会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 5. 发明授权
    • Synergistic immunosuppressant composition containing a 2,2'-bi-1H-pyrrole compound
    • 含有2,2'-双-1H-吡咯化合物的协同免疫抑制剂组合物
    • US06291509B1
    • 2001-09-18
    • US09068555
    • 1998-05-19
    • Mario FerrariPaola GnocchiMaria Chiara FornasieroFrancesco ColottaRoberto D′AlessioAnna Maria Isetta
    • Mario FerrariPaola GnocchiMaria Chiara FornasieroFrancesco ColottaRoberto D′AlessioAnna Maria Isetta
    • A61K3140
    • A61K45/06A61K38/13A61K31/40A61K2300/00
    • A product containing: (a) an immunosuppressant agent (A) and (b) at least one immunosuppressant 2,2′-bi-1H-pyrrole compound (B) having formula (I) wherein R1 is hydrogen, phenyl, C1-C20 alkyl or C2-C20 alkenyl, wherein the alkyl and alkenyl groups are unsubstituted or substituted by 1 to 3 substituents, which are the same or different, chosen independently from halogen, C1-C6 alkoxy, hydroxy, aryl and aryloxy; R2 is hydrogen, C1-C6 alkyl, cyano, carboxy or (C1-C6 alkoxy)carbonyl; R3 is halogen, hydroxy or C1-C11 alkoxy unsubstitued or substituted by phenyl; R4 is hydrogen, C1-C6 alkyl or phenyl; each of R5 and R6, which are the same or different, is independently hydrogen, C2-C20 alkanoyl, C3-C20 alkenoyl, phenyl, C1-C20 alkyl or C2-C20 alkenyl; or two of R4, R5 and R6, taken together, form a C4-C12 polymethylene chain, which is unsubstituted or substituted by a C1-C12 alkyl, by a C2-C12 alkenyl or by a C1-C12 alkylidene group; or a pharmaceutically acceptable salt thereof; as a combined preparation for simultaneous, separate or sequential use in immunosuppressant therapy, said preparation having a potentiated immunosuppressive activity with respect to products containing either the immunosuppressive agent (A) or the 2,2′-bi-1H-pyrrole immunosuppressive compound (B).
    • 一种产品,其包含:(a)免疫抑制剂(A)和(b)至少一种具有式(I)的至少一种免疫抑制剂2,2'-双-1H-吡咯化合物(B),其中R 1是氢,苯基,C 1 -C 20 烷基或C 2 -C 20烯基,其中烷基和烯基是未取代的或被1至3个取代基取代,所述取代基相同或不同,独立地选自卤素,C 1 -C 6烷氧基,羟基,芳基和芳氧基; R2是氢,C1-C6烷基,氰基,羧基或(C1-C6烷氧基)羰基; R3是卤素,羟基或未取代或被苯基取代的C1-C11烷氧基; R4是氢,C1-C6烷基或苯基; R 5和R 6各自相同或不同,独立地为氢,C 2 -C 20烷酰基,C 3 -C 20链烯酰基,苯基,C 1 -C 20烷基或C 2 -C 20烯基; 一起形成C4-C12聚亚甲基链,其未被取代或被C 1 -C 12烷基取代,被C 2 -C 12烯基或C 1 -C 12亚烷基组成; 或其药学上可接受的盐; 作为用于免疫抑制剂治疗的同时,单独或顺序使用的组合制剂,所述制剂对于含有免疫抑制剂(A)或2,2'-双-1H-吡咯免疫抑制化合物(B)的产品具有增强的免疫抑制活性 )。