专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06372883B1 Antiviral medicaments 失效
标题翻译：抗病毒药物
公开(公告)号：US06372883B1
公开(公告)日：2002-04-16
申请号：US09265617
申请日：1999-03-10
申请人： Michael Richard Attwood , David Nigel Hurst , Philip Stephen Jones , Paul Brittain Kay , Tony Michael Raynham , Francis Xavier Wilson
发明人： Michael Richard Attwood , David Nigel Hurst , Philip Stephen Jones , Paul Brittain Kay , Tony Michael Raynham , Francis Xavier Wilson
IPC分类号： A61K3808
CPC分类号： C07K7/06 , A61K38/00 , Y02P20/55
摘要： The invention is concerned with amino acid derivatives of the formula and salts of acidic compounds of formula I with bases, which are viral proteinase inhibitors useful as antiviral agents, especially for the treatment or prophylaxis of infections caused by Hepatitis C, Hepatitis G and human GB viruses.
摘要翻译：本发明涉及式I的氨基酸衍生物和式I酸性化合物与碱的盐，其为用作抗病毒剂的病毒蛋白酶抑制剂，特别是用于治疗或预防由丙型肝炎，丙型肝炎和人类GB病毒引起的感染。

2. 发明授权

US06187905B1 Alpha-ketoamide derivatives 失效
标题翻译： α-酮酰胺衍生物
公开(公告)号：US06187905B1
公开(公告)日：2001-02-13
申请号：US09305030
申请日：1999-05-04
申请人： David Nigel Hurst , Philip Stephen Jones , Paul Brittain Kay , Tony Michael Raynham , Francis Xavier Wilson
发明人： David Nigel Hurst , Philip Stephen Jones , Paul Brittain Kay , Tony Michael Raynham , Francis Xavier Wilson
IPC分类号： C07K706
CPC分类号： C07K7/06 , A61K38/00 , Y02P20/55
摘要： The invention relates to &agr;-ketoamides of the general formula wherein R1 to R12 have the significances given in the description, and their salts. The &agr;-ketoamide derivatives provided by the present invention inhibit proteinases of viral origin, such as HCV protease, and can be used in the treatment of viral infections, especially viral infections caused by hepatitis C, hepatitis G and human GB viruses.
摘要翻译：本发明涉及R1至R12一般形式的α-酮酰胺具有说明书中给出的意义及其盐。由本发明提供的α-酮酰胺衍生物抑制病毒来源的蛋白酶，如HCV蛋白酶，可用于治疗病毒感染，特别是由丙型肝炎，丙型肝炎和人类GB病毒引起的病毒感染。

3. 发明授权

US06018020A Amino acid derivatives 失效
标题翻译：氨基酸衍生物
公开(公告)号：US06018020A
公开(公告)日：2000-01-25
申请号：US96570
申请日：1998-06-12
申请人： Michael Richard Attwood , David Nigel Hurst , Philip Stephen Jones , Paul Brittain Kay , Tony Michael Raynham , Francis Xavier Wilson
发明人： Michael Richard Attwood , David Nigel Hurst , Philip Stephen Jones , Paul Brittain Kay , Tony Michael Raynham , Francis Xavier Wilson
IPC分类号： C12N15/09 , A01N43/34 , A01N43/36 , A61K38/00 , A61P31/12 , A61P31/14 , C07C205/04 , C07C205/45 , C07C271/18 , C07D207/12 , C07D207/20 , C07D211/70 , C07D223/04 , C07D227/04 , C07D405/10 , C07D407/10 , C07D409/10 , C07K7/06 , A61K38/08
CPC分类号： C07K7/06 , A61K38/00
摘要： The invention provides amino acid derivatives of the formula ##STR1## wherein E represents CHO or B(OH).sub.2 ;R.sup.1 represents lower alkyl (optionally substituted by halo, cyano, lower alkylthio, aryl-lower alkylthio, aryl or heteroaryl), lower alkenyl or lower alkynyl;R.sup.2 represents lower alkyl optionally substituted by hydroxy, carboxy, aryl, aminocarbonyl or lower cycloalkyl; andR.sup.3 represents hydrogen or lower alkyl; orR.sup.2 and R.sup.3 together represent di- or trimethylene optionally substituted by hydroxy;R.sup.4 represents lower alkyl (optionally substituted by hydroxy, lower cycloalkyl, carboxy, aryl, lower alkylthio, cyano-lower alkylthio or aryl-lower alkylthio), lower alkenyl, aryl or lower cycloalkyl;R.sup.5 represents lower alkyl (optionally substituted by hydroxy, lower alkylthio, aryl, aryl-lower alkylthio or cyano-lower alkylthio) or lower cycloalkyl;R.sup.6 represents hydrogen or lower alkyl;R.sup.7 represent lower alkyl (optionally substituted by hydroxy, carboxy, aryl or lower cycloalkyl) or lower cycloalkyl;R.sup.8 represents lower alkyl optionally substituted by hydroxy, carboxy or aryl; andR.sup.9 represents lower alkylcarbonyl, carboxy-lower alkylcarbonyl, arylcarbonyl, lower alkylsulphonyl, arylsulphonyl, lower alkoxycarbonyl or aryl-lower alkoxycarbonyl,and salts of acidic compounds of formula I with bases, which are viral proteinase inhibitors useful as antiviral agents, especially for the treatment or prophylaxis of infections caused by Hepatitis C, Hepatitis G and human GB viruses.
摘要翻译：本发明提供下式的氨基酸衍生物，其中E代表CHO或B（OH）2; R 1表示低级烷基（任选被卤素，氰基，低级烷硫基，芳基 - 低级烷硫基，芳基或杂芳基取代），低级烯基或低级炔基; R 2表示任选被羟基，羧基，芳基，氨基羰基或低级环烷基取代的低级烷基; 并且R 3表示氢或低级烷基; 或R 2和R 3一起表示任选被羟基取代的二 - 或三亚甲基; R4代表低级烷基（任选被羟基，低级环烷基，羧基，芳基，低级烷硫基，氰基 - 低级烷硫基或芳基 - 低级烷硫基取代），低级烯基，芳基或低级环烷基; R5代表低级烷基（任选被羟基，低级烷硫基，芳基，芳基 - 低级烷硫基或氰基 - 低级烷硫基取代）或低级环烷基; R6代表氢或低级烷基; R7代表低级烷基（任选被羟基，羧基，芳基或低级环烷基取代）或低级环烷基; R8代表任选被羟基，羧基或芳基取代的低级烷基; 并且R 9表示低级烷基羰基，羧基 - 低级烷基羰基，芳基羰基，低级烷基磺酰基，芳基磺酰基，低级烷氧基羰基或芳基 - 低级烷氧基羰基，以及式I酸性化合物与碱的碱，其为用作抗病毒剂的病毒蛋白酶抑制剂，治疗或预防丙型肝炎，丙型肝炎和人类GB病毒引起的感染。

4. 发明授权

US06867299B2 Oxamide IMPDH inhibitors 失效
标题翻译： Oxamide IMPDH抑制剂
公开(公告)号：US06867299B2
公开(公告)日：2005-03-15
申请号：US09779116
申请日：2001-02-08
申请人： Michael John Broadhurst , Christopher Huw Hill , David Nigel Hurst , Philip Stephen Jones , Paul Brittain Kay , Ian Reginald Kilford , Robert Murray McKinnell
发明人： Michael John Broadhurst , Christopher Huw Hill , David Nigel Hurst , Philip Stephen Jones , Paul Brittain Kay , Ian Reginald Kilford , Robert Murray McKinnell
IPC分类号： C07D263/34 , A61K31/00 , A61K31/421 , A61K31/422 , A61K31/427 , A61K31/443 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/5377 , A61K38/21 , A61K45/06 , A61P1/18 , A61P11/00 , A61P11/06 , A61P19/02 , A61P29/00 , A61P31/00 , A61P31/04 , A61P31/12 , A61P31/14 , A61P31/16 , A61P31/18 , A61P31/20 , A61P31/22 , A61P33/00 , A61P35/00 , A61P37/00 , A61P37/02 , A61P43/00 , C07D249/08 , C07D263/32 , C07D263/48 , C07D413/12 , C07D417/12 , C07D413/14
CPC分类号： C07D413/12 , A61K31/00 , A61K38/21 , A61K45/06 , C07D263/32 , C07D263/48 , C07D417/12 , A61K2300/00
摘要： Disclosed are compounds of the general formula which are oxamide derivatives and inhibitors of the enzyme inosine monophosphate dehydrogenase (IMPDH).
摘要翻译：公开了一般形式的化合物，其是草酰胺衍生物和肌苷单磷酸脱氢酶（IMPDH）的抑制剂。

5. 发明授权

US5866684A Peptidyl inhibitors of viral proteases 失效
标题翻译：肽基蛋白酶抑制剂
公开(公告)号：US5866684A
公开(公告)日：1999-02-02
申请号：US971036
申请日：1997-11-14
申请人： Michael Richard Attwood , David Nigel Hurst , Philip Stephen Jones , Paul Brittain Kay , Tony Michael Raynham , Francis Xavier Wilson
发明人： Michael Richard Attwood , David Nigel Hurst , Philip Stephen Jones , Paul Brittain Kay , Tony Michael Raynham , Francis Xavier Wilson
IPC分类号： C12N15/09 , A01N43/34 , A01N43/36 , A61K38/00 , A61P31/12 , A61P31/14 , C07C205/04 , C07C205/45 , C07C271/18 , C07D207/12 , C07D207/20 , C07D211/70 , C07D223/04 , C07D227/04 , C07D405/10 , C07D407/10 , C07D409/10 , C07K7/06 , A61K38/08
CPC分类号： C07K7/06 , A61K38/00
摘要： The invention provides amino acid derivatives of the formula ##STR1## wherein E represents CHO or B(OH).sub.2 ;R.sup.1 represents lower alkyl (optionally substituted by halo, cyano, lower alkylthio, aryl-lower alkylthio, aryl or heteroaryl), lower alkenyl or lower alkynyl;R.sup.2 represents lower alkyl optionally substituted by hydroxy, carboxy, aryl, aminocarbonyl or lower cycloalkyl; andR.sup.3 represents hydrogen or lower alkyl; orR.sup.2 and R.sup.3 together represent di- or trimethylene optionally substituted by hydroxy;R.sup.4 represents lower alkyl (optionally substituted by hydroxy, lower cycloalkyl, carboxy, aryl, lower alkylthio, cyano-lower alkylthio or aryl-lower alkylthio), lower alkenyl, aryl or lower cycloalkyl;R.sup.5 represents lower alkyl (optionally substituted by hydroxy, lower alkylthio, aryl, aryl-lower alkylthio or cyano-lower alkylthio) or lower cycloalkyl;R.sup.6 represents hydrogen or lower alkyl;R.sup.7 represent lower alkyl (optionally substituted by hydroxy, carboxy, aryl or lower cycloalkyl) or lower cycloalkyl;R.sup.8 represents lower alkyl optionally substituted by hydroxy, carboxy or aryl; andR.sup.9 represents lower alkylcarbonyl, carboxy-lower alkylcarbonyl, arylcarbonyl, lower alkylsulphonyl, arylsulphonyl, lower alkoxycarbonyl or aryl-lower al koxycarbonyl,and salts of acidic compounds of formula I with bases, which are viral proteinase inhibitors useful as antiviral agents, especially for the treatment or prophylaxis of infections caused by Hepatitis C, Hepatitis G and human GB viruses.
摘要翻译：本发明提供式（I）的氨基酸衍生物，其中E表示CHO或B（OH）2; R 1表示低级烷基（任选被卤素，氰基，低级烷硫基，芳基 - 低级烷硫基，芳基或杂芳基取代），低级烯基或低级炔基; R 2表示任选被羟基，羧基，芳基，氨基羰基或低级环烷基取代的低级烷基; 并且R 3表示氢或低级烷基; 或R 2和R 3一起表示任选被羟基取代的二 - 或三亚甲基; R4代表低级烷基（任选被羟基，低级环烷基，羧基，芳基，低级烷硫基，氰基 - 低级烷硫基或芳基 - 低级烷硫基取代），低级烯基，芳基或低级环烷基; R5代表低级烷基（任选被羟基，低级烷硫基，芳基，芳基 - 低级烷硫基或氰基 - 低级烷硫基取代）或低级环烷基; R6代表氢或低级烷基; R7代表低级烷基（任选被羟基，羧基，芳基或低级环烷基取代）或低级环烷基; R8代表任选被羟基，羧基或芳基取代的低级烷基; 并且R 9表示低级烷基羰基，羧基 - 低级烷基羰基，芳基羰基，低级烷基磺酰基，芳基磺酰基，低级烷氧基羰基或芳基 - 低级烷氧基羰基，以及式I酸性化合物与碱的碱，其为用作抗病毒剂的病毒蛋白酶抑制剂，治疗或预防丙型肝炎，丙型肝炎和人类GB病毒引起的感染。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式