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1. 发明申请

US20070178497A1 Identification 审中-公开
标题翻译：识别
公开(公告)号：US20070178497A1
公开(公告)日：2007-08-02
申请号：US11615046
申请日：2006-12-22
申请人： Peter Gill , Javaid Hussain , Adam Long , Gillian Tully
发明人： Peter Gill , Javaid Hussain , Adam Long , Gillian Tully
IPC分类号： C12Q1/68 , G06F19/00
CPC分类号： C12Q1/6881 , C12Q1/6858 , C12Q2600/156 , G16B30/00 , G16B40/00 , C12Q2537/143 , C12Q2535/125
摘要： The invention provides a method for obtaining additional information about DNA mixtures arising from a variety of sources and/or a variety of concentrations. In particular, the invention provides a method for indicating the likelihood that a DNA mixture arose from sources of a defined type where: the DNA mixture is formed by DNA samples from more than one source, the method involving the determination of the identity of the alleles present at a locus for the DNA in the mixture; determining a first probability function for the situation where the DNA mixture is formed from samples arising from the given person and from a first other person; determining a second probability function for the situation where the DNA mixture is formed from samples arising from a second other person and a first other person; using the first probability function as numerator and the second probability function as denominator in determining a likelihood ratio for the mixture having arisen from the defined type of sources considered in the first probability function; determining such likelihood ratios for a plurality of loci; and combining the likelihood ratios to give a combined likelihood ratio for the mixture having arisen from the defined type of sources considered in the first probability function.
摘要翻译：本发明提供了一种获得关于由各种来源和/或多种浓度产生的DNA混合物的附加信息的方法。特别地，本发明提供了一种用于指示DNA混合物从定义类型的来源产生的可能性的方法，其中：DNA混合物由来自多于一个来源的DNA样品形成，所述方法涉及确定等位基因的身份存在于混合物中DNA的位点; 确定由给定人和第一另一个人产生的样品形成DNA混合物的情况的第一概率函数; 确定由第二另一个人和第一另一个人产生的样品形成DNA混合物的情况的第二概率函数; 使用第一概率函数作为分子，并且将第二概率函数作为分母来确定从在第一概率函数中考虑的限定类型的源产生的混合物的似然比; 确定多个基因座的似然比; 并且将似然比组合以给出从在第一概率函数中考虑的所定义类型的源产生的混合物的组合似然比。

2. 发明申请

US20050064500A1 Analysis of DNA samples 审中-公开
标题翻译： DNA样品分析
公开(公告)号：US20050064500A1
公开(公告)日：2005-03-24
申请号：US10977698
申请日：2004-10-29
申请人： Peter Gill , Jonathon Whitaker , John Buckleton
发明人： Peter Gill , Jonathon Whitaker , John Buckleton
IPC分类号： C12Q1/68 , G06F19/18 , G06F19/22
CPC分类号： G16B30/00 , G16B20/00
摘要： The invention provides an improved method for obtaining information about DNA analysis of samples of uncertain origin by establishing the likelihood that they arose in certain manners compared with other possible manners. In this way all of the analysis information is taken into account and likelihood ratios are provided to express the results. The invention is particularly useful in analysing small DNA samples or DNA samples where the contribution from one or more sources is small.
摘要翻译：本发明提供了一种改进的方法，用于通过确定与其他可能方式相比以某种方式产生的可能性来获得关于不确定来源的样品的DNA分析的信息。以这种方式考虑所有的分析信息，并提供似然比来表达结果。本发明特别可用于分析来自一个或多个来源的贡献较小的小DNA样品或DNA样品。

3. 发明申请

US20050014183A1 Amplification 审中-公开
标题翻译：放大
公开(公告)号：US20050014183A1
公开(公告)日：2005-01-20
申请号：US10892854
申请日：2004-07-15
申请人： Peter Gill , Javaid Hussain , Adam Long
发明人： Peter Gill , Javaid Hussain , Adam Long
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C12Q1/6876 , C12Q2600/156 , C12Q2600/16
摘要： Primer mixtures and methods of investigating single nucleotide polymorphisms in samples of DNA are provided having particular primer sequences. The primer mixtures and methods are aimed at achieving optimised performance in multiplexes.
摘要翻译：提供引物混合物和研究DNA样品中单核苷酸多态性的方法，其具有特定的引物序列。引物混合物和方法旨在实现多路复用中的优化性能。

4. 发明申请

US20100114500A1 ANALYSIS OF DNA 有权
标题翻译： DNA分析
公开(公告)号：US20100114500A1
公开(公告)日：2010-05-06
申请号：US12686174
申请日：2010-01-12
申请人： Peter GILL , Amanda Kirkham
发明人： Peter GILL , Amanda Kirkham
IPC分类号： G06F19/00 , G06F17/18
CPC分类号： C12Q1/6809
摘要： The invention provides methods for providing information on the probability of DNA samples being contaminated over days, weeks and months in relation to collection, processing and analysis of DNA samples. Methods are also provided for analysing the likelihood of a result arising due to contamination and/or determining the analysis protocol to be applied to a DNA sample and/or methods of operating databases, particularly containing DNA profiles.Improvements in accounting for sporadic and undetected contamination and improvements in the operation of DNA sampling of analysis are provided by the invention.
摘要翻译：本发明提供了关于DNA样品在DNA样品的收集，处理和分析方面在几天，几周和几个月内被污染的可能性的信息的方法。还提供了用于分析由于污染引起的结果的可能性和/或确定要应用于DNA样品的分析方案和/或操作数据库的方法，特别是含有DNA谱的方法。通过本发明提供了散发性和未检测到的污染物的改进，以及分析的DNA取样操作的改进。

5. 发明授权

US07668660B2 Analysis of DNA 有权
标题翻译： DNA分析
公开(公告)号：US07668660B2
公开(公告)日：2010-02-23
申请号：US10564682
申请日：2004-07-09
申请人： Peter Gill , Amanda Kirkham
发明人： Peter Gill , Amanda Kirkham
IPC分类号： G01N33/48
CPC分类号： C12Q1/6809
摘要： The invention provides methods for providing information on the probability of DNA samples being contaminated over days, weeks and months in relation to collection, processing and analysis of DNA samples. Methods are also provided for analysing the likelihood of a result arising due to contamination and/or determining the analysis protocol to be applied to a DNA sample and/or methods of operating databases, particularly containing DNA profiles.Improvements in accounting for sporadic and undetected contamination and improvements in the operation of DNA sampling of analysis are provided by the invention.
摘要翻译：本发明提供了关于DNA样品在DNA样品的收集，处理和分析方面在几天，几周和几个月内被污染的可能性的信息的方法。还提供了用于分析由于污染引起的结果的可能性和/或确定要应用于DNA样品的分析方案和/或操作数据库的方法，特别是含有DNA谱的方法。通过本发明提供了散发性和未检测到的污染物的改进，以及分析的DNA取样操作的改进。

6. 发明申请

US20090234621A1 METHOD OF OPTIMIZING PARAMETERS IN THE ENTIRE PROCESS OF ANALYSING A DNA CONTAINING SAMPLE AND METHOD OF MODELING SAID PROCESS 审中-公开
标题翻译：在分析样品的DNA的整个过程中优化参数的方法和建模过程的方法
公开(公告)号：US20090234621A1
公开(公告)日：2009-09-17
申请号：US11720721
申请日：2005-12-05
申请人： Peter Gill , James Curran
发明人： Peter Gill , James Curran
IPC分类号： G06F17/10 , G06G7/48 , G06F19/00 , G01N33/48
CPC分类号： C12Q1/6851 , G16B40/00 , G16B45/00 , C12Q2537/165
摘要： A method of optimizing one or more parameters in a process for considering a DNA containing sample using a method of modeling and a method of modeling itself are provided. The method of modeling the process for considering a DNA containing sample uses a graphical model. The model seeks to provide one or more optimized parameters for the consideration process. The methods aim to consider the whole process, for instance, the number of cells required for the process and/or the extraction efficiency and/or the sub-sample volume relative to the sample volume and/or the amplification efficiency and/or the optimum number of amplification cycles and/or the effect of degradation on the amount of amplifiable DNA in the sample.
摘要翻译：提供了一种在使用建模方法考虑含DNA样品的过程中优化一个或多个参数的方法和自身建模方法。用于考虑含DNA样品的过程进行建模的方法使用图形模型。该模型试图为考虑过程提供一个或多个优化参数。该方法旨在考虑整个过程，例如，相对于样品体积和/或放大效率和/或最佳值，该方法所需的细胞数量和/或提取效率和/或亚样品体积扩增循环数和/或降解对样品中可扩增DNA量的影响。

7. 发明申请

US20080161196A1 METHODS AND APPARATUS FOR GENOTYPING 失效
标题翻译：用于基因分析的方法和装置
公开(公告)号：US20080161196A1
公开(公告)日：2008-07-03
申请号：US11937825
申请日：2007-11-09
申请人： Peter Gill , Lindsey Dixon
发明人： Peter Gill , Lindsey Dixon
IPC分类号： C40B30/00 , C12Q1/68
CPC分类号： C12Q1/6827
摘要： A method for establishing the genotype of the locus is provided in which a series of calibration samples are analysed, the results being one of three indication types, a window being defined relative to the indication for each of the indication types, unknown samples being similarly analysed with the window that they fall within being taken to determine the indication type for the unknown sample and hence the genotype of the relevant locus.The technique provides a robust, reliable and accurate method of genotyping which is suited to automation.
摘要翻译：提供了一种用于建立基因座基因型的方法，其中分析了一系列校准样本，结果是三种指示类型之一，相对于每种指示类型的指示定义了窗口，类似地分析了未知样本随着它们落入的窗口被采取以确定未知样品的指示类型，并因此确定相关基因座的基因型。该技术提供了一种强大，可靠和准确的基因分型方法，适用于自动化。

8. 发明申请

US20070143028A1 Analysis of dna 有权
标题翻译： dna分析
公开(公告)号：US20070143028A1
公开(公告)日：2007-06-21
申请号：US10564682
申请日：2004-07-09
申请人： Peter Gill , Amanda Kirkham
发明人： Peter Gill , Amanda Kirkham
IPC分类号： G01N33/48
CPC分类号： C12Q1/6809
摘要： The invention provides methods for providing information on the probability of DNA samples being contaminated over days, weeks and months in relation to collection, processing and analysis of DNA samples. Methods are also provided for analysing the likelihood of a result arising due to contamination and/or determining the analysis protocol to be applied to a DNA sample and/or methods of operating databases, particularly containing DNA profiles. Improvements in accounting for sporadic and undetected contamination and improvements in the operation of DNA sampling of analysis are provided by the invention.
摘要翻译：本发明提供了关于DNA样品在DNA样品的收集，处理和分析方面在几天，几周和几个月内被污染的可能性的信息的方法。还提供了用于分析由于污染引起的结果的可能性和/或确定要应用于DNA样品的分析方案和/或操作数据库的方法，特别是含有DNA谱的方法。通过本发明提供了散发性和未检测到的污染物的改进，以及分析的DNA取样操作的改进。

9. 发明申请

US20060099614A1 Analysis of DNA 审中-公开
公开(公告)号：US20060099614A1
公开(公告)日：2006-05-11
申请号：US11223848
申请日：2005-09-08
申请人： Peter Gill , Javaid Hussain , Adam Long
发明人： Peter Gill , Javaid Hussain , Adam Long
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C12Q1/6881 , C12Q1/6858 , C12Q2600/156 , C12Q2537/149 , C12Q2531/113
摘要： The invention provides improved techniques for investigating DNA samples, which offers improved sensitivity and specifity. The invention provides a method of investigating single nucleotide polymorphisms in a sample of DNA, the method comprising contacting the DNA containing sample with at least one first set of primers, amplifying the DNA using those primers to give an amplified product, contacting at least a portion of the amplified product with at least one second set of primers, amplifying the DNA using those second set of primers to give a further amplified product and examining one or more characteristics of the further amplified product, one or more of the primers of the first set of primers including a locus specific portion and a further portion, the locus specific portion of one of those one or more of the primers annealing to one side of the SNP under investigation.

10. 发明申请

US20060046263A1 Analysis 审中-公开
标题翻译：分析
公开(公告)号：US20060046263A1
公开(公告)日：2006-03-02
申请号：US11212370
申请日：2005-08-25
申请人： Peter Gill , Lindsey Dixon , Pieris Koumi
发明人： Peter Gill , Lindsey Dixon , Pieris Koumi
IPC分类号： C12Q1/68 , G06F19/00
CPC分类号： G16B20/00
摘要： A method for processing results, particularly from, the method comprising: obtaining from the results information concerning the single nucleotide polymorphisms implied for one or more loci, the information including identity information on the single nucleotide polymorphism or polymorphisms of a locus and a value related to the level detected for each identity; comparing each value with a first threshold and a second threshold, the comparison for the value or values for a locus determining the single nucleotide polymorphism identities considered to be possible for that locus.
摘要翻译：一种处理结果的方法，特别是包括：从结果获得关于一个或多个基因座所暗示的单核苷酸多态性的信息，所述信息包括单核苷酸多态性或基因座多态性的身份信息以及与检测每个身份的级别; 将每个值与第一阈值和第二阈值进行比较，确定被认为是该基因座可能的单核苷酸多态性身份的基因座的值或值的比较。

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