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1. 发明申请

US20150203841A1 TEMPLATE DIRECTED SPLIT AND MIX SYNTHESIS OF SMALL MOLECULE LIBRARIES 审中-公开
标题翻译：小分子图书馆的模式分类和混合综合
公开(公告)号：US20150203841A1
公开(公告)日：2015-07-23
申请号：US14676381
申请日：2015-04-01
申请人： Peter Birk Rasmussen
发明人： Peter Birk Rasmussen
IPC分类号： C12N15/10
CPC分类号： C12N15/1065 , B01J19/0046 , C12N15/1068
摘要： The invention combines the advantages of split and mix synthesis with the advantages of template directed synthesis. The method comprises the steps of a) adding a linker molecule L to one or more reaction wells; b) adding a molecule fragment to each of said reaction wells; c) adding an oligonucleotide identifier to each of said reaction wells; d) subjecting said wells to conditions sufficient to allow said molecule fragments and said oligonucleotide identifiers to become attached to said linker molecule, or conditions sufficient for said molecule fragments to bind to other molecule fragments and sufficient for said oligonucleotide identifiers to bind to other oligonucleotide identifiers; e) combining the contents of said one or more reaction wells; and f) contacting the resulting bifunctional molecule(s) of step e) with one or more (oligonucleotide) templates each capable of hybridizing to at least one of the oligonucleotide identifiers added step c).
摘要翻译：本发明将分裂和混合合成的优点与模板定向合成的优点相结合。该方法包括以下步骤：a）将连接体分子L加入到一个或多个反应孔中; b）向每个所述反应孔中加入分子片段; c）向每个所述反应孔中加入寡核苷酸标识符; d）对所述孔进行足以使所述分子片段和所述寡核苷酸标识符与所述连接分子连接的条件，或足以使所述分子片段与其它分子片段结合并足以使所述寡核苷酸标识符与其它寡核苷酸标识符结合的条件 ; e）组合所述一个或多个反应孔的内容物; 和f）使所得到的步骤e）的双功能分子与一种或多种（寡核苷酸）模板接触，每个寡核苷酸模板能够与添加的步骤c）中的至少一个寡核苷酸标识符杂交。

2. 发明授权

US08871212B2 Amyloid-beta polypeptide vaccine 有权
标题翻译：淀粉样蛋白-β多肽疫苗
公开(公告)号：US08871212B2
公开(公告)日：2014-10-28
申请号：US12339841
申请日：2008-12-19
申请人： Peter Birk Rasmussen , Martin Roland Jensen , Klaus Gregorius Nielsen , Peter Koefoed , Florence Dal Degan
发明人： Peter Birk Rasmussen , Martin Roland Jensen , Klaus Gregorius Nielsen , Peter Koefoed , Florence Dal Degan
IPC分类号： A61K39/00 , A61K39/385 , A61K39/08 , A01K67/027 , C07K14/47
CPC分类号： A61K39/0007 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0312 , A61K39/385 , A61K45/06 , A61K2039/53 , A61K2039/6037 , A61K2039/6068 , A61K2039/6087 , A61K2039/6093 , A61K2039/64 , C07K14/4711 , Y02A50/412
摘要： Disclosed are novel methods and compositions for combating diseases characterized by deposition of amyloid. The methods generally rely on immunization against amyloid precursor protein (APP) or beta amyloid (Aβ). Immunization is preferably effected by administration of analogs of autologous APP or Aβ, said analogs being capable of inducing antibody production against the autologous amyloidogenic polypeptides. Especially preferred as an immunogen is autologous Aβ which has been modified by introduction of one single or a few foreign, immunodominant and promiscuous T-cell epitopes. Such methods and means include methods for the preparation of analogs and pharmaceutical formulations, as well as nucleic acid fragments, vectors, transformed cells, polypeptides and pharmaceutical formulations.
摘要翻译：公开了用于防治以沉淀淀粉样蛋白为特征的疾病的新颖方法和组合物。所述方法通常依赖于针对淀粉样前体蛋白（APP）或β淀粉样蛋白（A＆bgr）的免疫。免疫优选通过施用自体APP或A＆bgr的类似物来实现;所述类似物能够诱导针对自体淀粉样蛋白形成多肽的抗体产生。特别优选作为免疫原是自体A＆bgr; 其通过引入一种或几种外来的免疫显性和混杂的T细胞表位而被修饰。这些方法和手段包括制备类似物和药物制剂以及核酸片段，载体，转化细胞，多肽和药物制剂的方法。

3. 发明申请

US20100047262A1 NOVEL METHOD FOR DOWN-REGULATION OF AMYLOID 有权
标题翻译：用于下调AMYLOID的新方法
公开(公告)号：US20100047262A1
公开(公告)日：2010-02-25
申请号：US12339841
申请日：2008-12-19
申请人： Peter Birk Rasmussen , Martin Roland Jensen , Klaus Gregorius Nielsen , Peter Koefoed , Florence Dal Degan
发明人： Peter Birk Rasmussen , Martin Roland Jensen , Klaus Gregorius Nielsen , Peter Koefoed , Florence Dal Degan
IPC分类号： A61K39/00 , A61P37/04 , A61P25/28
CPC分类号： A61K39/0007 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0312 , A61K39/385 , A61K45/06 , A61K2039/53 , A61K2039/6037 , A61K2039/6068 , A61K2039/6087 , A61K2039/6093 , A61K2039/64 , C07K14/4711 , Y02A50/412
摘要： Disclosed are novel methods and compositions for combating diseases characterized by deposition of amyloid. The methods generally rely on immunization against amyloid precursor protein (APP) or beta amyloid (Aβ). Immunization is preferably effected by administration of analogues of autologous APP or Aβ, said analogues being capable of inducing antibody production against the autologous amyloidogenic polypeptides. Especially preferred as an immunogen is autologous Aβ which has been modified by introduction of one single or a few foreign, immunodominant and promiscuous T-cell epitopes. Such methods and means include methods for the preparation of analogues and pharmaceutical formulations, as well as nucleic acid fragments, vectors, transformed cells, polypeptides and pharmaceutical formulations.
摘要翻译：公开了用于防治以沉淀淀粉样蛋白为特征的疾病的新颖方法和组合物。所述方法通常依赖于针对淀粉样前体蛋白（APP）或β淀粉样蛋白（A＆bgr）的免疫。免疫优选通过施用自体APP或A＆bgr的类似物来实现;所述类似物能够诱导针对自体淀粉样变性多肽的抗体产生。特别优选作为免疫原是自体A＆bgr; 其通过引入一种或几种外来的免疫显性和混杂的T细胞表位而被修饰。这些方法和手段包括制备类似物和药物制剂以及核酸片段，载体，转化细胞，多肽和药物制剂的方法。

4. 发明授权

US06982085B2 TB diagnostic based on antigens from M. tuberculosis 失效
公开(公告)号：US06982085B2
公开(公告)日：2006-01-03
申请号：US10138473
申请日：2002-05-02
申请人： Peter Andersen , Karin Weldingh , Christina Veggerby Hansen , Walter Florio , Li Mei Meng Okkels , Rikke Louise Vinther Skjot , Peter Birk Rasmussen
发明人： Peter Andersen , Karin Weldingh , Christina Veggerby Hansen , Walter Florio , Li Mei Meng Okkels , Rikke Louise Vinther Skjot , Peter Birk Rasmussen
IPC分类号： A61K39/02 , A61K39/40 , A61K39/04 , C12N1/12 , C12N1/34
CPC分类号： C07K14/35 , A61K38/00 , A61K39/00 , A61K2039/51 , C07K2319/00
摘要： The present invention is based on the identification and characterization of a number of novel M. tuberculosis derived proteins and protein fragments. The invention is directed to the polypeptides and immunologically active fragments thereof, the genes encoding them, immunological compositions such as diagnostic reagents containing the polypeptides.

5. 发明授权

US07807441B2 Methods for therapeutic vaccination 有权
标题翻译：治疗性接种方法
公开(公告)号：US07807441B2
公开(公告)日：2010-10-05
申请号：US11202516
申请日：2005-08-11
申请人： Lucilla Steinaa , Søren Mouritsen , Anand Gautam , Iben Dalum , Jesper Haaning , Dana Leach , Klaus Gregorius Nielsen , Gunilla Karlsson , Peter Birk Rasmussen
发明人： Lucilla Steinaa , Søren Mouritsen , Anand Gautam , Iben Dalum , Jesper Haaning , Dana Leach , Klaus Gregorius Nielsen , Gunilla Karlsson , Peter Birk Rasmussen
IPC分类号： C12N1/00 , C12N1/10 , C12N1/14 , C12N1/16 , C12N1/20 , C12N5/10 , C12N5/14 , C12N5/16 , C12N15/00 , A61K38/00 , C07K14/00
CPC分类号： C07K16/3069 , A61K39/0011 , C07K14/50 , C07K14/705 , C07K14/70539 , C07K14/71 , C07K2317/34 , C12N2799/021 , Y02A50/412
摘要： A method is disclosed for inducing cell-mediated immunity against cellular antigens. More specifically, the invention provides for a method for inducing cytotoxic T-lymphocyte immunity against weak antigens, notably self-proteins. The method entails that antigen presenting cells are induced to present at least one CTL epitope of the weak antigen and at the same time presenting at least one foreign T-helper lymphocyte epitope. In a preferred embodiment, the antigen is a cancer specific antigen, e.g. PSM, Her2, or FGF8b. The method can be exercised by using traditional polypeptide vaccination, but also by using live attenuated vaccines or nucleic acid vaccination. The invention furthermore provides immunogenic analogues of PSM, Her2 and FGF8b, as well as nucleic acid molecules encoding these analogues. Also vectors and transformed cells are disclosed. The invention also provides for a method for identification of immunogenic analogues of weak or non-immunogenic antigens.
摘要翻译：公开了一种用于诱导针对细胞抗原的细胞介导的免疫的方法。更具体地，本发明提供了一种诱导针对弱抗原，特别是自身蛋白的细胞毒性T淋巴细胞免疫的方法。该方法需要抗原呈递细胞被诱导以呈现弱抗原的至少一个CTL表位，并且同时呈现至少一种外来T辅助淋巴细胞表位。在优选的实施方案中，抗原是癌特异性抗原，例如 PSM，Her2或FGF8b。该方法可以通过使用传统的多肽疫苗接种，也可以通过使用活减毒疫苗或核酸接种来进行。本发明还提供了PSM，Her2和FGF8b的免疫原性类似物以及编码这些类似物的核酸分子。还公开了载体和转化的细胞。本发明还提供了用于鉴定弱或非免疫原性抗原的免疫原性类似物的方法。

6. 发明申请

US20090209430A1 TEMPLATE DIRECTED SPLIT AND MIX SYSTHESIS OF SMALL MOLECULE LIBRARIES 有权
标题翻译：小分子图书馆的模式分类和混合综合
公开(公告)号：US20090209430A1
公开(公告)日：2009-08-20
申请号：US11719846
申请日：2005-11-22
申请人： Peter Birk Rasmussen
发明人： Peter Birk Rasmussen
IPC分类号： C40B20/04 , C40B50/18 , C40B50/06 , C40B40/08
CPC分类号： C12N15/1065 , B01J19/0046 , C12N15/1068
摘要： The present invention provides a method for combining the advantages of encoded molecule fragments made by split and mix synthesis with the advantages of template directed synthesis of molecules. The method provided in the invention comprises the steps of: Adding a linker molecule L to one or more reaction wells; Adding a molecule fragment to each of said reaction wells; Adding an oligonucleotide identifier to each of said reaction wells; Subjecting said wells to conditions sufficient to allow said molecule fragments and said oligonucleotide identifiers to become attached to said linker molecule, or conditions sufficient for said molecule fragments to bind to other molecule fragments and sufficient for said oligonucleotide identifiers to bind to other oligonucleotide identifiers; Combining the contents of said one or more reaction wells; Optionally, distributing the combined product to one or more new reaction wells; Optionally, repeating steps b) to e) one or more times; Contacting the resulting bifunctional molecule(s) of step e) or g) with one or more Contacting the resulting bifunctional molecule(s) of step e) or g) with one or more (oligonucleotide) templates each capable of hybridizing to at least one of the oligonucleotide identifiers added in step c).
摘要翻译：本发明提供了通过分裂和混合合成制备的编码分子片段的优点与分子的模板定向合成的优点组合的方法。本发明提供的方法包括以下步骤：向一个或多个反应孔中加入连接分子L; 向每个所述反应孔中加入分子片段; 向每个所述反应孔中加入寡核苷酸标识符; 使所述孔承受足以允许所述分子片段和所述寡核苷酸标识符连接到所述连接分子的条件，或足以使所述分子片段与其它分子片段结合并足以使所述寡核苷酸标识符与其它寡核苷酸标识符结合的条件; 组合所述一个或多个反应孔的内容物; 任选地，将组合的产物分配到一个或多个新的反应孔中; 任选地，重复步骤b）至e）一次或多次; 将所得到的步骤e）或g）的双官能分子与一个或多个接触步骤e）或g）的所得双功能分子与一种或多种（寡核苷酸）模板接触，每种能够与至少一种的步骤c）中添加的寡核苷酸标识符。

7. 发明授权

US07135181B2 Method for down-regulation of amyloid 有权
标题翻译：淀粉样蛋白下调方法
公开(公告)号：US07135181B2
公开(公告)日：2006-11-14
申请号：US09785215
申请日：2001-02-20
申请人： Martin Roland Jensen , Peter Birk Rasmussen , Klaus Gregorius Nielsen
发明人： Martin Roland Jensen , Peter Birk Rasmussen , Klaus Gregorius Nielsen
IPC分类号： A61K39/00 , A61K38/19 , A61K38/20
CPC分类号： A61K39/385 , A61K38/00 , A61K38/1709 , A61K39/0007 , A61K47/646 , A61K2039/53 , A61K2039/6037 , A61K2039/6087 , A61K2039/64 , C07K14/4711 , C07K2319/00 , G01N33/6896 , G01N2333/4709 , G01N2500/04
摘要： A method for in vivo down-regulation of amyloid protein in an animal, including a human being, the method comprising effecting presentation to the animal's immune system of an immunogenically effective amount of at least one amyloidogenic polypeptide or subsequence thereof which has been formulated so that immunization of the animal with the amyloidgenic polypeptide or subsequence thereof induces production of antibodies against the amyloidogenic polypeptide, and/or at least one analogue of the amyloidogenic polypeptide wherein is introduced at least one modification in the amino acid sequence of the amyloidogenic polypeptide which has as a result the immunization of the animal with the analogue induces production of antibodies against the amyloidogenic polypeptide.
摘要翻译：一种用于动物体内下调淀粉样蛋白的方法，包括人，所述方法包括向动物的免疫系统呈递免疫有效量的至少一种淀粉样变性多肽或其子序列，其被配制成使得用淀粉样蛋白生成多肽或其子序列免疫动物诱导针对淀粉样变性多肽和/或淀粉样变性多肽的至少一种类似物的抗体的产生，其中引入淀粉样变性多肽的氨基酸序列中的至少一个修饰，其具有如结果，用该类似物的动物的免疫诱导产生针对淀粉样变性多肽的抗体。

8. 发明授权

US07037510B2 Hybrids of M. tuberculosis antigens 有权
公开(公告)号：US07037510B2
公开(公告)日：2006-05-02
申请号：US09805427
申请日：2001-03-13
申请人： Peter Andersen , Anja Weinreich Olsen , Rikke Louise Vinther Skjøt , Peter Birk Rasmussen
发明人： Peter Andersen , Anja Weinreich Olsen , Rikke Louise Vinther Skjøt , Peter Birk Rasmussen
IPC分类号： A61K39/04 , A61K39/00 , A61K49/00
CPC分类号： C07K14/35 , A61K38/00 , A61K39/00 , A61K2039/51 , C07K2319/00
摘要： The present invention discloses fusion proteins of the immunodominant antigens ESAT-6 and Ag85B from Mycobacterium tuberculosis or homologues thereof, and a tuberculosis vaccine based on the fusion proteins, which vaccine induces efficient immunological memory.

9. 发明授权

US06641814B1 Nucleic acids fragments and polypeptide fragments derived from M. tuberculosis 失效
标题翻译：衍生自结核分枝杆菌的核酸片段和多肽片段
公开(公告)号：US06641814B1
公开(公告)日：2003-11-04
申请号：US09050739
申请日：1998-03-30
申请人： Peter Andersen , Rikke Nielsen , Thomas Oettinger , Peter Birk Rasmussen , Ida Rosenkrands , Karin Weldingh , Walter Florio
发明人： Peter Andersen , Rikke Nielsen , Thomas Oettinger , Peter Birk Rasmussen , Ida Rosenkrands , Karin Weldingh , Walter Florio
IPC分类号： A61K3902
CPC分类号： C07K14/35 , A61K38/00 , A61K39/00 , A61K2039/51 , C07K2319/00
摘要： The present invention is based on the identification and characterization of a number of M. tuberculosis derived novel proteins and protein fragments (SEQ ID NOs: 2, 4, 6, 8, 10, 12, 14, 16, 17-23, 42, 48, 50, 52, 54, 56, 58, 60, 62, 64, 66, 68, 70, 72-86, 88, 90, 92, 94, 141, 143, 145, 147, 149, 151, 153, and 168-171). The invention is directed to the polypeptides and immunologically active fragments thereof, the genes encoding them, immunological compositions such as vaccines and skin test reagents containing the polypeptides. Another part of the invention is based on the surprising discovery that fusions between ESAT-6 and MPT59 are superior immunogens compared to each of the unfused proteins, respectively.
摘要翻译：本发明基于许多结核分枝杆菌来源的新蛋白质和蛋白质片段的鉴定和表征（SEQ ID NO：2,4,6,8,10,12,14,16,17-23,42， 48，50，52，54，56，58，60，62，64，66，68，70，72-86，88，90，92，94，141，143，145，147，149，151，153，和168-171）。本发明涉及多肽及其免疫活性片段，编码它们的基因，免疫组合物如疫苗和含有多肽的皮肤试验试剂。本发明的另一部分是基于惊人的发现，即分别与每种未融合的蛋白质相比，ESAT-6和MPT59之间的融合是优越的免疫原。

10. 发明申请

US20180163199A1 TEMPLATE DIRECTED SPLIT AND MIX SYNTHESIS OF SMALL MOLECULE LIBRARIES 审中-公开
公开(公告)号：US20180163199A1
公开(公告)日：2018-06-14
申请号：US15884214
申请日：2018-01-30
申请人： Peter Birk Rasmussen
发明人： Peter Birk Rasmussen
IPC分类号： C12N15/10 , B01J19/00
CPC分类号： C12N15/1065 , B01J19/0046 , C12N15/1068
摘要： The invention combines the advantages of split and mix synthesis with the advantages of template directed synthesis. The method comprises the steps of: a) adding a linker molecule L to one or more reaction wells; b) adding a molecule fragment to each of said reaction wells; c) adding an oligonucleotide identifier to each of said reaction wells; d) subjecting said wells to conditions sufficient to allow said molecule fragments and said oligonucleotide identifiers to become attached to said linker molecule, or conditions sufficient for said molecule fragments to bind to other molecule fragments and sufficient for said oligonucleotide identifiers to bind to other oligonucleotide identifiers; e) combining the contents of said one or more reaction wells; and f) contacting the resulting bifunctional molecule(s) of step e) with one or more (oligonucleotide) templates each capable of hybridizing to at least one of the oligonucleotide identifiers added step c).

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