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1. 发明授权

US09018214B2 Bicyclic heterocycle compounds and their uses in therapy 有权
标题翻译：双环杂环化合物及其在治疗中的应用
公开(公告)号：US09018214B2
公开(公告)日：2015-04-28
申请号：US14112597
申请日：2012-04-20
申请人： Alison Jo-Anne Woolford , Steven Howard , Ildiko Maria Buck , Gianni Chessari , Christopher Norbert Johnson , Emiliano Tamanini , James Edward Harvey Day , Elisabetta Chiarparin , Thomas Daniel Heightman , Martyn Frederickson , Charlotte Mary Griffiths-Jones
发明人： Alison Jo-Anne Woolford , Steven Howard , Ildiko Maria Buck , Gianni Chessari , Christopher Norbert Johnson , Emiliano Tamanini , James Edward Harvey Day , Elisabetta Chiarparin , Thomas Daniel Heightman , Martyn Frederickson , Charlotte Mary Griffiths-Jones
IPC分类号： A61K31/497 , A61K31/501 , C07D403/04 , C07D419/00 , C07D403/14 , C07D401/06 , C07D471/04 , C07D471/10 , C07D403/06 , C07D487/10
CPC分类号： C07D471/04 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/5025 , A61K31/506 , A61K31/5377 , C07D401/06 , C07D403/06 , C07D403/14 , C07D413/14 , C07D471/10 , C07D487/04 , C07D487/10 , C07D519/00
摘要： The invention relates to bicyclic heterocycle compounds of formula (I): or tautomeric or stereochemically isomeric forms, N-oxides, pharmaceutically acceptable salts or the solvates thereof; wherein R1, R2a, R2b, R3a, R3b, R5, R6, R7, R8, R9, p and E are as defined herein; to pharmaceutical compositions comprising said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
摘要翻译：本发明涉及式（I）的双环杂环化合物：或互变异构体或立体化学异构形式，N-氧化物，药学上可接受的盐或其溶剂合物; 其中R1，R2a，R2b，R3a，R3b，R5，R6，R7，R8，R9，p和E如本文所定义; 包含所述化合物的药物组合物和所述化合物在治疗疾病中的用途。癌症。

2. 发明申请

US20110237792A1 QUINOLINE DERIVATIVES AND THEIR USE AS 5-HT6 LIGANDS 有权
标题翻译：喹啉衍生物及其作为5-HT6配体使用
公开(公告)号：US20110237792A1
公开(公告)日：2011-09-29
申请号：US13152356
申请日：2011-06-03
申请人： Mahmood AHMED , Christopher Norbert Johnson , Martin C. Johnes , Gregor James MacDonald , Stephen Frederick Moss , Mervyn Thompson , Charles Edward Wade , David R. Witty
发明人： Mahmood AHMED , Christopher Norbert Johnson , Martin C. Johnes , Gregor James MacDonald , Stephen Frederick Moss , Mervyn Thompson , Charles Edward Wade , David R. Witty
IPC分类号： C07D403/10 , C07D401/10 , C07D487/04
CPC分类号： C07D487/04 , C07D215/00 , C07D487/08
摘要： Disclosed are quinoline compounds having affinity for the 5-HT6 receptor and having the formula: where R1, R2, R3, R4, R5, n, m, p and A are defined herein, and salts thereof, compositions containing these compounds and salts and processes for making and using the same.
摘要翻译：公开了对5-HT 6受体具有亲和性并具有下式的喹啉化合物：其中R1，R2，R3，R4，R5，n，m，p和A如本文所定义，及其盐，含有这些化合物和盐的组合物制作和使用相同的过程。

3. 发明授权

US07928125B2 N-aroyl cyclic amine derivatives as orexin receptor antagonists 失效
标题翻译： N-芳酰基环胺衍生物作为食欲素受体拮抗剂
公开(公告)号：US07928125B2
公开(公告)日：2011-04-19
申请号：US11926409
申请日：2007-10-29
申请人： Clive Leslie Branch , Wai Ngor Chan , Amanda Johns , Christopher Norbert Johnson , David John Nash , Riccardo Novelli , Jean-Pierre Pilleux , Roderick Alan Porter , Rachel Elizabeth Anne Stead , Geoffrey Stemp
发明人： Clive Leslie Branch , Wai Ngor Chan , Amanda Johns , Christopher Norbert Johnson , David John Nash , Riccardo Novelli , Jean-Pierre Pilleux , Roderick Alan Porter , Rachel Elizabeth Anne Stead , Geoffrey Stemp
IPC分类号： A61K31/454 , A61K31/4525 , C07D401/14
CPC分类号： C07D417/14 , C07D401/06 , C07D401/14 , C07D403/14 , C07D405/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/04 , C07D471/04 , C07D491/04
摘要： Disclosed are N-aroyl cyclic amine derivatives having the formula: where the variables are as define herein, and their use as pharmaceuticals, specifically as orexin receptor antagonists.
摘要翻译：公开了具有下式的N-芳酰基环胺衍生物：其中变量如本文所定义，以及它们作为药物的用途，特别是作为食欲素受体拮抗剂。

4. 发明申请

US20100305107A1 QUINOLINE DERIVATIVES AND THEIR USE AS 5-HT6 LIGANDS 有权
标题翻译：喹啉衍生物及其作为5-HT6配体使用
公开(公告)号：US20100305107A1
公开(公告)日：2010-12-02
申请号：US12847039
申请日：2010-07-30
申请人： Mahmood AHMED , Christopher Norbert Johnson , Martin C. Jones , Gregor James MacDonald , Stephen Frederick Moss , Mervyn Thompson , Charles Edward Wade , David R. Witty
发明人： Mahmood AHMED , Christopher Norbert Johnson , Martin C. Jones , Gregor James MacDonald , Stephen Frederick Moss , Mervyn Thompson , Charles Edward Wade , David R. Witty
IPC分类号： A61K31/4709 , A61K31/496 , A61K31/551 , A61K31/4985 , A61P25/00 , A61P25/06 , A61P25/16 , A61P25/24 , A61P25/30
CPC分类号： C07D487/04 , C07D215/00 , C07D487/08
摘要： Disclosed are quinoline compounds having affinity for the 5-HT6 receptor and having the formula: where R1, R2, R3, R4, R5, n, m, p and A are defined herein, and salts thereof, compositions containing these compounds and salts and processes for making and using the same.
摘要翻译：公开了对5-HT 6受体具有亲和性并具有下式的喹啉化合物：其中R1，R2，R3，R4，R5，n，m，p和A如本文所定义，及其盐，含有这些化合物和盐的组合物制作和使用相同的过程。

5. 发明申请

US20100273770A1 1, 2, 4 -OXADIAZOLE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASES 审中-公开
标题翻译： 1，2，4 - 用于治疗自身免疫性疾病的奥多唑类化合物
公开(公告)号：US20100273770A1
公开(公告)日：2010-10-28
申请号：US12747198
申请日：2008-12-19
申请人： Jag Paul Heer , Thomas Daniel Heightman , David Nigel Hurst , Christopher Norbert Johnson , John Skidmore , Ian David Wall
发明人： Jag Paul Heer , Thomas Daniel Heightman , David Nigel Hurst , Christopher Norbert Johnson , John Skidmore , Ian David Wall
IPC分类号： A61K31/55 , C07D413/10 , C07D413/14 , A61K31/553
CPC分类号： C07D413/04 , C07D413/14
摘要： The present invention relates to novel oxadiazole derivatives having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.
摘要翻译：本发明涉及具有药理活性的新型恶二唑衍生物，其制备方法，含有它们的药物组合物及其在治疗各种病症中的用途。

6. 发明授权

US07799774B2 Quinoline derivatives and their use as 5-HT6 ligands 有权
标题翻译：喹啉衍生物及其作为5-HT6配体的用途
公开(公告)号：US07799774B2
公开(公告)日：2010-09-21
申请号：US12541456
申请日：2009-08-14
申请人： Mahmood Ahmed , Christopher Norbert Johnson , Martin C Jones , Gregor James MacDonald , Stephen Frederick Moss , Mervyn Thompson , Charles Edward Wade , David R Witty
发明人： Mahmood Ahmed , Christopher Norbert Johnson , Martin C Jones , Gregor James MacDonald , Stephen Frederick Moss , Mervyn Thompson , Charles Edward Wade , David R Witty
IPC分类号： A61K31/496 , A61K31/47 , C07D215/40 , C07D471/04 , C07D487/08
CPC分类号： C07D487/04 , C07D215/00 , C07D487/08
摘要： Disclosed are quinoline compounds having affinity for the 5-HT6 receptor and having the formula: where R1, R2, R3, R4, R5, n, m, p and A are defined herein, and salts thereof, compositions containing these compounds and salts and processes for making and using the same.
摘要翻译：公开了对5-HT 6受体具有亲和性并具有下式的喹啉化合物：其中R1，R2，R3，R4，R5，n，m，p和A如本文所定义，及其盐，含有这些化合物和盐的组合物制作和使用相同的过程。

7. 发明申请

US20100174065A1 COMPOUNDS 审中-公开
公开(公告)号：US20100174065A1
公开(公告)日：2010-07-08
申请号：US12360886
申请日：2009-01-28
申请人： Jag Paul HEER , Thomas Daniel HEIGHTMAN , David Nigel HURST , Christopher Norbert JOHNSON , John SKIDMORE , Ian David WALL
发明人： Jag Paul HEER , Thomas Daniel HEIGHTMAN , David Nigel HURST , Christopher Norbert JOHNSON , John SKIDMORE , Ian David WALL
IPC分类号： C07D413/10
CPC分类号： C07D223/16 , C07D267/14 , C07D271/06 , C07D413/04 , C07D413/14
摘要： The present invention relates to novel oxadiazole derivatives having pharmacological activity, processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of various disorders.

8. 发明申请

US20100142671A1 SYSTEMS AND METHODS FOR IMAGING LARGE FIELD-OF-VIEW OBJECTS 有权
标题翻译：用于成像大型现场视觉对象的系统和方法
公开(公告)号：US20100142671A1
公开(公告)日：2010-06-10
申请号：US12684430
申请日：2010-01-08
申请人： Eugene A. Gregerson , Richard K. Grant , Norbert Johnson
发明人： Eugene A. Gregerson , Richard K. Grant , Norbert Johnson
IPC分类号： H05G1/60 , H05G1/02
CPC分类号： A61B6/4452 , A61B6/032 , A61B6/06 , A61B6/4021 , A61B6/4085 , A61B6/4233 , A61B6/4405 , G01N23/043 , G01N23/046 , G01N2223/419
摘要： An imaging apparatus and related method comprising a detector located a distance from a source and positioned to receive a beam of radiation in a trajectory; a detector positioner that translates the detector to an alternate position in a direction that is substantially normal to the trajectory; and a beam positioner that alters the trajectory of the radiation beam to direct the beam onto the detector located at the alternate position.
摘要翻译：一种成像设备和相关方法，包括位于距离源一定距离并被定位成接收轨迹中的辐射束的检测器; 检测器定位器，其将检测器在基本上垂直于轨迹的方向上平移到交替位置; 以及光束定位器，其改变辐射束的轨迹以将光束引导到位于交替位置的检测器上。

9. 发明授权

US07661881B2 Systems and methods for imaging large field-of-view objects 有权
标题翻译：用于对大型视野对象进行成像的系统和方法
公开(公告)号：US07661881B2
公开(公告)日：2010-02-16
申请号：US11522794
申请日：2006-09-18
申请人： Eugene A. Gregerson , Richard K. Grant , Norbert Johnson
发明人： Eugene A. Gregerson , Richard K. Grant , Norbert Johnson
IPC分类号： H05G1/04
CPC分类号： A61B6/4452 , A61B6/032 , A61B6/06 , A61B6/4021 , A61B6/4085 , A61B6/4233 , A61B6/4405 , G01N23/043 , G01N23/046 , G01N2223/419
摘要： An imaging apparatus and related method comprising a source that projects a beam of radiation in a first trajectory; a detector located a distance from the source and positioned to receive the beam of radiation in the first trajectory; an imaging area between the source and the detector, the radiation beam from the source passing through a portion of the imaging area before it is received at the detector; a detector positioner that translates the detector to a second position in a first direction that is substantially normal to the first trajectory; and a beam positioner that alters the trajectory of the radiation beam to direct the beam onto the detector located at the second position. The radiation source can be an x-ray cone-beam source, and the detector can be a two-dimensional flat-panel detector array. The invention can be used to image objects larger than the field-of-view of the detector by translating the detector array to multiple positions, and obtaining images at each position, resulting in an effectively large field-of-view using only a single detector array having a relatively small size. A beam positioner permits the trajectory of the beam to follow the path of the translating detector, which permits safer and more efficient dose utilization, as generally only the region of the target object that is within the field-of-view of the detector at any given time will be exposed to potentially harmful radiation.
摘要翻译：一种成像装置和相关方法，包括：在第一轨迹中投影辐射束的源; 位于距离源一定距离并被定位成接收第一轨迹中的辐射束的检测器; 在源和检测器之间的成像区域，来自源的辐射束在被检测器接收之前通过成像区域的一部分; 检测器定位器，其将检测器平移到基本上垂直于第一轨迹的第一方向上的第二位置; 以及光束定位器，其改变辐射束的轨迹以将光束引导到位于第二位置的检测器上。辐射源可以是X射线锥束源，并且检测器可以是二维平板检测器阵列。本发明可以用于通过将检测器阵列转换为多个位置来对检测器的视野进行成像，并且在每个位置获得图像，从而产生仅使用单个检测器的有效的大的视场阵列具有相对较小的尺寸。光束定位器允许光束的轨迹遵循平移检测器的路径，其允许更安全和更有效的剂量利用，因为通常仅在目标物体的位于检测器的视野内的区域处于任何给定的时间会暴露在潜在的有害辐射之下。

10. 发明申请

US20080167377A1 Novel compounds 审中-公开
标题翻译：新型化合物
公开(公告)号：US20080167377A1
公开(公告)日：2008-07-10
申请号：US11954815
申请日：2007-12-12
申请人： Alessandra Gaiba , Mark Patrick Healy , Christopher Norbert Johnson , Susan Roomans , Steven James Stanway , Martin Edward Swarbrick
发明人： Alessandra Gaiba , Mark Patrick Healy , Christopher Norbert Johnson , Susan Roomans , Steven James Stanway , Martin Edward Swarbrick
IPC分类号： A61K31/195 , C07C229/42 , A61P29/00
CPC分类号： C07C235/56
摘要： A compound of formula (I) or a pharmaceutically acceptable derivative thereof, wherein, R1, R2, R3, R4, R5, m, n and X are as defined in the specification; a process for preparing such compounds; a pharmaceutical composition comprising such compounds; and the use of such compounds in medicine.
摘要翻译：式（I）化合物或其药学上可接受的衍生物，其中R 1，R 2，R 3，R 3， 4，R 5，m，n和X如说明书中所定义; 制备这种化合物的方法; 包含这些化合物的药物组合物; 并在药物中使用这些化合物。

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