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1. 发明授权

US08597701B2 Transcription modulator compositions 有权
标题翻译：转录调节剂组合物
公开(公告)号：US08597701B2
公开(公告)日：2013-12-03
申请号：US11386985
申请日：2006-03-21
申请人： Pei-Wen Hsiao
发明人： Pei-Wen Hsiao
IPC分类号： A61K8/97 , A61K31/366 , A61K31/165
CPC分类号： A61K36/28
摘要： Disclosed herein is a method for treating an androgen-stimulated disease in a subject in need thereof by administering to the subject a composition containing an effective amount of an inhibitor of IκB kinase subunit α activity. The composition can also be administered to a subject at high risk for prostate cancer as a method for reducing the subject's risk thereof. A further method relates to identifying a modulator of transcriptional activity regulated by IκB kinase subunit α. Still another method relates to determining the IκB kinase subunit α-regulated transcriptional activity regulated by in a non-human mammalian test subject.
摘要翻译：本文公开了通过向受试者施用含有有效量的IkappaB激酶亚基α活性抑制剂的组合物来治疗有需要的受试者中的雄激素刺激的疾病的方法。该组合物也可以作为降低受试者风险的方法施用于患有前列腺癌的高风险的受试者。另一种方法涉及鉴定由IkappaB激酶亚基α调节的转录活性的调节剂。另一种方法涉及确定由非人哺乳动物测试受试者调节的IkappaB激酶亚基α调节的转录活性。

2. 发明申请

US20100166769A1 High-yield Transgenic Mammalian Expression System for Generating Virus-like Particles 有权
标题翻译：用于产生病毒样颗粒的高产量转基因哺乳动物表达系统
公开(公告)号：US20100166769A1
公开(公告)日：2010-07-01
申请号：US12704928
申请日：2010-02-12
申请人： Pei-Wen Hsiao , Chia- Ying Wu , Yi-Chun Yeh
发明人： Pei-Wen Hsiao , Chia- Ying Wu , Yi-Chun Yeh
IPC分类号： A61K39/42 , C12P21/00 , C12N9/26 , A61K39/145 , G01N33/53 , C07K16/08 , C12N5/07 , C12N15/00 , A61P31/16
CPC分类号： A61K39/145 , A61K39/12 , A61K39/215 , A61K2039/5258 , C07K14/005 , C07K16/1018 , C12N2760/16034 , C12N2760/16122 , C12N2760/16123 , C12N2760/16134 , C12N2770/20022 , C12N2770/20023 , C12N2770/20034 , C12N2830/006 , G01N33/56983 , G01N2333/11 , G01N2469/10 , G01N2469/20
摘要： Virus-like particles (VLPs) of mammalian-hosted viruses, such as SARS-CoV and influenza viruses, have been recombinantly produced from Vero cells. The VLPs closely emulate the exterior of authentic virus particles and are highly immunogenic. They can elicit not only humoral but also cellular immune responses in a mammal. Compositions and methods related to the VLPs are also described.
摘要翻译：从Vero细胞重组产生哺乳动物宿主病毒（如SARS-CoV和流感病毒）的病毒样颗粒（VLP）。 VLP密切模仿真实病毒颗粒的外观，具有高度的免疫原性。它们可以引起哺乳动物体液，但也可引起细胞免疫反应。还描述了与VLP相关的组合物和方法。

3. 发明申请

US20100022632A1 USE CERTAIN DITERPENE COMPOUNDS IN THE TREATMENT OF ANDROGEN RECEPTOR-ASSOCIATED DISEASES 有权
标题翻译：在治疗原发性受体相关疾病中使用某些DITERPENE化合物
公开(公告)号：US20100022632A1
公开(公告)日：2010-01-28
申请号：US12508832
申请日：2009-07-24
申请人： Pei-Wen HSIAO , Feng-Min Lin , Sheng-Yang Wang
发明人： Pei-Wen HSIAO , Feng-Min Lin , Sheng-Yang Wang
IPC分类号： A61K31/122 , A61K31/05 , A61K31/366 , A61K31/19 , A61P35/00 , A61P5/26 , A61P17/00
CPC分类号： A61K31/122 , A61K31/19 , A61K31/352
摘要： The present invention discloses certain diterpenes that can be used to inhibit androgen receptor activity, induce apoptosis and block cell cycle progression of androgen receptor-dependent cells. Androgen receptor has been associated with various diseases such as prostate cancer, androgeneic alopecia, breast cancer, acne etc. Accordingly, the present invention further discloses methods of treating androgen receptor-associated diseases by administering the disclosed diterpenes.
摘要翻译：本发明公开了可用于抑制雄激素受体活性，诱导凋亡并阻断雄激素受体依赖性细胞的细胞周期进程的某些二萜烯。雄激素受体与各种疾病如前列腺癌，雄激素性脱发，乳腺癌，痤疮等有关。因此，本发明还公开了通过施用所公开的二萜来治疗雄激素受体相关疾病的方法。

4. 发明申请

US20080063664A1 High-yield transgenic mammalian expression system for generating virus-like particles 审中-公开
标题翻译：用于产生病毒样颗粒的高产量转基因哺乳动物表达系统
公开(公告)号：US20080063664A1
公开(公告)日：2008-03-13
申请号：US11515843
申请日：2006-09-05
申请人： Pei-Wen Hsiao , Ning-Sun Yang , Chang-Jen Huang , En-Hau Lin
发明人： Pei-Wen Hsiao , Ning-Sun Yang , Chang-Jen Huang , En-Hau Lin
IPC分类号： A61K39/215 , C12N7/00
CPC分类号： A61K39/215 , A61K39/12 , A61K2039/5258 , C07K14/005 , C12N2770/20022 , C12N2770/20034
摘要： The present invention provides a method utilizing mammalian expression system for generating virus-like particles (VLPs) of mammalian-hosted viruses, particularly SARS-CoV. The method of the present invention involves expression of viral structural proteins in Vero cells and thereby obtaining recombinant VLPs in the culture medium. SARS-VLPs generated by the method of the present invention are highly immunogenic and can elicit not only humoral but also cellular immune responses in a mammal.
摘要翻译：本发明提供了利用哺乳动物表达系统产生哺乳动物宿主病毒特别是SARS-CoV的病毒样颗粒（VLPs）的方法。本发明的方法涉及在Vero细胞中表达病毒结构蛋白，从而在培养基中获得重组VLP。通过本发明的方法产生的SARS-VLP是高度免疫原性的，并且不仅可引起哺乳动物的体液，而且可引发细胞免疫应答。

5. 发明授权

US08980281B2 High-yield transgenic mammalian expression system for generating virus-like particles 有权
标题翻译：用于产生病毒样颗粒的高产量转基因哺乳动物表达系统
公开(公告)号：US08980281B2
公开(公告)日：2015-03-17
申请号：US12704928
申请日：2010-02-12
申请人： Pei-Wen Hsiao , Chia-Ying Wu , Yi-Chun Yeh
发明人： Pei-Wen Hsiao , Chia-Ying Wu , Yi-Chun Yeh
IPC分类号： A61K39/42 , C12P21/00 , C12N9/26 , C07K16/08 , C12N5/07 , C12N15/00 , A61P31/16 , A61K39/215 , A61K39/145 , C07K14/005 , A61K39/00
CPC分类号： A61K39/145 , A61K39/12 , A61K39/215 , A61K2039/5258 , C07K14/005 , C07K16/1018 , C12N2760/16034 , C12N2760/16122 , C12N2760/16123 , C12N2760/16134 , C12N2770/20022 , C12N2770/20023 , C12N2770/20034 , C12N2830/006 , G01N33/56983 , G01N2333/11 , G01N2469/10 , G01N2469/20
摘要： Virus-like particles (VLPs) of mammalian-hosted viruses, such as SARS-CoV and influenza viruses, have been recombinantly produced from Vero cells. The VLPs closely emulate the exterior of authentic virus particles and are highly immunogenic. They can elicit not only humoral but also cellular immune responses in a mammal. Compositions and methods related to the VLPs are also described.
摘要翻译：从Vero细胞重组产生哺乳动物宿主病毒（如SARS-CoV和流感病毒）的病毒样颗粒（VLP）。 VLP密切模仿真实病毒颗粒的外观，具有高度的免疫原性。它们可以引起哺乳动物体液，但也可引起细胞免疫反应。还描述了与VLP相关的组合物和方法。

6. 发明授权

US08519007B2 Use certain diterpene compounds in the treatment of androgen receptor-associated diseases 有权
标题翻译：使用某些二萜化合物治疗雄激素受体相关疾病
公开(公告)号：US08519007B2
公开(公告)日：2013-08-27
申请号：US12508832
申请日：2009-07-24
申请人： Pei-Wen Hsiao , Feng-Min Lin , Sheng-Yang Wang
发明人： Pei-Wen Hsiao , Feng-Min Lin , Sheng-Yang Wang
IPC分类号： A61K31/12
CPC分类号： A61K31/122 , A61K31/19 , A61K31/352
摘要： The present invention discloses certain diterpenes that can be used to inhibit androgen receptor activity, induce apoptosis and block cell cycle progression of androgen receptor-dependent cells. Androgen receptor has been associated with various diseases such as prostate cancer, androgeneic alopecia, breast cancer, acne etc. Accordingly, the present invention further discloses methods of treating androgen receptor-associated diseases by administering the disclosed diterpenes.
摘要翻译：本发明公开了可用于抑制雄激素受体活性，诱导凋亡并阻断雄激素受体依赖性细胞的细胞周期进程的某些二萜烯。雄激素受体与各种疾病如前列腺癌，雄激素性脱发，乳腺癌，痤疮等有关。因此，本发明还公开了通过施用所公开的二萜来治疗雄激素受体相关疾病的方法。

7. 发明申请

US20070224296A1 Transcription modulator compositions 有权
标题翻译：转录调节剂组合物
公开(公告)号：US20070224296A1
公开(公告)日：2007-09-27
申请号：US11386985
申请日：2006-03-21
申请人： Pei-Wen Hsiao
发明人： Pei-Wen Hsiao
IPC分类号： A61K36/18
CPC分类号： A61K36/28
摘要： Disclosed herein is a method for treating an androgen-stimulated disease in a subject in need thereof by administering to the subject a composition containing an effective amount of an inhibitor of IκB kinase subunit α activity. The composition can also be administered to a subject at high risk for prostate cancer as a method for reducing the subject's risk thereof. A further method relates to identifying a modulator of transcriptional activity regulated by IκB kinase subunit α. Still another method relates to determining the IκB kinase subunit α-regulated transcriptional activity regulated by in a non-human mammalian test subject.
摘要翻译：本文公开了通过向受试者施用含有有效量的IkappaB激酶亚基α活性抑制剂的组合物来治疗有需要的受试者中的雄激素刺激的疾病的方法。该组合物也可以作为降低受试者风险的方法施用于患有前列腺癌的高风险的受试者。另一种方法涉及鉴定由IkappaB激酶亚基α调节的转录活性的调节剂。另一种方法涉及确定由非人哺乳动物测试受试者调节的IkappaB激酶亚基α调节的转录活性。

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