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1. 发明授权

US07314879B2 Melanocortin receptor agonists 失效
标题翻译：黑皮质素受体激动剂
公开(公告)号：US07314879B2
公开(公告)日：2008-01-01
申请号：US10500476
申请日：2003-01-21
申请人： Ryan Thomas Backer , Caño Ivan Collado , Oscar De Frutos-Garcia , Christopher William Doecke , Matthew Joseph Fisher , Steven Lee Kuklish , Vincent Mancuso , Michael John Martinelli , Jeffrey Thomas Mullaney , Paul Leslie Ornstein , Chaoyu Xie
发明人： Ryan Thomas Backer , Caño Ivan Collado , Oscar De Frutos-Garcia , Christopher William Doecke , Matthew Joseph Fisher , Steven Lee Kuklish , Vincent Mancuso , Michael John Martinelli , Jeffrey Thomas Mullaney , Paul Leslie Ornstein , Chaoyu Xie
IPC分类号： A61K31/496 , C07D401/12 , C07D405/12 , C07D407/12
CPC分类号： C07D217/26 , C07D209/44 , C07D211/26 , C07D211/96 , C07D295/033 , C07D309/04 , C07D335/02 , C07D401/12 , C07D405/12 , C07D409/12
摘要： The present invention relates to melanocortin receptor agonist of the formula (I): which is useful in the treatment for obesity, diabetes, and male and/or female sexual dysfunction
摘要翻译：本发明涉及式（I）的黑皮质素受体激动剂：其可用于治疗肥胖症，糖尿病和男性和/或女性性功能障碍

2. 发明申请

US20100018920A1 REACTION AND SEPARATION METHODS 审中-公开
标题翻译：反应和分离方法
公开(公告)号：US20100018920A1
公开(公告)日：2010-01-28
申请号：US12507073
申请日：2009-07-22
申请人： Dennis P. Curran , Oscar de Frutos Garcia , Yoji Oderaotoshi
发明人： Dennis P. Curran , Oscar de Frutos Garcia , Yoji Oderaotoshi
IPC分类号： B01D15/08
CPC分类号： C07B63/00 , G01N27/44726 , G01N2030/884 , G01N2030/8845
摘要： A method of separating compounds that includes the steps of: tagging at least a first organic compound with a first tagging moiety to result in a first tagged compound; tagging at least a second organic compound with a second tagging moiety different from the first tagging moiety to result in a second tagged compound; and separating the first tagged compound from a mixture including the second tagged compound using a separation technique based upon differences between the first tagging moiety and the second tagging moiety. Preferably, the separation technique is based upon difference in the fluorous nature of the first tagged compound and the second tagged compound, differences in total charge between the first tagged compound and the second tagged compound, differences in size between the first tagged compound and the second tagged compound, and/or differences in polarity between the first tagged compound and the second tagged compound. The present invention also provides a method for carrying out a chemical reaction including the steps of: tagging a plurality of compounds with different tagging moieties to create tagged compounds, conducting at least one chemical reaction on a mixture of the tagged compounds to produce a mixture of tagged products, and separating the mixture of tagged products by a separation technique based upon differences in the tagging moieties.
摘要翻译：一种分离化合物的方法，包括以下步骤：用至少第一有机化合物标记第一标记部分以产生第一标记化合物; 标记至少第二有机化合物与第二标记部分不同于第一标记部分以产生第二标记化合物; 以及使用基于第一标记部分和第二标记部分之间的差异的分离技术从含有第二标记化合物的混合物中分离第一标记化合物。优选地，分离技术基于第一标记化合物和第二标记化合物的氟性质的差异，第一标记化合物和第二标记化合物之间的总电荷差异，第一标记化合物与第二标记化合物之间的尺寸差异标记化合物和/或第一标记化合物和第二标记化合物之间的极性差异。本发明还提供了一种用于进行化学反应的方法，包括以下步骤：用不同标记部分标记多种化合物以产生标记化合物，在标记化合物的混合物上进行至少一种化学反应以产生基于标记部分的差异，通过分离技术分离标记产物的混合物。

3. 发明授权

US07169777B2 Melanocortin receptor agonists 失效
标题翻译：黑皮质素受体激动剂
公开(公告)号：US07169777B2
公开(公告)日：2007-01-30
申请号：US10466250
申请日：2002-01-23
申请人： Ryan Thomas Backer , Karin Briner , Ivan Collado Caño , Oscar De Frutos Garcia , Christopher William Doecke , Matthew Joseph Fisher , Cristina Garcia-Paredes , Steven Lee Kuklish , Vincent Mancuso , Michael John Martinelli , Ana Isabel Mateo Herranz , Jeffrey Thomas Mullaney , Paul Leslie Ornstein , Zhipei Wu , Chaoyu Xie
发明人： Ryan Thomas Backer , Karin Briner , Ivan Collado Caño , Oscar De Frutos Garcia , Christopher William Doecke , Matthew Joseph Fisher , Cristina Garcia-Paredes , Steven Lee Kuklish , Vincent Mancuso , Michael John Martinelli , Ana Isabel Mateo Herranz , Jeffrey Thomas Mullaney , Paul Leslie Ornstein , Zhipei Wu , Chaoyu Xie
IPC分类号： A61K31/496 , A61K31/5377 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D413/14 , A61K31/551
CPC分类号： C07D209/48 , A61K38/00 , C07D209/44 , C07D217/12 , C07D217/16 , C07D217/26 , C07K5/06191
摘要： The present invention relates to melanocortin receptor agonist of the formula I useful in the treatment of obesity, diabetes, and male and/or female sexual dysfunction
摘要翻译：本发明涉及式I的黑皮质素受体激动剂，其用于治疗肥胖症，糖尿病以及男性和/或女性性功能障碍

4. 发明授权

US06749756B1 Reaction and separation methods 失效
标题翻译：反应和分离方法
公开(公告)号：US06749756B1
公开(公告)日：2004-06-15
申请号：US09506779
申请日：2000-02-18
申请人： Dennis P. Curran , Oscar de Frutos Garcia , Yoji Oderaotoshi
发明人： Dennis P. Curran , Oscar de Frutos Garcia , Yoji Oderaotoshi
IPC分类号： B01D1508
CPC分类号： C07B63/00 , G01N27/44726 , G01N2030/884 , G01N2030/8845
摘要： A method of separating compounds that includes the steps of: tagging at least a first organic compound with a first tagging moiety to result in a first tagged compound; tagging at least a second organic compound with a second tagging moiety different from the first tagging moiety to result in a second tagged compound; and separating the first tagged compound from a mixture including the second tagged compound using a separation technique based upon differences between the first tagging moiety and the second tagging moiety. The present invention also provides a method for carrying out a chemical reaction including the steps of: tagging a plurality of compounds with different tagging moieties to create tagged compounds, conducting at least one chemical reaction on a mixture of the tagged compounds to produce a mixture of tagged products, and separating the mixture of tagged products by a separation technique based upon differences in the tagging moieties.
摘要翻译：一种分离化合物的方法，包括以下步骤：用至少第一有机化合物标记第一标记部分以产生第一标记化合物; 标记至少第二有机化合物与第二标记部分不同于第一标记部分以产生第二标记化合物; 以及使用基于第一标记部分和第二标记部分之间的差异的分离技术从含有第二标记化合物的混合物中分离第一标记化合物。本发明还提供了一种用于进行化学反应的方法，包括以下步骤：用不同标记部分标记多种化合物以产生标记化合物，在标记化合物的混合物上进行至少一种化学反应以产生基于标记部分的差异，通过分离技术分离标记产物的混合物。

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