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1. 发明授权

US07812010B2 Pharmaceutical preparations for treatments of diseases and disorders of the breast 有权
标题翻译：用于治疗乳腺疾病和疾病的药物制剂
公开(公告)号：US07812010B2
公开(公告)日：2010-10-12
申请号：US10751056
申请日：2004-01-02
申请人： Gerianne T. DiPiano , Peter Kevin Mays , John Ziemniak
发明人： Gerianne T. DiPiano , Peter Kevin Mays , John Ziemniak
IPC分类号： A61K31/56 , A61K9/00 , A61K9/14
CPC分类号： A61K9/0041 , A61K9/0014 , A61K31/445 , A61K47/10
摘要： Formulations for topical or local administration of drugs directly to the breast or chest to produce a regional or local effect with lower systemic drug levels than when an effective amount is administered systemically are disclosed herein. In a preferred embodiment, the drug is administered to the surface of the breast, areola, or directly to the nipple. The formulations provide increased patient comfort, increased bioavailability and relatively high blood levels in the region to be treated with a reduction of side effects compared to those administered systemically. The preferred formulations contain drugs in the form of micro or nanoparticles, which may be formed of drug alone or in combination with an excipient or carrier. The excipient or carrier may modify the release rates or enhance absorption into the affected area. The drug formulation may be in the form of a cream, lotion or foam.
摘要翻译：在本文中公开了用于局部或局部施用药物的制剂直接进入乳房或胸部以产生具有比全身施用有效量的更低的全身药物水平的区域或局部作用。在优选的实施方案中，将药物施用于乳房，乳晕或者乳头的表面。与全身施用的那些相比，该制剂提供了增加的患者舒适度，增加的生物利用度和待治疗的区域中相对较高的血液水平，同时减少副作用。优选的制剂含有微量或纳米颗粒形式的药物，其可以单独使用药物或与赋形剂或载体组合形成。赋形剂或载体可以改变释放速率或增强对受影响区域的吸收。药物制剂可以是霜剂，洗剂或泡沫剂的形式。

2. 发明授权

US09173836B2 Pharmaceutical preparations for treatments of diseases and disorders of the breast 有权
标题翻译：用于治疗乳腺疾病和疾病的药物制剂
公开(公告)号：US09173836B2
公开(公告)日：2015-11-03
申请号：US12871678
申请日：2010-08-30
申请人： Gerianne Tringali DiPiano , Peter Kevin Mays , John Ziemniak
发明人： Gerianne Tringali DiPiano , Peter Kevin Mays , John Ziemniak
IPC分类号： A61K31/58 , A61P15/00 , A61P21/00 , A61K38/09 , A61K31/137 , A61K9/00 , A61K9/06 , A61K31/445 , A61K47/10 , A61K47/22
CPC分类号： A61K9/0014 , A61K9/0041 , A61K9/06 , A61K31/445 , A61K47/10 , A61K47/22
摘要： Formulations for topical or local administration of drugs directly to the breast or chest to produce a regional or local effect with lower systemic drug levels than when an effective amount is administered systemically are disclosed herein. In a preferred embodiment, the drug is administered to the surface of the breast, areola, or directly to the nipple. The formulations provide increased patient comfort, increased bioavailability and relatively high blood levels in the region to be treated with a reduction of side effects compared to those administered systemically. The preferred formulations contain drugs in the form of micro or nanoparticles, which may be formed of drug alone or in combination with an excipient or carrier. The excipient or carrier may modify the release rates or enhance absorption into the affected area. The drug formulation may be in the form of a cream, lotion or foam.
摘要翻译：在本文中公开了用于局部或局部施用药物的制剂直接进入乳房或胸部以产生具有比全身施用有效量的更低的全身药物水平的区域或局部作用。在优选的实施方案中，将药物施用于乳房，乳晕或者乳头的表面。与全身施用的那些相比，该制剂提供了增加的患者舒适度，增加的生物利用度和待治疗的区域中相对较高的血液水平，同时减少副作用。优选的制剂含有微量或纳米颗粒形式的药物，其可以单独使用药物或与赋形剂或载体组合形成。赋形剂或载体可以改变释放速率或增强对受影响区域的吸收。药物制剂可以是霜剂，洗剂或泡沫剂的形式。

3. 发明申请

US20110212934A1 PHARMACEUTICAL PREPARATIONS FOR TREATMENTS OF DISEASES AND DISORDERS OF THE BREAST 有权
标题翻译：用于治疗乳腺疾病和疾病的药物制剂
公开(公告)号：US20110212934A1
公开(公告)日：2011-09-01
申请号：US12871678
申请日：2010-08-30
申请人： Gerianne Tringali DiPiano , Peter Kevin Mays , John Ziemniak
发明人： Gerianne Tringali DiPiano , Peter Kevin Mays , John Ziemniak
IPC分类号： A61K31/58 , A61P15/00 , A61P21/00
CPC分类号： A61K9/0014 , A61K9/0041 , A61K9/06 , A61K31/445 , A61K47/10 , A61K47/22
摘要： Formulations for topical or local administration of drugs directly to the breast or chest to produce a regional or local effect with lower systemic drug levels than when an effective amount is administered systemically are disclosed herein. In a preferred embodiment, the drug is administered to the surface of the breast, areola, or directly to the nipple. The formulations provide increased patient comfort, increased bioavailability and relatively high blood levels in the region to be treated with a reduction of side effects compared to those administered systemically. The preferred formulations contain drugs in the form of micro or nanoparticles, which may be formed of drug alone or in combination with an excipient or carrier. The excipient or carrier may modify the release rates or enhance absorption into the affected area. The drug formulation may be in the form of a cream, lotion or foam.
摘要翻译：在本文中公开了用于局部或局部施用药物的制剂直接进入乳房或胸部以产生具有比全身施用有效量的更低的全身药物水平的区域或局部作用。在优选的实施方案中，将药物施用于乳房，乳晕或者乳头的表面。与全身施用的那些相比，该制剂提供了增加的患者舒适度，增加的生物利用度和待治疗的区域中相对较高的血液水平，同时减少副作用。优选的制剂含有微量或纳米颗粒形式的药物，其可以单独使用药物或与赋形剂或载体组合形成。赋形剂或载体可以改变释放速率或增强对受影响区域的吸收。药物制剂可以是霜剂，洗剂或泡沫剂的形式。

4. 发明申请

US20110003000A1 Transvaginal Delivery of Drugs 审中-公开
标题翻译：经阴道递送药物
公开(公告)号：US20110003000A1
公开(公告)日：2011-01-06
申请号：US12497865
申请日：2009-07-06
申请人： Gerianne Tringali DiPiano , Thomas I. Janicki , Peter Kevin Mays , John Andrew Ziemniak
发明人： Gerianne Tringali DiPiano , Thomas I. Janicki , Peter Kevin Mays , John Andrew Ziemniak
IPC分类号： A61K9/14 , A61K9/12 , A61K31/56 , A61K31/24 , A61P13/00 , A61P15/02
CPC分类号： A61K9/0036 , A61K9/06
摘要： Drug delivery compositions which are suitable for transvaginal administration for the treatment of diseases and disorders of the urogenital tract are described. The drug delivery compositions are administered directly to the vagina using a convenient transvaginal application that deposits a very small volume of drug at the desired site for delivery. This method of administration reduces the systemic levels of the drugs and decreases the side effects which are associated with systemic administration. In the preferred embodiment, the compositions are in the form of a gel. The formulation is administered in volumes of less than or equal to 1 milliliter. In the preferred embodiment, the composition contains an antimuscarinc drug, such as oxybutynin.
摘要翻译：描述了适用于经阴道给药以治疗泌尿生殖道疾病和病症的药物递送组合物。药物递送组合物使用方便的经阴道应用直接施用于阴道，其在期望的部位沉积非常小体积的药物用于递送。这种给药方法降低了药物的全身水平并降低了与全身给药有关的副作用。在优选的实施方案中，组合物为凝胶形式。制剂以小于或等于1毫升的体积施用。在优选的实施方案中，组合物含有抗马克唐金氏药物，例如奥昔布宁。

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