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1. 发明申请

US20200289629A1 TOXOPLASMA GONDII VACCINES AND THEIR USE 审中-公开
公开(公告)号：US20200289629A1
公开(公告)日：2020-09-17
申请号：US16892083
申请日：2020-06-03
申请人： Rima MCLEOD , Kamal EL BISSATI , Ying ZHOU , Jeff ALEXANDER , Lo VANG , Steve REED , Sara M. PAULILLO , Senthil K. RAMAN , Peter BURKHARD , Mariane MELO , Darrel IRVINE , Ron WEISS , Yuan ZHANG , Alessandro SETTE , John SIDNEY , Brian D. LIVINGSTON , Hernan LORENZI
发明人： Rima MCLEOD , Kamal EL BISSATI , Ying ZHOU , Jeff ALEXANDER , Lo VANG , Steve REED , Sara M. PAULILLO , Senthil K. RAMAN , Peter BURKHARD , Mariane MELO , Darrel IRVINE , Ron WEISS , Yuan ZHANG , Alessandro SETTE , John SIDNEY , Brian D. LIVINGSTON , Hernan LORENZI
IPC分类号： A61K39/002 , A61P33/02 , A61K9/00 , A61K39/012
摘要： Disclosed herein are polynucleotides encoding multi-epitope polypeptides and assemblies thereof, and their use for treating or limiting Toxoplasma gondii infection.

2. 发明授权

US08575110B2 Peptidic nanoparticles as drug delivery and antigen display systems 有权
标题翻译：肽纳米粒子作为药物递送和抗原显示系统
公开(公告)号：US08575110B2
公开(公告)日：2013-11-05
申请号：US10545676
申请日：2004-02-16
申请人： Peter Burkhard
发明人： Peter Burkhard
IPC分类号： A61K38/00 , A61K39/00 , C07K14/00 , C07K2/00
CPC分类号： A61K9/5169 , C07K14/001 , Y02A50/409 , Y02A50/411
摘要： Described is a new type of nanoparticle using the concept of self-organization of a single continuous chain to form peptidic nanoparticles. In particular, nanoparticles of the invention consist of aggregates of a continuous chain comprising two peptidic oligomerization domains connected by a linker segment. Preferred are coiled-coil oligomerization domains with a contiguous pattern of hydrophobic residues spaced 3 and 4 residues apart. The invention provides a drug targeting and delivery system comprising a functionalized peptidic nanoparticle comprising ligands capable of binding a receptor and drugs, and a method of treating or diagnosing humans using such functionalized peptidic nanoparticles. The invention further provides an antigen display system to be used as efficient vaccines comprising a functionalized peptidic nanoparticle comprising an antigen, and a method of vaccinating humans or non-human animals using such functionalized peptidic nanoparticles. The invention also provides processes for making peptidic nanoparticles and functionalized peptidic nanoparticles, and monomeric building blocks suitable for forming such nanoparticles.
摘要翻译：描述了一种新型的纳米颗粒，其使用单一连续链的自组织的概念来形成肽纳米颗粒。特别地，本发明的纳米颗粒由包含通过接头片段连接的两个肽低聚结构域的连续链的聚集体组成。优选的是具有间隔3和4个残基的疏水残基的连续图案的卷曲螺旋低聚结构域。本发明提供了药物靶向和递送系统，其包含官能化的肽纳米颗粒，其包含能够结合受体和药物的配体，以及使用这种官能化肽类纳米颗粒治疗或诊断人的方法。本发明进一步提供了一种用作高效疫苗的抗原展示系统，其包含含有抗原的功能性肽类纳米颗粒，以及使用这种官能化肽类纳米颗粒接种人或非人类动物的方法。本发明还提供了制备肽纳米颗粒和功能化肽类纳米颗粒的方法，以及适用于形成这种纳米颗粒的单体结构单元。

3. 发明申请

US20190282679A1 TOXOPLASMA GONDII VACCINES AND THEIR USE 审中-公开
公开(公告)号：US20190282679A1
公开(公告)日：2019-09-19
申请号：US16094394
申请日：2017-04-14
申请人： Rima MCLEOD , Kamal EL BISSATI , Ying ZHOU , Jeff ALEXANDER , Lo VANG , Steve REED , Sara M. PAULILLO , Senthil K. RAMAN , Peter BURKHARD , Mariane MELO , Darrel IRVINE , Ron WEISS , Yuan ZHANG , Alessandro SETTE , John SIDNEY , Brian D. LIVINGSTON , Hernan LORENZI
发明人： Rima MCLEOD , Kamal EL BISSATI , Ying ZHOU , Jeff ALEXANDER , Lo VANG , Steve REED , Sara M. PAULILLO , Senthil K. RAMAN , Peter BURKHARD , Mariane MELO , Darrel IRVINE , Ron WEISS , Yuan ZHANG , Alessandro SETTE , John SIDNEY , Brian D. LIVINGSTON , Hernan LORENZI
IPC分类号： A61K39/002 , A61K9/00 , A61P33/02
摘要： Disclosed herein are polynucleotides encoding multi-epitope polypeptides and assemblies thereof, and their use for treating or limiting Toxoplasma gondii infection.

4. 发明申请

US20070014804A1 Peptidic nanoparticles as drug delivery and antigen display systems 有权
标题翻译：肽纳米粒子作为药物递送和抗原显示系统
公开(公告)号：US20070014804A1
公开(公告)日：2007-01-18
申请号：US10545676
申请日：2004-02-16
申请人： Peter Burkhard
发明人： Peter Burkhard
IPC分类号： A61K39/00
CPC分类号： A61K9/5169 , C07K14/001 , Y02A50/409 , Y02A50/411
摘要： Described is a new type of nanoparticle using the concept of self-organization of a single continuous chain to form peptidic nanoparticles. In particular, nanoparticles of the invention consist of aggregates of a continuous chain comprising two peptidic oligomerization domains connected by a linker segment. Preferred are coiled-coil oligomerization domains with a contiguous pattern of hydrophobic residues spaced 3 and 4 residues apart. The invention provides a drug targeting and delivery system comprising a functionalized peptidic nanoparticle comprising ligands capable of binding a receptor and drugs, and a method of treating or diagnosing humans using such functionalized peptidic nanoparticles. The invention further provides an antigen display system to be used as efficient vaccines comprising a functionalized peptidic nanoparticle comprising an antigen, and a method of vaccinating humans or non-human animals using such functionalized peptidic nanoparticles. The invention also provides processes for making peptidic nanoparticles and functionalized peptidic nanoparticles, and monomeric building blocks suitable for forming such nanoparticles.
摘要翻译：描述了一种新型的纳米颗粒，其使用单一连续链的自组织的概念来形成肽纳米颗粒。特别地，本发明的纳米颗粒由包含通过接头片段连接的两个肽低聚结构域的连续链的聚集体组成。优选的是具有间隔3和4个残基的疏水残基的连续图案的卷曲螺旋低聚结构域。本发明提供了药物靶向和递送系统，其包含官能化的肽纳米颗粒，其包含能够结合受体和药物的配体，以及使用这种官能化肽类纳米颗粒治疗或诊断人的方法。本发明进一步提供了一种用作高效疫苗的抗原展示系统，其包含含有抗原的功能性肽类纳米颗粒，以及使用这种官能化肽类纳米颗粒接种人或非人类动物的方法。本发明还提供了制备肽纳米颗粒和功能化肽类纳米颗粒的方法，以及适用于形成这种纳米颗粒的单体结构单元。

5. 发明申请

US20120015000A1 MALARIA VACCINE OF SELF-ASSEMBLING POLYPEPTIDE NANOPARTICLES 审中-公开
标题翻译：自组装多肽纳米颗粒的MALARIA疫苗
公开(公告)号：US20120015000A1
公开(公告)日：2012-01-19
申请号：US13056298
申请日：2009-06-29
申请人： David Lanar , Peter Burkhard
发明人： David Lanar , Peter Burkhard
IPC分类号： A61K9/14 , A61P33/06 , A61K39/015 , A61P37/04 , B82Y5/00
CPC分类号： A61K39/015 , A61K39/385 , A61K2039/5258 , A61K2039/6031 , A61K2039/64 , Y02A50/412
摘要： The invention is directed to functionalized self-assembling polypeptide nanoparticles, and to methods of using these nanoparticles to vaccinate against malaria. The functionalized SAPN comprises a self-assembling core, and at least one epitope fused to the self-assembling core. The self-assembling core comprises a pentameric coiled-coil domain, a trimeric coiled-coil domain, and a linker. The linker joins the pentameric coiled-coil domain and the trimeric coiled-coil domain. Particular sequences of the epitopes used in the vaccine are from the Plasmodium parasite.
摘要翻译：本发明涉及功能化的自组装多肽纳米颗粒，以及使用这些纳米颗粒免疫疟疾的方法。功能化SAPN包括自组装核心和至少一个与自组装核心融合的表位。自组装芯包括五聚体卷曲螺旋结构域，三聚螺旋线圈结构域和连接体。连接体连接五聚体线圈结构域和三聚体螺旋线圈结构域。疫苗中使用的表位的特定序列来自疟原虫寄生虫。

6. 发明申请

US20110020378A1 SELF-ASSEMBLING PEPTIDE NANOPARTICLES USEFUL AS VACCINES 有权
标题翻译：自组装肽纳米粒子作为疫苗有用
公开(公告)号：US20110020378A1
公开(公告)日：2011-01-27
申请号：US12864576
申请日：2009-01-29
申请人： Peter BURKHARD
发明人： Peter BURKHARD
IPC分类号： A61K39/00 , C07K2/00 , C07K14/00 , A61P37/04 , C07K14/155 , C07K14/445 , C07K14/11
CPC分类号： C07K14/001 , A61K39/015 , A61K39/12 , A61K39/145 , A61K39/21 , A61K39/385 , A61K2039/6031 , A61K2039/64 , C12N2740/16134 , C12N2760/16134 , Y02A50/39 , Y02A50/394 , Y02A50/41 , Y02A50/412 , Y02A50/466 , Y02A50/484 , Y02A50/487
摘要： Self-assembling peptide nanoparticles (SAPN) incorporating T-cell epitopes and/or B-cell epitopes are described. The nanoparticles of the invention consist of aggregates of a continuous peptidic chain comprising two oligomerization domains connected by a linker segment wherein one or both oligomerization domains incorporate T-cell epitopes and/or B-cell epitopes within their peptide sequence. These nanoparticles are useful as vaccines and adjuvants.
摘要翻译：描述了结合T细胞表位和/或B细胞表位的自组装肽纳米颗粒（SAPN）。本发明的纳米颗粒由包含通过接头片段连接的两个寡聚化结构域的连续肽链的聚集体组成，其中一个或两个寡聚化结构域在其肽序列内结合T细胞表位和/或B细胞表位。这些纳米颗粒可用作疫苗和佐剂。

7. 发明授权

US08546337B2 Self-assembling peptide nanoparticles useful as vaccines 有权
标题翻译：自组装肽纳米颗粒可用作疫苗
公开(公告)号：US08546337B2
公开(公告)日：2013-10-01
申请号：US12864576
申请日：2009-01-29
申请人： Peter Burkhard
发明人： Peter Burkhard
IPC分类号： A61K38/00 , A61K39/00 , C07K14/00 , C07K2/00
CPC分类号： C07K14/001 , A61K39/015 , A61K39/12 , A61K39/145 , A61K39/21 , A61K39/385 , A61K2039/6031 , A61K2039/64 , C12N2740/16134 , C12N2760/16134 , Y02A50/39 , Y02A50/394 , Y02A50/41 , Y02A50/412 , Y02A50/466 , Y02A50/484 , Y02A50/487
摘要： Self-assembling peptide nanoparticles (SAPN) incorporating T-cell epitopes and/or B-cell epitopes are described. The nanoparticles of the invention consist of aggregates of a continuous peptidic chain comprising two oligomerization domains connected by a linker segment wherein one or both oligomerization domains incorporate T-cell epitopes and/or B-cell epitopes within their peptide sequence. These nanoparticles are useful as vaccines and adjuvants.
摘要翻译：描述了结合T细胞表位和/或B细胞表位的自组装肽纳米颗粒（SAPN）。本发明的纳米颗粒由包含通过接头片段连接的两个寡聚化结构域的连续肽链的聚集体组成，其中一个或两个寡聚化结构域在其肽序列内结合T细胞表位和/或B细胞表位。这些纳米颗粒可用作疫苗和佐剂。

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