K8/42 , A61K31/17 , A61P17/00 , A61Q5/00 , A61Q19/00 , A01N32/00
CPC分类号： A61K8/361 , A61K8/42 , A61Q19/00 , A61K2800/522 , A61K2800/56 , Y10S514/844 , Y10S514/846 , Y10S514/847
摘要： A urea-containing component of a skin care agent or skin preparation, wherein the urea forms inclusion compounds with fatty acids and/or fatty acid compounds, so that fat is made available for skin care which is protected against oxidation. A method of manufacturing the urea-containing component of a skin care agent includes cooking an oil or a mixture of fatty acid ethyl esters manufactured from an oil with urea in a solvent in a non-oxidizing atmosphere until the urea has been dissolved, permitting the mixture to cool, and finally cooling the mixture to a final temperature of below 10.degree. C. and separating the resulting precipitate.
摘要翻译：皮肤护理剂或皮肤制剂的含尿素成分，其中尿素与脂肪酸和/或脂肪酸化合物形成包合物，使得脂肪可用于防止氧化的皮肤护理。制造护肤剂的含尿素成分的方法包括在非氧化性气氛中在溶剂中将油或由油制成的脂肪酸乙酯的混合物与尿素一起烹饪直至尿素溶解，混合物冷却，最后将混合物冷却至10℃以下的最终温度，并分离所得沉淀。

5. 发明授权

US08063235B2 Cromatography process for recovering a substance or a group of substances from a mixture 有权
标题翻译：用于从混合物中回收物质或一组物质的色谱法
公开(公告)号：US08063235B2
公开(公告)日：2011-11-22
申请号：US12305942
申请日：2007-06-19
申请人： Rudolf Krumbholz , Peter Lembke , Norbert Schirra
发明人： Rudolf Krumbholz , Peter Lembke , Norbert Schirra
IPC分类号： C11B7/00 , C11B3/10
CPC分类号： G01N30/28 , B01D15/161 , B01D15/163 , B01D15/40 , B01J20/286 , G01N30/02 , G01N30/32 , G01N30/8658 , G01N30/8689 , G01N2030/3076
摘要： Method for improving the performance of a preparative batchwise Super Critical Fluid Chromatographic separation for the recovery of a target fatty acid or derivative thereof, or of a group of target fatty acids or of derivatives thereof from a mixture, characterized in that the said Super Critical Fluid Chromatographic separation employs a chromatographic column charged with a stationary phase chosen from the group consisting of aluminium oxide or aluminium oxides, titanium oxide or titanium oxides, silica gel or silica gels, amino propyl modified silica gels, diol modified silica gels, phenyl modified silica gels and “reversed phase” phases, the former in turn chosen from the group consisting of RP18, RP8 and RP3, and in that the said Super Critical Fluid Chromatographic Separation further employs a mobile phase chosen from the group consisting of ethylene, propane, ammonia, dinitrogen dioxide and CO2, wherein in the said method, during the run of the said mixture on the chromatographic column, a pressure and/or temperature gradient is applied to the chromatographic column during the elution of the target fatty acid or derivative thereof.
摘要翻译：用于改进用于从混合物中回收目标脂肪酸或其衍生物或一组目标脂肪酸或其衍生物的制备型间歇超临界流体色谱分离的性能的方法，其特征在于所述超临界流体色谱分离采用带有选自氧化铝或氧化铝，氧化钛或氧化钛，硅胶或硅胶，氨基丙基改性硅胶，二醇改性硅胶，苯基改性硅胶的固定相的色谱柱和“反相”相，前者反过来选自RP18，RP8和RP3组成，并且所述超临界流体色谱分离还采用选自乙烯，丙烷，氨，二氧化氮和二氧化碳，其中在所述方法中，在所述混合物在色谱柱上运行期间在目标脂肪酸或其衍生物洗脱期间，将色谱柱施加压力和/或温度梯度至色谱柱。

6. 发明申请

US20060247455A1 Process for extracting a substance or a substance group from a mixture 有权
标题翻译：从混合物中提取物质或物质组的方法
公开(公告)号：US20060247455A1
公开(公告)日：2006-11-02
申请号：US11479538
申请日：2006-06-30
申请人： Rudolf Krumbholz , Peter Lembke
发明人： Rudolf Krumbholz , Peter Lembke
IPC分类号： C07C51/43
CPC分类号： C11C1/007 , B01D15/14 , B01D15/18 , B01D15/40 , C11B1/104
摘要： A process for extracting a substance or a substance group from a mixture utilizes a solvent for separation. The mixture is treated with the solvent in the presence of a sorbent as the stationary phase, wherein the solvent is conducted past the sorbent in a co-current flow with the mixture or in a counter-current flow against the mixture, or wherein the solvent is conducted past the non-moving mixture and the sorbent. The solvent and the sorbent are selected such that the holding effect of the sorbent supports the separation by the solvent during the separation procedure and/or subsequently supplements the separation by interacting with the solvent as the mobile phase.
摘要翻译：从混合物中提取物质或物质组的方法利用溶剂进行分离。在作为固定相的吸附剂存在下，用溶剂处理该混合物，其中溶剂通过混合物或逆流反应混合物的并流流过吸附剂，或其中溶剂经过不动的混合物和吸附剂。选择溶剂和吸附剂使得吸附剂的保持作用在分离过程期间支持溶剂分离和/或随后通过与作为流动相的溶剂相互作用补充分离。

7. 发明申请

US20110033595A1 Fatty acid fractionation process, fatty acid products and use thereof 审中-公开
$Fatty acid fractionation process, fatty acid products and use thereof$
标题翻译：脂肪酸分馏过程，脂肪酸产物及其用途
公开(公告)号：US20110033595A1
公开(公告)日：2011-02-10
申请号：US12462840
申请日：2009-08-10
申请人： Rudolf Krumbholz , Peter Lembke
发明人： Rudolf Krumbholz , Peter Lembke
IPC分类号： C11B5/00 , C11B7/00 , A61K31/20 , A61P43/00
CPC分类号： C11C3/003 , A23V2002/00 , A61K8/361 , A61K31/20 , A61Q19/00 , C11B7/00 , C11C1/005 , A61K2300/00 , A23V2250/186 , A23V2300/18
摘要： The present invention relates to a concentration- and purification method for compositions containing phytanic acid and/or derivatives thereof besides other fatty acids and/or their derivatives, preferably besides polyunsaturated fatty acids and/or their derivatives, such as esters or salts. With the fractionation process the phytanic acid (derivative) can become concentrated and the fatty acid mixture, preferably PUFA-mixture, can be purified from this particular component.
摘要翻译：本发明涉及包含除了多不饱和脂肪酸和/或其衍生物如酯或盐以外的其它脂肪酸和/或其衍生物的植酸和/或其衍生物的组合物的浓缩和纯化方法。通过分馏过程，可以使植酸（衍生物）浓缩，并且可以从该特定组分中纯化脂肪酸混合物，优选PUFA-混合物。

8. 发明授权

US5362895A Method of recovering unsaturated fatty acids 失效
标题翻译：回收不饱和脂肪酸的方法
公开(公告)号：US5362895A
公开(公告)日：1994-11-08
申请号：US25041
申请日：1993-03-01
申请人： Heinz Engelhardt , Rudolf Krumbholz , Peter Lembke
发明人： Heinz Engelhardt , Rudolf Krumbholz , Peter Lembke
IPC分类号： C07C69/587 , B01D15/08 , C07C51/47 , C07C57/03 , C07C57/12 , C07C67/56 , C11B3/10 , C11C1/00 , C11C1/08
CPC分类号： C11C1/005 , B01D15/40 , C07C51/47 , C07C67/56 , Y02P20/544
摘要： A method for recovering at least one unsaturated fatty acid having sixteen or more carbon atoms and/or at least one compound of such a fatty acid from a mixture derived from vegetable, animal or marine sources is provided. Fatty acids and/or fatty acid compounds of the mixture, in free acid or esterified form, are passed into a mobile phase of liquid carbon dioxide in a column over a stationary phase. The stationary phase contains a support and a material bound to the support which contains at least one free electron pair and/or multiple bond. After eluting any saturated fatty acid or fatty acid compound of the same number of carbon atoms from the column, the unsaturated fatty acid and/or fatty acid compound is recovered in pure chemical form or as an enriched mixture.
摘要翻译：提供了一种从植物，动物或海洋来源的混合物中回收至少一种具有十六个或更多个碳原子的不饱和脂肪酸和/或至少一种这样的脂肪酸化合物的方法。混合物中的游离酸或酯化形式的脂肪酸和/或脂肪酸化合物在固定相中通入柱中液体二氧化碳的流动相。固定相包含载体和与载体结合的材料，其含有至少一个自由电子对和/或多个键。在从柱中洗脱相同数目的碳原子的饱和脂肪酸或脂肪酸化合物后，以纯化学形式或富集的混合物回收不饱和脂肪酸和/或脂肪酸化合物。

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