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1. 发明授权

US08961985B2 Immunotherapy against several tumors including neuronal and brain tumors 有权
标题翻译：免疫治疗几种肿瘤，包括神经元和脑肿瘤
公开(公告)号：US08961985B2
公开(公告)日：2015-02-24
申请号：US13346598
申请日：2012-01-09
申请人： Toni Weinschenk , Oliver Schoor , Claudia Trautwein , Norbert Hilf , Steffan Walter , Harpreet Singh
发明人： Toni Weinschenk , Oliver Schoor , Claudia Trautwein , Norbert Hilf , Steffan Walter , Harpreet Singh
IPC分类号： A61K39/00 , C07K4/12 , C07K7/06 , C07K7/08
CPC分类号： C07K7/06 , A61K35/17 , A61K38/00 , A61K39/0011 , A61K2039/5154 , A61K2039/5158 , A61K2039/53 , A61K2039/55511 , A61K2039/55516 , A61K2039/55522 , A61K2039/55561 , A61K2039/55588 , A61K2039/572 , A61K2039/605 , A61K2039/6081 , A61K2039/6093 , A61M5/002 , C07K7/08 , C07K14/70539 , C07K2319/00 , C07K2319/40 , C12N5/0638 , C12N2501/50 , G01N33/57492 , Y02A50/472
摘要： The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated cytotoxic T cell (CTL) peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses. The present invention relates to 30 peptide sequences and their variants derived from HLA class I and class II molecules of human tumor cells that can be used in vaccine compositions for eliciting anti-tumor immune responses.
摘要翻译：本发明涉及用于免疫治疗方法的肽，核酸和细胞。特别地，本发明涉及癌症的免疫治疗。本发明还涉及肿瘤相关的细胞毒性T细胞（CTL）肽表位，其单独或与作为刺激抗肿瘤免疫应答的疫苗组合物的活性药物成分的其它肿瘤相关肽的组合。本发明涉及可以用于引发抗肿瘤免疫应答的疫苗组合物中的来自人类肿瘤细胞的HLA I类和II类分子的30个肽序列及其变体。

2. 发明授权

US08669230B2 Immunogenic epitopes for immunotherapy 有权
标题翻译：免疫治疗的免疫原性表位
公开(公告)号：US08669230B2
公开(公告)日：2014-03-11
申请号：US12915473
申请日：2010-10-29
申请人： Harpreet Singh , Steffen Walter , Toni Weinschenk , Norbert Hilf , Oliver Schoor , Claudia Lemmel
发明人： Harpreet Singh , Steffen Walter , Toni Weinschenk , Norbert Hilf , Oliver Schoor , Claudia Lemmel
IPC分类号： C07K7/00
CPC分类号： A61K39/0011 , A61K35/17 , A61K2039/5158 , A61K2039/572 , C07K7/06 , C07K7/08 , C07K14/47 , C07K14/4748 , C07K14/495 , C07K14/7051 , C07K16/40 , C07K19/00 , C07K2317/34 , C07K2319/00 , C12N5/0638 , C12N9/0036 , C12N9/13 , C12N2502/1157 , C12Y208/02011
摘要： The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-helper cell peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions which stimulate anti-tumor immune responses. The present invention relates to novel peptide sequences and their variants derived from HLA class I and class II molecules of human tumor cells which can be used in vaccine compositions for eliciting anti-tumor immune responses.
摘要翻译：本发明涉及用于免疫治疗方法的肽，核酸和细胞。特别地，本发明涉及癌症的免疫治疗。本发明还涉及肿瘤相关的T辅助细胞肽表位，其单独或与作为刺激抗肿瘤免疫应答的疫苗组合物的活性药物成分的其它肿瘤相关肽组合。本发明涉及可用于引发抗肿瘤免疫应答的疫苗组合物中的HLA I类和II类分子的新型肽序列及其变体。

3. 发明授权

US08318677B2 Composition of tumor-associated peptides and related anti-cancer vaccine for the treatment of glioblastoma (GBM) and other cancers 有权
标题翻译：用于治疗胶质母细胞瘤（GBM）和其他癌症的肿瘤相关肽和相关抗癌疫苗的组成
公开(公告)号：US08318677B2
公开(公告)日：2012-11-27
申请号：US12571602
申请日：2009-10-01
申请人： Toni Weinschenk , Oliver Schoor , Claudia Trautwein , Norbert Hilf , Steffen Walter , Harpreet Singh
发明人： Toni Weinschenk , Oliver Schoor , Claudia Trautwein , Norbert Hilf , Steffen Walter , Harpreet Singh
IPC分类号： A61K38/00
CPC分类号： C07K7/06 , A61K35/17 , A61K38/00 , A61K39/0011 , A61K2039/5154 , A61K2039/5158 , A61K2039/53 , A61K2039/55511 , A61K2039/55516 , A61K2039/55522 , A61K2039/55561 , A61K2039/55588 , A61K2039/572 , A61K2039/605 , A61K2039/6081 , A61K2039/6093 , A61M5/002 , C07K7/08 , C07K14/70539 , C07K2319/00 , C07K2319/40 , C12N5/0638 , C12N2501/50 , G01N33/57492 , Y02A50/472
摘要： The present invention relates to immunotherapeutic peptides and their use in immunotherapy, in particular the immunotherapy of cancer. The present invention discloses tumor-associated T-helper cell peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions which stimulate anti-tumor immune responses. In particular, the composition of the peptides of the present invention can be used in vaccine compositions for eliciting anti-tumor immune responses against gliomas.
摘要翻译：本发明涉及免疫治疗肽及其在免疫治疗中的用途，特别是癌症的免疫治疗。本发明公开了肿瘤相关的T辅助细胞肽表位，其单独或与作为刺激抗肿瘤免疫应答的疫苗组合物的活性药物成分的其它肿瘤相关肽组合。特别地，本发明的肽的组合物可用于引发针对胶质瘤的抗肿瘤免疫应答的疫苗组合物中。

4. 发明授权

US08080634B2 Immunogenic epitope for immunotherapy 有权
标题翻译：免疫治疗的免疫原性表位
公开(公告)号：US08080634B2
公开(公告)日：2011-12-20
申请号：US12180045
申请日：2008-07-25
申请人： Harpreet Singh , Steffen Walter , Toni Weinschenk , Norbert Hilf , Oliver Schoor , Claudia Lemmel
发明人： Harpreet Singh , Steffen Walter , Toni Weinschenk , Norbert Hilf , Oliver Schoor , Claudia Lemmel
IPC分类号： C07K5/00
CPC分类号： A61K39/0011 , A61K35/17 , A61K2039/5158 , A61K2039/572 , C07K7/06 , C07K7/08 , C07K14/47 , C07K14/4748 , C07K14/495 , C07K14/7051 , C07K16/40 , C07K19/00 , C07K2317/34 , C07K2319/00 , C12N5/0638 , C12N9/0036 , C12N9/13 , C12N2502/1157 , C12Y208/02011
摘要： The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-helper cell peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions which stimulate anti-tumor immune responses. The present invention relates to novel peptide sequences and their variants derived from HLA class I and class II molecules of human tumor cells which can be used in vaccine compositions for eliciting anti-tumor immune responses.
摘要翻译：本发明涉及用于免疫治疗方法的肽，核酸和细胞。特别地，本发明涉及癌症的免疫治疗。本发明还涉及肿瘤相关的T辅助细胞肽表位，其单独或与作为刺激抗肿瘤免疫应答的疫苗组合物的活性药物成分的其它肿瘤相关肽组合。本发明涉及可用于引发抗肿瘤免疫应答的疫苗组合物中的HLA I类和II类分子的新型肽序列及其变体。

5. 发明授权

US07994276B2 Composition of tumour-associated peptides and related anti-cancer vaccine 有权
标题翻译：肿瘤相关肽和相关抗癌疫苗的组成
公开(公告)号：US07994276B2
公开(公告)日：2011-08-09
申请号：US12180113
申请日：2008-07-25
申请人： Harpreet Singh , Steffen Walter , Toni Weinschenk , Norbert Hilf , Oliver Schoor , Claudia Trautwein , Peter Lewandrowski
发明人： Harpreet Singh , Steffen Walter , Toni Weinschenk , Norbert Hilf , Oliver Schoor , Claudia Trautwein , Peter Lewandrowski
IPC分类号： A61K38/00 , A61K38/04 , C07K4/00 , C07K7/00 , C07K14/00 , A61P35/00
CPC分类号： A61K39/0011 , A61K38/193 , A61K45/06 , A61K2039/5158 , A61K2039/53 , A61K2039/572 , C07K14/4748 , A61K2300/00
摘要： The present invention relates to immunotherapeutic peptides and their use in immunotherapy, in particular the immunotherapy of cancer. The present invention discloses tumor-associated T-helper cell peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions which stimulate anti-tumor immune responses. In particular, the composition of the peptides of the present invention can be used in vaccine compositions for eliciting anti-tumor immune responses against colorectal cancer.
摘要翻译：本发明涉及免疫治疗肽及其在免疫治疗中的用途，特别是癌症的免疫治疗。本发明公开了肿瘤相关的T辅助细胞肽表位，其单独或与作为刺激抗肿瘤免疫应答的疫苗组合物的活性药物成分的其它肿瘤相关肽组合。特别地，本发明的肽的组合物可用于引发针对结肠直肠癌的抗肿瘤免疫应答的疫苗组合物中。

6. 发明申请

US20060171988A1 Method of treatment using foams as artificial lymph nodes 审中-公开
标题翻译：使用泡沫作为人造淋巴结的治疗方法
公开(公告)号：US20060171988A1
公开(公告)日：2006-08-03
申请号：US11045596
申请日：2005-01-28
申请人： Norbert Hilf , Juergen Pinocy
发明人： Norbert Hilf , Juergen Pinocy
IPC分类号： A61K39/00 , A61K39/38 , A61F2/00 , A61K38/17
CPC分类号： A61K39/0011 , A61K38/17
摘要： The present invention relates to pharmaceutical compositions for the improved activation of cells of the immune system that comprise a biocompatible implantable and an active pharmaceutical ingredient to be integrated into said foam, wherein said composition specifically activates cells of the immune system. In one preferred embodiment, said active pharmaceutical ingredient is selected from endogenous antigens that are selected from tumor-associated antigens. Said foam material can be implanted into a subject in order to produce the pharmaceutical composition in situ. Preferably, said pharmaceutical composition can be present in the form of an artificial lymph node, wherein said artificial lymph node functions as a reservoir for cells of the immune system. The invention also relates to methods for improved immunotherapy, in particular cancer immunotherapy.
摘要翻译：本发明涉及用于改善免疫系统细胞活化的药物组合物，其包含生物相容的可植入物和将被整合到所述泡沫中的活性药物成分，其中所述组合物特异性地激活免疫系统的细胞。在一个优选的实施方案中，所述活性药物成分选自选自肿瘤相关抗原的内源性抗原。所述泡沫材料可以植入受试者以便原位制备药物组合物。优选地，所述药物组合物可以以人造淋巴结的形式存在，其中所述人造淋巴结用作免疫系统细胞的储库。本发明还涉及用于改善免疫治疗，特别是癌症免疫治疗的方法。

7. 发明申请

US20120141517A1 NOVEL IMMUNOTHERAPY AGAINST SEVERAL TUMORS INCLUDING NEURONAL AND BRAIN TUMORS 有权
标题翻译：对包括神经和脑肿瘤在内的几种肿瘤的新型免疫学
公开(公告)号：US20120141517A1
公开(公告)日：2012-06-07
申请号：US13346598
申请日：2012-01-09
申请人： Toni Weinschenk , Oliver Schoor , Claudia Trautwein , Norbert Hilf , Steffan Walter , Harpreet Singh
发明人： Toni Weinschenk , Oliver Schoor , Claudia Trautwein , Norbert Hilf , Steffan Walter , Harpreet Singh
IPC分类号： A61K39/00 , C07K7/08 , C12N15/12 , A61K35/14 , A61P35/00 , A61P35/02 , C12N15/63 , C12N1/21 , C12P21/06 , C12N5/02 , C12N5/00 , C12Q1/68 , G01N33/53 , C12N1/19 , C12N1/15 , C12N5/10 , C07K7/06
CPC分类号： C07K7/06 , A61K35/17 , A61K38/00 , A61K39/0011 , A61K2039/5154 , A61K2039/5158 , A61K2039/53 , A61K2039/55511 , A61K2039/55516 , A61K2039/55522 , A61K2039/55561 , A61K2039/55588 , A61K2039/572 , A61K2039/605 , A61K2039/6081 , A61K2039/6093 , A61M5/002 , C07K7/08 , C07K14/70539 , C07K2319/00 , C07K2319/40 , C12N5/0638 , C12N2501/50 , G01N33/57492 , Y02A50/472
摘要： The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated cytotoxic T cell (CTL) peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses. The present invention relates to 30 peptide sequences and their variants derived from HLA class I and class II molecules of human tumor cells that can be used in vaccine compositions for eliciting anti-tumor immune responses.
摘要翻译：本发明涉及用于免疫治疗方法的肽，核酸和细胞。特别地，本发明涉及癌症的免疫治疗。本发明还涉及肿瘤相关的细胞毒性T细胞（CTL）肽表位，其单独或与作为刺激抗肿瘤免疫应答的疫苗组合物的活性药物成分的其它肿瘤相关肽的组合。本发明涉及可以用于引发抗肿瘤免疫应答的疫苗组合物中的来自人类肿瘤细胞的HLA I类和II类分子的30个肽序列及其变体。

8. 发明授权

US08119139B2 Immunotherapy against several tumors including neuronal and brain tumors 有权
标题翻译：免疫治疗几种肿瘤，包括神经元和脑肿瘤
公开(公告)号：US08119139B2
公开(公告)日：2012-02-21
申请号：US12571776
申请日：2009-10-01
申请人： Toni Weinschenk , Oliver Schoor , Claudia Trautwein , Norbert Hilf , Steffen Walter , Harpreet Singh
发明人： Toni Weinschenk , Oliver Schoor , Claudia Trautwein , Norbert Hilf , Steffen Walter , Harpreet Singh
IPC分类号： A61K39/00 , C07K4/12
CPC分类号： C07K7/06 , A61K35/17 , A61K38/00 , A61K39/0011 , A61K2039/5154 , A61K2039/5158 , A61K2039/53 , A61K2039/55511 , A61K2039/55516 , A61K2039/55522 , A61K2039/55561 , A61K2039/55588 , A61K2039/572 , A61K2039/605 , A61K2039/6081 , A61K2039/6093 , A61M5/002 , C07K7/08 , C07K14/70539 , C07K2319/00 , C07K2319/40 , C12N5/0638 , C12N2501/50 , G01N33/57492 , Y02A50/472
摘要： The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated cytotoxic T cell (CTL) peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses. The present invention relates to 30 peptide sequences and their variants derived from HLA class I and class II molecules of human tumor cells that can be used in vaccine compositions for eliciting anti-tumor immune responses.
摘要翻译：本发明涉及用于免疫治疗方法的肽，核酸和细胞。特别地，本发明涉及癌症的免疫治疗。本发明还涉及肿瘤相关的细胞毒性T细胞（CTL）肽表位，其单独或与作为刺激抗肿瘤免疫应答的疫苗组合物的活性药物成分的其它肿瘤相关肽的组合。本发明涉及可以用于引发抗肿瘤免疫应答的疫苗组合物中的来自人类肿瘤细胞的HLA I类和II类分子的30个肽序列及其变体。

9. 发明申请

US20110002963A1 COMPOSITION OF TUMOR-ASSOCIATED PEPTIDES AND RELATED ANTI-CANCER VACCINE FOR THE TREATMENT OF GLIOBLASTOMA (GBM) AND OTHER CANCERS 有权
标题翻译：肿瘤相关肽和相关抗癌药组合物用于治疗青光眼（GBM）和其他癌症
公开(公告)号：US20110002963A1
公开(公告)日：2011-01-06
申请号：US12571602
申请日：2009-10-01
申请人： Toni WEINSCHENK , Oliver Schoor , Claudia Trautwein , Norbert Hilf , Steffen Walter , Harpreet Singh
发明人： Toni WEINSCHENK , Oliver Schoor , Claudia Trautwein , Norbert Hilf , Steffen Walter , Harpreet Singh
IPC分类号： A61K39/00 , A61K38/08 , A61K38/10 , A61K31/7088 , A61K38/16 , A61K35/12 , A61P35/00
CPC分类号： C07K7/06 , A61K35/17 , A61K38/00 , A61K39/0011 , A61K2039/5154 , A61K2039/5158 , A61K2039/53 , A61K2039/55511 , A61K2039/55516 , A61K2039/55522 , A61K2039/55561 , A61K2039/55588 , A61K2039/572 , A61K2039/605 , A61K2039/6081 , A61K2039/6093 , A61M5/002 , C07K7/08 , C07K14/70539 , C07K2319/00 , C07K2319/40 , C12N5/0638 , C12N2501/50 , G01N33/57492 , Y02A50/472
摘要： The present invention relates to immunotherapeutic peptides and their use in immunotherapy, in particular the immunotherapy of cancer. The present invention discloses tumor-associated T-helper cell peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions which stimulate anti-tumor immune responses. In particular, the composition of the peptides of the present invention can be used in vaccine compositions for eliciting anti-tumor immune responses against gliomas.
摘要翻译：本发明涉及免疫治疗肽及其在免疫治疗中的用途，特别是癌症的免疫治疗。本发明公开了肿瘤相关的T辅助细胞肽表位，其单独或与作为刺激抗肿瘤免疫应答的疫苗组合物的活性药物成分的其它肿瘤相关肽组合。特别地，本发明的肽的组合物可用于引发针对胶质瘤的抗肿瘤免疫应答的疫苗组合物中。

10. 发明申请

US20100158931A1 NOVEL IMMUNOTHERAPY AGAINST SEVERAL TUMORS INCLUDING NEURONAL AND BRAIN TUMORS 有权
标题翻译：对包括神经和脑肿瘤在内的几种肿瘤的新型免疫学
公开(公告)号：US20100158931A1
公开(公告)日：2010-06-24
申请号：US12571776
申请日：2009-10-01
申请人： Toni Weinschenk , Oliver Schoor , Claudia Trautwein , Norbert Hilf , Steffen Walter , Harpreet Singh
发明人： Toni Weinschenk , Oliver Schoor , Claudia Trautwein , Norbert Hilf , Steffen Walter , Harpreet Singh
IPC分类号： A61K39/00 , C07K7/06 , C07K7/08 , C07H21/04 , A61K38/08 , A61K38/10 , C12N5/00 , C12P21/06 , C12N5/02 , A61K35/26 , A61K31/7088 , C12Q1/02
CPC分类号： C07K7/06 , A61K35/17 , A61K38/00 , A61K39/0011 , A61K2039/5154 , A61K2039/5158 , A61K2039/53 , A61K2039/55511 , A61K2039/55516 , A61K2039/55522 , A61K2039/55561 , A61K2039/55588 , A61K2039/572 , A61K2039/605 , A61K2039/6081 , A61K2039/6093 , A61M5/002 , C07K7/08 , C07K14/70539 , C07K2319/00 , C07K2319/40 , C12N5/0638 , C12N2501/50 , G01N33/57492 , Y02A50/472
摘要： The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated cytotoxic T cell (CTL) peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses. The present invention relates to 30 peptide sequences and their variants derived from HLA class I and class II molecules of human tumor cells that can be used in vaccine compositions for eliciting anti-tumor immune responses.
摘要翻译：本发明涉及用于免疫治疗方法的肽，核酸和细胞。特别地，本发明涉及癌症的免疫治疗。本发明还涉及肿瘤相关的细胞毒性T细胞（CTL）肽表位，其单独或与作为刺激抗肿瘤免疫应答的疫苗组合物的活性药物成分的其它肿瘤相关肽的组合。本发明涉及可以用于引发抗肿瘤免疫应答的疫苗组合物中的来自人类肿瘤细胞的HLA I类和II类分子的30个肽序列及其变体。

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