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1. 发明申请

US20110319954A1 METRICS AND TECHNIQUES FOR OPTIMIZATION OF CARDIAC THERAPIES 审中-公开
标题翻译：用于优化心脏病治疗的方法和技术
公开(公告)号：US20110319954A1
公开(公告)日：2011-12-29
申请号：US12825063
申请日：2010-06-28
申请人： Imran Niazi , Kyungmoo Ryu , Peter Chelius , Scott Patrick Simon , Michael Kane , Timothy A. Fayram
发明人： Imran Niazi , Kyungmoo Ryu , Peter Chelius , Scott Patrick Simon , Michael Kane , Timothy A. Fayram
IPC分类号： A61N1/00
CPC分类号： A61N1/3627 , A61B5/0215 , A61B5/0452 , A61B5/046 , A61B5/0464 , A61B5/11 , A61B5/686 , A61N1/3684 , A61N1/3686 , G06F19/3481 , G16H50/20
摘要： An exemplary method includes, based on metrics available as input to a chronic phase optimization algorithm for selecting an optimal electrode configuration for delivery of a cardiac pacing therapy, executing the chronic phase optimization algorithm during an acute phase to select an optimal electrode configuration for delivery of a cardiac pacing therapy; during the acute phase, acquiring position information with respect to time for electrodes implanted in a body; determining one or more acute phase metrics based on the acquired position information; and validating the chronic phase optimization algorithm based at least in part on the one or more acute phase metrics.
摘要翻译：示例性方法包括：基于可用作用于选择用于递送心脏起搏治疗的最佳电极配置的慢性相位优化算法的输入的度量，在急性期期间执行慢性相位优化算法，以选择用于递送心脏起搏治疗; 在急性期，获取相对于植入体内的电极的时间的位置信息; 基于所获取的位置信息确定一个或多个急性相位度量; 以及至少部分地基于所述一个或多个急性相位度量来验证所述慢性相位优化算法。

2. 发明申请

US20130261481A1 SYSTEMS AND METHODS FOR ST SEGMENT STABILITY DISCRIMINATION DURING CARDIAC ISCHEMIA DETECTION FOR USE WITH IMPLANTABLE MEDICAL DEVICES 审中-公开
标题翻译：用于带有可移植医疗设备的心脏缺血检测期间ST段分段稳定性鉴别的系统和方法
公开(公告)号：US20130261481A1
公开(公告)日：2013-10-03
申请号：US13434546
申请日：2012-03-29
申请人： Kathleen Kresge , Carol Hudgins , Peter Chelius
发明人： Kathleen Kresge , Carol Hudgins , Peter Chelius
IPC分类号： A61B5/0456
CPC分类号： A61B5/0452 , A61B5/0031
摘要： Techniques are provided for discriminating episodes of cardiac ischemia indicated based on shifts in ST segment elevation from false detections due to atrial fibrillation (AF) or other confounding factors such as premature ventricular contractions (PVCs.) In an example for use with a single-chamber device, in response to a possible ischemic event, the single-chamber device assesses ventricular stability based an examination of ventricular intracardiac electrogram (IEGM) signals. If the ventricular IEGM is unstable due to paroxysmal AF or frequent PVCs, the ischemic event is rejected as a false detection. Otherwise, the device responds to the event by, for example, generating warning signals, recording diagnostic data or controlling device therapy. The stability discrimination techniques are particularly advantageous for use within single-chamber devices that lack automatic mode switching but are also beneficial within at least some dual-chamber devices or multi-chamber systems.
摘要翻译：提供了用于区分心脏缺血发作的技术，其基于由于心房纤维性颤动（AF）或其他混杂因素（例如早产性心室收缩（PVC））引起的ST段升高的变化而指示。在用于单室的实例中装置，响应于可能的缺血事件，单室装置基于心室心电图（IEGM）信号的检查来评估心室稳定性。如果心室IEGM由于阵发性房颤或频繁的PVC不稳定，则缺血事件被拒绝为错误检测。否则，设备通过例如生成警告信号，记录诊断数据或控制设备治疗来响应事件。稳定性鉴别技术特别有利于在缺少自动模式切换的单室装置内使用，但在至少一些双室装置或多腔室系统中也是有益的。

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