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1. 发明授权

US08497112B2 Method for producing viral vaccines 有权
标题翻译：生产病毒疫苗的方法
公开(公告)号：US08497112B2
公开(公告)日：2013-07-30
申请号：US12199977
申请日：2008-08-28
申请人： Otfried Kistner , Christa Tauer , Noel Barrett , Wolfgang Mundt
发明人： Otfried Kistner , Christa Tauer , Noel Barrett , Wolfgang Mundt
IPC分类号： C12N7/02 , C12N7/04 , C12N7/06
CPC分类号： A61K39/145 , A61K39/12 , C12N7/00 , C12N2760/16134 , C12N2760/16151 , C12N2760/16161 , C12N2760/16234 , C12N2760/16251 , C12N2760/16261
摘要： The present invention provides a method for the manufacture of a preparation comprising virus antigens comprising a) inoculation of cells with infectious virus in a fluid, b) propagation of said virus in said cells, c) collecting said propagated virus, d) inactivating said collected virus, and e) treating said inactivated virus with a detergent, resulting in a preparation comprising viral antigens.
摘要翻译：本发明提供了一种制备包含病毒抗原的制备方法，包括：a）在流体中接种具有感染性病毒的细胞，b）所述病毒在所述细胞中的繁殖，c）收集所述繁殖的病毒，d）使所收集的所述病毒病毒，和e）用洗涤剂处理所述灭活的病毒，产生包含病毒抗原的制剂。

2. 发明申请

US20060270017A1 Inactivation of a pathogen in a sample by a treatment with formalin and UV light 有权
标题翻译：通过用福尔马林和紫外光处理使样品中的病原体失活
公开(公告)号：US20060270017A1
公开(公告)日：2006-11-30
申请号：US11138158
申请日：2005-05-26
申请人： Manfred Reiter , Wolfgang Mundt , Noel Barrett , Otfried Kistner
发明人： Manfred Reiter , Wolfgang Mundt , Noel Barrett , Otfried Kistner
IPC分类号： C12N7/00
CPC分类号： C12N7/00 , C12N2770/32161 , C12N2770/32163
摘要： The present invention relates to a method for inactivating virus in a sample by treating a virus containing sample with an effective concentration of formalin and by treating the sample with an effective dose of UV light in a flow-through apparatus.
摘要翻译：本发明涉及通过用有效浓度的福尔马林处理含有病毒的样品并且在流通装置中用有效剂量的UV光处理样品来灭活样品中的病毒的方法。

3. 发明申请

US20110159031A1 Vaccine to Influenza A Virus 审中-公开
标题翻译：疫苗对甲型流感病毒
公开(公告)号：US20110159031A1
公开(公告)日：2011-06-30
申请号：US12976145
申请日：2010-12-22
申请人： Falko G. Falkner , Otfried Kistner , Annett Hessel , P. Noel Barrett , Hartmut Ehrlich , Georg Holzer
发明人： Falko G. Falkner , Otfried Kistner , Annett Hessel , P. Noel Barrett , Hartmut Ehrlich , Georg Holzer
IPC分类号： A61K39/285 , C12N15/63 , C12N15/863 , C12N7/01 , A61P37/04 , A61P31/16
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/5256 , C12N2710/24143 , C12N2760/16134
摘要： The present invention relates, in general, to compositions and methods for administering a vaccine against influenza to a subject, the vaccine comprising a vaccinia virus vector and a hemagglutinin and neuraminidase gene, separate or in combination, from an influenza A virus.
摘要翻译：本发明一般涉及用于向受试者施用针对流感的疫苗的组合物和方法，所述疫苗包含与甲型流感病毒分离或组合的痘苗病毒载体和血凝素和神经氨酸酶基因。

4. 发明授权

US06372223B1 Influenza virus vaccine composition 失效
标题翻译：流感病毒疫苗组合物
公开(公告)号：US06372223B1
公开(公告)日：2002-04-16
申请号：US09787322
申请日：2001-06-12
申请人： Otfried Kistner , Noel Barrett , Wolfgang Mundt , Friedrich Dorner
发明人： Otfried Kistner , Noel Barrett , Wolfgang Mundt , Friedrich Dorner
IPC分类号： A61K39145
CPC分类号： A61K39/39 , A61K39/12 , A61K39/145 , A61K2039/525 , A61K2039/5252 , A61K2039/55505 , C12N2760/16134 , C12N2760/16234
摘要： This invention describes an influenza virus vaccine containing an influenza virus antigen obtained from a cell culture, with an influenza virus antigen content between 1 &mgr;g and 5 &mgr;g per dose and aluminum as an adjuvant as well as a method for its preparation.
摘要翻译：本发明描述了一种流感病毒疫苗，其含有从细胞培养物获得的流感病毒抗原，流感病毒抗原含量在1μg至5mug /剂量之间，铝作为佐剂，以及其制备方法。

5. 发明授权

US5698433A Method for producing influenza virus and vaccine 失效
标题翻译：生产流感病毒和疫苗的方法
公开(公告)号：US5698433A
公开(公告)日：1997-12-16
申请号：US684729
申请日：1996-07-22
申请人： Otfried Kistner , Noel Barrett , Wolfgang Mundt , Friedrich Dorner
发明人： Otfried Kistner , Noel Barrett , Wolfgang Mundt , Friedrich Dorner
IPC分类号： A61K39/00 , A61K39/145 , A61K39/15 , A61K39/245 , C07K14/11 , C12N7/00 , C12N7/02
CPC分类号： C07K14/005 , A61K39/12 , A61K39/145 , A61K39/15 , A61K39/245 , C12N7/00 , A61K2039/5252 , A61K2039/55505 , A61K39/00 , C12N2760/16122 , C12N2760/16134 , C12N2760/16151 , C12N2760/16234
摘要： A method of producing an influenza virus and vaccines derived from the virus utilizes cultured vertebrate biomass aggregates comprising a plurality of cell types derived from a plurality of vertebrate tissues and is particularly suitable for use with chicken embryo cultures. The method both eliminates the necessity to use costly methods requiring whole chicken embryos and provides proteases suitable for the activation of a wide variety of viruses. After infecting the cells of the culture with an influenza virus, which is preferably modified to create a cleavage site in the hemagglutinin of the virus, a substance such as a protease is introduced that cleaves the hemagglutinin. The culture then is incubated under conditions that permit growth of the virus. The method provides also for the augmentation of virus activation in the culture by the continuous or batchwise removal of culture media, treatment of the media with substances such as proteases which increase cellular activation, attenuation of any undesired effects of the augmentation and return of the augmented media to the culture. The vaccines produced from the harvested virus therefore are free of egg proteins and are much more economical to produce. The methodology of the present invention allows the large scale continuous production of many viruses to a high titre.
摘要翻译：生产流感病毒的方法和源自病毒的疫苗利用培养的脊椎动物生物质聚集体，其包含多种衍生自多个脊椎动物组织的细胞类型，并且特别适用于鸡胚培养。该方法既消除了使用需要全部鸡胚胎的昂贵方法的必要性，并提供了适用于激活各种病毒的蛋白酶。在用流感病毒感染培养物的细胞后，其优选被修饰以在病毒的血凝素中产生切割位点，引入了裂解血凝素的诸如蛋白酶的物质。然后将培养物在允许病毒生长的条件下孵育。该方法还用于通过连续或分批地去除培养基来增加培养物中的病毒活化，用诸如增加细胞活化的蛋白酶的物质处理培养基，减少增加的任何不期望的影响和增加的媒体对文化。因此，从收获的病毒产生的疫苗不含蛋蛋白，并且生产更经济。本发明的方法允许大规模连续生产许多病毒到高滴度。

6. 发明授权

US09884105B2 Production of viral vaccine 有权
公开(公告)号：US09884105B2
公开(公告)日：2018-02-06
申请号：US12639917
申请日：2009-12-16
申请人： Otfried Kistner , Falko-Guenter Falkner , Hartmut Ehrlich , Noel Barrett
发明人： Otfried Kistner , Falko-Guenter Falkner , Hartmut Ehrlich , Noel Barrett
IPC分类号： A61K39/145 , C12N7/00 , A61K39/12 , A61K39/00
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/5254 , A61K2039/5258 , C12N7/00 , C12N2760/16134 , C12N2760/16161
摘要： The present invention relates, in general, to materials and methods for production of an improved vaccine against influenza virus, wherein the vaccine comprises a reassortant virus having a hemagglutinin gene and a neuraminidase gene from the same influenza A virus subtype or influenza B strain of virus and internal genes from a different influenza A virus subtype or influenza B strain of virus. In one aspect, the HA and NA genes and the internal genes are from a highly pathogenic H5N1 strain of influenza A.

7. 发明授权

US08703467B2 Inactivation of a pathogen in a sample by a treatment with formalin and UV light 有权
标题翻译：通过用福尔马林和紫外光处理使样品中的病原体失活
公开(公告)号：US08703467B2
公开(公告)日：2014-04-22
申请号：US11138158
申请日：2005-05-26
申请人： Manfred Reiter , Wolfgang Mundt , Noel Barrett , Otfried Kistner
发明人： Manfred Reiter , Wolfgang Mundt , Noel Barrett , Otfried Kistner
IPC分类号： C12N7/04 , C12N7/06
CPC分类号： C12N7/00 , C12N2770/32161 , C12N2770/32163
摘要： The present invention relates to a method for inactivating virus in a sample by treating a virus containing sample with an effective concentration of formalin and by treating the sample with an effective dose of UV light in a flow-through apparatus.
摘要翻译：本发明涉及通过用有效浓度的福尔马林处理含有病毒的样品并且在流通装置中用有效剂量的UV光处理样品来灭活样品中的病毒的方法。

8. 发明授权

US06635246B1 Inactivated influenza virus vaccine for nasal or oral application 有权
标题翻译：用于鼻腔或口腔应用的灭活流感病毒疫苗
公开(公告)号：US06635246B1
公开(公告)日：2003-10-21
申请号：US09913400
申请日：2001-12-05
申请人： Noel Barrett , Otfried Kistner , Marijan Gerencer , Friedrich Dorner
发明人： Noel Barrett , Otfried Kistner , Marijan Gerencer , Friedrich Dorner
IPC分类号： A01N6300
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/542 , A61K2039/543 , A61K2039/55505 , A61K2039/55544 , C12N2760/16134 , C12N2760/16234 , Y10S530/826
摘要： The invention relates to nasal or oral administration of a compound containing inactivated influenza virus antigen and aluminum as adjuvant for the prophylaxis of influenza virus infections. Said vaccine is especially suitable for inducing a mucosal IgA immune response and systemic IgG immune response.
摘要翻译：本发明涉及含有灭活流感病毒抗原和铝作为预防流感病毒感染佐剂的化合物的鼻腔或口服给药。所述疫苗特别适用于诱导粘膜IgA免疫应答和全身IgG免疫应答。

9. 发明授权

US5756341A Method for controlling the infectivity of viruses 失效
标题翻译：控制病毒感染性的方法
公开(公告)号：US5756341A
公开(公告)日：1998-05-26
申请号：US483522
申请日：1995-06-07
申请人： Otfried Kistner , Noel Barrett , Wolfgang Mundt , Friedrich Dorner
发明人： Otfried Kistner , Noel Barrett , Wolfgang Mundt , Friedrich Dorner
IPC分类号： A61K39/00 , A61K39/145 , A61K39/15 , A61K39/245 , C07K14/11 , C12N7/00 , C12N7/02
CPC分类号： A61K39/145 , A61K39/12 , A61K39/245 , C07K14/005 , C12N7/00 , A61K2039/5252 , A61K2039/55505 , A61K39/00 , C12N2500/90 , C12N2760/16122 , C12N2760/16134 , C12N2760/16151 , C12N2760/16161 , C12N2760/16163 , C12N2760/16222 , C12N2760/16234 , C12N2760/16251 , C12N2760/16261 , C12N2760/16263
摘要： A method for producing Influenza and other viruses and vaccines derived therefrom utilizes serum-free cultured vertebrate cells or vertebrate biomass aggregates to both eliminate the necessity to use costly methods requiring whole chicken embryos and, optionally, to provide proteases suitable for the activation of a wide variety of viruses. In one aspect, the method comprises the periodic or continuous removal of "treatment portions" of virus-containing culture medium into an "augmentation loop" for treatment with a broad range of substances, such as proteases that augment the activation of the virus. Use of the loop allows utilization of such substances at high concentrations while eliminating their cell toxic effects. Another aspect of the invention provides for the alteration of cleavage sites in virus proteins to thereby render them more susceptible to activation in culture. Thus, the method provides for the high yield production of many viruses that can be easily scaled up to continuous large scale production volumes and for resultant vaccines which are free of egg proteins and are much more economical to produce.
摘要翻译：用于生产流感和其他病毒的方法及其衍生的疫苗利用无血清培养的脊椎动物细胞或脊椎动物生物质聚集体，以消除使用需要全部鸡胚胎的昂贵方法的必要性，并且任选地提供适于激活广泛的蛋白酶各种病毒。在一个方面，该方法包括将含有病毒的培养基的“处理部分”定期或连续地移除到用于增加病毒活化的广泛范围的物质例如蛋白酶的“增加环”中。循环使用可以高浓度地利用这些物质，同时消除它们的细胞毒性作用。本发明的另一方面提供了病毒蛋白中切割位点的改变，从而使得它们更容易受到培养中的活化。因此，该方法提供了可以容易地扩大到连续大规模生产体积的许多病毒的高产量生产以及没有蛋蛋白并且生产更经济的所得疫苗。

10. 发明申请

US20090060950A1 Method for Producing Viral Vaccines 有权
标题翻译：生产病毒疫苗的方法
公开(公告)号：US20090060950A1
公开(公告)日：2009-03-05
申请号：US12199977
申请日：2008-08-28
申请人： Otfried Kistner , Christa Tauer , Noel Barrett , Wolfgang Mundt
发明人： Otfried Kistner , Christa Tauer , Noel Barrett , Wolfgang Mundt
IPC分类号： A61K39/145 , A61K39/12 , A61P31/16
CPC分类号： A61K39/145 , A61K39/12 , C12N7/00 , C12N2760/16134 , C12N2760/16151 , C12N2760/16161 , C12N2760/16234 , C12N2760/16251 , C12N2760/16261
摘要： The present invention provides a method for the manufacture of a preparation comprising virus antigens comprising a) inoculation of cells with infectious virus in a fluid, b) propagation of said virus in said cells, c) collecting said propagated virus, d) inactivating said collected virus, and e) treating said inactivated virus with a detergent, resulting in a preparation comprising viral antigens.
摘要翻译：本发明提供了一种制备包含病毒抗原的制备方法，包括：a）在流体中接种具有感染性病毒的细胞，b）所述病毒在所述细胞中的繁殖，c）收集所述繁殖的病毒，d）使所收集的所述病毒病毒，和e）用洗涤剂处理所述灭活的病毒，产生包含病毒抗原的制剂。

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