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1. 发明申请

US20120211698A1 STABILIZATION OF LIQUID SOLUTIONS OF RECOMBINANT PROTEIN FOR FROZEN STORAGE 有权
标题翻译：用于冷冻储存的重组蛋白质液体溶液的稳定性
公开(公告)号：US20120211698A1
公开(公告)日：2012-08-23
申请号：US13459806
申请日：2012-04-30
申请人： Nelly Tsvetkova , Omkar Joshi , Paul Wu , Deqian Wang , Arnaud Desponds
发明人： Nelly Tsvetkova , Omkar Joshi , Paul Wu , Deqian Wang , Arnaud Desponds
IPC分类号： C09K3/00
CPC分类号： A61K38/37 , A61K9/08 , A61K47/02
摘要： The invention relates to a method for stabilizing a bulk solution of recombinant protein for frozen storage, which comprises providing a partially-purified solution of recombinant protein which has a monovalent salt concentration of at least 100 mM, and adding a carbohydrate to said solution in an amount sufficient that, upon freezing, the solution has a glass transition temperature of −56° C. or higher.
摘要翻译：本发明涉及一种用于稳定用于冷冻储存的重组蛋白质的本体溶液的方法，其包括提供部分纯化的重组蛋白质的溶液，所述重组蛋白质具有至少100mM的一价盐浓度，并且在所述溶液中加入碳水化合物足以在冷冻时溶液的玻璃化转变温度为-56℃以上。

2. 发明申请

US20100113744A1 Stabilization Of Liquid Solutions Of Recombinant Protein For Frozen Storage 有权
标题翻译：用于冷冻储存的重组蛋白液体溶液的稳定化
公开(公告)号：US20100113744A1
公开(公告)日：2010-05-06
申请号：US12597333
申请日：2008-04-22
申请人： Nelly Tsvetkova , Omkar Joshi , Paul Wu , Deqian Wang , Amaud Desponds
发明人： Nelly Tsvetkova , Omkar Joshi , Paul Wu , Deqian Wang , Amaud Desponds
IPC分类号： C07K14/755 , C07K1/00 , C07K14/00
CPC分类号： A61K38/37 , A61K9/08 , A61K47/02
摘要： The invention relates to a method for stabilizing a bulk solution of recombinant protein for frozen storage, which comprises providing a partially-purified solution of recombinant protein which has a monovalent salt concentration of at least 100 mM, and adding a carbohydrate to said solution in an amount sufficient that, upon freezing, the solution has a glass transition temperature of −56° C. or higher.
摘要翻译：本发明涉及一种用于稳定用于冷冻储存的重组蛋白质的本体溶液的方法，其包括提供部分纯化的重组蛋白质的溶液，所述重组蛋白质具有至少100mM的一价盐浓度，并且在所述溶液中加入碳水化合物足以在冷冻时溶液的玻璃化转变温度为-56℃以上。

3. 发明授权

US07102817B1 Objective lens device for a microscope 有权
标题翻译：用于显微镜的物镜装置
公开(公告)号：US07102817B1
公开(公告)日：2006-09-05
申请号：US11334415
申请日：2006-01-19
申请人： Paul Wu
发明人： Paul Wu
IPC分类号： G02B21/00 , G02B23/00 , G02B15/01
CPC分类号： G02B21/025
摘要： An objective lens for a microscope has a casing, a telescopic tube assembly and a cap. The casing is tubular and has a through hole and a window. The telescopic tube assembly has an outer tube, an inner tube and an objective lens. The outer tube is mounted rotatably in the casing and has an inner thread and an annular knob aligned with the window. The inner tube mounted rotatably and moveably in the outer tube. The objective lens is mounted in the inner tube. The cap is mounted on the casing and has two guides mounted between the casing and the cap and slidably engaging the inner tube so the inner tube can move along the guides. The magnification and focal length of the microscope changes when the inner tube with the objective lens moves in the outer tube.
摘要翻译：用于显微镜的物镜具有壳体，伸缩管组件和盖。壳体是管状的并且具有通孔和窗口。伸缩管组件具有外管，内管和物镜。外管可旋转地安装在壳体中，并且具有与窗口对准的内螺纹和环形旋钮。内管可旋转并可移动地安装在外管中。物镜安装在内管中。盖安装在壳体上，并且具有安装在壳体和盖之间的两个引导件并且可滑动地接合内管，使得内管可以沿着引导件移动。当物镜的内管在外管中移动时，显微镜的放大倍率和焦距发生变化。

4. 发明授权

US08536125B2 Stabilization of liquid solutions of recombinant protein for frozen storage 有权
标题翻译：用于冷冻储存的重组蛋白液体溶液的稳定化
公开(公告)号：US08536125B2
公开(公告)日：2013-09-17
申请号：US13459806
申请日：2012-04-30
申请人： Nelly Tsvetkova , Omkar Joshi , Paul Wu , Deqian Wang , Arnaud Desponds
发明人： Nelly Tsvetkova , Omkar Joshi , Paul Wu , Deqian Wang , Arnaud Desponds
IPC分类号： A61K38/37
CPC分类号： A61K38/37 , A61K9/08 , A61K47/02
摘要： The invention relates to a method for stabilizing a bulk solution of recombinant protein for frozen storage, which comprises providing a partially-purified solution of recombinant protein which has a monovalent salt concentration of at least 100 mM, and adding a carbohydrate to said solution in an amount sufficient that, upon freezing, the solution has a glass transition temperature of −56° C. or higher.
摘要翻译：本发明涉及一种用于稳定用于冷冻储存的重组蛋白质的本体溶液的方法，其包括提供部分纯化的重组蛋白质的溶液，所述重组蛋白质具有至少100mM的一价盐浓度，并且在所述溶液中加入碳水化合物足以在冷冻时溶液的玻璃化转变温度为-56℃以上。

5. 发明授权

US08404565B2 Manufacturing method and structure of a surface-mounting type diode co-constructed from a silicon wafer and a base plate 有权
标题翻译：由硅晶片和基板共构造的表面安装型二极管的制造方法和结构
公开(公告)号：US08404565B2
公开(公告)日：2013-03-26
申请号：US12662792
申请日：2010-05-04
申请人： Wen-Ping Huang , Paul Wu
发明人： Wen-Ping Huang , Paul Wu
IPC分类号： H01L21/00
CPC分类号： H01L29/861 , H01L21/2007 , H01L21/78 , H01L29/66136 , H01L2224/32245 , H01L2224/33 , H01L2224/48247 , H01L2924/181 , H01L2924/00012
摘要： A manufacturing method and a structure of a surface-mounting type diode co-constructed from a silicon wafer and a base plate, in the method, a diffused wafer is stacked with a high temperature durable high strength base plate to have them sintered and molten together for connecting with each other to form a co-constructure; then the diffused wafer is processed by etching and ditching for filling with insulation material, electrodes of the diffused wafer are metalized and all on an identical plane, then production of all functional lines is completed; and then the co-constructure is cut to form a plurality of separated individuals which each forms a surface-mounting type diode to be applied straight. In comparison with the conventional techniques, manufacturing of the present invention is simplified and economic in reducing working hours, size and cost of production and the wafer is not subjected to breaking during manufacturing.
摘要翻译：在该方法中，将散射晶片与硅晶片和基板共构成的表面安装型二极管的制造方法和结构与高温耐用的高强度基板层叠，使其烧结并熔融在一起用于连接以形成共同结构; 然后通过蚀刻和沟槽处理扩散晶片以填充绝缘材料，扩散晶片的电极被金属化并且都在相同的平面上，然后完成所有功能线的生产; 然后切割共同结构以形成多个分离的个体，每个个体形成要被直线施加的表面安装型二极管。与传统技术相比，简化了本发明的制造，并且在减少工作时间，生产的尺寸和成本以及制造过程中不会损坏晶片的经济性。

6. 发明授权

US08187799B2 Stabilization of liquid solutions of recombinant protein for frozen storage 有权
标题翻译：用于冷冻储存的重组蛋白液体溶液的稳定化
公开(公告)号：US08187799B2
公开(公告)日：2012-05-29
申请号：US12597333
申请日：2008-04-22
申请人： Nelly Tsvetkova , Omkar Joshi , Paul Wu , Deqian Wang , Arnaud Desponds
发明人： Nelly Tsvetkova , Omkar Joshi , Paul Wu , Deqian Wang , Arnaud Desponds
IPC分类号： A01N1/00
CPC分类号： A61K38/37 , A61K9/08 , A61K47/02
摘要： The invention relates to a method for stabilizing a bulk solution of recombinant protein for frozen storage, which comprises providing a partially-purified solution of recombinant protein which has a monovalent salt concentration of at least 100 mM, and adding a carbohydrate to said solution in an amount sufficient that, upon freezing, the solution has a glass transition temperature of −56° C. or higher.
摘要翻译：本发明涉及一种用于稳定用于冷冻储存的重组蛋白质的本体溶液的方法，其包括提供部分纯化的重组蛋白质的溶液，所述重组蛋白质具有至少100mM的一价盐浓度，并且在所述溶液中加入碳水化合物足以在冷冻时溶液的玻璃化转变温度为-56℃以上。

7. 发明授权

US07289211B1 System and method for imaging sub-surface polarization-sensitive material structures 失效
标题翻译：用于成像亚表面极化敏感材料结构的系统和方法
公开(公告)号：US07289211B1
公开(公告)日：2007-10-30
申请号：US11103726
申请日：2005-04-11
申请人： Joseph T. Walsh, Jr. , Paul Wu
发明人： Joseph T. Walsh, Jr. , Paul Wu
IPC分类号： G01J4/00
CPC分类号： G01J4/04 , A61B5/0086 , A61B5/4325 , A61B5/444 , A61B5/4519 , A61B5/4533 , G01N21/21 , G01N2201/0634
摘要： A method of visually quantifying a test material along with an imaging apparatus for practicing the method is disclosed. The method comprises: (a) illuminating the test material at a known angle of incidence with diffuse light of a known and adjustable polarization state; (b) receiving light from the test material with a polarization state modified by the test material; (c) measuring an intensity of the polarization components of the received light for each illuminated pixel substantially simultaneously; (d) calculating the Stokes Vector in two dimensions for each illuminated pixel; and (e) creating an image map for the known polarization state. The method may also include adjusting the known polarization or the incident angle of the diffuse light to create additional image maps. The method and apparatus are intended for use in medical imaging including minimally invasive surgery.
摘要翻译：公开了一种视觉量化测试材料以及用于实施该方法的成像设备的方法。该方法包括：（a）以已知和可调偏振状态的漫射光以已知的入射角照射测试材料; （b）以测试材料改性的极化状态接收来自测试材料的光; （c）基本上同时测量每个照明像素的接收光的偏振分量的强度; （d）为每个照明像素计算二维的斯托克斯矢量; 和（e）创建已知偏振状态的图像映射。该方法还可以包括调整漫射光的已知偏振或入射角以产生附加的图像映射。该方法和装置旨在用于包括微创手术在内的医学成像。

8. 发明授权

US06711812B1 Method of making metal core substrate printed circuit wiring board enabling thermally enhanced ball grid array (BGA) packages 失效
标题翻译：制造金属芯基板印刷电路布线板的方法，使热增强球栅阵列（BGA）封装
公开(公告)号：US06711812B1
公开(公告)日：2004-03-30
申请号：US09544263
申请日：2000-04-06
申请人： Jane Lu , Paul Wu , Ray Chen , Scott Chen , Jeff Chang
发明人： Jane Lu , Paul Wu , Ray Chen , Scott Chen , Jeff Chang
IPC分类号： H01K310
CPC分类号： H05K3/445 , H01L23/3677 , H01L2924/0002 , H05K3/427 , H05K3/4608 , H05K3/4641 , H05K2201/09536 , H05K2201/09554 , H05K2201/0959 , H05K2203/143 , Y10S428/901 , Y10T29/49126 , Y10T29/49155 , Y10T29/49165 , H01L2924/00
摘要： A method of making a thermally enhanced BGA substrate in which a metal (copper) core, has dielectric layers applied to each side thereof and conductive through-core build-up vias are provided. Rigidifying non-conductive dielectric sheets are laminated to the oppositely facing surfaces and then conductive layers are applied to at least one of the rigidifying non-conductive sheets and via connections are made through the dielectric layer(s) to the core conductive layer.
摘要翻译：提供了一种制造热增强BGA基板的方法，其中金属（铜）芯具有施加到其每一侧的电介质层和导电的穿芯堆积通孔。刚性非导电介电片被层压到相对的表面上，然后将导电层施加到至少一个刚性非导电片，并且通孔连接通过介电层制成到芯导电层。

9. 发明授权

US09045725B2 Devices and methods for integrated continuous manufacturing of biological molecules 有权
公开(公告)号：US09045725B2
公开(公告)日：2015-06-02
申请号：US11576097
申请日：2005-09-30
申请人： Jens Holger Vogel , Roberto Giovannini , Konstantin B. Konstantinov , Huong My Nguyen , Paul Wu
发明人： Jens Holger Vogel , Roberto Giovannini , Konstantin B. Konstantinov , Huong My Nguyen , Paul Wu
IPC分类号： C07K1/34 , C07K1/18 , C12N5/02 , C12N5/07 , C12M1/00 , C07K1/14 , B01D61/14 , C07K14/755 , A61K38/00
CPC分类号： C12M47/12 , B01D61/145 , B01D2311/14 , B01D2311/16 , B01D2313/10 , B01D2313/18 , B01D2317/04 , C07K1/14 , C07K1/145 , C07K1/34 , C07K14/755
摘要： The present invention relates to a process and apparatus for purifying a molecule of interest from a heterogeneous clarified fluid mixture. The apparatus of the invention generally comprises a continuous perfusion fermentation system, a continuous particle removal system integrated with the perfusion fermentation system; and a continuous purification system integrated with the particle removal system, which is maintained under sterile conditions. The process comprises filtering a heterogeneous clarified fluid mixture by continuous ultrafiltration at a specific flow rate below the transition point of the molecule of interest in the pressure-dependent region of the flux versus TMP curve, wherein the specific flow rate is maintained substantially constant throughout the continuous ultrafiltration.

10. 发明申请

US20110133011A1 MULTIEND PACKAGE OF MULTIFILAMENT POLYESTER BICOMPONENT YARN 审中-公开
标题翻译：多重聚酯纤维复合纱的多重包装
公开(公告)号：US20110133011A1
公开(公告)日：2011-06-09
申请号：US12922564
申请日：2009-03-19
申请人： Kah Leap Lee , Young D. Nguyen , Raymond S.P. Leung , Paul Wu
发明人： Kah Leap Lee , Young D. Nguyen , Raymond S.P. Leung , Paul Wu
IPC分类号： D02G3/04 , D02H1/00 , D02G1/20 , B65H55/00
CPC分类号： D02G3/362 , B65H51/015 , B65H54/026 , B65H55/005 , B65H2701/3132 , D01F8/14 , D02G3/36
摘要： Included are multiend packages of multicomponent yarns, where the yarn is separable into individual ends upon unwinding. The multicomponent yarn may be a bicomponent yarn, such as a yarn including compositionally different polyesters in a side-by-side or eccentric sheath-core configuration. Uses of such multiend packages are also included.
摘要翻译：包括多组分纱线的多重包装，其中纱线在展开时可分离成各个端部。多组分纱线可以是双组分纱线，例如并列或偏心皮芯型构造的包含组成不同的聚酯的纱线。还包括使用这种多重包装。

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