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    • 7. 发明授权
    • Systems and methods for targeted magnetic resonance imaging of the vascular system
    • 用于血管系统靶向磁共振成像的系统和方法
    • US07412279B2
    • 2008-08-12
    • US10209416
    • 2002-07-30
    • Robert M. WeisskoffPeter D. CaravanSonia WitteRandall B. LaufferAlan P. Carpenter, Jr.
    • Robert M. WeisskoffPeter D. CaravanSonia WitteRandall B. LaufferAlan P. Carpenter, Jr.
    • A61B5/05
    • A61B5/416A61B5/055
    • This invention relates to MRI-based methods and systems useful for diagnosing and clinically assessing the presence, location, and size of cardiovascular disease-associated stationary targets, e.g., thrombi and atherosclerotic lesions, within the vascular system. Methods and systems of the invention allow for improved anatomical information to be obtained from MRI images and allow the clinician to develop more effective treatment plans. In one aspect, the invention provides a method of determining the presence or absence of a stationary target within the vascular system of a mammal wherein two MRI data sets representing images of the vascular system and the stationary target are acquired after administration of a targeted MRI contrast agent. In another embodiment, both a targeted MRI contrast agent and a vascular MRI contrast agent are administered to a mammal, and both a vascular MRI and a targeted MRI data set are acquired.
    • 本发明涉及基于MRI的方法和系统,其可用于诊断和临床评估血管系统内心血管疾病相关的静止目标(例如血栓和动脉粥样硬化病变)的存在,位置和大小。 本发明的方法和系统允许从MRI图像获得改进的解剖信息,并允许临床医生开发更有效的治疗计划。 一方面,本发明提供一种确定哺乳动物血管系统中静止靶的存在或不存在的方法,其中在施用靶向MRI对比后获取表示血管系统和静止靶的图像的两个MRI数据集 代理商 在另一个实施方案中,向哺乳动物施用靶向MRI造影剂和血管MRI造影剂,并且获取血管MRI和靶向MRI数据组。