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1. 发明授权

US09632094B2 Transcutaneous organ function measurement 有权
公开(公告)号：US09632094B2
公开(公告)日：2017-04-25
申请号：US13060260
申请日：2009-08-20
申请人： Norbert Gretz , Johannes Pill , Daniel Schock-Kusch , Thomas Walter , Jürgen Hesser , Maliha Sadick , Felix Eickemeyer , Jae Hyung Hwang , Christian Schildknecht , Soichi Watanabe , Wolfgang Wach , Thomas Rose
发明人： Norbert Gretz , Johannes Pill , Daniel Schock-Kusch , Thomas Walter , Jürgen Hesser , Maliha Sadick , Felix Eickemeyer , Jae Hyung Hwang , Christian Schildknecht , Soichi Watanabe , Wolfgang Wach , Thomas Rose
IPC分类号： A61B5/00 , G01N33/58 , A61B5/145 , A61B5/1455 , A61B5/20 , A61K49/00
CPC分类号： A61B5/201 , A61B5/0002 , A61B5/0071 , A61B5/0082 , A61B5/145 , A61B5/14546 , A61B5/1455 , A61B5/6832 , A61B5/6833 , A61B90/39 , A61B2090/3941 , A61B2560/0219 , A61B2560/0412 , A61K49/0043 , G01N33/582 , G01N2800/065 , G01N2800/28 , G01N2800/347
摘要： A sensor plaster (116) for the transcutaneous measurement of an organ function, more particularly of a kidney function, is proposed. The sensor plaster (116) comprises at least one flexible carrier element (134) having at least one adhesive surface (138) which can be stuck onto a body surface. Furthermore, the sensor plaster (116) comprises at least one radiation source, more particularly a light source (142), wherein the radiation source is designed to irradiate the body surface with at least one interrogation light (162). Furthermore, the sensor plaster (116) comprises at least one detector (146) designed to detect at least one response light (176) incident from the direction of the body surface.

2. 发明授权

US06995019B2 Fluorescent isothiocyanate (fitc) sinistrin, its production and use 失效
标题翻译：荧光异硫氰酸酯（fitc）sinistrin，其生产和使用
公开(公告)号：US06995019B2
公开(公告)日：2006-02-07
申请号：US10276025
申请日：2001-05-08
申请人： Heinz-Michael Hein , Uwe Kraemer , Rudolf Reiter , Norbert Gretz , Carsten Deus
发明人： Heinz-Michael Hein , Uwe Kraemer , Rudolf Reiter , Norbert Gretz , Carsten Deus
IPC分类号： G01N21/64
CPC分类号： A61K49/0054 , A61K49/0043 , C08B37/0051 , Y10T436/143333
摘要： The invention concerns fluorescein isothiocyanate-sinistrin (FITC-sinistrin), a method for its production, its use as a marker substance in a diagnostic agent and a corresponding diagnostic agent.
摘要翻译：本发明涉及异硫氰酸荧光素 - 西硝杆菌（FITC-sinistrin）的荧光素，其生产方法，其作为诊断剂中的标记物质和相应的诊断剂。

3. 发明申请

US20230092002A1 MEANS AND METHODS FOR VISUALIZATION OF TISSUE STRUCTURES 有权
公开(公告)号：US20230092002A1
公开(公告)日：2023-03-23
申请号：US17900526
申请日：2022-08-31
申请人： Norbert Gretz , Ruediger Rudolf , Stepfanie Weinfurter , Cinzia Brenna , Jiaguo Huang , Arif ul Maula Khan
发明人： Norbert GRETZ , Ruediger RUDOLF , Stefanie WEINFURTER , Cinzia BRENNA , Jiaguo HUANG , Arif ul Maula KHAN
IPC分类号： G01N1/30 , C08G69/08 , C08G73/02 , C09B69/10 , C09K11/07 , G01N33/50 , G01N33/52
摘要： The present invention relates to a chemical compound comprising (i) a polycationic polymer, coupled to (ii) a dye. The present invention further relates to a method for visualizing a glycosamine-containing structure in a biological sample comprising a) contacting an inner lumen of said biological sample with a dye-conjugated polycationic polymer, preferably with the chemical compound according to the present invention; b) tissue-clearing said biological sample; and, thereby, c) visualizing an internal glycosamine-containing structure in said biological sample. The present invention also relates to a method for determining the number and/or size of glomeruli in a kidney or a sample thereof making use of the method for visualizing a glycosamine-containing structure; and also relates to kits and uses related to said chemical compounds and said methods.

4. 发明申请

US20170112425A1 TRANSCUTANEOUS ORGAN FUNCTION MEASUREMENT 审中-公开
公开(公告)号：US20170112425A1
公开(公告)日：2017-04-27
申请号：US15267657
申请日：2016-09-16
申请人： Norbert Gretz
发明人： Norbert Gretz , Johannes Pill , Daniel Schock-Kusch , Thomas Walter , Jürgen Hesser , Maliha Sadick , Felix Eickemeyer , Jae Hyung Hwang , Christian Schildknecht , Soichi Watanabe , Wolfgang Wach , Thomas Rose
IPC分类号： A61B5/20 , A61B90/00 , A61B5/00 , G01N33/58 , A61K49/00
摘要： A sensor plaster (116) for the transcutaneous measurement of an organ function, more particularly of a kidney function, is proposed. The sensor plaster (116) comprises at least one flexible carrier element (134) having at least one adhesive surface (138) which can be stuck onto a body surface. Furthermore, the sensor plaster (116) comprises at least one radiation source, more particularly a light source (142), wherein the radiation source is designed to irradiate the body surface with at least one interrogation light (162). Furthermore, the sensor plaster (116) comprises at least one detector (146) designed to detect at least one response light (176) incident from the direction of the body surface.

5. 发明申请

US20150375008A1 PORTABLE ILLUMINATING DEVICE FOR MANIPULATING THE CIRCADIAN CLOCK OF A SUBJECT 审中-公开
公开(公告)号：US20150375008A1
公开(公告)日：2015-12-31
申请号：US14767998
申请日：2014-02-20
申请人： Norbert GRETZ , Yury SHULHEVICH
发明人： Norbert GRETZ , Yury SHULHEVICH
IPC分类号： A61N5/06 , H05B33/08
CPC分类号： A61N5/0618 , A61N2005/0627 , A61N2005/0647 , A61N2005/0648 , A61N2005/0651 , A61N2005/0652 , A61N2005/0653 , A61N2005/0662 , A61N2005/0666 , H05B33/0854
摘要： The present invention relates to a portable illuminating device (110) comprising at least one illuminating light source (112) emitting light of a wavelength comprised in the range of 450 to 495 nm, preferably, comprising at least one further illuminating light source (112) emitting light of a wavelength comprised in the range of 620 nm to 750 nm; a diffuser (113) scattering the light of said illuminating light source (112) at least in part in the direction of at least one eye, preferably at least one cornea and/or retina, of said subject; and a mounting mechanism (114) for fixing the portable illuminating device (110) to the body of a subject. Preferably, said diffuser (113) scatters the light of said illuminating light source (112) at least in part in the direction of at least one eye and in the direction of at least a part of the facial skin of a subject. Preferably, the portable illuminating device (110) further comprises a sensor for determining if illumination is advisable, preferably a melatonin sensor, and/or comprises an oxygen and/or pulse sensor. The present invention further relates to the portable illuminating device (110) for use in preventing and/or treating a disease or disorder caused by or associated with a distorted circadian rhythm; and to a method of improving physical and/or mental performance of a healthy subject, comprising the step of illuminating at least one cornea of said subject with light comprising light of a wavelength of 450 to 495 nm for at least 15 min, thereby improving physical and/or mental performance of a healthy subject. Preferably, the invention relates to a method of improving physical and/or mental performance of a healthy subject, comprising illuminating at least one eye and/or at least a part of the facial skin of said subject with light comprising light of a wavelength of 450 nm to 495 nm and/or illuminating said subject with light comprising light of a wavelength of 620 nm to 750 nm, thereby improving physical and/or mental performance of a healthy subject.

6. 发明申请

US20150245799A1 ADHESIVE FUNCTIONAL STRIP FOR TRANSCUTANEOUS FLUORESCENCE MEASUREMENT 有权
标题翻译：用于透明荧光测量的粘合功能条
公开(公告)号：US20150245799A1
公开(公告)日：2015-09-03
申请号：US14427889
申请日：2013-09-04
申请人： Norbert Gretz , Daniel Schock-Kusch , LOHMANN GMBH & CO. KG
发明人： Norbert Gretz , Daniel Schock-Kusch , Michael Herbertz , Ralf Nittenwilm
IPC分类号： A61B5/00 , C09J7/02 , A61B5/20 , A61B5/02 , A61B5/145 , A61B5/1455
CPC分类号： A61B5/6832 , A61B5/0071 , A61B5/02 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/201 , A61B5/4244 , A61B5/425 , A61B5/6833 , A61B2560/0285 , A61B2562/12 , C08K3/04 , C09J7/22 , C09J7/38 , C09J7/381 , C09J133/08 , C09J2201/134 , C09J2201/606 , C09J2205/102 , C09J2400/22 , C09J2421/00 , C09J2433/00 , C09J2467/006 , C09J2483/00 , C09J2483/005
摘要： The present invention pertains to a functional patch to be affixed to the skin, with the aim of measuring metabolic disruptions to organs, and general organ functions, of kidneys, liver, heart, pancreas and muscles (lactate), for example—more particularly it concerns the measurement of the glomerular filtration rate (GFR)—and also to a method for producing a functional patch of this kind.
摘要翻译：本发明涉及要贴在皮肤上的功能性贴片，其目的是测量器官的代谢紊乱以及肾脏，肝脏，心脏，胰腺和肌肉（乳酸）的一般器官功能，特别是它涉及肾小球滤过率（GFR）的测量以及生产这种功能性贴片的方法。

7. 发明申请

US20110230739A1 TRANSCUTANEOUS ORGAN FUNCTION MEASUREMENT 有权
标题翻译： TRANSCUTANEOUS ORGAN功能测量
公开(公告)号：US20110230739A1
公开(公告)日：2011-09-22
申请号：US13060260
申请日：2009-08-20
申请人： Norbert Gretz , Johannes Pill , Daniel Schock-Kusch , Thomas Walter , Jürgen Hesser , Maliha Sadick , Felix Eickemeyer , Jae Hyung Hwang , Christian Schildknecht , Soichi Watanabe , Wolfgang Wach , Thomas Rose
发明人： Norbert Gretz , Johannes Pill , Daniel Schock-Kusch , Thomas Walter , Jürgen Hesser , Maliha Sadick , Felix Eickemeyer , Jae Hyung Hwang , Christian Schildknecht , Soichi Watanabe , Wolfgang Wach , Thomas Rose
IPC分类号： A61B5/1455
CPC分类号： A61B5/201 , A61B5/0002 , A61B5/0071 , A61B5/0082 , A61B5/145 , A61B5/14546 , A61B5/1455 , A61B5/6832 , A61B5/6833 , A61B90/39 , A61B2090/3941 , A61B2560/0219 , A61B2560/0412 , A61K49/0043 , G01N33/582 , G01N2800/065 , G01N2800/28 , G01N2800/347
摘要： A sensor plaster (116) for the transcutaneous measurement of an organ function, more particularly of a kidney function, is proposed. The sensor plaster (116) comprises at least one flexible carrier element (134) having at least one adhesive surface (138) which can be stuck onto a body surface. Furthermore, the sensor plaster (116) comprises at least one radiation source, more particularly a light source (142), wherein the radiation source is designed to irradiate the body surface with at least one interrogation light (162). Furthermore, the sensor plaster (116) comprises at least one detector (146) designed to detect at least one response light (176) incident from the direction of the body surface.
摘要翻译：提出了用于经皮测量器官功能，特别是肾功能的传感器膏药（116）。传感器石膏（116）包括至少一个柔性载体元件（134），该柔性载体元件具有至少一个粘附表面（138），该粘合剂表面可粘附在体表上。此外，传感器石膏（116）包括至少一个辐射源，更具体地是光源（142），其中辐射源被设计成用至少一个询问光（162）照射身体表面。此外，传感器石膏（116）包括设计成检测从身体表面方向入射的至少一个响应光（176）的至少一个检测器（146）。

8. 发明申请

US20190353565A1 MEANS AND METHODS FOR VISUALIZATION OF TISSUE STRUCTURES 审中-公开
公开(公告)号：US20190353565A1
公开(公告)日：2019-11-21
申请号：US16465352
申请日：2017-11-30
申请人： Norbert GRETZ , Ruediger RUDOLF , Stefanie WEINFURTER , Cinzia BRENNA , Jiaguo HUANG , Arif ul Maula KHAN
发明人： Norbert GRETZ , Ruediger RUDOLF , Stefanie WEINFURTER , Cinzia BRENNA , Jiaguo HUANG , Arif ul Maula KHAN
IPC分类号： G01N1/30 , C08G69/08 , C08G73/02 , G01N33/50 , G01N33/52 , C09B69/10 , C09K11/07
摘要： The present invention relates to a chemical compound comprising (i) a polycationic polymer, coupled to (ii) a dye. The present invention further relates to a method for visualizing a glycosamine-containing structure in a biological sample comprising a) contacting an inner lumen of said biological sample with a dye-conjugated polycationic polymer, preferably with the chemical compound according to the present invention; b) tissue-clearing said biological sample; and, thereby, c) visualizing an internal glycosamine-containing structure in said biological sample. The present invention also relates to a method for determining the number and/or size of glomeruli in a kidney or a sample thereof making use of the method for visualizing a glycosamine-containing structure; and also relates to kits and uses related to said chemical compounds and said methods.

9. 发明授权

US09861315B2 Adhesive functional strip for transcutaneous fluorescence measurement 有权
公开(公告)号：US09861315B2
公开(公告)日：2018-01-09
申请号：US14427889
申请日：2013-09-04
申请人： Lohmann GmbH & Co. KG , Norbert Gretz , Daniel Schock-Kusch
发明人： Norbert Gretz , Daniel Schock-Kusch , Michael Herbertz , Ralf Nittenwilm
IPC分类号： A61B5/1455 , A61B5/00 , A61B5/20 , C09J7/02 , A61B5/02 , A61B5/145 , C08K3/04 , C09J133/08
CPC分类号： A61B5/6832 , A61B5/0071 , A61B5/02 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/201 , A61B5/4244 , A61B5/425 , A61B5/6833 , A61B2560/0285 , A61B2562/12 , C08K3/04 , C09J7/22 , C09J7/38 , C09J7/381 , C09J133/08 , C09J2201/134 , C09J2201/606 , C09J2205/102 , C09J2400/22 , C09J2421/00 , C09J2433/00 , C09J2467/006 , C09J2483/00 , C09J2483/005
摘要： The present invention pertains to a functional patch to be affixed to the skin, with the aim of measuring metabolic disruptions to organs, and general organ functions, of kidneys, liver, heart, pancreas and muscles (lactate), for example—more particularly it concerns the measurement of the glomerular filtration rate (GFR)—and also to a method for producing a functional patch of this kind.

10. 发明申请

US20120241628A1 DETECTOR FOR THE DETECTION OF IONIZING RADIATION 审中-公开
标题翻译：用于检测离子辐射的探测器
公开(公告)号：US20120241628A1
公开(公告)日：2012-09-27
申请号：US13320330
申请日：2010-05-11
申请人： Juergen Hesser , Frederik Wenz , Norbert Gretz
发明人： Juergen Hesser , Frederik Wenz , Norbert Gretz
IPC分类号： G01T1/20
CPC分类号： G01T1/2018 , A61B6/4258 , H01L27/308
摘要： The invention relates to a detector (110) for the detection of ionizing radiation (116). The detector (110) comprises at least one scintillator (112) which is adapted to convert the ionizing radiation (116) to electromagnetic radiation (118), especially to visible, ultraviolet or infrared light. The detector (110) further comprises at least one organic photovoltaic element (114) which is adapted to convert the electromagnetic radiation (118) to at least one electrical signal (120).
摘要翻译：本发明涉及用于检测电离辐射（116）的检测器（110）。检测器（110）包括至少一个闪烁器（112），其适于将电离辐射（116）转换成电磁辐射（118），特别是可见光，紫外或红外光。检测器（110）还包括至少一个有机光电元件（114），其适于将电磁辐射（118）转换成至少一个电信号（120）。

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