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1. 发明授权

US4115545A Pharmaceutical composition containing prostadienoic acid for regulating gastric secretion 失效
标题翻译：含有前列腺素的药物组合物用于调节胃分泌
公开(公告)号：US4115545A
公开(公告)日：1978-09-19
申请号：US823811
申请日：1977-08-11
申请人： Ned M. Weinshenker , Niels H. Anderson
发明人： Ned M. Weinshenker , Niels H. Anderson
IPC分类号： C07C405/00 , C07D307/935 , A61K31/22 , A61K31/19 , A61L9/04
CPC分类号： C07D307/935 , C07C405/00 , C07C405/0041
摘要： Novel alkyl diethers of prostaglandins of the formula; ##STR1## wherein R.sub.1 is hydrogen or lower alkyl; R.sub.2 and R.sub.6 are hydrogen when Y is a single bond and R.sub.2 and R.sub.6 are absent when Y is a double bond; R.sub.3 is keto, ##STR2## R'.sub.9 is hydrogen or lower alkyl; R'.sub.10 is lower alkyl; R'.sub.11 is lower alkyl; Z.sub.1 is cis or trans --CH.dbd.CH-- or --CH.sub.2 CH.sub.2 --; Z.sub.2 is trans --CH.dbd.CH-- or --CH.sub.2 CH.sub.2 --; X is a single bond or a double bond and X is a single bond when R.sub.4 and R.sub.5 are hydrogen; Y is a single bond or a double bond; n is 1 to 5, m is 0 to 4; and the non-toxic salts. The prostaglandin ethers possess valuable pharmacological properties as modifiers of smooth muscle activity, gastric secretion, blood pressure, lipolysis and the reproductive system. The compounds also induce labor and menses and they can be used for the relief of asthma and nasal congestion. The compounds are also useful as platelet anti-clumping agents and for the inhibition of peptic ulcers.
摘要翻译：式中前列腺素的新型烷基二醚; 其中R1是氢或低级烷基; 当Y是单键时，R2和R6是氢，当Y是双键时R2和R6不存在; R3是酮基，R'9是氢或低级烷基; R'10是低级烷基; R11为低级烷基; Z 1是顺式或反式-CH = CH-或-CH 2 CH 2 - ; Z2是反式-CH = CH-或-CH2CH2-; X是单键或双键，当R4和R5是氢时X是单键; Y是单键或双键; n为1〜5，m为0〜4; 和无毒盐。前列腺素醚具有作为平滑肌活动，胃分泌，血压，脂肪分解和生殖系统改性剂的有价值的药理学性质。这些化合物还可以诱发劳动和月经，并可用于缓解哮喘和鼻塞。该化合物也可用作血小板抗凝块剂和抑制消化性溃疡。

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