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1. 发明授权

US11950611B2 Highly soluble Rebaudioside D 有权
公开(公告)号：US11950611B2
公开(公告)日：2024-04-09
申请号：US17679682
申请日：2022-02-24
申请人： PURECIRCLE SDN BHD
发明人： Avetik Markosyan , Siddhartha Purkayastha
IPC分类号： C07D493/04 , A23L2/60 , A23L27/30 , A24B13/00 , A24B15/40 , A61K8/60 , A61K47/26 , A61Q11/00 , A61Q19/00 , C07H1/08 , C07H15/24
CPC分类号： A23L27/34 , A23L2/60 , A23L27/33 , A23L27/36 , A24B13/00 , A24B15/403 , A61K8/602 , A61K47/26 , A61Q19/00 , C07H1/08 , C07H15/24 , A23V2002/00 , A61K2800/10 , A61Q11/00
摘要： The invention relates to a process for producing highly soluble compositions containing purified steviol glycosides from Stevia rebaudiana Bertoni plant extract, more particularly Rebaudioside D. Obtained highly soluble compositions are useful as non-caloric sweeteners or in combination with sugar or high intensity sweeteners in edible and chewable compositions such as beverages, confectionaries, bakery products, chewing gums and the like.

2. 发明公开

US20240041071A1 STEVIA COMPOSITION 审中-公开
公开(公告)号：US20240041071A1
公开(公告)日：2024-02-08
申请号：US18488248
申请日：2023-10-17
申请人： PURECIRCLE SDN BHD
发明人： Avetik MARKOSYAN
IPC分类号： A23L2/60 , A23L27/00 , A23L27/30 , C07H15/256
CPC分类号： A23L2/60 , A23L27/88 , A23L27/33 , C07H15/256 , A23L27/36
摘要： Stevia compositions are prepared from steviol glycosides of Stevia rebaudiana Bertoni. The compositions are able to provide a superior taste profile and can be used as sweetness enhancers, flavor enhancers and sweeteners in foods, beverages, cosmetics and pharmaceuticals.

3. 发明授权

US11856974B2 Highly soluble stevia sweetener 有权
公开(公告)号：US11856974B2
公开(公告)日：2024-01-02
申请号：US15250550
申请日：2016-08-29
申请人： PureCircle Sdn Bhd
发明人： Avetik Markosyan
IPC分类号： A23L27/30 , A23L27/10 , A23L27/00 , A23L27/12 , A23L33/21 , A23G3/36 , A23G9/32 , A23L2/60 , A61K8/60 , A61Q19/00 , A61K36/28 , A61K8/9789 , A23L27/21
CPC分类号： A23L27/33 , A23G3/36 , A23G9/32 , A23L2/60 , A23L27/00 , A23L27/10 , A23L27/11 , A23L27/12 , A23L27/30 , A23L27/31 , A23L27/34 , A23L27/35 , A23L27/36 , A23L27/37 , A23L33/21 , A61K8/602 , A61K8/9789 , A61K36/28 , A61Q19/00 , A23L27/21 , A23V2002/00 , A61K2800/10 , A61K2800/92
摘要： A method for making a highly soluble Stevia sweetener is described. The resulting sweetener readily provides solutions with up to or greater than 30% concentration which are stable for more than 24 hours.

4. 发明公开

US20230413865A1 HIGH-PURITY STEVIOL GLYCOSIDES 审中-公开
公开(公告)号：US20230413865A1
公开(公告)日：2023-12-28
申请号：US18155002
申请日：2023-01-16
申请人： PURECIRCLE SDN BHD
发明人： Avetik MARKOSYAN , Indra PRAKASH , Cyrille JARRIN , Aurélien BADIE , Robert TER HALLE , Cynthia CURRAN , Daniel AURIOL
IPC分类号： A23L2/60 , A23L27/30 , C07H1/06 , C07H15/256 , C12P19/18 , C12P19/56
CPC分类号： A23L2/60 , A23L27/36 , C07H1/06 , C07H15/256 , C12P19/18 , C12P19/56 , C12Y204/01 , C12Y302/01021 , Y02P20/582 , A23V2002/00
摘要： Methods of preparing highly purified steviol glycosides, particularly rebaudiosides A, D and Mare described. The methods include utilizing recombinant microorganisms for converting various staring compositions to target steviol glycosides. In addition, novel steviol glycosides reb D2, reb M2, and reb I are disclosed, as are methods of preparing the same. The highly purified rebaudiosides are useful as non-caloric sweetener in edible and chewable compositions such as any beverages, confectioneries, bakery products, cookies, and chewing gums.

5. 发明申请

US20220346411A1 HIGH-PURITY MOGROSIDES AND PROCESS FOR THEIR PURIFICATION 有权
公开(公告)号：US20220346411A1
公开(公告)日：2022-11-03
申请号：US17865745
申请日：2022-07-15
申请人： PURECIRCLE SDN BHD
发明人： Avetik MARKOSYAN
IPC分类号： A23L2/60 , C07J17/00 , A61K8/63 , A23L27/30 , A61K8/97
摘要： The present invention provides a process for preparation of highly purified mogrosides mixture from low purity mogrosides mixture. The process comprises providing a mixture of low purity mogrosides, dissolving the low purity mogrosides mixture in water or an aqueous alcohol solution to form an initial solution of mogrosides, passing the initial solution through a column system, wherein the column system comprises a plurality of columns, and each column is packed with a sorbent having different affinities to impurities and mogrosides so that one or more columns retains more mogrosides than other columns, washing the columns to remove impurities with an acidic aqueous solution, a basic aqueous solution, and an aqueous alcoholic solution successively, eluting the columns with an aqueous alcohol solution that contains higher alcohol content than the aqueous alcohol solution used in the washing step, wherein the eluate from the columns with high content of mogrosides are combined, and drying the combined eluate to obtain high purity mogrosides with the content of the total mogrosides are more than 70% (w/w). The present invention also provides a sweetener mixture and product comprising high purity mogrosides.

6. 发明授权

US11202461B2 Stevia extracts 有权
公开(公告)号：US11202461B2
公开(公告)日：2021-12-21
申请号：US15507969
申请日：2015-08-27
申请人： PureCircle Sdn Bhd , The Coca-Cola Company
发明人： Avetik Markosyan , Indra Prakash
IPC分类号： A23L27/30 , A23L2/60 , A23C9/13 , A21D2/18 , A61Q11/00 , C07H15/256 , A23L2/06 , A23L2/54 , A23G4/06 , A01H6/14 , A21D2/36 , A21D13/062 , A23G3/36 , A61Q1/00 , C07H15/24 , C12N15/82 , C07H1/08 , A23L33/105 , A01H1/02 , A01H4/00 , A01H5/12 , A23L2/52 , A61K8/9789 , A61K36/00 , A23G3/42 , A23G4/10
摘要： A Stevia extract made from leaves of the Stevia rebaudiana plant is described. The extract has desired levels of steviol glycosides and is useful in food, beverage, and other consumable products.

7. 发明申请

US20210147463A1 Methods for Purifying Steviol Glycosides and Uses of the Same 有权
公开(公告)号：US20210147463A1
公开(公告)日：2021-05-20
申请号：US17077732
申请日：2020-10-22
申请人： The Coca-Cola Company , PureCircle Sdn Bhd
发明人： Indra Prakash , Avetik Markosyan , Venkata Sai Prakash Chaturvedula , Mary Campbell , Rafael San Miguel , Siddhartha Purkayastha , Marquita Johnson
IPC分类号： C07H15/24 , A23L2/00 , A23L33/125 , A23L29/30 , A23L27/30 , A23L2/60 , C07H1/08
摘要： Methods for purifying steviol glycosides, including Rebaudioside X, are provided herein. Sweetener and sweetened containing Rebaudioside X are also provided herein. Methods of improving the flavor and/or temporal profile of sweetenable compositions, such as beverages, are also provided.

8. 发明授权

US10626136B2 Compositions and methods for improving Rebaudioside X solubility 有权
公开(公告)号：US10626136B2
公开(公告)日：2020-04-21
申请号：US15171400
申请日：2016-06-02
申请人： The Coca-Cola Company , PureCircle Sdn Bhd
发明人： Indra Prakash , Avetik Markosyan , Venkata Sai Prakash Chaturvedula , Gil Ma
IPC分类号： A23L27/30 , C07H15/256 , C07H15/24 , A61K8/60 , A61K47/26 , A61Q11/00 , C07C31/24 , C08B37/00 , C08B37/16
CPC分类号： C07H15/256 , A23L27/33 , A23L27/36 , A61K8/602 , A61K47/26 , A61Q11/00 , C07C31/24 , C07H15/24 , C08B37/0009 , C08B37/0015 , A23V2002/00 , A23V2002/00 , A23V2250/262
摘要： Polymorphic and amorphous forms of Rebaudioside X and methods for preparing the same are provided herein. Also provided herein are Rebaudioside X complexes and methods for preparing the same. Sweetener compositions and sweetened compositions comprising Rebaudioside X forms and Rebaudioside X complexes are described, as well as and methods of their preparation. Methods of improving the flavor and/or temporal profile of sweetenable compositions, such as beverages, are also provided herein.

9. 发明授权

US10480019B2 Process for producing high-purity rubusoside 有权
公开(公告)号：US10480019B2
公开(公告)日：2019-11-19
申请号：US14560403
申请日：2014-12-04
申请人： PureCircle Sdn Bhd
发明人： Avetik Markosyan
IPC分类号： A23L1/236 , C12P19/44 , A24B15/10 , C12P19/14 , C12P19/56 , A23L27/30
摘要： The invention provides a process of producing Rubusoside from steviol glycosides of Stevia rebaudiana plant. The process is useful for producing high purity Rubusoside with purity greater than 95% (dry basis). High purity rubusoside is useful as in combination with other caloric and non-caloric sweeteners as well as non-caloric sweetener in various food and beverage compositions. The high purity rubusoside is useful as non-caloric sweetener in edible and chewable compositions such as any beverages, confectionaries, bakeries, cookies, chewing gums, and alike.

10. 发明授权

US10420359B2 Highly soluble rebaudioside D 有权
公开(公告)号：US10420359B2
公开(公告)日：2019-09-24
申请号：US15905414
申请日：2018-02-26
申请人： PureCircle Sdn Bhd
发明人： Avetik Markosyan , Siddhartha Purkayastha
IPC分类号： C07D493/04 , A23L27/30 , A23L2/60 , C07H15/24 , C07H1/08 , A24B13/00 , A61K8/60 , A61K47/26 , A61Q19/00 , A24B15/40 , A61Q11/00
摘要： The invention relates to a process for producing highly soluble compositions containing purified steviol glycosides from Stevia rebaudiana Bertoni plant extract, more particularly Rebaudioside D. Obtained highly soluble compositions are useful as non-caloric sweeteners or in combination with sugar or high intensity sweeteners in edible and chewable compositions such as beverages, confectionaries, bakery products, chewing gums and the like.

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