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1. 发明授权

US5401648A Peptides having peptidyl transferase inhibiting activity and methods of use thereof 失效
标题翻译：具有肽基转移酶抑制活性的肽及其使用方法
公开(公告)号：US5401648A
公开(公告)日：1995-03-28
申请号：US93858
申请日：1993-07-20
申请人： Paul S. Lovett
发明人： Paul S. Lovett
IPC分类号： A61K38/00 , C07K7/06 , C12N9/10 , C12N9/00 , C07K5/00 , A61K37/00 , A61K37/02
CPC分类号： C07K7/06 , C12N9/1033 , A61K38/00
摘要： 5-mer and 8-mer polypeptides have been demonstrated to inhibit peptidyl transferase and according constitutes synthetic antibiotics. Identified, sequence-specific peptides effective includeMet-Val-Lys-Thr-Asp (SEQ ID NO: 1),Met-Lys-Lys-Ala-Asp (SEQ ID NO: 2),Met-Lys-Lys-Ser-Glu (SEQ ID NO: 3) andMet-Ser-Thr-Ser-Lys-Asn-Ala-Asp (SEQ ID NO: 4)The polypeptides can be used as antibiotics, alone or together with a carrier.
摘要翻译：已证实5聚体和8聚体多肽抑制肽基转移酶，并构成合成抗生素。鉴定的有效的序列特异性肽包括Met-Val-Lys-Thr-Asp（SEQ ID NO：1），Met-Lys-Lys-Ala-Asp（SEQ ID NO：2），Met-Lys-Lys-Ser- Glu（SEQ ID NO：3）和Met-Ser-Thr-Ser-Lys-Asn-Ala-Asp（SEQ ID NO：4）多肽可单独或与载体一起用作抗生素。

2. 发明授权

US5162206A Plasmids for foreign gene expression in B. subtilis 失效
标题翻译：外源基因在枯草芽孢杆菌中表达的质粒
公开(公告)号：US5162206A
公开(公告)日：1992-11-10
申请号：US683490
申请日：1991-04-09
申请人： Paul S. Lovett
发明人： Paul S. Lovett
IPC分类号： C07K14/245 , C12N9/06 , C12N15/75
CPC分类号： C12N9/0028 , C07K14/245 , C12N15/75
摘要： A double-stranded DNA plasmid which includes a promoter DNA sequence that is not derived from a B. subtilis plasmid and a DNA sequence derived from a B. subtilis plasmid is useful for introducing into B. subtilis foreign DNA having a nucleic acid sequence which does for the production of a desired product. Preferably, the promoter sequence is also not derived from B. subtilis chromosomal DNA. When a foreign DNA sequence having a nucleic acid sequence coding for production of a desired product is introduced into this plasmid, another plasmid is produced which is useful for effecting expression in B. subtilis of the foreign DNA and production of the desired product. The plasmids may additionally include an inducible gene.B. subtilis cells transformed with plasmids carrying a gene or genes coding for the production of desired products may be grown in culture and the resulting products recovered.
摘要翻译：包含不衍生自枯草芽孢杆菌质粒的启动子DNA序列和源自枯草芽孢杆菌质粒的DNA序列的双链DNA质粒可用于将具有核酸序列的枯草芽孢杆菌外源DNA导入用于生产所需产品。优选地，启动子序列也不是来源于枯草芽孢杆菌染色体DNA。当将具有编码产生所需产物的核酸序列的外源DNA序列导入该质粒时，产生另外一种用于在枯草芽孢杆菌中表达外源DNA并产生所需产物的质粒。质粒可另外包含诱导型基因。用携带基因的质粒转化的枯草芽孢杆菌细胞或编码产生所需产物的基因可以在培养物中生长，并将所得产物回收。

3. 发明授权

US4585739A Plasmid for foreign gene expression in B. subtilis 失效
标题翻译：枯草芽孢杆菌外源基因表达质粒
公开(公告)号：US4585739A
公开(公告)日：1986-04-29
申请号：US472641
申请日：1983-03-07
申请人： Paul S. Lovett , Ronald G. Schoner
发明人： Paul S. Lovett , Ronald G. Schoner
IPC分类号： C07K14/565 , C12N15/75 , C12N1/20 , C12N1/00 , C12N15/00
CPC分类号： C12N15/75 , C07K14/565
摘要： The invention provides a mutant plasmid useful for introducing into B. subtilis foreign DNA, the nucleic acid sequence of which codes for production of a desired product. The plasmid is constructed from (1) a segment of B. pumllus DNA containing a chloramphenicol acetyltransferase gene plus an EcoRI* promoter fragment cloned from phage SPO2 DNA and a (2) portion of a B. subtilis plasmid, pUB110. The plasmid gives enhanced expression of genes coding for certain products, such as dihydrofolate reductase.
摘要翻译：本发明提供了可用于引入枯草芽孢杆菌外源DNA的突变质粒，其核酸序列编码产生所需产物。质粒由（1）含有氯霉素乙酰转移酶基因加上从噬菌体SPO2 DNA克隆的EcoRI启动子片段和枯草芽孢杆菌质粒（pUB110）的（2）部分的pum豆DNA片段构成。质粒提供了编码某些产物的基因（如二氢叶酸还原酶）的增强表达。

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