专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06699478B1 Enhanced immune response to attachment (G) protein of Respiratory Syncytial Virus 失效
标题翻译：增强对呼吸道合胞病毒附着（G）蛋白的免疫反应
公开(公告)号：US06699478B1
公开(公告)日：2004-03-02
申请号：US09526195
申请日：2000-03-15
申请人： Gerald E. Hancock , Paul W. Tebbey
发明人： Gerald E. Hancock , Paul W. Tebbey
IPC分类号： A61K39155
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/51 , C07K2319/00 , C12N2760/18522
摘要： An altered G protein or portion thereof of RSV which retains immunogenicity and which, when incorporated into an immunogenic composition or vaccine and administered to a vertebrate, does not induce enhanced disease (e.g., atypical pulmonary inflammation such as pulmonary eosinophilia) upon subsequent infection with RSV, is disclosed. In a particular embodiment, the altered G protein comprises an alteration in one or more regions selected from the group consisting of the region from amino acid 159 to amino acid 198, the region from amino acid 159 to amino acid 174, the region from amino acid 171 to amino acid 187, the region from amino acid 176 to amino acid 190, and the region from amino acid 184 to amino acid 198 of the RSV G protein. Immunogenic compositions and vaccines comprising the altered RSV G protein, and optionally comprising RSV F protein, are also disclosed.
摘要翻译：维持免疫原性的改变的G蛋白或其部分，并且当其并入免疫原性组合物或疫苗并且施用于脊椎动物时，在随后的RSV感染时不诱导增强的疾病（例如非典型的肺部炎症，例如肺嗜酸性粒细胞增多），被披露。在一个具体实施方案中，改变的G蛋白包括在一个或多个区域中的改变，所述区域选自氨基酸159至氨基酸198的区域，氨基酸159至氨基酸174的区域，氨基酸的区域 171至氨基酸187，氨基酸176至氨基酸190的区域，以及RSV G蛋白的氨基酸184至氨基酸198的区域。还公开了包含改变的RSV G蛋白和任选地包含RSV F蛋白的免疫原性组合物和疫苗。

IPRDB

热门服务

关于我们

友情链接

联系方式