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1. 发明授权

US6362228B2 Phenethyl-thiourea compounds and use 失效
标题翻译：苯乙基 - 硫脲化合物和用途
公开(公告)号：US6362228B2
公开(公告)日：2002-03-26
申请号：US74256300
申请日：2000-12-20
申请人： PARKER HUGHES INST
发明人： UCKUN FAITH M , VENTATACHALAM TARACAD K
IPC分类号： A61K31/44 , A61P31/18 , C07D213/75 , A61K31/17 , C07C335/06
CPC分类号： C07D213/75
摘要： Novel phenylethyl-thiourea (PHET) compounds as inhibitors of reverse transcriptase and effective agents for the treatment of HIV infection, including mutant, drug-sensitive, drug-resistant, and multi-drug resistant strains of HIV.
摘要翻译：新型苯乙基 - 硫脲（PHET）化合物作为逆转录酶的抑制剂和用于治疗HIV感染的有效药物，包括突变型，药物敏感型，耐药性和多重耐药性HIV病毒株。

2. 发明授权

US6410545B2 Lipid lowering quinazoline dietary supplement composition 失效
标题翻译：脂质降低喹唑啉膳食补充剂组成
公开(公告)号：US6410545B2
公开(公告)日：2002-06-25
申请号：US89204701
申请日：2001-06-26
申请人： PARKER HUGHES INST
发明人： UCKUN FATIH M , TRIEU VUONG N , LIU XING-PING
IPC分类号： C07D239/74 , A61K3/505
CPC分类号： C07D239/74
摘要： A novel carbonyl-substituted quinazoline, preferably 4-(3'-bromobenzoyl)-6,7-dimethoxyquinazoline (WHI-P164), and methods for lowering blood cholesterol, including reducing total cholesterol and LDL-cholesterol levels by administration of the carbonyl quinazolines and compositions thereof.
摘要翻译：一种新的羰基取代喹唑啉，优选4-（3'-溴苯甲酰基）-6,7-二甲氧基喹唑啉（WHI-P164）和降低血液胆固醇的方法，包括通过施用羰基喹唑啉降低总胆固醇和低密度脂蛋白胆固醇水平及其组合物。

3. 发明授权

US6391921B2 Treatment of inflammation with 2,4,6-trihydroxy-alpha-para-methoxyphenylacetophenone, or its pharmaceutically acceptable derivatives 失效
标题翻译：用2,4,6-三羟基-α对甲氧基苯乙酮或其药学上可接受的衍生物治疗炎症
公开(公告)号：US6391921B2
公开(公告)日：2002-05-21
申请号：US88424501
申请日：2001-06-19
申请人： PARKER HUGHES INST
发明人： UCKUN FATIH M , MALAVIYA RAVI
IPC分类号： A61K31/12
CPC分类号： A61K31/12
摘要： 2,4,6-trihydroxy-alpha-p-methoxyphenylacetophenone (also identified herein as "D-58"), or its pharmaceutically acceptable derivatives such as salt and ester forms, is administered for inhibiting inflammatory reactions. The treatment can be remedial or prophylactic. Examples of the conditions that can be treated include acute inflammatory reactions and allergic inflammatory reactions, and specific examples include allergy, asthma, arthritis, psoriasis, skin sunburn, inflammatory pelvic disease, inflammatory bowel disease, urethritis, uvitis, senusitis, pneumonitis, encephalitis, meningitis, myocarditis, nephritis, osteomyelitis, myositis, hepatitis, gastritis, enteritis, dermatitis, gingivitis, appendicitis, pancreatitis, cholocystitis and cholangitis. The 2,4,6-trihydroxy-alpha-p-methoxyphenylacetophenone can be administered by various routes as needed.
摘要翻译：施用2,4,6-三羟基-α-对甲氧基苯乙酮（本文中也称为“D-58”）或其药学上可接受的衍生物如盐和酯形式用于抑制炎性反应。治疗可以是补救或预防。可以治疗的病症的实例包括急性炎症反应和过敏性炎症反应，具体实例包括过敏，哮喘，关节炎，牛皮癣，皮肤晒伤，炎性骨盆疾病，炎性肠病，尿道炎，尿毒症，肾炎，肺炎，脑炎，脑膜炎，心肌炎，肾炎，骨髓炎，肌炎，肝炎，胃炎，肠炎，皮炎，牙龈炎，阑尾炎，胰腺炎，胆囊炎和胆管炎。 2,4,6-三羟基-α-对甲氧基苯乙酮可以根据需要通过各种途径施用。

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