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1. 发明申请

US20090181939A1 Azetidinecarboxamide Derivatives And Their Use In The Treatment Of CB1 Receptor Mediated Disorders 审中-公开
标题翻译：氮杂环丁烷酰胺衍生物及其用于治疗CB1受体介导的疾病
公开(公告)号：US20090181939A1
公开(公告)日：2009-07-16
申请号：US12407021
申请日：2009-03-19
申请人： James Edward Paul Davidson , Jonathan Mark Bentley , Claire Elizabeth Dawson , Kerry Harrison , Howard Langham Mansell , Alan Leslie Pither , Robert Mark Pratt , Jonathan Richard Anthony Roffey , Victoria Jane Ruston
发明人： James Edward Paul Davidson , Jonathan Mark Bentley , Claire Elizabeth Dawson , Kerry Harrison , Howard Langham Mansell , Alan Leslie Pither , Robert Mark Pratt , Jonathan Richard Anthony Roffey , Victoria Jane Ruston
IPC分类号： A61K31/551 , C07D403/02 , A61K31/397 , C07D205/04
CPC分类号： C07D401/12 , C07D205/04 , C07D211/46 , C07D403/06 , C07D405/12 , C07D409/06 , C07D409/12
摘要： Compounds of formula (I) and their use in therapy, particularly for the treatment of a disorder mediated by CB1 receptors, such as obesity, wherein: R1 is aryl or heteroaryl; R2 is alkyl, aryl or heteroaryl; R3 is alkyl, aryl, heteroaryl, NR9R10, OR15, or NR16C(O)R17; Y is C═O, C═S, SO2, or (CR7R8)p; m=1 or 2; n=1 or 2; and p=1, 2, 3 or 4, R7 to R17 being as defined in the specification; wherein if —Y—R3 is C(O)NH(alkyl) then: R1 and/or R2 is selected from heteroaryl; and/or m and/or n is 2; and/or R11 and/or R12 is lower alkyl, or a pharmaceutically acceptable salt or prodrug thereof.
摘要翻译：式（I）化合物及其在治疗中的用途，特别是用于治疗由CB1受体介导的障碍，例如肥胖症，其中：R1是芳基或杂芳基; R2是烷基，芳基或杂芳基; R3是烷基，芳基，杂芳基，NR9R10，OR15或NR16C（O）R17; Y是C-O，C-S，SO2或（CR7R8）p; m = 1或2; n = 1或2; 和p = 1,2,3或4，R7至R17如说明书中所定义; 其中如果-Y-R 3是C（O）NH（烷基），那么：R 1和/或R 2选自杂芳基; 和/或m和/或n为2; 和/或R 11和/或R 12是低级烷基，或其药学上可接受的盐或前药。

2. 发明授权

US07504522B2 Azetidinecarboxamide derivatives and their use in the treatment of cb1 receptor mediated disorders 失效
标题翻译：氮杂环丁酰胺衍生物及其在治疗cb1受体介导的疾病中的应用
公开(公告)号：US07504522B2
公开(公告)日：2009-03-17
申请号：US10552575
申请日：2004-04-29
申请人： James Edward Paul Davidson , Claire Elizabeth Dawson , Kerry Harrison , Howard Langham Mansell , Robert Mark Pratt , Sukhjit Sohal , Victoria Jane Ruston
发明人： James Edward Paul Davidson , Claire Elizabeth Dawson , Kerry Harrison , Howard Langham Mansell , Robert Mark Pratt , Sukhjit Sohal , Victoria Jane Ruston
IPC分类号： C07D205/00 , A61K31/397
CPC分类号： C07D405/12 , C07D205/04 , C07D409/12
摘要： Compounds of formula (I) and their use in therapy, particularly for the treatment of a disorder mediated by CB1 receptors such as obesity: Formula (I) wherein: R1 and R2 are independently selected from aryl; and R3 is hydrogen or alkyl; or a pharmaceutically acceptable salt or prodrug thereof, wherein at least one of R1 and R2 has a non-hydrogen substituent in the ortho-position(s) thereof relative to the point of attachment to the [—CH—O—] group.
摘要翻译：式（I）化合物及其在治疗中的用途，特别是用于治疗由CB1受体介导的障碍如肥胖症：式（I）其中：R 1和R 2独立地选自芳基; 并且R 3是氢或烷基; 或其药学上可接受的盐或前药，其中R 1和R 2中的至少一个在其邻位相对于[-CH-O-]基团的连接点具有非氢取代基。

3. 发明授权

US07328570B2 Pulse detonation system for a gas turbine engine having multiple spools 有权
标题翻译：具有多个阀芯的燃气涡轮发动机的脉冲爆震系统
公开(公告)号：US07328570B2
公开(公告)日：2008-02-12
申请号：US10932169
申请日：2004-09-01
申请人： Kattalaicheri Srinivasan Venkataramani , Lawrence Butler , James Paul Davidson
发明人： Kattalaicheri Srinivasan Venkataramani , Lawrence Butler , James Paul Davidson
IPC分类号： F02C5/02 , F02K3/02 , F02K5/02
CPC分类号： F02K7/005 , Y02T50/671
摘要： A gas turbine engine having a longitudinal centerline axis therethrough, including: a fan section at a forward end of the gas turbine engine including at least a first fan blade row connected to a first drive shaft; a booster compressor positioned downstream of the fan section, the booster compressor including a first compressor blade row and a second compressor blade row connected to a second drive shaft and interdigitated with the first compressor blade row; and, a pulse detonation system for powering the first and second drive shafts. The pulse detonation system powers only the second drive shaft during a first designated condition of the gas turbine engine and both the first drive shaft and the second drive shaft during a second designated condition of the gas turbine engine. The first and second drive shafts are powered independently of each other by the pulse detonation system.
摘要翻译：一种燃气涡轮发动机，其具有穿过其的纵向中心线轴线，包括：在所述燃气涡轮发动机的前端处的风扇部分，至少包括连接到第一驱动轴的第一风扇叶片排; 位于所述风扇部分下游的增压压缩机，所述增压压缩机包括连接到第二驱动轴并与所述第一压缩机叶片排交叉的第一压缩机叶片排和第二压缩机叶片排; 以及用于为第一和第二驱动轴供电的脉冲爆震系统。在燃气涡轮发动机的第一指定状态期间，在燃气涡轮发动机的第二指定状态期间，脉冲爆震系统仅为第二驱动轴供电，而在第一驱动轴和第二驱动轴两者之间。第一和第二驱动轴通过脉冲爆震系统彼此独立地供电。

4. 发明授权

US07166632B2 Condensed indoline derivatives and their use as 5HT, in particular 5HT2C, receptor ligands 失效
公开(公告)号：US07166632B2
公开(公告)日：2007-01-23
申请号：US11117460
申请日：2005-04-29
申请人： Jonathan Richard Anthony Roffey , James Edward Paul Davidson , Howard Langham Mansell , Richard John Hamlyn , David Reginald Adams
发明人： Jonathan Richard Anthony Roffey , James Edward Paul Davidson , Howard Langham Mansell , Richard John Hamlyn , David Reginald Adams
IPC分类号： A61K31/407 , C07D491/048 , C07D495/04
CPC分类号： C07D471/04 , A61K31/403 , A61K31/404 , A61K31/405 , A61K31/407 , A61K31/437 , A61K31/4745 , C07D209/60 , C07D209/70 , C07D209/90 , C07D471/06 , C07D491/04 , C07D491/06 , C07D495/04 , C07D495/06
摘要： A chemical compound of formula (I) wherein R1 and R2 are independently selected from hydrogen and alkyl; R3 is alkyl; R4 and R5 are selected from hydrogen and alkyl; R6 and R7 are independently selected from hydrogen, halogen, hydroxyl, alkyl, aryl, amino, alkylamino, dialkylamino, alkoxy, aryloxy, alkylthio, alkylsulfoxyl, nitro, carbonitrile, carbo-alkoxy, carbo-aryloxy and carboxyl; and A is a 5- or 6-membered ring optionally containing one or more heteroatoms wherein the atoms of the ring A, other than the unsaturated carbon atoms of the phenyl ring to which the ring A is fused, are saturated or unsaturated, and pharmaceutically acceptable salts, addition compounds and prodrugs thereof; and the use thereof in therapy, particularly as an agonist or antagonist of a 5HT receptor, particularly a 5HT2C receptor, for instance in the treatment of disorders of the central nervous system; damage to the central nervous system; cardiovascular disorders; gastrointestinal disorders; diabetes insipidus, and sleep apnea, and particularly for the treatment of obesity.

5. 发明授权

US07022707B2 Piperazine derivatives 失效
标题翻译：哌嗪衍生物
公开(公告)号：US07022707B2
公开(公告)日：2006-04-04
申请号：US10874662
申请日：2004-06-23
申请人： David Reginald Adams , Jonathan Mark Bentley , James Edward Paul Davidson , Claire Elizabeth Dawson , Ashley Roger George , Howard Langham Mansell , Patrizio Mattei , Jacques Mizrahi , Matthias Heinrich Nettekoven , Robert Mark Pratt , Stephan Roever , Jonathan Richard Anthony Roffey , Jean-Luc Specklin , Henri Stalder , Kerry Wilkinson
发明人： David Reginald Adams , Jonathan Mark Bentley , James Edward Paul Davidson , Claire Elizabeth Dawson , Ashley Roger George , Howard Langham Mansell , Patrizio Mattei , Jacques Mizrahi , Matthias Heinrich Nettekoven , Robert Mark Pratt , Stephan Roever , Jonathan Richard Anthony Roffey , Jean-Luc Specklin , Henri Stalder , Kerry Wilkinson
IPC分类号： A61K31/4965 , A61K31/497 , C07D295/185 , C07D295/192 , C07D241/04
CPC分类号： C07D207/325 , C07D213/30 , C07D213/64 , C07D213/643 , C07D261/08 , C07D277/24 , C07D285/14 , C07D295/205 , C07D295/21 , C07D307/12 , C07D307/42 , C07D333/16 , C07D413/04
摘要： The present invention is a chemical compound of formula (I) or a pharmaceutically acceptable salts, solvates and esters thereof, wherein R1 to R4, A1, A2 m and n are as described in the specification.
摘要翻译：本发明是式（I）的化合物或其药学上可接受的盐，溶剂化物和酯，其中R 1至R 4，A 1， / SUP>，A＆lt; 2＆gt; m和n如说明书中所述。

6. 发明授权

US06844221B2 Method of manufacturing a wire bond-less electronic component for use with an external circuit 有权
标题翻译：制造与外部电路一起使用的无接线电子部件的方法
公开(公告)号：US06844221B2
公开(公告)日：2005-01-18
申请号：US10821749
申请日：2004-04-09
申请人： Lakshminarayan Viswanathan , Pierre-Marie Piel , Garry D. Funk , Robert Paul Davidson
发明人： Lakshminarayan Viswanathan , Pierre-Marie Piel , Garry D. Funk , Robert Paul Davidson
IPC分类号： H01L23/02 , H01L23/053 , H01L23/10 , H01L23/66 , H01L21/44
CPC分类号： H01L23/10 , H01L23/053 , H01L23/66 , H01L2224/16 , H01L2924/01078 , H01L2924/01079 , H01L2924/01087 , H01L2924/01322 , H01L2924/09701 , H01L2924/16152 , H01L2924/16315 , H01L2924/3011
摘要： A wire bond-less electronic component is for use with a circuit external to the wire bond-less electronic component. The wire bond-less electronic component includes a support substrate (110, 410), an electronic device (130) over the support substrate, and a cover (140, 440, 540) located over the electronic device and the support substrate. The cover includes an interconnect structure (141, 441, 541) electrically coupled to the electronic device and adapted to electrically couple together the electronic device and the circuit for providing impedance transformation of an electrical signal between the electronic device and the circuit.
摘要翻译：无接线电子元件用于无引线接合电子元件外部的电路。无引线接合电子部件包括支撑基板（110,410），位于支撑基板上的电子器件（130）以及位于电子器件和支撑基板上的盖子（140,440,540）。所述盖包括电连接到所述电子设备并且适于将所述电子设备和所述电路电连接在一起以在所述电子设备和所述电路之间提供电信号的阻抗变换的互连结构（141,441,541）。

7. 发明授权

US06481086B1 Method for sealingly interconnecting a pipe with a structure such that the pipe is axially movable with respect thereto 失效
标题翻译：将管道与结构密封地互连以使得管道能够相对于其轴向移动的方法
公开(公告)号：US06481086B1
公开(公告)日：2002-11-19
申请号：US09554712
申请日：2000-10-11
申请人： Paul Davidson
发明人： Paul Davidson
IPC分类号： B23P1100
CPC分类号： F16L25/14 , F16L27/12 , Y10T29/49844 , Y10T29/49881
摘要： A method is provided for interconnecting an end of a pipe with a hollow structure having a screw-threaded tubular inlet thereto. The method includes applying a one-part annular sealing member around the pipe, wherein the annular sealing member has a screw-threaded portion for engagement with the screw-threaded tubular inlet and is provided with the first and second sealing means; distorting outwardly the end of the pipe around at least a portion of the periphery thereof; and effecting screw-threaded engagement between the annular sealing member and the tubular inlet, such that sealing engagement is effected between the annular sealing member and the pipe end over a plurality of relative axial positions therebetween. The first sealing means effects sealing engagement between the annular sealing member and the inlet, and the second sealing means effects sealing engagement between the annular sealing member and the pipe end. Axial movement of the pipe relative to the annular sealing member is permitted when the annular sealing member is in sealing engagement with the pipe end.
摘要翻译：提供了一种用于将管的端部与具有螺纹管状入口的中空结构互连的方法。该方法包括在管子周围施加一部分环形密封件，其中环形密封件具有用于与螺纹管状入口接合的螺纹部分，并且设有第一和第二密封装置; 向外扭曲管周围的至少一部分的端部; 并且在环形密封构件和管状入口之间实现螺纹接合，使得在环形密封构件和管端之间在多个相对轴向位置之间进行密封接合。第一密封装置实现环形密封构件和入口之间的密封接合，并且第二密封装置实现环形密封构件和管端之间的密封接合。当环形密封构件与管端密封接合时，允许管相对于环形密封构件的轴向运动。

8. 发明授权

US06479534B1 Indoline derivatives and method of treating obesity 失效
标题翻译：二氢吲哚衍生物和治疗肥胖症的方法
公开(公告)号：US06479534B1
公开(公告)日：2002-11-12
申请号：US09977783
申请日：2001-10-15
申请人： Jonathan Mark Bentley , James Edward Paul Davidson , Howard Langham Mansell , Nathaniel Julius Thomas Monck
发明人： Jonathan Mark Bentley , James Edward Paul Davidson , Howard Langham Mansell , Nathaniel Julius Thomas Monck
IPC分类号： A61K3140
CPC分类号： C07D209/94
摘要： The present invention relates to indoline derivatives. These compounds are especially useful for the prevention and treatment of disorders of the central nervous system; damage to the central nervous system; cardiovascular disorders; gastrointestinal disorders; diabetes, sleep apnea, and especially for the treatment and prevention of obesity.
摘要翻译：本发明涉及二氢吲哚衍生物。这些化合物特别适用于预防和治疗中枢神经系统疾病; 损害中枢神经系统; 心血管疾病; 胃肠道疾病; 糖尿病，睡眠呼吸暂停，尤其是治疗和预防肥胖。

9. 发明授权

US06286376B1 Sampling of a mixture to be analyzed for particle size/particle size distribution 失效
标题翻译：对待分析的混合物的样品的粒度/粒度分布进行抽样
公开(公告)号：US06286376B1
公开(公告)日：2001-09-11
申请号：US09173942
申请日：1998-10-16
申请人： Gregory Paul Davidson , Stephen John Fielding , Robert James Henry Jennings
发明人： Gregory Paul Davidson , Stephen John Fielding , Robert James Henry Jennings
IPC分类号： G01N1500
CPC分类号： G01N15/02 , G01N1/38
摘要： A particle size distribution analysis sample dilution apparatus in which a sample consisting of a batch of a slurry of particles is deposited on an inclined plate of a progressive sample delivery system from which a continuous supply of water progressively washes off the sample and dilutes it. The initially diluted sample is further diluted with water continuously supplied in a funnel from which the further diluted sample passes under gravity along a conduit to a particle size distribution analyzer through which the diluted sample flows continuously. The conduit may include a mixing chamber to which water is continuously supplied to further dilute the sample prior to analysis.
摘要翻译：一种粒度分布分析样品稀释装置，其中将由一批颗粒浆料组成的样品沉积在渐进式样品递送系统的倾斜板上，从该样品稀释装置中连续供水从样品中洗出并稀释。将初始稀释的样品进一步用在漏斗中连续供应的水进一步稀释，在该漏斗中，进一步稀释的样品在重力作用下沿导管通过粒度分布分析仪，稀释的样品通过该分析分析仪连续流过。导管可以包括混合室，连续供应水以在分析之前进一步稀释样品。

10. 发明授权

US09422521B2 Differentiation of pluripotent stem cells with a kinase inhibitor or PGI2 有权
标题翻译：多能干细胞与激酶抑制剂或PGI2的分化
公开(公告)号：US09422521B2
公开(公告)日：2016-08-23
申请号：US12066624
申请日：2006-09-12
申请人： Bruce Paul Davidson , Ralph Eberard Graichen , Robert Zweigerdt , Xiuqin Xu
发明人： Bruce Paul Davidson , Ralph Eberard Graichen , Robert Zweigerdt , Xiuqin Xu
IPC分类号： C12N5/0735 , C12N5/073 , C12N5/0797 , C12N5/077 , A61K35/12
CPC分类号： C12N5/0606 , A61K35/12 , C12N5/0603 , C12N5/0623 , C12N5/0657 , C12N2500/24 , C12N2500/38 , C12N2500/90 , C12N2501/02 , C12N2501/115 , C12N2501/155 , C12N2501/385 , C12N2501/727 , C12N2501/999 , C12N2502/02 , C12N2502/13 , C12N2503/02 , C12N2506/02
摘要： The present invention provides a process of differentiating stem cells, in particular hES cells, into cardiomyocytes and into neural progenitors by growing the hES cells in the presence of a defined medium that is substantially free of xeno- and serum-components and thus comprises a clinically compliant medium. The defined media comprises defined factors that contribute to the promotion of differentiation to cardiomyocytes and neural progenitors. The invention also includes defined culture media and cell populations and methods of using them.
摘要翻译：本发明提供了通过在基本上不含异种和血清成分的限定培养基存在下生长hES细胞，将干细胞特别是hES细胞分化成心肌细胞并进入神经祖细胞的方法，因此包括临床上兼容介质。定义的培养基包括有助于促进分化成心肌细胞和神经祖细胞的确定因子。本发明还包括定义的培养基和细胞群以及使用它们的方法。

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