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1. 发明申请

US20110311626A1 CONTROLLED RELEASE COMPOSITIONS COMPRISING ANTI-CHOLINERGIC DRUGS 审中-公开
标题翻译：包含抗胆碱药物的受控释放组合物
公开(公告)号：US20110311626A1
公开(公告)日：2011-12-22
申请号：US13202957
申请日：2010-02-23
申请人： Gopi Venkatesh , Vincent Parrino , Paolo Gatti , Flavio Fabiani
发明人： Gopi Venkatesh , Vincent Parrino , Paolo Gatti , Flavio Fabiani
IPC分类号： A61K9/22 , A61K31/215 , A61P1/00 , A61P25/04 , A61P25/08 , A61P3/10 , A61P31/00 , A61P25/16 , A61P29/00 , A61P9/00 , A61P25/00 , A61P1/08 , A61P25/18 , A61P11/06 , A61P21/02 , A61K9/14
CPC分类号： A61K9/5078 , A61K9/0056 , A61K9/1676 , A61K9/2081 , A61K9/5042 , A61K9/5047
摘要： The present invention provides compositions comprising dicyclomine, or salts, and/or solvates and methods of making and using the compositions to treat intestinal hypermotility or Irritable Bowel Syndrome (IBS). The present invention also provides once-a-day orally disintegrating dosage forms comprising compositions of the present invention.
摘要翻译：本发明提供包含双环胺或其盐和/或溶剂合物的组合物以及制备和使用该组合物以治疗肠蠕动性或肠易激综合征（IBS）的方法。本发明还提供了包含本发明组合物的每日一次的口腔崩解剂型。

2. 发明授权

US5564342A Railway vehicle with variable trim body 失效
标题翻译：铁路车辆与可变修剪体
公开(公告)号：US5564342A
公开(公告)日：1996-10-15
申请号：US519043
申请日：1995-08-24
申请人： Claudio Casetta , Paolo Gatti , Bruno Parussatti
发明人： Claudio Casetta , Paolo Gatti , Bruno Parussatti
IPC分类号： B61F5/24 , B60G99/00 , B61F5/22 , B61F5/00
CPC分类号： B61F5/22
摘要： A railway vehicle having a variable trim body, comprising two bogies with respective swinging transverse members pivotally connected to the body, and a control system for controlling roll of the body about its longitudinal axis, by use of linear actuators interposed between the swinging transverse members and the opposite sides of the body and operated through a regulation electronic unit connected to a first transducer device detecting the non-compensated centrifugal acceleration acting on the body, and to a second transducer device comprising at least two angular transducers for detecting the momentary relative angle between each swinging transverse member and the body.
摘要翻译：一种具有可变装饰体的铁路车辆，包括两个转向架，所述两个转向架具有可枢转地连接到车身的相应的摆动横向构件，以及控制系统，用于通过使用插入在摆动横向构件之间的线性致动器和围绕其纵向轴线身体的相对侧并且通过连接到检测作用在身体上的非补偿离心加速度的第一换能器装置的调节电子单元操作，以及包括至少两个角度换能器的第二换能器装置，用于检测第二换能器装置之间的瞬时相对角度每个摆动的横向构件和身体。

3. 发明授权

US08580313B2 Fexofenadine microcapsules and compositions containing them 有权
标题翻译：非索非那定微胶囊和含有它们的组合物
公开(公告)号：US08580313B2
公开(公告)日：2013-11-12
申请号：US12959113
申请日：2010-12-02
申请人： Luigi Mapelli , Flavio Fabiani , Luigi Boltri , Paolo Gatti , Mauro Serratoni , Roberto Cassanmagnago
发明人： Luigi Mapelli , Flavio Fabiani , Luigi Boltri , Paolo Gatti , Mauro Serratoni , Roberto Cassanmagnago
IPC分类号： A61K9/16 , A61K9/50 , A61K31/445 , A61P11/02 , A61P29/00 , B01J13/22
CPC分类号： A61K31/445 , A61K9/5026 , A61K9/5042 , A61K9/5047 , A61K9/5089
摘要： The present invention provides a pharmaceutical composition comprising taste-masked immediate release microcapsules which comprise fexofenadine and a water-insoluble polymer coating. These microcapsules and the pharmaceutical compositions comprising them have suitable drug content and desirable pharmaceutical properties, including a quick dissolution rate of fexofenadine combined with a taste masking effect.
摘要翻译：本发明提供一种药物组合物，其包含含有非索非那定和水不溶性聚合物涂层的味道掩蔽的立即释放微胶囊。这些微胶囊和包含它们的药物组合物具有合适的药物含量和期望的药学性质，包括非索非那定的快速溶解速率与味道掩蔽效果相结合。

4. 发明授权

US07400195B2 Variable-gain differential amplifier 有权
标题翻译：可变增益差分放大器
公开(公告)号：US07400195B2
公开(公告)日：2008-07-15
申请号：US11404585
申请日：2006-04-14
申请人： Paolo Gatti
发明人： Paolo Gatti
IPC分类号： H03F3/45
CPC分类号： H03F3/45475
摘要： A variable-gain amplifier with high input impedance includes positive and negative inputs, positive and negative outputs, first and second differential circuits and first, second and third impedances. The impedances form an impedance bridge between the outputs. The first and second differential circuits each have one input coupled to one of the inputs of the differential amplifier, one input coupled to the impedance bridge, and two outputs connected to the outputs of the differential amplifier. At least one of the impedances is a variable impedance.
摘要翻译：具有高输入阻抗的可变增益放大器包括正和负输入，正负输出，第一和第二差分电路以及第一，第二和第三阻抗。阻抗在输出之间形成阻抗桥。第一差分电路和第二差分电路各自具有耦合到差分放大器的一个输入的一个输入，耦合到阻抗桥的一个输入和连接到差分放大器的输出的两个输出。阻抗中的至少一个是可变阻抗。

5. 发明申请

US20050218981A1 Differential amplifier with two outputs and a single input of improved linearity 有权
标题翻译：差分放大器具有两路输出和单路输入，线性度提高
公开(公告)号：US20050218981A1
公开(公告)日：2005-10-06
申请号：US11096798
申请日：2005-03-31
申请人： Paolo Gatti , Marc Sabut
发明人： Paolo Gatti , Marc Sabut
IPC分类号： H03F3/45
CPC分类号： H03F3/45475 , H03F3/45179 , H03F2203/45521
摘要： A differential amplifier having a first and second output terminals and receiving an input signal at an input terminal. The amplifier comprises a first amplifier having a first input connected to the input terminal, a second input and a first output connected together to the first output terminal, and a second output connected to the second output terminal, the first amplifier reproducing the input signal on the first output. The amplifier comprises a second amplifier having a first input receiving a reference signal and a second input connected to the output terminals by resistive elements and controlling the provision by the first amplifier on the second output of a signal such that the signals received at the first and second inputs of the second amplifier are equal.
摘要翻译：一种具有第一和第二输出端并在输入端接收输入信号的差分放大器。放大器包括：第一放大器，其具有连接到输入端的第一输入端，第二输入端和与第一输出端子连接在一起的第一输出端，以及连接到第二输出端子的第二输出端，第一放大器将输入信号再现在第一个输出。所述放大器包括具有接收参考信号的第一输入端的第二放大器和由电阻元件连接到所述输出端子的第二输入端，并且控制所述第一放大器在所述第二输出端提供的信号，使得在所述第一和第二放大器的第二输入相等。

6. 发明申请

US20110250281A1 Fexofenadine Microcapsules and Compositions Containing Them 有权
标题翻译：非索非那定微胶囊和包含它们的组合物
公开(公告)号：US20110250281A1
公开(公告)日：2011-10-13
申请号：US12959113
申请日：2010-12-02
申请人： Luigi Mapelli , Flavio Fabiani , Luigi Boltri , Paolo Gatti , Mauro Serratoni , Roberto Cassanmagnago
发明人： Luigi Mapelli , Flavio Fabiani , Luigi Boltri , Paolo Gatti , Mauro Serratoni , Roberto Cassanmagnago
IPC分类号： A61K9/50 , B01J13/22 , A61P11/02 , A61K31/445 , A61P29/00
CPC分类号： A61K31/445 , A61K9/5026 , A61K9/5042 , A61K9/5047 , A61K9/5089
摘要： The present invention provides a pharmaceutical composition comprising taste-masked immediate release microcapsules which comprise fexofenadine and a water-insoluble polymer coating. These microcapsules and the pharmaceutical compositions comprising them have suitable drug content and desirable pharmaceutical properties, including a quick dissolution rate of fexofenadine combined with a taste masking effect.
摘要翻译：本发明提供一种药物组合物，其包含含有非索非那定和水不溶性聚合物涂层的味道掩蔽的立即释放微胶囊。这些微胶囊和包含它们的药物组合物具有合适的药物含量和期望的药学性质，包括非索非那定的快速溶解速率与味道掩蔽效果相结合。

7. 发明授权

US07960582B2 Process for the preparation and resolution of mandelic acid derivatives 失效
标题翻译：制备和分离扁桃酸衍生物的方法
公开(公告)号：US07960582B2
公开(公告)日：2011-06-14
申请号：US10579854
申请日：2004-11-25
申请人： Hans Jorgen Blixt , Bo Lars Gustaf Bosson , Roberto Guiseppe Paolo Gatti , Simone Zaramella , Michael William Senior , Kurt Vogtli , Andrea Zistler
发明人： Hans Jorgen Blixt , Bo Lars Gustaf Bosson , Roberto Guiseppe Paolo Gatti , Simone Zaramella , Michael William Senior , Kurt Vogtli , Andrea Zistler
IPC分类号： C07C59/48
CPC分类号： C07C59/64 , C07C51/487
摘要： The present invention relates to a new process for the resolution of mandelic acid derivatives from racemic mandelic acid derivative mixtures by salt formation with chiral base cyclic amides; to the resolved mandelic acid cyclic amide salts (see, for example, formula IIa), as well as certain other metal and amine salts of the mandelic acid derivatives, and to the use of the resolved mandelic acid derivatives as intermediates suitable for large-scale manufacturing of, for example, pharmaceutical compounds; Formula IIa, wherein R is selected from CHF2, H, C1-6 Alkyl, CH2F, CHCl2 and CClF2; and wherein n is 0, 1 or 2; R1 is H or C1-6 Alkyl and X is H, halo or C1-6 Alkyl.
摘要翻译：本发明涉及通过与手性碱性环状酰胺形成盐从外消旋扁桃酸衍生物混合物中分离扁桃酸衍生物的新方法。对于解析的扁桃酸环状酰胺盐（参见例如式IIa）以及扁桃酸衍生物的某些其它金属和胺盐，以及使用分解的扁桃酸衍生物作为适合于大规模的中间体制造例如药物化合物; 式IIa，其中R选自CHF 2，H，C 1-6烷基，CH 2 F，CHCl 2和CClF 2; 并且其中n为0,1或2; R 1是H或C 1-6烷基，X是H，卤素或C 1-6烷基。

8. 发明申请

US20060232336A1 Variable-gain differential amplifier 有权
标题翻译：可变增益差分放大器
公开(公告)号：US20060232336A1
公开(公告)日：2006-10-19
申请号：US11404585
申请日：2006-04-14
申请人： Paolo Gatti
发明人： Paolo Gatti
IPC分类号： H03F3/45
CPC分类号： H03F3/45475
摘要： A variable-gain amplifier with high input impedance includes positive and negative inputs, positive and negative outputs, first and second differential circuits and first, second and third impedances. The impedances form an impedance bridge between the outputs. The first and second differential circuits each have one input coupled to one of the inputs of the differential amplifier, one input coupled to the impedance bridge, and two outputs connected to the outputs of the differential amplifier. At least one of the impedances is a variable impedance.
摘要翻译：具有高输入阻抗的可变增益放大器包括正和负输入，正负输出，第一和第二差分电路以及第一，第二和第三阻抗。阻抗在输出之间形成阻抗桥。第一差分电路和第二差分电路各自具有耦合到差分放大器的一个输入的一个输入，耦合到阻抗桥的一个输入和连接到差分放大器的输出的两个输出。阻抗中的至少一个是可变阻抗。

9. 发明申请

US20130274297A1 PHARMACEUTICAL COMPOSITES OF POORLY WATER SOLUBLE DRUGS AND POLYMERS 审中-公开
标题翻译：不良水溶性药物和聚合物的药物组合物
公开(公告)号：US20130274297A1
公开(公告)日：2013-10-17
申请号：US13995396
申请日：2011-12-22
申请人： Paolo Gatti , Italo Colombo , Dario Gervasoni , Vincenza Pironti , Lia Alborghetti , Flavio Fabiani , Luigi Boltri
发明人： Paolo Gatti , Italo Colombo , Dario Gervasoni , Vincenza Pironti , Lia Alborghetti , Flavio Fabiani , Luigi Boltri
IPC分类号： A61K31/4422 , A61K31/18 , A61K31/216
CPC分类号： A61K31/4422 , A61K9/146 , A61K31/18 , A61K31/216 , A61K31/44
摘要： The invention provides a composite of drug, polymeric carrier and at least one not cross linked polymer useful to improve the solubility of poorly water soluble drugs. The present invention comprises manufacturing process of this composite material. The manufacturing process is carried out by the solvent induced activation process, wherein the not cross-linked polymer is loaded into the composite from organic solution, possibly together with the drug. Pharmaceutical compositions comprising said composite in combination with pharmaceutical acceptable excipients are also described herein.
摘要翻译：本发明提供药物，聚合物载体和至少一种非交联聚合物的复合物，其可用于改善难溶于水的药物的溶解度。本发明包括该复合材料的制造工艺。制造过程通过溶剂诱导的活化方法进行，其中未交联的聚合物可能与药物一起从有机溶液中加载到复合物中。包含所述复合物与药学上可接受的赋形剂组合的药物组合物也在本文中描述。

10. 发明申请

US20080312457A1 Process 失效
标题翻译：处理
公开(公告)号：US20080312457A1
公开(公告)日：2008-12-18
申请号：US10579854
申请日：2004-11-25
申请人： Hans Jorgen Blixt , Bo Lars Gustaf Bosson , Roberto Guiseppe Paolo Gatti , Simone Zaramella , Michael William Senior , Kurt Vogtli , Andrea Zistler
发明人： Hans Jorgen Blixt , Bo Lars Gustaf Bosson , Roberto Guiseppe Paolo Gatti , Simone Zaramella , Michael William Senior , Kurt Vogtli , Andrea Zistler
IPC分类号： C07D207/04 , C07C59/50
CPC分类号： C07C59/64 , C07C51/487
摘要： The present invention relates to a new process for the resolution of mandelic acid derivatives from racemic mandelic acid derivative mixtures by salt formation with chiral base cyclic amides; to the resolved mandelic acid cyclic amide salts (see, for example, formula IIa), as well as certain other metal and amine salts of the mandelic acid derivatives, and to the use of the resolved mandelic acid derivatives as intermediates suitable for large-scale manufacturing of, for example, pharmaceutical compounds; Formula IIa, wherein R is selected from CHF2, H, C1-6 Alkyl, CH2F, CHCl2 and CClF2; and wherein n is 0, 1 or 2; R1 is H or C1-6 Alkyl and X is H, halo or C1-6 Alkyl.
摘要翻译：本发明涉及通过与手性碱性环状酰胺形成盐从外消旋扁桃酸衍生物混合物中分离扁桃酸衍生物的新方法。对于解析的扁桃酸环状酰胺盐（参见例如式IIa）以及扁桃酸衍生物的某些其它金属和胺盐，以及使用分解的扁桃酸衍生物作为适合于大规模的中间体制造例如药物化合物; 式IIa，其中R选自CHF 2，H，C 1-6烷基，CH 2 F，CHCl 2和CClF 2; 并且其中n为0,1或2; R 1是H或C 1-6烷基，X是H，卤素或C 1-6烷基。

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