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1. 发明申请

US20070219177A1 AGENT FOR TREATMENT OF CEREBRAL ISCHEMIC DISEASES 失效
标题翻译：用于治疗脑缺血性疾病的药剂
公开(公告)号：US20070219177A1
公开(公告)日：2007-09-20
申请号：US11753425
申请日：2007-05-24
申请人： Kaneyoshi Honjo , Narito Tateishi , Nobuo Katsube
发明人： Kaneyoshi Honjo , Narito Tateishi , Nobuo Katsube
IPC分类号： A61K31/396
CPC分类号： A61K45/06 , A61K31/19 , A61K38/49 , A61K2300/00
摘要： A pharmaceutical composition for the treatment and/or prevention of cerebral ischemic diseases, which comprises two components, i.e. an astrocyte function-improving agent, preferably a compound represented by the formula (I): (wherein R6 is hydroxy, etc., (1) n is 1, R11 is hydrogen and R5 is (alkyl of which one carbon atom is substituted by fluorine)-CH2— or (2) n is 0 or 1, R11 is hydrogen, etc., and R5 is alkyl, etc.) and a thrombolytic agent, preferably tissue plasminogen activator, as active ingredients. The pharmaceutical composition of the present invention exhibits a synergistic therapeutic effect compared to independent administration of an astrocyte function-improving agent and a thrombolytic agent.
摘要翻译：一种用于治疗和/或预防脑缺血疾病的药物组合物，其包含两种组分，即星形胶质细胞功能改善剂，优选由式（I）表示的化合物：（其中R 6，是羟基等，（1）n是1，R 11是氢，R 5是（其中一个碳原子被氟取代的烷基）-CH （2）n为0或1，R 11为氢等，R 5为烷基等）和血栓溶解剂，优选组织纤溶酶原激活剂，作为活性成分。与独立施用星形胶质细胞功能改善剂和血栓溶解剂相比，本发明的药物组合物显示出协同的治疗效果。

2. 发明申请

US20060122275A1 Agentfor reducing side effects of diclofenac 审中-公开
标题翻译：用于减少双氯芬酸副作用的药剂
公开(公告)号：US20060122275A1
公开(公告)日：2006-06-08
申请号：US10524857
申请日：2003-08-21
申请人： Yoshiki Sakai , Nobuo Katsube , Akio Nishiura , Masanobu Yamamoto , Ken-ichi Sugishita
发明人： Yoshiki Sakai , Nobuo Katsube , Akio Nishiura , Masanobu Yamamoto , Ken-ichi Sugishita
IPC分类号： A61K31/557 , A61K31/195 , A61K31/192
CPC分类号： A61K31/215 , A61K9/4808 , A61K31/196 , A61K31/216 , A61K31/5575 , A61K45/06 , A61K2300/00
摘要： The present invention relates to reduction of side effects of diclofenac or a salt thereof An agent for reducing side effects of diclofenac or a salt thereof which comprises ornoprostil. It is expected that a combination agent of diclofenac or a non-toxic salt thereof and ornoprostil is comparable to even superior to marketed diclofenac tablets or Arthrotec tables in effects and fast-acting property while showing little side effects (particularly digestive disorders, gastric ulcer, diarrhea/vomiting and renal disorder) and exerting excellent antipyretic, analgesic and antiinlfammatory effects. Also, by formulating the combination agent into a preparation of separation type pharmaceutical preparation, the stability of ornoprostil can be improved.
摘要翻译：本发明涉及降低双氯芬酸或其盐的副作用。本发明涉及降低双氯芬酸或其盐的副作用的药剂，其包含鸟苷前列腺素。预期双氯芬酸或其无毒盐和奥罗前列素的组合剂与甚至优于市售的双氯芬酸片剂或Arthrotec的效果和速效性能相当，但几乎没有副作用（特别是消化系统疾病，胃溃疡，腹泻/呕吐和肾脏疾病），并具有优异的解热，镇痛和抗炎作用。此外，通过将组合剂配制成分离型药物制剂的制剂，可以提高奥斯匹林的稳定性。

3. 发明授权

US06555555B1 Fused thiophone derivatives and drugs containing the same as the active ingredient 失效
公开(公告)号：US06555555B1
公开(公告)日：2003-04-29
申请号：US10127409
申请日：2002-04-23
申请人： Mikio Konishi , Nobuo Katsube , Mitoshi Konno , Tadamitsu Kishimoto
发明人： Mikio Konishi , Nobuo Katsube , Mitoshi Konno , Tadamitsu Kishimoto
IPC分类号： A61K31445
CPC分类号： C07D333/62 , C07D231/12 , C07D233/56 , C07D249/08 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D417/12 , C07D495/04
摘要： The present invention relates to a fused thiophene derivative of the formula (I) (wherein all the symbols are defined as described in the specification) and an inhibitor of producing interleukin-6 and/or interleukin-12 comprising the said derivative as an active ingredient. A fused thiophene derivative of the formula (I) is useful as an agent for the prevention and/or treatment of various inflammatory diseases, sepsis, multiple myeloma, plasma cell leukemia, osteoporosis, cachexia, psoriasis, nephritis, renal cell carcinoma, Kaposi's sarcoma, rheumatoid arthritis, gammopathy, Castleman's disease, atrial myxoma, diabetes mellitus, autoimmune diseases, hepatitis, multiple sclerosis, colitis, graft versus host immune diseases, infectious diseases.

4. 发明授权

US06521743B1 Antibody against glyceraldehyde-3-phosphate dehydrogenase and use thereof 失效
标题翻译：抗甘油醛-3-磷酸脱氢酶的抗体及其用途
公开(公告)号：US06521743B1
公开(公告)日：2003-02-18
申请号：US09807386
申请日：2001-04-12
申请人： Ryoichi Ishitani , Nobuo Katsube
发明人： Ryoichi Ishitani , Nobuo Katsube
IPC分类号： C07K1640
CPC分类号： C07K16/40 , A61K2039/505
摘要： A novel monoclonal antibody against glyceraldehyde-3-phosphate dehydrogenase (GAPDH), its use and a hybridoma strain NCK-J24 which produces the antibody. Since the monoclonal antibody produced by the hybridoma of the present invention recognizes GAPDH selectively and strongly, it can be used in screening and diagnosis of an apoptosis-concerning protein and prevention and/or treatment of neurodegenerative diseases (Alzheimer's disease, Parkinson's disease, Parkinson's syndrome, Huntington's disease, Machado-Joseph's disease, amyotrophic lateral sclerosis, Creutzfeldt-Jacob's disease and the like) and GAPDH-concerning diseases (motor dysfunction and the like caused by spinal cord injury, spinal cord compression, cerebral ischemia, peripheral nerve injury and the like).
摘要翻译：一种抗甘油醛-3-磷酸脱氢酶（GAPDH）的新型单克隆抗体及其使用和产生该抗体的杂交瘤菌株NCK-J24。由于本发明的杂交瘤产生的单克隆抗体选择性和强烈地识别GAPDH，因此可以用于筛选和诊断凋亡相关蛋白，以及预防和/或治疗神经变性疾病（阿尔茨海默氏病，帕金森氏病，帕金森综合征，亨廷顿病，马查多 - 约瑟夫病，肌萎缩性侧索硬化，克雅氏综合征等）和GAPDH相关疾病（由脊髓损伤，脊髓压迫，脑缺血，周围神经损伤等引起的运动功能障碍等）。

5. 发明授权

US06348488B1 Remedies for motor dysfunction and GAPDH expression inhibitors 失效
标题翻译：运动功能障碍和GAPDH表达抑制剂的补救措施
公开(公告)号：US06348488B1
公开(公告)日：2002-02-19
申请号：US09806572
申请日：2001-04-02
申请人： Ryoichi Ishitani , Nobuo Katsube
发明人： Ryoichi Ishitani , Nobuo Katsube
IPC分类号： A61K3140
CPC分类号： A61K31/401 , A61K31/40
摘要： Remedies for motor dysfunction and GAPDH expression inhibitors containing as the active ingredient N-[3-[N-(4-chlorophenylmethyl)carbamoyl]propanoyl]-L-prolinal. Since it has an effect of ameliorating motor dysfunction, N-[3-[N-(4-chlorophenylmethyl)carbamoyl]propanoyl]-L-prolinal is useful in treating motor dysfunction caused by trauma, infection, degeneration, ischemia, tumor, etc. Also, it is useful in treating diseases caused by apoptosis in the cerebellum, spinal nerve nucleus or conduction route due to the overexpression of GAPDH (Parkinson's diseases, Parkinson's syndrome, Huntington's disease, MJD, ALS, CHJ diseases, etc.).
摘要翻译：运动功能障碍的补救措施和含有作为活性成分的N- [3- [N-（4-氯苯基甲基）氨基甲酰基]丙酰基] -L-脯氨酸的GAPDH表达抑制剂。由于其具有改善运动功能障碍的作用，N- [3- [N-（4-氯苯基甲基）氨基甲酰基]丙酰基] -L-脯氨酸可用于治疗由创伤，感染，变性，缺血，肿瘤等引起的运动功能障碍另外，由于GAPDH（帕金森病，帕金森综合征，亨廷顿病，MJD，ALS，CHJ疾病等）的过度表达，可以治疗由小脑，脊髓神经核或传导途径引起的细胞凋亡的疾病。

6. 发明授权

US07687489B2 Agent for treatment of cerebral ischemic diseases 失效
标题翻译：用于治疗脑缺血性疾病的药剂
公开(公告)号：US07687489B2
公开(公告)日：2010-03-30
申请号：US11753425
申请日：2007-05-24
申请人： Kaneyoshi Honjo , Narito Tateishi , Nobuo Katsube
发明人： Kaneyoshi Honjo , Narito Tateishi , Nobuo Katsube
IPC分类号： A61K31/397 , A61K31/20 , A61K31/445 , A61K31/195 , A61K31/40
CPC分类号： A61K45/06 , A61K31/19 , A61K38/49 , A61K2300/00
摘要： A pharmaceutical composition for the treatment and/or prevention of cerebral ischemic diseases, which comprises two components, i.e. an astrocyte function-improving agent, preferably a compound represented by the formula (I): (wherein R6 is hydroxy, etc., (1) n is 1, R11 is hydrogen and R5 is (alkyl of which one carbon atom is substituted by fluorine)-CH2— or (2) n is 0 or 1, R11 is hydrogen, etc., and R5 is alkyl, etc.) and a thrombolytic agent, preferably tissue plasminogen activator, as active ingredients. The pharmaceutical composition of the present invention exhibits a synergistic therapeutic effect compared to independent administration of an astrocyte function-improving agent and a thrombolytic agent.
摘要翻译：用于治疗和/或预防脑缺血疾病的药物组合物，其包含两种组分，即星形胶质细胞功能改善剂，优选由式（I）表示的化合物：（其中R 6为羟基等，（1 ）n为1，R11为氢，R5为（其中一个碳原子被氟取代的烷基）-CH2-或（2）n为0或1，R11为氢等，R5为烷基等。）和溶栓剂，优选组织纤溶酶原激活剂作为活性成分。与独立施用星形胶质细胞功能改善剂和血栓溶解剂相比，本发明的药物组合物显示出协同的治疗效果。

7. 发明授权

US06420391B1 Fused thiophone derivatives and drugs containing the same as the active ingredient 失效
标题翻译：熔化的噻吩衍生物和含有与活性成分相同的药物
公开(公告)号：US06420391B1
公开(公告)日：2002-07-16
申请号：US09647430
申请日：2000-10-02
申请人： Mikio Konishi , Nobuo Katsube , Mitoshi Konno , Tadamitsu Kishimoto
发明人： Mikio Konishi , Nobuo Katsube , Mitoshi Konno , Tadamitsu Kishimoto
IPC分类号： A61K31445
CPC分类号： C07D333/62 , C07D231/12 , C07D233/56 , C07D249/08 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D417/12 , C07D495/04
摘要： The present invention relates to a fused thiophene derivative of the formula (I) (wherein all the symbols are defined as described in the specification) and an inhibitor of producing interleukin-6 and/or interleukin-12 comprising the said derivative as an active ingredient. A fused thiophene derivative of the formula (I) is useful as an agent for the prevention and/or treatment of various inflammatory diseases, sepsis, multiple myeloma, plasma cell leukemia, osteoporosis, cachexia, psoriasis, nephritis, renal cell carcinoma, Kaposi's sarcoma, rheumatoid arthritis, gammopathy, Castleman's disease, atrial myxoma, diabetes mellitus, autoimmune diseases, hepatitis, multiple sclerosis, colitis, graft versus host immune diseases, infectious diseases.
摘要翻译：本发明涉及式（I）的稠合噻吩衍生物（其中全部符号如本说明书所述定义）和产生白细胞介素-6和/或白介素-12的抑制剂，其包含所述衍生物作为活性成分式（I）的稠合噻吩衍生物可用作预防和/或治疗各种炎性疾病，败血症，多发性骨髓瘤，浆细胞白血病，骨质疏松症，恶病质，牛皮癣，肾炎，肾细胞癌，卡波西氏病肉瘤，类风湿关节炎，丙种球蛋白病，卡斯尔曼氏病，心房粘液瘤，糖尿病，自身免疫疾病，肝炎，多发性硬化，结肠炎，移植物抗宿主免疫疾病，传染病。

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