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1. 发明授权

US08377398B2 Methods and compositions related to determination and use of white blood cell counts 失效
标题翻译：与确定和使用白细胞计数相关的方法和组合物
公开(公告)号：US08377398B2
公开(公告)日：2013-02-19
申请号：US11997396
申请日：2006-05-31
申请人： John T. McDevitt , Nicolaos J. Christodoulides , Pierre N. Floriano , Gary N. Douglas , Patrick E. Rogers
发明人： John T. McDevitt , Nicolaos J. Christodoulides , Pierre N. Floriano , Gary N. Douglas , Patrick E. Rogers
IPC分类号： G01N21/00 , G01N33/00 , G01N33/543 , B01D21/00 , B01D35/00
CPC分类号： G01N21/6456 , G01N21/6428 , G01N33/56972 , G01N2021/6419 , G01N2021/6421 , Y10T436/112499 , Y10T436/25125 , Y10T436/25375 , Y10T436/255
摘要： Described herein is an analyte detection device and method related to a portable instrument suitable for point-of-care analyses. In some embodiments, a portable instrument may include a disposable cartridge, an optical detector, a sample collection device and/or sample reservoir, reagent delivery systems, fluid delivery systems, one or more channels, and/or waste reservoirs. Use of a portable instrument may reduce the hazard to an operator by reducing an operator's contact with a sample for analysis. The device is capable of obtaining diagnostic information using cellular- and/or particle-based analyses and may be used in conjunction with membrane- and/or particle-based analysis cartridges. Analytes, including proteins and cells and/or microbes may be detected using the membrane and/or particle based analysis system.
摘要翻译：本文描述了与适合于点护理分析的便携式仪器相关的分析物检测装置和方法。在一些实施例中，便携式仪器可以包括一次性盒，光学检测器，样品收集装置和/或样品储存器，试剂递送系统，流体输送系统，一个或多个通道和/或废物储存器。使用便携式仪器可能会降低操作员与样品的接触以分析危害操作员的危险。该设备能够使用基于细胞和/或基于粒子的分析获得诊断信息，并且可以与基于膜和/或基于粒子的分析盒结合使用。可以使用基于膜和/或基于粒子的分析系统检测分析物，包括蛋白质和细胞和/或微生物。

2. 发明授权

US5217704A Methods and materials for the preparation of metal labelled antibody solutions 失效
标题翻译：用于制备金属标记抗体溶液的方法和材料
公开(公告)号：US5217704A
公开(公告)日：1993-06-08
申请号：US815598
申请日：1991-12-27
申请人： David K. Johnson , Patrick E. Rogers
发明人： David K. Johnson , Patrick E. Rogers
IPC分类号： A61K51/10
CPC分类号： A61K51/1093 , A61K2121/00 , A61K2123/00
摘要： The present invention provides a metal ion scavenging procedure and antibody compositions for radioimmunoscintigraphy and cytotoxic radioimmunotherapy having chelator concentrations of greater than about 10.sup.-4 M which are optimized with respect to their metal binding capacity such that highly efficient labelling of the antibody is achieved in a simple one step procedure using readily available sources of radiometal ions.
摘要翻译：本发明提供金属离子清除方法和用于放射免疫印迹和细胞毒性放射免疫疗法的抗体组合物，其具有大于约10-4M的螯合剂浓度，其相对于其金属结合能力而被优化，使得以简单的方式实现抗体的高效标记使用容易获得的放射性金属离子源的一步法。

3. 发明授权

US5130118A Methods and materials for the preparation of metal labelled antibody solutions 失效
标题翻译：用于制备金属标记抗体溶液的方法和材料
公开(公告)号：US5130118A
公开(公告)日：1992-07-14
申请号：US118148
申请日：1987-11-06
申请人： David K. Johnson , Patrick E. Rogers
发明人： David K. Johnson , Patrick E. Rogers
IPC分类号： A61K51/10
CPC分类号： A61K51/1093 , A61K2121/00 , A61K2123/00 , Y10T436/24 , Y10T436/25125
摘要： The present invention provides a metal ion scavenging procedure and antibody compositions for radioimmunoscintigraphy and cytotoxic radioimmunotherapy having chelator concentrations of greater than about 10.sup.-4 M which are optimized with respect to their metal binding capacity such that highly efficient labelling of the antibody is achieved in a simple one step procedure using readily available sources of radiometal ions.
摘要翻译：本发明提供金属离子清除方法和用于放射免疫印迹和细胞毒性放射免疫疗法的抗体组合物，其具有大于约10-4M的螯合剂浓度，其相对于其金属结合能力而被优化，使得抗体的高效标记在简单的一步程序使用容易获得的放射性金属离子源。

4. 发明申请

US20090215072A1 METHODS AND COMPOSITIONS RELATED TO DETERMINATION AND USE OF WHITE BLOOD CELL COUNTS 失效
标题翻译：与白细胞计数的确定和使用相关的方法和组合
公开(公告)号：US20090215072A1
公开(公告)日：2009-08-27
申请号：US11997396
申请日：2006-05-31
申请人： John T. McDevitt , Nicolaos J. Christodoulides , Pierre N. Floriano , Gary N. Douglas , Patrick E. Rogers
发明人： John T. McDevitt , Nicolaos J. Christodoulides , Pierre N. Floriano , Gary N. Douglas , Patrick E. Rogers
IPC分类号： G01N33/566 , C12M1/34
CPC分类号： G01N21/6456 , G01N21/6428 , G01N33/56972 , G01N2021/6419 , G01N2021/6421 , Y10T436/112499 , Y10T436/25125 , Y10T436/25375 , Y10T436/255
摘要： Described herein is an analyte detection device and method related to a portable instrument suitable for point-of-care analyses. In some embodiments, a portable instrument may include a disposable cartridge, an optical detector, a sample collection device and/or sample reservoir, reagent delivery systems, fluid delivery systems, one or more channels, and/or waste reservoirs. Use of a portable instrument may reduce the hazard to an operator by reducing an operator's contact with a sample for analysis. The device is capable of obtaining diagnostic information using cellular- and/or particle-based analyses and may be used in conjunction with membrane- and/or particle-based analysis cartridges. Analytes, including proteins and cells and/or microbes may be detected using the membrane and/or particle based analysis system.
摘要翻译：本文描述了与适合于点护理分析的便携式仪器相关的分析物检测装置和方法。在一些实施例中，便携式仪器可以包括一次性盒，光学检测器，样品收集装置和/或样品储存器，试剂递送系统，流体输送系统，一个或多个通道和/或废物储存器。使用便携式仪器可能会降低操作员与样品的接触以分析危害操作员的危险。该设备能够使用基于细胞和/或基于粒子的分析获得诊断信息，并且可以与基于膜和/或基于粒子的分析盒结合使用。可以使用基于膜和/或基于粒子的分析系统检测分析物，包括蛋白质和细胞和/或微生物。

5. 发明授权

US06843453B1 Bag holder assembly 失效
标题翻译：袋支架组件
公开(公告)号：US06843453B1
公开(公告)日：2005-01-18
申请号：US10281487
申请日：2002-10-28
申请人： Patrick E. Rogers
发明人： Patrick E. Rogers
IPC分类号： B65B67/12 , B65B67/04
CPC分类号： B65B67/1205
摘要： A bag holder assembly is provided for suspending a storage bag and maintaining the orifice of the bag in the open position. The bag holder includes a base member, a plurality of bag support members, and a bag attachment means. The base member is preferably comprised of multiple beams joined together by a connecting means. The bag support members attach to and extend from the base member. Each bag support member comprises a bag attachment means for grasping and securing a portion of the bag to the bag support member. Once the opposing lips of the bag are secured against opposing bag support members, the orifice of the bag will remain open due to tension generated by the respective bag support members, thus allowing the use of two hands to place items in the bag or remove contents from the bag. Once loading or unloading has been accomplished, the user can rotate the bag support members approximately 270 degrees about the opposing ends of the base member until the opposing bag support members lie substantially flat against the underside of the base member. The invention further includes a method for loading and unloading a storage bag.
摘要翻译：提供袋保持器组件用于悬挂储存袋并将袋的孔保持在打开位置。袋保持器包括基部构件，多个袋支撑构件和袋附接装置。基部构件优选地由通过连接装置连接在一起的多个梁构成。袋支撑构件附接到基部构件并从基部构件延伸。每个袋支撑构件包括用于将袋的一部分抓握并固定到袋支撑构件的袋附接装置。一旦袋子的相对的嘴唇被固定在相对的袋支撑件上，袋子的孔口由于相应的袋支撑件产生的张力而保持打开，从而允许使用两只手将物品放置在袋中或者去除内容物从包里。一旦装载或卸载已经完成，用户可以围绕基部构件的相对端旋转袋支撑构件约270度，直到相对的袋支撑构件基本上平坦地抵靠基座构件的下侧。本发明还包括一种用于装载和卸载存储袋的方法。

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