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1. 发明申请

US20120280600A1 Retail Product Display System With A Drawer Provided With A Movable Demonstration Product Locator At Its Front 有权
标题翻译：零售产品展示系统，带有可移动演示产品定位器的抽屉
公开(公告)号：US20120280600A1
公开(公告)日：2012-11-08
申请号：US13395524
申请日：2010-09-17
申请人： Harold Noel , Fabien Brossard , Patrick Ple-Boishardy
发明人： Harold Noel , Fabien Brossard , Patrick Ple-Boishardy
IPC分类号： A47F3/00 , A47F5/00
CPC分类号： A47F7/286
摘要： A retail product display system 72, comprising a retail product drawer 20 slideable between a closed position and an open position, a demonstration product locator 30 arranged at the front of the retail product drawer 20 and movable between two extreme positions respectively an inclined display position and a horizontal display position, wherein the system is arranged for allowing the demonstration product locator 30 to be in the inclined display position when the retail product drawer 20 is in the closed position and for allowing the demonstration product locator 30 to be in the horizontal display position when the retail product drawer 20 is in the open position.The invention makes it possible to offer greater space for accommodating demonstration products or displaying information with easy access to the retail product for purchase by the customer.
摘要翻译：一种零售产品展示系统72，包括可在关闭位置和打开位置之间滑动的零售商品抽屉20，布置在零售产品抽屉20的前部的演示产品定位器30，分别可在两个极限位置之间移动倾斜显示位置和水平显示位置，其中系统被布置成当零售产品抽屉20处于关闭位置时允许演示产品定位器30处于倾斜显示位置，并且允许演示产品定位器30处于水平显示位置当零售产品抽屉20处于打开位置时。本发明使得可以提供更大的空间用于容纳示范产品或显示信息，容易地访问零售商品以供客户购买。

2. 发明授权

US07696214B2 Quinazoline derivatives for the treatment of tumours 有权
标题翻译：喹唑啉衍生物用于治疗肿瘤
公开(公告)号：US07696214B2
公开(公告)日：2010-04-13
申请号：US11283415
申请日：2005-11-21
申请人： Laurent François André Hennequin , Patrick Ple
发明人： Laurent François André Hennequin , Patrick Ple
IPC分类号： C07D239/72 , A01N43/54 , A61K31/517
CPC分类号： C07D401/14 , C07D231/12 , C07D233/56 , C07D239/94 , C07D249/08 , C07D401/12 , C07D405/12 , C07D405/14
摘要： The invention concerns quinazoline derivatives of Formula (I) wherein each of Q1, Z, m, R1, R2, R3 and Q2 have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an anti-invasive agent in the containment and/or treatment of solid tumor disease.
摘要翻译：本发明涉及式（I）的喹唑啉衍生物，其中Q1，Z，m，R1，R2，R3和Q2各自具有本说明书中定义的任何含义; 其制备方法，含有它们的药物组合物及其在制备用作在实体瘤疾病的遏制和/或治疗中作为抗侵入剂的药物的用途。

3. 发明授权

US07498335B2 Method of producing an antiangiogenic or vascular permeability reducing effect 失效
标题翻译：产生抗血管生成或血管通透性降低作用的方法
公开(公告)号：US07498335B2
公开(公告)日：2009-03-03
申请号：US10220140
申请日：2001-03-01
申请人： Laurent Francois Andre Hennequin , Graham Charles Crawley , Darren McKerrecher , Patrick Ple , Jeffrey Philip Poyser , Christine Marie Paul Lambert
发明人： Laurent Francois Andre Hennequin , Graham Charles Crawley , Darren McKerrecher , Patrick Ple , Jeffrey Philip Poyser , Christine Marie Paul Lambert
IPC分类号： A61K31/517
CPC分类号： A61K31/519 , A61K31/517 , A61K31/5377
摘要： The invention concerns the use of a quinazoline derivative of Formula (I) wherein Q1 includes a quinazoline ring optionally substituted with a group such as halogeno, trifluoromethyl and cyano, or a group of the formula: Q3—X1— wherein X1 includes a direct bond and O and Q3includes aryl, aryl-(1-6C)alkyl, heterocyclyl and heterocyclyl-(1-6C)alkyl; each of R2 and R3 is hydrogen or (1-6C)alkyl; Z includes O, S and NH; and Q2 includes aryl and aryl-(1-3C)alkyl or a pharmaceutically-acceptable salt thereof, in the manufacture of a medicament for use in the production of an antiangiogenic and/or vascular permeability reducing effect in a warm-blooded animal such as a human.
摘要翻译：本发明涉及使用式（I）的喹唑啉衍生物，其中Q1包括任选被诸如卤代，三氟甲基和氰基的基团取代的喹唑啉环，或下式的基团：Q 3 -X 1，其中X 1包括直接键和O和Q3包括芳基，芳基 - （1-6C）烷基，杂环基和杂环基 - （1-6C）烷基; R2和R3各自为氢或（1-6C）烷基; Z包括O，S和NH; 和Q2包括芳基和芳基 - （1-3C）烷基或其药学上可接受的盐在制备用于在温血动物中产生抗血管生成和/或血管通透性降低作用的药物中，例如一个人。

4. 发明授权

US07115615B2 Quinazoline derivatives 失效
标题翻译：喹唑啉衍生物
公开(公告)号：US07115615B2
公开(公告)日：2006-10-03
申请号：US10344678
申请日：2001-08-15
申请人： Laurent Francois Andre Hennequin , Patrick Ple , Christine Marie Paul Lambert
发明人： Laurent Francois Andre Hennequin , Patrick Ple , Christine Marie Paul Lambert
IPC分类号： A01N43/54 , A61K31/517 , A61K31/535 , C07D239/70 , C07D413/00 , C07D419/00
CPC分类号： C07D405/12 , C07D405/14
摘要： The invention concerns quinazoline derivatives of Formula (I) wherein each of m, R1, n, R2 and R3 have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an anti-invasive agent in the containment and/or treatment of solid tumour disease.
摘要翻译：本发明涉及式（I）的喹唑啉衍生物，其中m，R 1，n，R 2和R 3 3中的每一个具有描述中定义的含义; 其制备方法，含有它们的药物组合物及其在制备用作在实体瘤疾病的遏制和/或治疗中作为抗侵入剂的药物的用途。

5. 发明授权

US07049438B2 Quinazoline derivatives for treatment of tumours 有权
标题翻译：喹唑啉衍生物治疗肿瘤
公开(公告)号：US07049438B2
公开(公告)日：2006-05-23
申请号：US10275382
申请日：2001-06-01
申请人： Laurent François André Hennequin , Patrick Ple
发明人： Laurent François André Hennequin , Patrick Ple
IPC分类号： C07D239/72 , A01N43/54
CPC分类号： C07D401/14 , C07D231/12 , C07D233/56 , C07D239/94 , C07D249/08 , C07D401/12 , C07D405/12 , C07D405/14
摘要： The invention concerns quinazoline derivatives of Formula (I) wherein each of Q1, Z, m, R1, R2, R3 and Q2 have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an anti-invasive agent in the containment and/or treatment of solid tumour disease
摘要翻译：本发明涉及式（I）的喹唑啉衍生物，其中Q 1，Z，m，R 1，R 2，R 2， > 3＆gt;和＆lt; 2＆gt; 2具有在说明书中定义的任何含义; 其制备方法，含有它们的药物组合物及其在制备用于在遏制和/或治疗实体瘤疾病中作为抗侵入剂的药物的用途

6. 发明授权

US5482966A Oxime derivatives 失效
标题翻译：肟衍生物
公开(公告)号：US5482966A
公开(公告)日：1996-01-09
申请号：US240464
申请日：1994-06-13
申请人： Thomas G. C. Bird , Patrick Ple
发明人： Thomas G. C. Bird , Patrick Ple
IPC分类号： A61K31/425 , A61K31/505 , A61P29/00 , A61P37/08 , A61P43/00 , C07D239/42 , C07D307/20 , C07D309/08 , C07D309/10 , C07D317/22 , C07D405/04 , C07D409/02 , C07D409/04 , C07D409/12 , C07D417/04 , C07D417/12 , A61K31/35 , A61K31/34
CPC分类号： C07D405/04 , C07D307/20 , C07D309/10 , C07D317/22 , C07D409/04 , C07D417/04
摘要： The invention concerns oxime derivatives of the formula I ##STR1## wherein R.sup.4 includes hydrogen, carboxy, carbamoyl, amino, cyano, trifluoromethyl, (1-4C)alkylamino, di-(1-4C)alkylamino and (1-4C)alkyl;R.sup.5 includes hydrogen, (1-4C)alkyl, (3-4C)alkenyl, (3-4C)alkynyl, (2-5C)alkanoyl, halogeno-(2-4C)alkyl and hydroxy-(2-4C)alkyl;Ar.sup.1 is phenylene or a heteroaryl diradical;A.sup.1 is a direct link to X.sup.1, or A.sup.1 is (1-4C)alkylene;X.sup.1 is oxy, thio, sulphinyl or sulphonyl;Ar.sup.2 is phenylene or a heteroaryl diradical;R.sup.1 is (1-4C)alkyl, (3-4C)alkenyl or (3-4C)alkynyl; andR.sup.2 and R.sup.3 together form a group of the formula --A.sup.2 --X.sup.2 --A.sup.3 -- which together with the carbon atom to which A.sup.2 and A.sup.3 are attached define a ring having 5 or 6 ring atoms, wherein each of A.sup.2 and A.sup.3 is (1-3C)alkylene and X.sup.2 is oxy, thio, sulphinyl, sulphonyl or imino;or a pharmaceutically-acceptable salt thereof;processes for their manufacture; pharmaceutical compositions containing them and their use as 5-lipoxygenase inhibitors.
摘要翻译：本发明涉及式I的肟衍生物，其中R 4包括氢，羧基，氨基甲酰基，氨基，氰基，三氟甲基，（1-4C）烷基氨基，二（1-4C）烷基氨基和（1-4C）烷基 ; R5包括氢，（1-4C）烷基，（3-4C）烯基，（3-4C）炔基，（2-5C）烷酰基，卤代 - （2-4C）烷基和羟基 - （2-4C）烷基; Ar1是亚苯基或杂芳基双基; A1是直接连接到X1，或A1是（1-4C）亚烷基; X1是氧基，硫基，亚磺酰基或磺酰基; Ar 2是亚苯基或杂芳基双基; R1是（1-4C）烷基，（3-4C）烯基或（3-4C）炔基; 并且R2和R3一起形成式-A2-X2-A3-的基团，其与A2和A3所连接的碳原子一起形成具有5或6个环原子的环，其中A2和A3各自为（1 -3C）亚烷基，X 2为氧基，硫基，亚磺酰基，磺酰基或亚氨基; 或其药学上可接受的盐; 制造过程; 含有它们的药物组合物及其作为5-脂肪氧合酶抑制剂的用途。

7. 发明申请

US20120264731A1 CHROMENONE DERIVATIVES 有权
标题翻译：铬酮衍生物
公开(公告)号：US20120264731A1
公开(公告)日：2012-10-18
申请号：US13444221
申请日：2012-04-11
申请人： Bernard Christophe BARLAAM , Sebastien Louis DEGORCE , Christine Marie Paul LAMBERT-VAN DER BREMPT , Jean-Jacques Marcel LOHMANN , Patrick PLE
发明人： Bernard Christophe BARLAAM , Sebastien Louis DEGORCE , Christine Marie Paul LAMBERT-VAN DER BREMPT , Jean-Jacques Marcel LOHMANN , Patrick PLE
IPC分类号： A61K31/5377 , A61K31/541 , C07D417/14 , C07D413/14 , A61P35/00
CPC分类号： C07D413/14 , A61K31/5377 , A61K31/715 , C07D417/14
摘要： The invention concerns chromenone compounds of Formula I; or pharmaceutically-acceptable salts thereof, wherein each of R1, R2, R3, R4, R5, n and R6 has any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the treatment of cell proliferative disorders.
摘要翻译：本发明涉及式I的色烯酮化合物; 或其药学上可接受的盐，其中R 1，R 2，R 3，R 4，R 5，n和R 6中的每一个在本说明书中具有上文定义的任何含义; 其制备方法，含有它们的药物组合物及其在制备用于治疗细胞增殖性疾病的药物中的用途。

8. 发明授权

US07973164B2 Quinoline derivatives 失效
标题翻译：喹啉衍生物
公开(公告)号：US07973164B2
公开(公告)日：2011-07-05
申请号：US12280848
申请日：2007-03-01
申请人： Frederic Henri Jung , Patrick Ple
发明人： Frederic Henri Jung , Patrick Ple
IPC分类号： C07D215/38
CPC分类号： C07D401/12 , C07D215/233
摘要： The invention concerns quinoline derivatives of Formula I or a pharmaceutically-acceptable salt thereof, wherein each of X1, p, R1, q, R2, R3, R4, R5, Ring A, r and R6 has any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the treatment of cell proliferative disorders.
摘要翻译：本发明涉及式I的喹啉衍生物或其药学上可接受的盐，其中X 1，p，R 1，q，R 2，R 3，R 4，R 5，环A，r和R 6中的每一个在描述; 其制备方法，含有它们的药物组合物及其在制备用于治疗细胞增殖性疾病的药物中的用途。

9. 发明申请

US20090036474A1 Quinazoline derivatives for use against cancer 审中-公开
标题翻译：用于抗癌的喹唑啉衍生物
公开(公告)号：US20090036474A1
公开(公告)日：2009-02-05
申请号：US11665115
申请日：2005-10-07
申请人： Patrick Ple , Frederic Henri Jung
发明人： Patrick Ple , Frederic Henri Jung
IPC分类号： A61K31/517 , C07D403/12 , A61P9/00
CPC分类号： C07D417/14 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14
摘要： The invention concerns quinazoline derivatives of Formula (I) or a pharmaceutically-acceptable salt, solvate or pro-drug thereof, wherein each of p, R1, q, R2, R3, R4, R5, Ring A, X1, R6, r and R7 has any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the treatment of cell proliferative disorders or in the treatment of disease states associated with angiogenesis and/or vascular permeability.
摘要翻译：本发明涉及式（I）的喹唑啉衍生物或其药学上可接受的盐，溶剂化物或前体药物，其中p，R1，q，R2，R3，R4，R5，环A，X1，R6，r和 R7具有描述中定义的任何含义; 其制备方法，含有它们的药物组合物及其在制备用于治疗细胞增殖性疾病或治疗与血管生成和/或血管通透性相关的疾病状态的药物中的用途。

10. 发明授权

US06849625B2 Quinazoline derivatives with anti-tumour activity 失效
标题翻译：喹唑啉衍生物具有抗肿瘤活性
公开(公告)号：US06849625B2
公开(公告)日：2005-02-01
申请号：US10398793
申请日：2001-10-09
申请人： Christine Marie Paul Lambert , Patrick Ple
发明人： Christine Marie Paul Lambert , Patrick Ple
IPC分类号： A61K31/517 , A61K31/5377 , A61P1/04 , A61P1/16 , A61P3/10 , A61P5/50 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/12 , A61P17/00 , A61P17/06 , A61P19/02 , A61P25/00 , A61P27/02 , A61P29/00 , A61P35/00 , A61P37/08 , C07D401/14 , C07D405/12 , C07D405/14
CPC分类号： C07D401/14 , C07D405/12 , C07D405/14
摘要： The invention concerns quinazoline derivatives of Formula I wherein each of m, R1, n, R2 and R3 have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an anti-invasive agent in the containment and/or treatment of solid tumour disease.
摘要翻译：本发明涉及式I的喹唑啉衍生物，其中m，R 1，n，R 2和R 3中的每一个具有说明书中定义的任何含义; 其制备方法，含有它们的药物组合物及其在制备用作在实体瘤疾病的遏制和/或治疗中作为抗侵入剂的药物的用途。

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