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1. 发明申请

US20070156042A1 Medical device system and method for tracking and visualizing a medical device system under MR guidance 审中-公开
标题翻译：医疗设备系统和方法，用于跟踪和可视化MR指导下的医疗设备系统
公开(公告)号：US20070156042A1
公开(公告)日：2007-07-05
申请号：US11322458
申请日：2005-12-30
申请人： Orhan Unal
发明人： Orhan Unal
IPC分类号： A61B5/05
CPC分类号： G01R33/286
摘要： A medical device system capable of being tracked and visualized using a magnetic resonance (MR) device, and a method for tracking and visualizing a medical device system using MR imaging. The medical device system can include a medical device, a tracking device, and a visualizing device. The tracking device can provide feedback indicative of the position of the tracking device. The visualizing device can be coupled to at least a portion of the medical device such that the respective portion of the medical device is visualized using magnetic resonance. The method for tracking and visualizing a medical device system can include providing a medical device having a nonlinear configuration, tracking a tracking device, and visualizing a visualizing device to allow visualization of the nonlinear configuration of the medical device. Some embodiments include a medical device system capable of being visualized in the presence and absence of contrast agents.
摘要翻译：能够使用磁共振（MR）装置跟踪和可视化的医疗装置系统，以及使用MR成像跟踪和可视化医疗装置系统的方法。医疗装置系统可以包括医疗装置，跟踪装置和可视化装置。跟踪装置可以提供指示跟踪装置的位置的反馈。可视化装置可以耦合到医疗装置的至少一部分，使得医疗装置的相应部分使用磁共振可视化。用于跟踪和可视化医疗设备系统的方法可以包括提供具有非线性配置的医疗设备，跟踪跟踪设备以及可视化设备，以允许可视化医疗设备的非线性配置。一些实施例包括能够在存在和不存在造影剂的情况下可视化的医疗装置系统。

2. 发明申请

US20050272997A1 MRI method for assessing myocardial viability 有权
标题翻译：用于评估心肌存活力的MRI方法
公开(公告)号：US20050272997A1
公开(公告)日：2005-12-08
申请号：US10860210
申请日：2004-06-03
申请人： Thomas Grist , Orhan Unal
发明人： Thomas Grist , Orhan Unal
IPC分类号： A61B5/05 , G01R33/28 , G01R33/567
CPC分类号： G01R33/5673 , G01R33/281
摘要： An assessment of myocardial viability in a subject is performed by acquiring an MR image which distinguishes infarcted myocardium from normal myocardium. A contrast agent is used and after a waiting period, a cardiac-gated segmented inversion recovery gradient-recalled radial sampling technique is employed to acquire NMR data over a substantial portion of the cardiac cycle. By interleaving the radial sampling patterns, images can be reconstructed over a range of possible TI intervals enabling the optimal TI for maximum contrast to be retrospectively selected.
摘要翻译：通过获取将梗塞的心肌与正常心肌区分开的MR图像来进行受试者心肌存活力的评估。使用造影剂，并且在等待期之后，使用心脏门控分段反转恢复梯度回收的径向采样技术在心脏周期的大部分时间上获取NMR数据。通过交织径向采样图案，可以在可能的TI间隔的范围内重建图像，使得能够追溯地选择用于最大对比度的最佳TI。

3. 发明授权

US08112145B2 MRI method for assessing myocardial viability 有权
标题翻译：用于评估心肌存活力的MRI方法
公开(公告)号：US08112145B2
公开(公告)日：2012-02-07
申请号：US10860210
申请日：2004-06-03
申请人： Thomas M. Grist , Orhan Unal
发明人： Thomas M. Grist , Orhan Unal
IPC分类号： A61B5/05
CPC分类号： G01R33/5673 , G01R33/281
摘要： An assessment of myocardial viability in a subject is performed by acquiring an MR image which distinguishes infarcted myocardium from normal myocardium. A contrast agent is used and after a waiting period, a cardiac-gated segmented inversion recovery gradient-recalled radial sampling technique is employed to acquire NMR data over a substantial portion of the cardiac cycle. By interleaving the radial sampling patterns, images can be reconstructed over a range of possible TI intervals enabling the optimal TI for maximum contrast to be retrospectively selected.
摘要翻译：通过获取将梗塞的心肌与正常心肌区分开的MR图像来进行受试者心肌存活力的评估。使用造影剂，并且在等待期之后，使用心脏门控分段反转恢复梯度回收的径向采样技术在心脏周期的大部分时间上获取NMR数据。通过交织径向采样图案，可以在可能的TI间隔的范围内重建图像，使得能够追溯地选择用于最大对比度的最佳TI。

4. 发明授权

US06896873B2 MR signal-emitting coatings 有权
标题翻译： MR信号发射涂层
公开(公告)号：US06896873B2
公开(公告)日：2005-05-24
申请号：US10096368
申请日：2002-03-12
申请人： Richard Frayne , Charles M. Strother , Orhan Unal , Zhihao Yang , Abukar Wehelie , Hyuk Yu
发明人： Richard Frayne , Charles M. Strother , Orhan Unal , Zhihao Yang , Abukar Wehelie , Hyuk Yu
IPC分类号： A61B5/055 , A61K49/08 , A61L29/18 , A61L31/18
CPC分类号： A61K49/12 , A61K49/085 , A61K49/18 , A61L29/18 , A61L31/18
摘要： The present invention provides a coating that emits magnetic resonance signals and a method for coating medical devices therewith. The coating includes a paramagnetic metal ion-containing polymer complex that facilitates diagnostic and therapeutic techniques by readily visualizing medical devices coated with the complex.
摘要翻译：本发明提供了发射磁共振信号的涂层和用于涂覆医疗装置的方法。该涂层包括含顺磁金属离子的聚合物复合物，其通过容易地观察涂覆有复合物的医疗装置来促进诊断和治疗技术。

5. 发明授权

US08457712B2 Multi-mode medical device system and methods of manufacturing and using same 有权
标题翻译：多模式医疗器械系统及其制造和使用方法
公开(公告)号：US08457712B2
公开(公告)日：2013-06-04
申请号：US11322451
申请日：2005-12-30
申请人： Orhan Unal , Krishna N. Kurpad
发明人： Orhan Unal , Krishna N. Kurpad
IPC分类号： A61B5/05
CPC分类号： G01R33/286 , A61B5/055 , A61B5/06
摘要： A multi-mode medical device system and method of performing an interventional procedure. The multi-mode medical device system can be capable of MR internal imaging and of being tracked using an MRI system. The multi-mode medical device system can include a medical device, and an electrical circuit coupled to the medical device and electrically coupled to the MRI system. The electrical circuit can include a tracking device configured to transmit a signal to the MRI system indicative of the position of the tracking device relative to a roadmap image, and an imaging device electrically coupled to the tracking device and configured to internally image anatomical structures from the point of view of the medical device. The imaging device can be further configured to be visualized using MR imaging. Tracking the tracking device and internally imaging with the imaging device can be performed in a single pass of the multi-mode medical device system.
摘要翻译：一种执行介入手术的多模式医疗装置系统和方法。多模式医疗设备系统能够进行MR内部成像并使用MRI系统进行跟踪。多模式医疗设备系统可以包括医疗设备和耦合到医疗设备并电耦合到MRI系统的电路。电路可以包括跟踪装置，其被配置为向MRI系统发送指示跟踪装置相对于路线图图像的位置的信号;以及成像装置，电耦合到跟踪装置，并且被配置为从医疗器械的观点。成像装置可以进一步被配置为使用MR成像可视化。使用成像装置跟踪跟踪装置和内部成像可以在多模式医疗装置系统的单程中进行。

6. 发明申请

US20080114235A1 System and method for simultaneous 3DPR device tracking and imaging under MR-guidance for therapeutic endovascular interventions 有权
标题翻译：用于治疗性血管内介入治疗的MR指导下同步3DPR设备跟踪和成像的系统和方法
公开(公告)号：US20080114235A1
公开(公告)日：2008-05-15
申请号：US11714018
申请日：2007-03-05
申请人： Orhan Unal , Ethan K. Brodsky , Krishna N. Kurpad
发明人： Orhan Unal , Ethan K. Brodsky , Krishna N. Kurpad
IPC分类号： A61B5/055
CPC分类号： G01R33/286 , G01R33/287 , G01R33/34084 , G01R33/4824 , G01R33/561
摘要： A system and method of both tracking a medical device and generating an image in real time from the same set of radial data. A multi-mode medical device system having tracking, imaging, and visualizing capabilities is coupled to an MR scanner and multiple-echo VIPR acquisition sequence is applied to simultaneously provide conventional real-time imaging of the target region using an external coil, 3D tip-tracking information, and a localized higher-quality image showing the region surrounding the medical device using an internal multi-mode coil.
摘要翻译：一种跟踪医疗设备并从同一组径向数据实时生成图像的系统和方法。具有跟踪，成像和可视化能力的多模式医疗装置系统被耦合到MR扫描仪，并且应用多回波VIPR采集序列以使用外部线圈，3D尖端 - 跟踪信息和使用内部多模式线圈显示医疗设备周围区域的本地化的更高质量的图像。

7. 发明申请

US20070167726A1 Multi-mode medical device system and methods of manufacturing and using same 有权
标题翻译：多模式医疗器械系统及其制造和使用方法
公开(公告)号：US20070167726A1
公开(公告)日：2007-07-19
申请号：US11322451
申请日：2005-12-30
申请人： Orhan Unal , Krishna Kurpad
发明人： Orhan Unal , Krishna Kurpad
IPC分类号： A61B5/05
CPC分类号： G01R33/286 , A61B5/055 , A61B5/06
摘要： A multi-mode medical device system and method of performing an interventional procedure. The multi-mode medical device system can be capable of MR internal imaging and of being tracked using an MRI system. The multi-mode medical device system can include a medical device, and an electrical circuit coupled to the medical device and electrically coupled to the MRI system. The electrical circuit can include a tracking device configured to transmit a signal to the MRI system indicative of the position of the tracking device relative to a roadmap image, and an imaging device electrically coupled to the tracking device and configured to internally image anatomical structures from the point of view of the medical device. The imaging device can be further configured to be visualized using MR imaging. Tracking the tracking device and internally imaging with the imaging device can be performed in a single pass of the multi-mode medical device system.
摘要翻译：一种执行介入手术的多模式医疗装置系统和方法。多模式医疗设备系统能够进行MR内部成像并使用MRI系统进行追踪。多模式医疗设备系统可以包括医疗设备和耦合到医疗设备并电耦合到MRI系统的电路。电路可以包括跟踪装置，其被配置为向MRI系统发送指示跟踪装置相对于路线图图像的位置的信号;以及成像装置，电耦合到跟踪装置，并且被配置为从医疗器械的观点。成像装置可以进一步被配置为使用MR成像可视化。使用成像装置跟踪跟踪装置和内部成像可以在多模式医疗装置系统的单程中进行。

8. 发明授权

US06896874B2 MR-signal emitting coatings 有权
标题翻译： MR信号发射涂层
公开(公告)号：US06896874B2
公开(公告)日：2005-05-24
申请号：US10142363
申请日：2002-05-09
申请人： Junwei Li , Orhan Unal , Xiqun Jiang , Charles Milton Strother , Hyuk Yu
发明人： Junwei Li , Orhan Unal , Xiqun Jiang , Charles Milton Strother , Hyuk Yu
IPC分类号： A61B5/055 , A61K49/08 , A61K49/18 , A61L29/00 , A61L29/18 , A61L31/00 , A61L31/18 , A61M25/00 , G01R33/28
CPC分类号： A61K49/085 , A61K49/128 , A61K49/1803 , A61L29/085 , A61L29/18 , A61L31/10 , A61L31/18 , G01R33/285
摘要： The present invention provides a coating that emits magnetic resonance signals and a method for coating medical devices therewith. The coating includes a paramagnetic metal ion-containing polymer complex that facilitates diagnostic and therapeutic techniques by readily visualizing medical devices coated with the complex. The present invention also provides methods by which pre-existing polymers and medical devices may be made MR-imageable. The invention also provides methods of improving MR-imageability of polymers and medical devices by encapsulating the polymers and medical devices with hydrogels.
摘要翻译：本发明提供了发射磁共振信号的涂层和用于涂覆医疗装置的方法。该涂层包括含顺磁金属离子的聚合物复合物，其通过容易地观察涂覆有复合物的医疗装置来促进诊断和治疗技术。本发明还提供可以将预先存在的聚合物和医疗装置制成可MR成像的方法。本发明还提供了通过用水凝胶包封聚合物和医疗装置来改善聚合物和医疗装置的MR-可塑性的方法。

9. 发明授权

US08412306B2 Voltage standing wave suppression for MR-guided therapeutic interventions 有权
标题翻译： MR指导治疗干预的电压驻波抑制
公开(公告)号：US08412306B2
公开(公告)日：2013-04-02
申请号：US11728874
申请日：2007-03-27
申请人： Krishna N. Kurpad , Orhan Unal
发明人： Krishna N. Kurpad , Orhan Unal
IPC分类号： A61B5/05
CPC分类号： G01R33/34053 , A61B5/06 , A61B34/20 , A61B90/36 , A61B2034/2051 , A61B2090/374 , A61B2090/3954 , G01R33/286 , G01R33/287 , G01R33/34084 , G01R33/3657 , G01R33/3685
摘要： A system and method of tracking a medical device and generating an image of a target area. The medical device includes a tracking device to create an imaging field-of-view that extends beyond the tip of the medical device while allowing the tip of the medical device to be visualized. The medical device further includes an imaging/visualization device to create an imaging field from the point of view of the medical device. A voltage standing wave suppression device is formed on the exterior surface of the medical device to prevent the formation of voltage standing waves and localized tissue heating. The voltage standing wave suppression device includes two cable traps spaced apart from one another with each cable trap being formed of a closely packed coiled region of a conductor extending the length of the medical device.
摘要翻译：一种跟踪医疗装置并产生目标区域的图像的系统和方法。该医疗装置包括跟踪装置，用于产生延伸超过医疗装置的尖端的成像视场，同时允许医疗装置的尖端可视化。医疗装置还包括成像/可视化装置，用于从医疗装置的角度创建成像场。在医疗装置的外表面上形成电压驻波抑制装置，以防止电压驻波和局部组织加热的形成。电压驻波抑制装置包括彼此间隔开的两个电缆陷阱，每个电缆陷阱由延伸医疗装置的长度的导体的密集卷绕区域形成。

10. 发明申请

US20080208031A1 Voltage standing wave suppression for MR-guided therapeutic interventions 有权
标题翻译： MR指导治疗干预的电压驻波抑制
公开(公告)号：US20080208031A1
公开(公告)日：2008-08-28
申请号：US11728874
申请日：2007-03-27
申请人： Krishna N. Kurpad , Orhan Unal
发明人： Krishna N. Kurpad , Orhan Unal
IPC分类号： A61B5/055
CPC分类号： G01R33/34053 , A61B5/06 , A61B34/20 , A61B90/36 , A61B2034/2051 , A61B2090/374 , A61B2090/3954 , G01R33/286 , G01R33/287 , G01R33/34084 , G01R33/3657 , G01R33/3685
摘要： A system and method of tracking a medical device and generating an image of a target area. The medical device includes a tracking device to create an imaging field-of-view that extends beyond the tip of the medical device while allowing the tip of the medical device to be visualized. The medical device further includes an imaging/visualization device to create an imaging field from the point of view of the medical device. A voltage standing wave suppression device is formed on the exterior surface of the medical device to prevent the formation of voltage standing waves and localized tissue heating. The voltage standing wave suppression device includes two cable traps spaced apart from one another with each cable trap being formed of a closely packed coiled region of a conductor extending the length of the medical device.
摘要翻译：一种跟踪医疗装置并产生目标区域的图像的系统和方法。该医疗装置包括跟踪装置，用于产生延伸超过医疗装置的尖端的成像视场，同时允许医疗装置的尖端可视化。医疗装置还包括成像/可视化装置，用于从医疗装置的角度创建成像场。在医疗装置的外表面上形成电压驻波抑制装置，以防止电压驻波和局部组织加热的形成。电压驻波抑制装置包括彼此间隔开的两个电缆陷阱，每个电缆陷阱由延伸医疗装置的长度的导体的密集卷绕区域形成。

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