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1. 发明授权

US06949242B2 Retroviral vector for the transfer and expression of genes for therapeutic purposes in eukaryotic cells 失效
标题翻译：用于在真核细胞中用于治疗目的的基因的转移和表达的逆转录病毒载体
公开(公告)号：US06949242B2
公开(公告)日：2005-09-27
申请号：US09970597
申请日：2001-10-04
申请人： Odile Cohen-Haguenauer
发明人： Odile Cohen-Haguenauer
IPC分类号： C12N15/09 , A61K31/70 , A61K31/7088 , A61K48/00 , C07H21/04 , C12N5/10 , C12N15/867 , C12N15/63
CPC分类号： C12N15/86 , C12N2740/13043 , C12N2830/32 , C12N2830/85 , C12N2840/203 , C12N2840/206 , C12N2840/44
摘要： The invention relates to a recombinant vector for the cloning and/or expression and/or transfer of an exogenous nucleotide sequence characterized in that it consists of any sequence contained in the ClaI-PvuII fragment comprising nucleotides 7702 to 1527 (SEQ ID NO: 11) of the sequence given in FIGS. 1A-1D and comprising the LTR sequence included between nucleotides 7842 and 144, the PBS site starting at nucleotides 145, the packaging sequence included in the sequences of 250 nucleotides following the end of the LTR sequence, the said sequence being capable of controlling the cloning and/or expression and/or transfer at the exogenous sequence whatever its transcriptional orientation with respect to the transcriptional orientation of the virus. It relates to the use of this vector for the transfer and/or cloning and/or expression of genes, in particular in the context of gene therapy.
摘要翻译：本发明涉及用于克隆和/或表达和/或转移外源核苷酸序列的重组载体，其特征在于其由包含核苷酸7702至1527（SEQ ID NO：11）的ClaI-PvuII片段中包含的任何序列组成，的序列。 1A-1D并且包含核苷酸7842和144之间的LTR序列，从核苷酸145开始的PBS位点，包含在LTR序列结束后的250个核苷酸的序列中的包装序列，所述序列能够控制克隆和/或表达和/或在外源序列上转移，无论其关于病毒的转录取向的转录取向如何。它涉及使用该载体用于转移和/或克隆和/或表达基因，特别是在基因治疗的背景下。

2. 发明授权

US08828718B2 Gene transfer vectors comprising genetic insulator elements and methods to identify genetic insulator elements 有权
标题翻译：包含遗传绝缘子元件的基因转移载体和识别遗传绝缘子元件的方法
公开(公告)号：US08828718B2
公开(公告)日：2014-09-09
申请号：US13262696
申请日：2010-04-02
申请人： Odile Cohen-Haguenauer , Christian Auclair
发明人： Odile Cohen-Haguenauer , Christian Auclair
IPC分类号： C12N15/00 , C12N5/071
CPC分类号： C12N15/86 , A61K48/00 , C12N2740/13043 , C12N2740/15043 , C12N2830/40
摘要： The present invention relates to a gene transfer vector (GTV) and in particular to an integrating gene transfer vector (IGTV), which comprises at least one genetic insulator element (GIE), wherein the each comprises at least two copies of an element selected from the group consisting of: a CTF binding site; a first CTCF binding site and a second CTCF binding site, wherein the first and the second CTCF binding sites are derived from the regulatory sequences of different genes.
摘要翻译：本发明涉及基因转移载体（GTV），特别涉及包含至少一个遗传绝缘子元件（GIE）的整合基因转移载体（IGTV），其中每个包含选自以下的元件的至少两个拷贝：该组由以下组成：CTF结合位点; 第一CTCF结合位点和第二CTCF结合位点，其中第一和第二CTCF结合位点来源于不同基因的调控序列。

3. 发明授权

US06312948B1 Retroviral vector for the transfer and expression of genes for therapeutic purposes in eukaryotic cells 失效
标题翻译：用于在真核细胞中用于治疗目的的基因的转移和表达的逆转录病毒载体
公开(公告)号：US06312948B1
公开(公告)日：2001-11-06
申请号：US09433322
申请日：1999-11-03
申请人： Odile Cohen-Haguenauer
发明人： Odile Cohen-Haguenauer
IPC分类号： C12N1563
CPC分类号： C12N15/86 , C12N2740/13043 , C12N2830/32 , C12N2830/85 , C12N2840/203 , C12N2840/206 , C12N2840/44
摘要： The invention relates to a recombinantvector for the cloning and/or expression and/or transfer of an exogenous nucleotide sequence characterized in that it consists of any sequence contained in the ClaI—PvuII fragment comprising nucleotides 7702 to 1527 of the sequence given in FIG. 1 and comprising the LTR sequence included between nucleotides 7842 and 144, the PBS site starting at nucleotides 145, the packaging sequence included in the sequences of 250 nucleotides following the end of the LTR sequence, the said sequence being capable of controlling the cloning and/or expression and/or transfer of the exogenous sequence whatever its transcriptional orientation with respect to the transcriptional orientation of the virus. It relates to the use of this vector for the transfer and/or cloning and/or expression of genes, in particular in the contest of gene therapy.
摘要翻译：本发明涉及用于克隆和/或表达和/或转移外源核苷酸序列的重组载体，其特征在于其由包含在图1中给出的序列的核苷酸7702至1527的ClaI-PvuII片段中包含的任何序列组成。 1，并且包含核苷酸7842和144之间的LTR序列，从核苷酸145开始的PBS位点，包含在LTR序列结束后的250个核苷酸的序列中的包装序列，所述序列能够控制克隆和/ 或外源序列的表达和/或转移，无论其关于病毒的转录取向的转录方向如何。它涉及该载体用于转移和/或克隆和/或表达基因，特别是在基因治疗比赛

4. 发明申请

US20120115227A1 GENE TRANSFER VECTORS COMPRISING GENETIC INSULATOR ELEMENTS AND METHODS TO IDENTIFY GENETIC INSULATOR ELEMENTS 有权
标题翻译：包含遗传绝缘子元件的基因转移载体和识别遗传绝缘子元件的方法
公开(公告)号：US20120115227A1
公开(公告)日：2012-05-10
申请号：US13262696
申请日：2010-04-02
申请人： Odile Cohen-Haguenauer , Christian Auclair
发明人： Odile Cohen-Haguenauer , Christian Auclair
IPC分类号： C12N15/85 , C12N5/10
CPC分类号： C12N15/86 , A61K48/00 , C12N2740/13043 , C12N2740/15043 , C12N2830/40
摘要： The present invention relates to a gene transfer vector (GTV) and in particular to an integrating gene transfer vector (IGTV), which comprises at least one genetic insulator element (GIE), wherein the each comprises at least two copies of an element selected from the group consisting of: a CTF binding site; a first CTCF binding site and a second CTCF binding site, wherein the first and the second CTCF binding sites are derived from the regulatory sequences of different genes.
摘要翻译：本发明涉及基因转移载体（GTV），特别涉及包含至少一个遗传绝缘子元件（GIE）的整合基因转移载体（IGTV），其中每个包含选自以下的元件的至少两个拷贝：该组由以下组成：CTF结合位点; 第一CTCF结合位点和第二CTCF结合位点，其中第一和第二CTCF结合位点来源于不同基因的调控序列。

5. 发明授权

US06432709B1 Encapsidation cell lines and expression vectors for transcomplementation of defective retroviral vectors 失效
标题翻译：封闭细胞系和表达载体用于有缺陷的逆转录病毒载体的反式互补
公开(公告)号：US06432709B1
公开(公告)日：2002-08-13
申请号：US08564989
申请日：1995-11-30
申请人： Odile Cohen-Haguenauer
发明人： Odile Cohen-Haguenauer
IPC分类号： C12N510
CPC分类号： C12N15/86 , A61K48/00 , C07K14/005 , C12N2740/17022 , C12N2740/17052
摘要： The present invention relates to novel cell lines, so-called transcomplementation cell lines, which enable the packaging of recombinant retroviral RNAs carrying nucleotide sequences of interest. The present invention aims at transferring and expressing these sequences in eucaryotic target cells. The invention also related to expression vectors for the transcomplementation of defective retroviral vectors.
摘要翻译：本发明涉及新型细胞系，即所谓的反式互补细胞系，其能够包装携带感兴趣的核苷酸序列的重组逆转录病毒RNA。本发明的目的是在真核靶细胞中转移和表达这些序列。本发明还涉及用于有缺陷的逆转录病毒载体的反式实现的表达载体。

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