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1. 发明授权

US08899229B2 Powder delivery devices 有权
标题翻译：送粉装置
公开(公告)号：US08899229B2
公开(公告)日：2014-12-02
申请号：US11816984
申请日：2006-02-23
申请人： Per Gisle Djupesland , Roderick Peter Hafner , Colin David Sheldrake
发明人： Per Gisle Djupesland , Roderick Peter Hafner , Colin David Sheldrake
IPC分类号： A61M15/08 , A61M15/00 , A61M16/12 , A61M16/10 , A61M16/00
CPC分类号： A61M15/08 , A61M15/0021 , A61M15/0028 , A61M15/003 , A61M15/0035 , A61M15/0041 , A61M15/0086 , A61M15/0098 , A61M16/0066 , A61M16/105 , A61M16/1075 , A61M16/127 , A61M2016/0021 , A61M2016/0027 , A61M2202/064 , A61M2205/07 , A61M2205/076 , A61M2205/3606 , A61M2205/3673 , A61M2205/8218 , A61M2206/14 , A61M2210/0618 , A61M2210/0625
摘要： A nasal delivery device for delivering substance to a nasal cavity of a subject, the delivery device comprising: a substance supply unit for supplying a dose of substance to be delivered to the nasal cavity of the subject, the substance supply unit including an inlet and an outlet; a nosepiece unit including a nosepiece for fitting to a nasal cavity of the subject and being in fluid communication with the outlet of the substance supply unit; and a mouthpiece unit including a mouthpiece in fluid communication with the inlet of the substance supply unit and through which the subject in use exhales such as to entrain substance from the container chamber and deliver the same through the nosepiece, and at least one temperature modifier for reducing a temperature of the exhaled air flow such as to reduce the absolute humidity thereof.
摘要翻译：一种用于将物质输送到受试者的鼻腔的鼻输送装置，所述输送装置包括：物质供应单元，用于将待递送到物体的剂量的物质供应到受试者的鼻腔，所述物质供应单元包括入口和出口; 鼻梁单元，其包括用于装配到被检体的鼻腔并与物质供应单元的出口流体连通的鼻梁; 以及接口单元，其包括与所述物质供应单元的入口流体连通的接口管，并且使用中的被检体呼气，从而将容器从容器室中夹带并将其输送通过喷嘴，以及至少一个用于降低呼出气流的温度，以降低其绝对湿度。

2. 发明授权

US08551492B2 Vaccine peptide combinations against cat allergy 有权
标题翻译：针对猫过敏的疫苗肽组合
公开(公告)号：US08551492B2
公开(公告)日：2013-10-08
申请号：US12602313
申请日：2008-05-30
申请人： Roderick Peter Hafner , Mark Larche , Anthony Barrington Kay
发明人： Roderick Peter Hafner , Mark Larche , Anthony Barrington Kay
IPC分类号： A61K38/00 , A61K38/04 , A61K39/00 , A61K39/35 , A61K39/36 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K17/00
CPC分类号： A61K39/0005 , A61K39/35 , A61K2039/53 , A61K2039/577 , C07K7/08 , G01N33/56977
摘要： The present invention relates to compositions comprising peptides for preventing or treating allergy to cats, and in particular to optimal combinations of peptides.
摘要翻译：本发明涉及包含用于预防或治疗对猫的过敏的肽，特别是肽的最佳组合的组合物。

3. 发明申请

US20090293873A1 POWDER DELIVERY DEVICES 有权
标题翻译：粉末递送装置
公开(公告)号：US20090293873A1
公开(公告)日：2009-12-03
申请号：US11816984
申请日：2006-02-23
申请人： Per Gisle Djupesland , Roderick Peter Hafner , Colin David Sheldrake
发明人： Per Gisle Djupesland , Roderick Peter Hafner , Colin David Sheldrake
IPC分类号： A61M15/08
CPC分类号： A61M15/08 , A61M15/0021 , A61M15/0028 , A61M15/003 , A61M15/0035 , A61M15/0041 , A61M15/0086 , A61M15/0098 , A61M16/0066 , A61M16/105 , A61M16/1075 , A61M16/127 , A61M2016/0021 , A61M2016/0027 , A61M2202/064 , A61M2205/07 , A61M2205/076 , A61M2205/3606 , A61M2205/3673 , A61M2205/8218 , A61M2206/14 , A61M2210/0618 , A61M2210/0625
摘要： A nasal delivery device for delivering substance to a nasal cavity of a subject, the delivery device comprising: a substance supply unit for supplying a dose of substance to be delivered to the nasal cavity of the subject, she substance supply unit including an inlet and an outlet; a nosepiece unit including a nosepiece for fitting to a nasal cavity of the subject and being in fluid communication with the outlet of the substance supply unit; and a mouthpiece unit including a mouthpiece in fluid communication with the inlet of the substance supply unit and through which the subject in use exhales such as to entrain substance from the container chamber and deliver the same through the nosepiece, and at least one temperature modifier for reducing a temperature of the exhaled air flow such as to reduce the absolute humidity thereof.
摘要翻译：一种用于将物质输送到受试者的鼻腔的鼻输送装置，所述输送装置包括：物质供应单元，用于将待递送到物体的剂量的剂量提供给受试者的鼻腔，所述物质供应单元包括入口和出口; 鼻梁单元，其包括用于装配到被检体的鼻腔并与物质供应单元的出口流体连通的鼻梁; 以及接口单元，其包括与所述物质供应单元的入口流体连通的接口管，并且使用中的被检体呼气，从而将容器从容器室中夹带并将其输送通过喷嘴，以及至少一个用于降低呼出气流的温度，以降低其绝对湿度。

4. 发明申请

US20080289629A1 Nasal Delivery Devices 审中-公开
标题翻译：鼻输送装置
公开(公告)号：US20080289629A1
公开(公告)日：2008-11-27
申请号：US11663099
申请日：2005-09-15
申请人： Per Gisle Djupesland , Roderick Peter Hafner , Colin David Sheldrake
发明人： Per Gisle Djupesland , Roderick Peter Hafner , Colin David Sheldrake
IPC分类号： A61M15/08
CPC分类号： A61M15/002 , A61M15/0008 , A61M15/0021 , A61M15/0028 , A61M15/0035 , A61M15/0041 , A61M15/0045 , A61M15/0086 , A61M15/0091 , A61M15/0098 , A61M15/08 , A61M16/1055 , A61M16/1065 , A61M16/1075 , A61M2202/064
摘要： A nasal delivery device for and method of delivering substance to a nasal cavity of a subject, the delivery device comprising: a container-receiving unit comprising a container chamber for receiving a substance-containing container which contains substance to be delivered to the nasal cavity of the subject, the container chamber including an inlet and an outlet; a nosepiece unit including a nosepiece for fitting to a nasal cavity of the subject and being in fluid communication with the outlet of the container chamber; a mouthpiece unit including a mouthpiece in fluid communication with the inlet of the container chamber and through which the subject in use exhales, such as to entrain substance from the container and deliver the same through the nosepiece; and moisture-mitigation means for mitigating an effect of moisture in an exhaled breath on the entrainment of substance from the container, which means are provided, for example, by providing the container in a replaceable container-containing member, by a pressure-sensitive valve which normally closes the fluid connection between the container chamber and the mouthpiece, and a temperature regulator upstream of the container chamber.
摘要翻译：一种用于将物质递送到受试者鼻腔的鼻输送装置和方法，所述输送装置包括：容器接收单元，其包括用于接收含物质的容器的容器室，所述容器容纳物容纳要输送到鼻腔的物质所述物体，所述容器室包括入口和出口; 鼻梁单元，其包括用于装配到被检体的鼻腔并与容器室的出口流体连通的鼻梁; 接口单元，其包括与容器室的入口流体连通的接口，并且被吸入物体通过其吸入，从而将物质夹带在容器中并将其传送通过喷嘴; 以及用于减轻呼出气中的湿气对来自容器的物质夹带的影响的减湿装置，该装置例如通过将容器设置在可更换容器的构件中，通过压敏阀其通常关闭容器室和接口之间的流体连接，以及容器室上游的温度调节器。

5. 发明授权

US4932268A Electromagnetic flow measuring arrangement 失效
标题翻译：电磁流量测量装置
公开(公告)号：US4932268A
公开(公告)日：1990-06-12
申请号：US251689
申请日：1988-09-29
申请人： Peter Hafner
发明人： Peter Hafner
IPC分类号： G01F1/58 , G01F15/02
CPC分类号： G01F1/58 , G01F1/586 , G01F15/02
摘要： In an electromagnetic flow measuring arrangement an electrically conductive fluid flows through a measuring tube in which a magnetic field is generated transversely of the flow direction, whereby a voltage is induced which is proportional to the flow velocity. This voltage is tapped by means of two electrodes. The cavity of the measuring tube has an elliptical cross-section with two major axes, the first major axis coinciding with the connecting line of the two electrodes, and the second major axis coinciding with the direction of the magnetic field. The flow to be measured is proportional to the product of the measured flow velocity and the cross-section area of the cavity of the measuring tube. The flow measuring arrangement is constructed so that on changes of the cavity cross-section caused by external influences the cross-section retains substantially the profile of an ellipse and the length of the second major axis remains substantially constant. In this way external influences, such as pressure and temperature, that change the cross-section of the cavity of the measuring tube, do not affect the measuring result.
摘要翻译：在电磁流量测量装置中，导电流体流过其中横向于流动方向产生磁场的测量管，由此产生与流速成比例的电压。该电压通过两个电极进行抽头。测量管的空腔具有两个长轴的椭圆形截面，第一长轴与两个电极的连接线重合，第二个长轴与磁场的方向一致。要测量的流量与测量流速和测量管腔的横截面面积的乘积成比例。流量测量装置被构造成使得在由外部影响导致的空腔横截面的变化上，横截面基本上保持椭圆的轮廓并且第二长轴的长度保持基本恒定。以这种方式，改变测量管的腔体横截面的诸如压力和温度的外部影响不影响测量结果。

6. 发明授权

US4382387A Method of compensating the interference DC voltages in the electrode circuit in magnetic-conductive flow measurement 失效
标题翻译：在导磁流量测量中补偿电极电路中的干扰直流电压的方法
公开(公告)号：US4382387A
公开(公告)日：1983-05-10
申请号：US254634
申请日：1981-04-16
申请人： Peter Hafner
发明人： Peter Hafner
IPC分类号： G01F1/60
CPC分类号： G01F1/60
摘要： A method of compensating interference DC voltages in the electrode circuit in magnetic-conductive flow measurement with periodically reversed DC magnetic field in which the useful signal is obtained by sampling and storing the signal voltage after each reversal of the magnetic field at opposite polarity values of the magnetic field during a sampling time interval and forming the difference of the stored sampled values, and wherein in a compensating time interval following each sampling time interval a compensation voltage is produced by sampling and storing the signal voltage, which compensation voltage is superimposed oppositely on the signal voltage for compensating the signal voltage within the compensation time interval to the value zero and is retained until the next compensation time interval, wherein each compensation time interval lies within the time interval corresponding to the switched-on magnetic field, in which also the preceding sampling time interval lies.
摘要翻译：一种通过周期性反转的直流磁场对导电流量测量中的电极电路中的干扰直流电压进行补偿的方法，其中有用信号通过在每次反转磁场的相反极性值之后采样和存储信号电压而获得并且形成所存储的采样值的差，并且其中在每个采样时间间隔之后的补偿时间间隔中，通过对所述信号电压进行采样和存储来产生补偿电压，所述补偿电压相对地叠加在所述补偿电压上信号电压，用于将补偿时间间隔内的信号电压补偿到零值，并被保持直到下一个补偿时间间隔，其中每个补偿时间间隔位于与接通磁场对应的时间间隔内，其中也是前一个采样时间间隔在于。

7. 发明授权

US09649456B2 Nasal administration 有权
公开(公告)号：US09649456B2
公开(公告)日：2017-05-16
申请号：US12594365
申请日：2008-04-07
申请人： Per Gisle Djupesland , Roderick Peter Hafner
发明人： Per Gisle Djupesland , Roderick Peter Hafner
IPC分类号： A61M15/08 , A61M16/00 , A61M15/00 , A61K31/4045 , A61M16/08 , A61M16/10
CPC分类号： A61M15/08 , A61K31/4045 , A61M15/0005 , A61M15/0008 , A61M15/0021 , A61M15/0028 , A61M15/003 , A61M15/0035 , A61M15/0041 , A61M15/0098 , A61M16/0808 , A61M16/1045 , A61M16/1055 , A61M16/1065 , A61M2202/064 , A61M2205/3606 , A61M2210/0618 , A61M2210/0625
摘要： A delivery device for and method of delivering a powdered substance, in particular a triptan, such as sumatriptan, to the posterior region of a nasal cavity of a subject, in particular for the treatment of headaches, for example, cluster headaches and migraine, and neuropathic pain, the delivery device comprising: a nosepiece (47) for insertion into a nasal cavity of a subject through which the powdered substance is delivered to the posterior region of the nasal cavity of the subject, in particular the upper posterior two thirds of the nasal cavity; and a substance supply unit (16) which is operable to deliver the powdered substance through the nosepiece (47).

8. 发明授权

US09180098B2 Compositions with reduced dimer formation 有权
标题翻译：具有减少的二聚体形成的组合物
公开(公告)号：US09180098B2
公开(公告)日：2015-11-10
申请号：US13131505
申请日：2009-11-27
申请人： Roderick Peter Hafner , Paul Laidler
发明人： Roderick Peter Hafner , Paul Laidler
IPC分类号： A61K38/00 , A61K38/04 , A61K39/00 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K17/00 , A61K9/19 , A61K39/35 , A61K47/10 , A61K47/26
CPC分类号： A61K39/35 , A61K9/08 , A61K9/19 , A61K39/0008 , A61K47/10 , A61K47/20 , A61K47/26
摘要： The present invention relates to the use of a non-reducing carbohydrate or carbohydrate derivative and at least one agent which inhibits dimer formation in a freeze-dried composition comprising at least one peptide that contains a free cysteine residue, to provide a freeze-dried composition with improved long-term storage stability.
摘要翻译：本发明涉及非还原性碳水化合物或碳水化合物衍生物和至少一种抑制二聚物形成的试剂在包含至少一种含有游离半胱氨酸残基的肽的冷冻干燥组合物中的用途，以提供冷冻干燥组合物具有改善的长期储存稳定性。

9. 发明授权

US08821887B2 T-cell antigen peptide from allergen for stimulation of IL-10 production 有权
标题翻译：来自变应原的T细胞抗原肽用于刺激IL-10产生
公开(公告)号：US08821887B2
公开(公告)日：2014-09-02
申请号：US13057377
申请日：2009-08-14
申请人： Mark Larche , Roderick Peter Hafner , Paul Laidler
发明人： Mark Larche , Roderick Peter Hafner , Paul Laidler
IPC分类号： A61K39/00 , A61K39/35 , A61K39/36 , A61K38/00
CPC分类号： A61K39/35 , A61K39/36 , A61K2039/577 , C07K5/06113 , C07K5/1008 , C07K5/1021 , C07K14/43531 , C07K14/705
摘要： A first or second polypeptide for use in a method of treating or preventing a disorder by tolerization, wherein said method comprises administration of the first and second polypeptide; and wherein both first and second polypeptides: i) are of 7 to 30 amino acids in length; ii) comprise at least one MHC Class II-binding T cell epitope; and iii) are a fragment of a protein allergen or a homologous variant of said fragment; wherein said first polypeptide induces the release of an amount of IL-10 that is greater than the amount of IL-10 released in response to the whole protein allergen from which the first polypeptide derives; wherein said disorder is characterized by an inappropriate immune response to the protein allergen from which the second polypeptide derives.
摘要翻译：用于通过耐受治疗或预防病症的方法中的第一或第二多肽，其中所述方法包括施用第一和第二多肽; 并且其中第一和第二多肽均为：i）长度为7至30个氨基酸; ii）包含至少一种MHC II类结合T细胞表位; 和iii）是蛋白质变应原或所述片段的同源变体的片段; 其中所述第一多肽诱导释放一定量的IL-10，其量大于响应于第一多肽衍生的全蛋白变应原释放的IL-10的量; 其中所述病症的特征在于对第二多肽衍生的蛋白质过敏原的不适当的免疫应答。

10. 发明授权

US08551493B2 Peptide with reduced dimer formation 有权
标题翻译：具有减少的二聚体形成的肽
公开(公告)号：US08551493B2
公开(公告)日：2013-10-08
申请号：US12673334
申请日：2008-08-15
申请人： Roderick Peter Hafner , Paul Laidler
发明人： Roderick Peter Hafner , Paul Laidler
IPC分类号： A61K38/00 , A61K38/04 , A61K39/00 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K17/00
CPC分类号： A61K39/0003 , A61K38/00 , A61K39/0002 , A61K39/0005 , A61K39/0008 , A61K39/35 , A61K39/36 , A61K39/39 , C07K7/06 , C07K7/08 , C07K14/415 , C07K14/435 , C07K14/43531 , C07K16/16 , C07K16/18 , C07K2319/00 , G01N33/56977
摘要： The present invention relates to peptides which are formulated or engineered to prevent or reduce the formation of dimers.
摘要翻译：本发明涉及配制或工程化以防止或减少二聚体形成的肽。

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