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1. 发明申请

US20090104712A1 HEPATITIS B PRE-S2 NUCLEIC ACID 有权
标题翻译： HEPATITIS B PRE-S2核酸
公开(公告)号：US20090104712A1
公开(公告)日：2009-04-23
申请号：US12209093
申请日：2008-09-11
申请人： Paul F. Coleman , Sandra K. Pearce
发明人： Paul F. Coleman , Sandra K. Pearce
IPC分类号： G01N33/566 , C12N15/11 , C12N15/00 , C12N5/06 , C07K14/00
CPC分类号： C07K14/005 , C12N2730/10122
摘要： This invention relates to a nucleic acid molecule encoding a middle Hepatitis B virus (HBV) surface protein, a vector comprising the nucleic acid molecule, a host cell comprising the vector, and a composition comprising the expression products of this vector, which may comprise middle HBV surface protein, or a mixture of middle HBV surface protein and small HBV surface protein. The compositions of the invention may be useful for expressing a middle HBV surface protein, or a mixture of small and middle HBV surface proteins in defined ratios, determining the binding of an antibody to a middle or small HBV surface protein, determining the quality of an anti-middle or an anti-small HBV surface protein antibody, or determining the quality of a kit containing anti-middle or anti-small HBV surface protein antibodies.
摘要翻译：本发明涉及编码中乙型肝炎病毒（HBV）表面蛋白的核酸分子，包含核酸分子的载体，包含载体的宿主细胞和包含该载体的表达产物的组合物，其可以包含中间 HBV表面蛋白，或中等HBV表面蛋白和小HBV表面蛋白的混合物。本发明的组合物可用于以确定的比例表达中等HBV表面蛋白或中小型HBV表面蛋白的混合物，确定抗体与中小型HBV表面蛋白的结合，确定抗中抗体或抗小乙肝表面蛋白抗体，或确定含有抗中抗或抗小表面抗体的抗体表面蛋白质抗体的质量。

2. 发明授权

US07202354B2 Hepatitis B virus surface antigen mutant and methods of detection thereof 失效
标题翻译：乙型肝炎病毒表面抗原突变体及其检测方法
公开(公告)号：US07202354B2
公开(公告)日：2007-04-10
申请号：US09821877
申请日：2001-03-30
申请人： Paul F. Coleman , Isa K. Mushahwar
发明人： Paul F. Coleman , Isa K. Mushahwar
IPC分类号： C07H21/00 , C12N15/00 , C12N15/51 , A61K39/29 , G01N33/53
CPC分类号： C07K14/005 , C12N2730/10122 , G01N33/5764 , Y10S435/975 , Y10S530/826
摘要： The subject invention relates to a novel hepatitis B surface antigen mutant and methods of detecting this mutant, and/or antibodies thereto, in patient samples. In particular, the mutant contains a substitution of amino acid threonine for the amino acid alanine at position 123 in the amino acid sequence of the hepatitis B surface antigen (HBsAg) protein.
摘要翻译：本发明涉及一种新型乙型肝炎表面抗原突变体和在该患者样品中检测该突变体和/或其抗体的方法。特别地，突变体含有氨基酸苏氨酸取代乙型肝炎表面抗原（HBsAg）蛋白质的氨基酸序列中123位的氨基酸丙氨酸。

3. 发明授权

US08138318B2 Hepatitis B pre-S2 nucleic acid 有权
标题翻译：乙型肝炎前S2核酸
公开(公告)号：US08138318B2
公开(公告)日：2012-03-20
申请号：US12209093
申请日：2008-09-11
申请人： Paul F. Coleman , Sandra K. Pearce
发明人： Paul F. Coleman , Sandra K. Pearce
IPC分类号： A61K39/29 , C12N15/51
CPC分类号： C07K14/005 , C12N2730/10122
摘要： This invention relates to a nucleic acid molecule encoding a middle Hepatitis B virus (HBV) surface protein, a vector comprising the nucleic acid molecule, a host cell comprising the vector, and a composition comprising the expression products of this vector, which may comprise middle HBV surface protein, or a mixture of middle HBV surface protein and small HBV surface protein. The compositions of the invention may be useful for expressing a middle HBV surface protein, or a mixture of small and middle HBV surface proteins in defined ratios, determining the binding of an antibody to a middle or small HBV surface protein, determining the quality of an anti-middle or an anti-small HBV surface protein antibody, or determining the quality of a kit containing anti-middle or anti-small HBV surface protein antibodies.
摘要翻译：本发明涉及编码中乙型肝炎病毒（HBV）表面蛋白的核酸分子，包含核酸分子的载体，包含载体的宿主细胞和包含该载体的表达产物的组合物，其可以包含中间 HBV表面蛋白，或中等HBV表面蛋白和小HBV表面蛋白的混合物。本发明的组合物可用于以确定的比例表达中等HBV表面蛋白或中小型HBV表面蛋白的混合物，确定抗体与中小型HBV表面蛋白的结合，确定抗中抗体或抗小乙肝表面蛋白抗体，或确定含有抗中抗或抗小表面抗体的抗体表面蛋白质抗体的质量。

4. 发明申请

US20080107672A1 Hepatitis B virus surface antigen mutant and methods of detection thereof 失效
标题翻译：乙型肝炎病毒表面抗原突变体及其检测方法
公开(公告)号：US20080107672A1
公开(公告)日：2008-05-08
申请号：US11709364
申请日：2007-02-22
申请人： Paul F. Coleman , Isa K. Mushahwar
发明人： Paul F. Coleman , Isa K. Mushahwar
IPC分类号： A61K39/29 , A61P31/00 , C07K16/00 , C12N15/09 , C12Q1/70
CPC分类号： C07K14/005 , C12N2730/10122 , G01N33/5764 , Y10S435/975 , Y10S530/826
摘要： The subject invention relates to a novel hepatitis B surface antigen mutant and methods of detecting this mutant, and/or antibodies thereto, in patient samples. In particular, the mutant contains a substitution of amino acid threonine for the amino acid alanine at position 123 in the amino acid sequence of the hepatitis B surface antigen (HBsAg) protein.
摘要翻译：本发明涉及一种新型乙型肝炎表面抗原突变体和在该患者样品中检测该突变体和/或其抗体的方法。特别地，突变体含有氨基酸苏氨酸取代乙型肝炎表面抗原（HBsAg）蛋白质的氨基酸序列中123位的氨基酸丙氨酸。

5. 发明申请

US20100136520A1 DETECTING HEPATITIS B VIRUS 审中-公开
标题翻译：检测乙型肝炎病毒
公开(公告)号：US20100136520A1
公开(公告)日：2010-06-03
申请号：US12629901
申请日：2009-12-03
申请人： Paul F. Coleman , Akhtar X. Ali , Tanseem Ali
发明人： Paul F. Coleman , Akhtar X. Ali , Tanseem Ali
IPC分类号： C12Q1/70
CPC分类号： C07K16/082 , C12N2730/10111 , C12Q1/706 , G01N33/5764 , G01N2469/10
摘要： This invention is related to methods for detecting hepatitis B virus by determining the level of hepatitis B virus surface antigen protein. This invention is also related to methods for detecting mutant hepatitis B virus surface antigen protein and kits for detecting hepatitis B virus.
摘要翻译：本发明涉及通过确定乙型肝炎病毒表面抗原蛋白的水平来检测乙型肝炎病毒的方法。本发明还涉及用于检测突变型乙型肝炎病毒表面抗原蛋白的方法和用于检测乙型肝炎病毒的试剂盒。

6. 发明授权

US07556815B2 Hepatitis B virus surface antigen mutant and methods of detection thereof 失效
公开(公告)号：US07556815B2
公开(公告)日：2009-07-07
申请号：US11709364
申请日：2007-02-22
申请人： Paul F. Coleman , Isa K. Mushahwar
发明人： Paul F. Coleman , Isa K. Mushahwar
IPC分类号： A61K39/29 , C07H21/00 , C12N15/00 , C12N15/51 , G01N33/53
CPC分类号： C07K14/005 , C12N2730/10122 , G01N33/5764 , Y10S435/975 , Y10S530/826
摘要： The subject invention relates to a novel hepatitis B surface antigen mutant and methods of detecting this mutant, and/or antibodies thereto, in patient samples. In particular, the mutant contains a substitution of amino acid threonine for the amino acid alanine at position 123 in the amino acid sequence of the hepatitis B surface antigen (HBsAg) protein.

7. 发明授权

US07141242B2 Hepatitis B virus surface antigen mutant and methods of detection thereof 有权
公开(公告)号：US07141242B2
公开(公告)日：2006-11-28
申请号：US10847493
申请日：2004-05-17
申请人： Paul F. Coleman , Isa K. Mushahwar
发明人： Paul F. Coleman , Isa K. Mushahwar
IPC分类号： A61K39/29 , G01N33/53
CPC分类号： C07K14/005 , C12N2730/10122 , G01N33/5764 , Y10S435/975 , Y10S530/826
摘要： The subject invention relates to a novel hepatitis B surface antigen mutant and methods of detecting this mutant, and/or antibodies thereto, in patient samples. In particular, the mutant contains a substitution of amino acid threonine for the amino acid alanine at position 123 in the amino acid sequence of the hepatitis B surface antigen (HBsAg) protein.

8. 发明申请

US20090098531A1 DETECTING HEPATITIS B VIRUS 审中-公开
标题翻译：检测乙型肝炎病毒
公开(公告)号：US20090098531A1
公开(公告)日：2009-04-16
申请号：US12209054
申请日：2008-09-11
申请人： Paul F. Coleman , Akhtar X. Ali
发明人： Paul F. Coleman , Akhtar X. Ali
IPC分类号： C12Q1/70 , G01N33/53
CPC分类号： G01N33/5764 , C12Q1/706
摘要： This invention is related to methods for detecting hepatitis B virus by determining the level of hepatitis B virus surface antigen protein. This invention is also related to methods for detecting mutant hepatitis B virus surface antigen protein and kits for detecting hepatitis B virus.
摘要翻译：本发明涉及通过确定乙型肝炎病毒表面抗原蛋白的水平来检测乙型肝炎病毒的方法。本发明还涉及用于检测突变型乙型肝炎病毒表面抗原蛋白的方法和用于检测乙型肝炎病毒的试剂盒。

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