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1. 发明申请

US20100312324A1 IMPLANTATION DEVICE FOR STENTS WITH A FUNCTIONALLY STRUCTURED SURFACE 审中-公开
标题翻译：具有功能结构化表面的椎弓根植入装置
公开(公告)号：US20100312324A1
公开(公告)日：2010-12-09
申请号：US12774931
申请日：2010-05-06
申请人： Nina Adden , Bettina Surber
发明人： Nina Adden , Bettina Surber
IPC分类号： A61F2/84
CPC分类号： A61F2/958 , A61F2002/9583 , A61M25/10 , A61M25/104
摘要： The invention relates to an implantation device for stents, which device has hair-like extensions on at least one part of the outwardly-facing surface of that section of the device, which section is provided to attach or crimp on the stent to be implanted, wherein the mean diameter D, the mean length L, and the averaged center-to-center distance P of the hair-like extensions relative to each other are selected such that a stent is affixable on the surface covered with hair-like extensions essentially by means of van der Waals forces.
摘要翻译：本发明涉及一种用于支架的植入装置，该装置在装置的该部分的面向外的表面的至少一部分上具有头发状的延伸部，该部分设置成附着或卷曲在待植入的支架上，其中选择毛发状延伸部相对于彼此的平均直径D，平均长度L和平均的中心到中心距离P，使得支架基本上由主要由毛发状延伸部覆盖的表面上固定范德华力的手段。

2. 发明申请

US20100023116A1 BIOCORRODIBLE IMPLANT WITH A COATING CONTAINING A DRUG ELUTING POLYMER MATRIX 审中-公开
标题翻译：含有药物涂布聚合物基质的涂层的生物可蚀性植入物
公开(公告)号：US20100023116A1
公开(公告)日：2010-01-28
申请号：US12509831
申请日：2009-07-27
申请人： Alexander Borck , Nina Adden
发明人： Alexander Borck , Nina Adden
IPC分类号： A61F2/06
CPC分类号： A61L31/022 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/00
摘要： The invention relates to an implant having a base body, consisting completely or partially of a biocorrodible metallic material, such that it decomposes in an aqueous environment to form an alkaline product, and the base body has a coating or a cavity filling, comprising a polymer matrix and at least one drug embedded in the polymer matrix, characterized in that at least one polymer of the matrix and the at least one drug are coordinated so that the drug elution rate from the matrix is increased with an increase in pH.
摘要翻译：本发明涉及具有基体的植入体，其完全或部分地由生物可腐蚀的金属材料组成，使得其在水性环境中分解以形成碱性产品，并且基体具有涂层或空腔填充物，其包含聚合物基质和包埋在聚合物基质中的至少一种药物，其特征在于，基质和至少一种药物的至少一种聚合物被配位，使得来自基质的药物洗脱速率随着pH的增加而增加。

3. 发明申请

US20090076596A1 STENT HAVING A COATING 审中-公开
标题翻译：具有涂层
公开(公告)号：US20090076596A1
公开(公告)日：2009-03-19
申请号：US12208808
申请日：2008-09-11
申请人： Nina Adden , Alexander Borck
发明人： Nina Adden , Alexander Borck
IPC分类号： A61F2/06
CPC分类号： A61L31/16 , A61L31/10
摘要： A stent having a coating comprising either L-3,4-dihydroxyphenylalanine (L-DOPA) or a derivative of L-3,4-dihydroxyphenylalanine (L-DOPA), the foregoing obtained by either ionic or covalent bonding of a pharmaceutical active ingredient to either the amino or the acid function of L-3,4-dihydroxyphenylalanine (L-DOPA).
摘要翻译：具有包含L-3,4-二羟基苯丙氨酸（L-DOPA）或L-3,4-二羟基苯丙氨酸（L-DOPA）衍生物的包衣的支架，其通过离子或共价键合药物活性成分为L-3,4-二羟基苯丙氨酸（L-DOPA）的氨基或酸的功能。

4. 发明申请

US20080215140A1 STENTS COATED WITH BIOMOLECULES AND PROCESS FOR THEIR PRODUCTION 审中-公开
标题翻译：用生物分子和其生产方法涂覆的手套
公开(公告)号：US20080215140A1
公开(公告)日：2008-09-04
申请号：US12018295
申请日：2008-01-23
申请人： Alexander Borck , Nina Adden
发明人： Alexander Borck , Nina Adden
IPC分类号： A61F2/82 , A61L33/04 , A61K47/24
CPC分类号： A61L31/16 , A61L2300/00 , A61L2300/80
摘要： A stent comprising a basic stent body, at least one anchor group on the surface of the basic stent body, and at least one biomolecule which is bound to the at least one anchor group, the anchor group being the same or different and selected from the group of compounds with the general formula (I) (R2O)2(O)P-L-(CH2)x-M-R1 (I) in which R1 represents —COOH, —OH, —SH, —NH2, benzophenone or benzophenone derivatives, R2 represents hydrogen, —CH2CH3 or —CH3, L represents a single bond or —O—, M represents a single bond or —(CH2—CH2—O)y, x represents an integer from 1 to 25, y represents an integer from 1 to 25 and the biomolecule or biomolecules are selected as the same or different from the group consisting of compounds which promote the attachment of the endothelial progenitor cells to the stent surface.
摘要翻译：一种支架，其包括基本支架主体，所述基本支架主体的表面上的至少一个锚定组以及与所述至少一个锚定基团结合的至少一个生物分子，所述锚定基团相同或不同，并且选自一组具有通式（I）的化合物<？in-line-formula description =“In-line Formulas”end =“lead”？>（R 2 O 2）（O）PL-（CH 2 2）x -MR 1（I）<？in-line-formula description =“In 其中R 1表示-COOH，-OH，-SH，-NH 2，二苯甲酮或二苯甲酮衍生物的式“末端=”尾“ SUP> 2表示氢，-CH 2 CH 3或-CH 3，L表示单键或-O- ，M表示单键或 - （CH 2 CH 2 -CH 2 -O）y X，x表示1〜25的整数，y表示表示1至25的整数，并且生物分子或生物分子选自与化合物组合相同或不同的化合物促进内皮祖细胞与支架表面的连接。

5. 发明申请

US20100131052A1 METHOD FOR PRODUCING A CORROSION-INHIBITING COATING ON AN IMPLANT MADE OF A BIOCORRODIBLE MAGNESIUM ALLOY AND IMPLANT PRODUCED ACCORDING TO THE METHOD 审中-公开
标题翻译：用于生产可生物降解的镁合金和根据该方法生产的植入物的植入物的腐蚀抑制涂层的方法
公开(公告)号：US20100131052A1
公开(公告)日：2010-05-27
申请号：US12614020
申请日：2009-11-06
申请人： Gerhard Kappelt , Peter Kurze , Dora Banerjee , Nina Adden
发明人： Gerhard Kappelt , Peter Kurze , Dora Banerjee , Nina Adden
IPC分类号： A61F2/82
CPC分类号： A61L31/086 , A61L31/022 , A61L31/088 , A61L31/148 , C25D11/026 , C25D11/30
摘要： The invention relates to a method for producing corrosion-inhibiting coatings on an implant made of a biocorrodible magnesium alloy and to implants obtained or obtainable according to the method.
摘要翻译：本发明涉及一种在由生物可腐蚀镁合金制成的植入物上制备抗腐蚀涂层的方法以及根据该方法获得或可获得的植入物。

6. 发明申请

US20100249900A1 Drug eluting medical implant with porous surface 审中-公开
标题翻译：药物洗脱医学植入物与多孔表面
公开(公告)号：US20100249900A1
公开(公告)日：2010-09-30
申请号：US12730472
申请日：2010-03-24
申请人： Laura Sager , Bjoern Klocke , Heinz Mueller , Nina Adden , Gerhard Kappelt
发明人： Laura Sager , Bjoern Klocke , Heinz Mueller , Nina Adden , Gerhard Kappelt
IPC分类号： A61F2/82
CPC分类号： A61L31/022 , A61L31/086 , A61L31/146
摘要： An implant is proposed, in particular made from a base material including a biodegradable metal and/or a biodegradable metal alloy, wherein the implant includes a coating made of crystalline calcium phosphate and/or amorphous calcium phosphate.
摘要翻译：提出了植入物，特别是由包括可生物降解的金属和/或可生物降解的金属合金的基材制成，其中植入物包括由结晶磷酸钙和/或无定形磷酸钙制成的涂层。

7. 发明申请

US20090270979A1 BIODEGRADABLE METALLIC STENT 审中-公开
标题翻译：生物可降解金属支架
公开(公告)号：US20090270979A1
公开(公告)日：2009-10-29
申请号：US12429898
申请日：2009-04-24
申请人： Nina Adden
发明人： Nina Adden
IPC分类号： A61F2/06
CPC分类号： A61L31/022 , A61L31/10 , A61L31/148
摘要： A biodegradable metal stent having delayed degradation after implantation, the stent comprising a stent material coated with at least one wax material, Also provided is a method for manufacturing and use of such a stent.
摘要翻译：一种生物降解金属支架，其在植入后具有延迟降解，所述支架包括涂覆有至少一种蜡材料的支架材料。还提供了制造和使用这种支架的方法。

8. 发明申请

US20090048660A1 IMPLANT OF A BIOCORRODABLE MAGNESIUM ALLOY AND HAVING A COATING OF A BIOCORRODABLE POLYPHOSPHAZENE 审中-公开
标题翻译：生物可降解镁合金的植入物，并具有生物可降解的聚磷酸酯的涂层
公开(公告)号：US20090048660A1
公开(公告)日：2009-02-19
申请号：US12192729
申请日：2008-08-15
申请人： Nina Adden
发明人： Nina Adden
IPC分类号： A61F2/06 , A61F2/02
CPC分类号： A61L31/022 , A61L31/10 , A61L31/148 , C08L43/02
摘要： An implant of a biocorrodable metallic material comprising a coating having a biocorrodable polyphosphazene.
摘要翻译：生物可蚀性金属材料的植入物，其包含具有生物可蚀性聚磷腈的涂层。

9. 发明授权

US10786657B2 Structured drug-eluting balloon catheter 有权
公开(公告)号：US10786657B2
公开(公告)日：2020-09-29
申请号：US12774894
申请日：2010-05-06
申请人： Nina Adden , Bettina Surber
发明人： Nina Adden , Bettina Surber
IPC分类号： A61M25/10
摘要： The invention relates to a balloon catheter featuring—at least on portions of the outward-turned surface of the dilatable area—hair-like extensions, with the average diameter D, the average length L, and the average center-to-center distance P of the hair-like extensions to each other being selected such that a drug on the balloon surface covered with hair-like extensions can essentially be secured by means of capillary forces.

10. 发明申请

US20100312182A1 STRUCTURED DRUG-ELUTING BALLOON CATHETER 审中-公开
标题翻译：结构化药液气囊导管
公开(公告)号：US20100312182A1
公开(公告)日：2010-12-09
申请号：US12774894
申请日：2010-05-06
申请人： Nina Adden , Bettina Surber
发明人： Nina Adden , Bettina Surber
IPC分类号： A61L31/16 , A61M25/10 , B05D7/00
摘要： The invention relates to a balloon catheter featuring—at least on portions of the outward-turned surface of the dilatable area—hair-like extensions, with the average diameter D, the average length L, and the average center-to-center distance P of the hair-like extensions to each other being selected such that a drug on the balloon surface covered with hair-like extensions can essentially be secured by means of capillary forces.
摘要翻译：本发明涉及一种球囊导管，其特征在于至少在可扩张区域的头发状延伸部的向外转动表面的一部分上具有平均直径D，平均长度L和平均中心至中心距离P 的毛发状延伸部被选择成使得覆盖有毛发状延伸部的气球表面上的药物基本上可以通过毛细管力来固定。

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